Browsing by Author "Aydin H."
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Item A whole genome screen for linkage in Turkish multiple sclerosis(Elsevier, 2003) Eraksoy M.; Kurtuncu M.; Akman-Demir G.; Kilinc M.; Gedizlioglu M.; Mirza M.; Anlar Ö.; Kutlu C.; Demirkiran M.; Idrisoglu H.A.; Compston A.; Sawcer S.; Tombul T.; Asker Ö.; Balkan S.; Seçkin D.; Aydin H.; Akman-Demir G.; Kiyat A.; Yapici Z.; Epçeliden T.; Çe P.; Goldenberg E.; Gültiken B.; Güvenç A.; Işik N.; Seleker T.; Idiman E.; Özakbaş S.; Irkeç C.; Nazlier B.; Forta H.; Seleker F.; Güner K.; Karabudak R.; Kilinç M.; Komsuoǧlu S.; Efendi H.; Mert M.; Mirza M.; Erdoǧan F.; Müngen B.; Bulut S.; Özer F.; Yayla V.; Petek-Balci B.; Saǧduyu A.; Sarica Y.; Demirkiran M.; Selçuki D.; Mavioǧlu H.; Siva A.; Altintaş A.; Saip S.; Sütlaş N.; Kuşçu Yandim D.; Tireli H.; Özalp K.; Türkoǧlu R.; Örken C.; Özmanoǧlu M.; Velioǧlu S.; Özdemir G.; Gücüyener D.; Özkan S.; Tunali G.; Turan F.; Utku U.; Turgut N.; Ümit S.; Us Ö.; Ince Günal D.; Ütkür Y.; Aluçlu U.; Yavaşoǧlu Ö.; Yücemen N.; Yücesan C.; Zadikoǧlu A.; Zorlu Y.Factors exerting recessive effects on susceptibility to complex traits are expected to be over-represented in communities having a higher frequency of consanguineous marriage. Multiple sclerosis, a typical complex trait, is relatively common in Turkey where cultural factors also determine a high rate of consanguineous marriage. Previous genetic studies of multiple sclerosis in Turkey have been confined to the search for associations with candidate genes. In order to exploit the special genetic features of the Turkish population, we performed a whole genome screen for linkage in 43 Turkish multiplex families employing 392 microsatellite markers. Two genomic regions where maximum lod score (MLS) values were suggestive of linkage were identified (chromosomes 13q and 18q23) along with a further 14 regions of potential linkage. Parametric analysis of these data using a recessive model, appropriate for populations with a high frequency of consanguinity, increased the LOD scores in four regions. © 2003 Elsevier B.V. All rights reserved.Item Poisonous plants distributed naturally in Turkey(2005) Dogan Y.; Baslar S.; Ay G.; Aydin H.; Yorek N.; Mert H.H.From the flora point of view, Turkey is the richest country in Europe and the Middle East, with more than 10 000 vascular plant taxa, and more than 3000 of which are endemics. Therefore, poisonous plant taxa distributing in Turkey is expected to be higher. In this study, the poisonous natural plant taxa distributed in Turkey are identified and given in the table. Results of this study show that 2359 plant species belonging to 97 families are identified as poisonous in Turkey. The families with the highest number of poisonous plant species are identified as Fabaceae (571), Liliaceae (243), Ranunculaceae (140) and Asteraceae (126). Families with the highest number of poisonous genera are Fabaceae (15), Asteraceae (14), Liliaceae (14) and Ranunculaceae (11). Among the determined genera, all the members of 90 genera are poisonous. Among these genera, the top three numbers of poisonous species are Astragalus (347), Verbascum (220) and Allium (141).Item Dinoflagellate cyst assemblages in the surface sediments from Izmir bay, Aegean sea, Eastern Mediterranean(2010) Uzar S.; Aydin H.; Minareci E.The present study was conducted on dinoflagellate cyst assemblages from Izmir Bay, Aegean Sea subject to high human impact. Sediment cores were taken from twelve stations. Twenty-eight dinoflagellate cyst types, representing nine genera, were identified. The most common cysts were those of Lingulodinium machaerophorum, Polykrikos kofoidii, Quinquecuspis concreta and Dubridinium caperatum. Potentially toxic species were widely distributed in the study area. This finding is also important to know the seed-bank areas in the Bay of Izmir. © 2010 Academic Journals.Item Distribution of dinoflagellate cysts in recent sediments from Izmir Bay (Aegean Sea, Eastern Mediterranean)(2011) Aydin H.; Matsuoka K.; Minareci E.To determine the species composition, abundance and horizontal distribution of dinoflagellate cysts in recent marine sediments, samples were collected at 13 stations in Izmir Bay, Aegean Sea. At least thirty-six dinoflagellate cyst types were identified, with the assemblages mainly dominated by Lingulodinium machaerophorum, Polykrikos kofoidii, Operculodinium centrocarpum, Gymnodinium cf. nolleri and Quinquecuspis concreta. Total cyst concentrations ranged from 41 to 3292cystsg-1 dry weight sediment. The majority of the cysts occurred in the inner and middle parts of the bay, where higher cyst concentrations were observed. According to the One Way Anova test, the difference between stations was significant statistically (p<0.05). Two of the dinoflagellate cyst species have not been recorded previously as cysts or motile stages in Aegean marine waters; Gymnodinium cf. nolleri and Oblea acanthocysta. Alexandrium minutum and Alexandrium affine type cyst were observed at almost all stations although the cyst type of the Alexandrium catenella/tamarense complex was only found in the outer bay. These findings indicate potential seedbeds for initiation of future blooms and outbreaks of potentially toxic species in Izmir Bay. © 2011 Elsevier B.V.Item Etiology of hypopituitarism in tertiary care institutions in Turkish population: Analysis of 773 patients from pituitary study group database(Humana Press Inc., 2014) Tanriverdi F.; Dokmetas H.S.; Kebapci N.; Kilicli F.; Atmaca H.; Yarman S.; Ertorer M.E.; Erturk E.; Bayram F.; Tugrul A.; Culha C.; Cakir M.; Mert M.; Aydin H.; Taskale M.; Ersoz N.; Canturk Z.; Anaforoglu I.; Ozkaya M.; Oruk G.; Hekimsoy Z.; Kelestimur F.; Erbas T.Hypopituitarism in adult life is commonly acquired and the main causes are known as pituitary tumors and/or their treatments. Since there are new insights into the etiology of hypopituitarism and presence of differences in various populations, more studies regarding causes of hypopituitarism are needed to be done in different ethnic groups with sufficient number of patients. Therefore, we performed a multi-center database study in Turkish population investigating the etiology of hypopituitarism in 773 patients in tertiary care institutions. The study was designed and coordinated by the Pituitary Study Group of SEMT (The Society of Endocrinology and Metabolism of Turkey). Nineteen tertiary reference centers (14 university hospitals and 5 training hospitals) from the different regions of Turkey participated in the study. It is a cross-sectional database study, and the data were recorded for 18 months. We mainly classified the causes of hypopituitarism as pituitary tumors (due to direct effects of the pituitary tumors and/or their treatments), extra-pituitary tumors and non-tumoral causes. Mean age of 773 patients (49.8 % male, 50.2 % female) was 43.9 ± 16.1 years (range 16-84 years). The most common etiology of pituitary dysfunction was due to non-tumoral causes (49.2 %) among all patients. However, when we analyze the causes according to gender, the most common etiology in males was pituitary tumors, but the most common etiology in females was non-tumoral causes. According to the subgroup analysis of the causes of hypopituitarism in all patients, the most common four causes of hypopituitarism which have frequencies over 10 % were as follows: non-secretory pituitary adenomas, Sheehan's syndrome, lactotroph adenomas and idiopathic. With regard to the type of hormonal deficiencies; FSH/LH deficiency was the most common hormonal deficit (84.9 % of the patients). In 33.8 % of the patients, 4 anterior pituitary hormone deficiencies (FSH/LH, ACTH, TSH, and GH) were present. Among all patients, the most frequent cause of hypopituitarism was non-secretory pituitary adenomas. However, in female patients, present study clearly demonstrates that Sheehan's syndrome is still one of the most important causes of hypopituitarism in Turkish population. Further, population-based prospective studies need to be done to understand the prevalence and incidence of the causes of hypopituitarism in different countries. © 2013 Springer Science+Business Media.Item Distribution and abundance of modern dinoflagellate cysts from Marmara, Aegean and Eastern Seas of Turkey(Triveni Enterprises, 2014) Aydin H.; Uzar S.Twenty-one surface sediment samples were collected from coastal areas of Turkey to determine horizontal distribution and abundance of the cysts. A total of 40 dinoflagellate cyst types were identified and recorded in the range of 34 and 31532 cyst g-1 d.wt. in the sediments. The concentration of Lingulodinium machaerophorum, Polykrikos kofoidii, Quinquecuspis concreta, Dubridinium caperatum and Spiniferites bulloideus cysts dominated over other species. Although cysts of potentially toxic species of Alexandrium affine type and A. catenella/tamarense complex were found only in Izmir Bay. A. minutum type, Lingulodinium machaerophorum and Operculodinium centrocarpum were observed in the surface sediments of Marmara Sea and Fethiye Bay. The present study provides a database on the distribution and composition of dinoflagellate cysts in the Eastern Mediterranean sea coastal waters of Turkey where modern dinoflagellate cysts have been little studied. © Triveni Enterprises, Lucknow (India).Item Dinoflagellate cyst assemblages in surface sediments from Homa Lagoon (Izmir Bay, eastern Aegean Sea, the Mediterranean)(Parlar Scientific Publications, 2014) Aydin H.; Yürür E.E.; Uzar S.The occurrence and abundance of dinoflagellate cysts was investigated for the first time in Homa Lagoon, one of the most important lagoons of Aegean Coast of Turkey. Twelve cyst morphotypes were identified and cyst abundance was ranged between 15 and 71 cyst g-1 dry weight sediment in the study area. Dinoflagellate cyst assemblages were mainly dominated by cyst of Alexandrium minutum, Spiniferites delicatus, Spiniferites bulloideus. Sediment types were mainly clay and silty sand. Dinoflagellate cysts were particularly distributed in the clay and silty sediment. © by PSP.Item Relationship between the dinoflagellate cyst Spiniferites pachydermus and Gonyaulax ellegaardiae sp. nov. from Izmir Bay, Turkey, and molecular characterization(2015) Mertens K.N.; Aydin H.; Uzar S.; Takano Y.; Yamaguchi A.; Matsuoka K.Here, we established the cyst-motile stage relation-ship for Spiniferites pachydermus through incubation of cysts with a characteristically microreticulate/perforate surface isolated from Izmir Bay in the eastern Aegean Sea of the eastern Mediterranean. The morphology of the motile stage was similar to Gonyaulax spinifera but had a different size, overhang, displacement and reticulations. Based on the distinct morphology of the cyst and morphological differences in motile cells, we assigned S. pachydermus from Izmir Bay to the new species Gonyaulax ellegaardiae. We elucidate the phylogenetic relationship of G. ellegaardiae through large and small subunit ribosomal DNA and show that it forms a clade with other species that belong to the G. spinifera complex. © 2015 Phycological Society of America.Item Impact of industrial pollution on recent dinoflagellate cysts in Izmir Bay (Eastern Aegean)(Elsevier Ltd, 2015) Aydin H.; Yürür E.E.; Uzar S.; Küçüksezgin F.The spatial distribution of dinoflagellate cysts was studied to understand the impact of industrial pollution on the surface sediment of Izmir Bay, Turkey. Forty two dinoflagellate cyst morphotypes belonging to 12 genera were identified and qualified at 12 sampling points. The cyst of Gymnodinium nolleri dominated the bay and had the highest abundance in most of the stations, following Spiniferites bulloideus and Lingulodinium machaerophorum. The highest cyst concentration was recorded in the inner part of the bay. Cyst concentration ranged between 384 and 9944cystg-1 dry weight of sediment in the sampling area. Sediment metal concentrations were determined. Heavy metal levels in Izmir Inner Bay were higher than the Middle and Outer Bay. L. machaerophorum, Dubridinium caperatum and Polykrikos kofoidii showed significant positive correlation with some metals (Cd, Pb, Cu, Zn) and organic carbon content. However, there was no significant correlation between dinoflagellate cyst abundance and sediment type. © 2015 Elsevier Ltd.Item Dinoflagellate cyst assemblages in surface sediments of southwestern black sea and Çanakkale strait (dardanelles)(Parlar Scientific Publications, 2015) Aydin H.; Balci M.; Uzar S.; Balkis N.In order to document the distribution of dinoflagellate cyst assemblages, eight surface sediment samples were collected in surface sediments from southwestern Black Sea and Çanakkale Strait. A total of 25 cyst types and 1 unknown cyst type were identified. Samples displays low total cyst concentrations with values ranging from 8 to 346 cyst g-1 dry weight sediment. Autotrophic dinoflagellates highly and significantly contributes (p<0.01) to the total cyst concentration. Lingulodinium machaerophorum, cyst type of Al-exandrium minutum and Spiniferites bulloideus were dominant at the sampling points. Higher cyst concentration and diversity observed at stations in Black Sea could be linked to the type of sediment. Small-sized sediment (sand-silt) were mostly dominant at the Black Sea stations compare to the more sandy type sediment of Çanakkale Strait. Present study provides the first modern dinoflagellate cyst records from surface sediments of southwestern Black Sea and Çanakkale Strait. © by PSP.Item Prevalence of sleep disorders in the Turkish adult population epidemiology of sleep study(Springer, 2015) Demir A.U.; Ardic S.; Firat H.; Karadeniz D.; Aksu M.; Ucar Z.Z.; Sevim S.; Ozgen F.; Yilmaz H.; Itil O.; Peker Y.; Aygul F.; Kiran S.; Gelbal S.; Cepni Z.; Akozer M.; Neyal A.; Cilli A.; Ozsancak A.; Kutlu A.; Salepci B.; Baklan B.; Oktay B.; Tuncel D.; Levent E.; Ekinci E.; Eyuboglu F.; Yildiz F.; Kirbas G.; Kaynak H.; Aydin H.; Boyaci H.; Bora I.; Oztura I.; Aslan K.; Gunhan K.; Habesoglu M.A.; Unlu M.; Demet M.; Dursunoglu N.; Tascilar N.; Yavuz N.; Erdinc O.; Araz O.; Dogan O.T.; Yetkin O.; Celik P.; Alp R.; Altin R.; Bilgin S.; Ismailogullari S.; Gazioglu S.; Ozkurt S.; Velioglu S.; Yetkin S.; Kuyucu T.; Atay T.; Uygunoglu U.; Tutar U.; Celik Y.; Bulbul Y.Sleep disorders constitute an important public health problem. Prevalence of sleep disorders in Turkish adult population was investigated in a nationwide representative sample of 5021 Turkish adults (2598 women and 2423 men, response rate: 91%) by an interviewer-administered questionnaire. Insomnia was defined by the DSM-IV criteria, habitual snoring and risk for sleep-related breathing disorders (SDB) by the Berlin questionnaire, excessive daytime sleepiness (EDS) by the Epworth sleepiness scale score, and restless legs syndrome (RLS) by the complaints according to the International Restless Legs Syndrome Study Group criteria. Mean age of the participants was 40.7 ± 15.1 (range 18 to 90) years. Prevalence rates (men/women) were insomnia 15.3% (10.5%/20.2%; P < 0.001), high probability of SDB 13.7% (11.1%/20.2%; P < 0.001), EDS 5.4% (5.0%/5.7%; P: 0.09), RLS 5.2% (3.0%/7.3%; P < 0.001). Aging and female gender were associated with higher prevalence of sleep disorders except for habitual snoring. Prevalence rates of the sleep disorders among Turkish adults based on the widely used questionnaires were close to the lower end of the previous estimates reported from different parts of the world. These findings would help for the assessment of the health burden of sleep disorders and addressing the risk groups for planning and implementation of health care. Sleep and Biological Rhythms © 2015 Japanese Society of Sleep Research.Item Variables affecting quality of care of the outpatients having a chronic condition; [Kronik hastalığı nedeniyle ayaktan izlenen hastaların aldıkları sağlık hizmetlerinin niteliğini etkileyen değişkenler](Gulhane Military Medical Academy, 2016) Dede B.; Sarı M.; Gürsul A.; Hanedar A.; Gadis A.; Görgülü B.; Eti B.; Kalay C.; Aydin H.; Güler H.A.; Kala İ.; Görgülü K.; Dilşen M.; Yıldırımkaya U.; Tuğba S.; Eser E.Objective: The best known, most effective and widely used model for chronic illness management is “Chronic Care Model”. Patient Assessment of Care for Chronic Conditions (PACIC) (KBDh) is designed according to this model. The objectives of this study are; 1. To test the sensitivity of PACIC to diverse socio-economic and condition specific variables and 2. To define the quality of care (QOC) and the affecting variables on QOC of the patients in the outpatient wards of CBU hospital. Materials and Methods: In this descriptive study, we enrolled patients from Celal Bayar University Hospital, Departments of Internal Medicine (Endocrinology, Nephrology, Rheumatology, Oncology, and Gastroenterology), Neurology, Dermatology, and Pulmonary Medicine outpatient clinics. Patients were under follow-up care for more than 6 months (n=295) and they were asked to fill the survey containing PACIC scale, socio-demographic variables and other morbidity variables. Type 1 error was adopted as 0.05 and the SPSS 15.0 was used for statistical analysis. Results: The mean age was 51.6±15.2; 18.3% of patients aged 65 and over, and 64.7% were female. 28.8% of patients had type 2diabetes, 29.5% had hypertension, 16.7% had COPD, 15.5% had neurological disease (migraine, epilepsy, MS) and 9.5% had chronic allergic diseases. The mean duration of disease was 9.3±7.9 years, and there was at least one comorbidity in 48.8% of the patients. The overall PACIC scale score was 2.81±0.86. Lower education and income status; the lack of social security and migration to the region negatively affected the quality of follow-up (p<0.05). Patients with hypertension were more negatively affected than the other chronic illness patients in terms of patient activation and goal setting/tailoring dimension scores (p<0.05). Having continuous monitoring by a particular physician and having this physician as primary care physician increased the quality of monitoring (p<0.05). Also, for all chronic diseases and for all dimensions, improvement in quantity of monitoring improved quality of monitoring. Conclusion: Given the PACIC (KBDh) the total score and dimension scores and considering that patients were followed at a university hospital, the scores in this study show that the quality of monitoring is not sufficient level of. Monitoring of the patients in primary care conditions instead of at the second level improves the quality of follow-up. © GATA.Item Cyst-theca relationship and phylogenetic positions of Scrippsiella plana sp. nov. and S. spinifera (Peridiniales, Dinophyceae)(Taylor and Francis Ltd., 2016) Luo Z.; Mertens K.N.; Bagheri S.; Aydin H.; Takano Y.; Matsuoka K.; McCarthy F.M.G.; Gu H.Abstract: Species belonging to the dinophyte genus Scrippsiella are frequently reported in marine waters, but information on their distribution in brackish environments is limited. Here we describe a new species, S. plana, through incubation of non-calcified cysts from sediments collected in the South China Sea and Caspian Sea. The vegetative cells consist of a conical epitheca and a rounded hypotheca with the plate formula of Po, X, 4′, 3a, 7′′, 5C+t, 5S, 5′′′, 2′′′′. It differs from other Scrippsiella species by its flattened body in dorsoventral view and a small first anterior intercalary (1a) plate (half the size of plate 3a). Scrippsiellaplana strains from the South China Sea and Caspian Sea share identical internal transcribed spacer (ITS) sequences, and show phenotypic plasticity and local adaptation in growth rate at various salinities, consistent with the environments in which they originated. In addition, two strains of S. spinifera were obtained by incubating ellipsoid cysts with calcareous spines from sediments collected along the Turkish and Hawaiian coast. They also share identical ITS sequences and differ from Duboscquodinium collinii (a parasite of tintinnids) only at two base pair positions (in the ITS2 region). Molecular phylogeny based on ITS and large subunit ribosomal DNA (LSU rDNA) sequences revealed that S. plana was nested within the Calciodinellum (CAL) clade and S. spinifera within the S. trochoidea (STR) clade. The phylogenetic position of ‘Peridinium’ wisconsinense is reported for the first time, which supports multiple transitions of the Peridiniales to freshwater. © 2016 British Phycological Society.Item Impact of telephonic interviews on persistence and daily adherence to insulin treatment in insulin-naïve type 2 diabetes patients: Dropout study(Dove Medical Press Ltd., 2016) Yavuz D.G.; Bilen H.; Sancak S.; Garip T.; Hekimsoy Z.; Sahin I.; Yilmaz M.; Aydin H.; Atmaca A.; Sert M.; Karakaya P.; Arpaci D.; Oguz A.; Guvener N.Objective: The objective of this study is to evaluate the impact of sequential telephonic interviews on treatment persistence and daily adherence to insulin injections among insulin-naïve type 2 diabetes patients initiated on different insulin regimens in a 3-month period. Methods: A total of 1,456 insulin-naïve patients with type 2 diabetes (mean [standard deviation, SD] age: 56.0 [12.0] years, 49.1% were females) initiated on insulin therapy and consecutively randomized to sequential (n=733) and single (n=723) telephonic interview groups were included. Data on insulin treatment and self-reported blood glucose values were obtained via telephone interview. Logistic regression analysis was performed for factors predicting increased likelihood of persistence and skipping an injection. Results: Overall, 76.8% patients (83.2% in sequential vs 70.3% in single interview group, (P<0.001) remained on insulin treatment at the third month. Significantly higher rate for skipping doses was noted in basal bolus than in other regimens (27.0% vs 15.0% for premixed and 15.8% basal insulin, respectively, P<0.0001). Logistic regression analysis revealed sequential telephonic interview (odds ratio [OR], 1.531 95% confidence interval [CI], 1.093-2.143 P=0.013), higher hemoglobin A1c levels (OR, 1.090 95% CI, 0.999-1.189 P=0.049), and less negative appraisal of insulin therapy as significant predictors of higher persistence. Basal bolus regimen (OR, 1.583 95% CI, 1.011-2.479 P=0.045) and higher hemoglobin A1c levels (OR, 1.114 95% CI, 1.028-1.207 P=0.008) were the significant predictors of increased likelihood of skipping an injection. Conclusion: Our findings revealed positive influence of sequential telephonic interview, although including no intervention in treatment, on achieving better treatment persistence in type 2 diabetes patients initiating insulin. © 2016 Yavuz et al.Item Turkish nationwide survEy of glycemic and other Metabolic parameters of patients with Diabetes mellitus (TEMD study)(Elsevier Ireland Ltd, 2018) Sonmez A.; Haymana C.; Bayram F.; Salman S.; Dizdar O.S.; Gurkan E.; Kargili Carlıoglu A.; Barcin C.; Sabuncu T.; Satman I.; Guldiken S.; Ayturk S.; Yilmaz M.; Asik M.; Dinccag N.; Cakmak R.; Turker F.; Idiz C.; Hacisahinogullari H.; Bagdemir E.; Yildiz B.; Yumuk V.D.; Haliloglu O.; Sancak S.; Ozsari L.; Cagiltay E.; Deyneli O.; Imre E.; Gonen S.; Boysan S.N.; Altuntas Y.; Ozturk F.Y.; Mert M.; Piskinpasa H.; Aydin H.; Imamoglu S.; Ersoy C.; Gul O.O.; Kucuksarac Kiyici S.; Cetinarslan B.; Selek A.; Dogru T.; Kirik A.; Kebapci N.; Efe B.; Kaya A.; Cordan I.; Baldane S.; Kirac C.O.; Demirci I.; Capa Z.; Cesur M.; Yetkin I.; Corapcioglu D.; Canlar S.; Bulent Yildiz O.; Sendur S.N.; Cakir B.; Ozdemir D.; Corakci A.; Kutlu M.; Bascil Tutuncu N.; Bozkus Y.; Cakal E.; Demirbas B.; Ertek S.; Altay M.; Dagdeviren M.; Abedi A.H.; Cetinkalp S.; Ozisik H.; Oruk G.G.; Yener S.; Saydam B.O.; Guney E.; Unubol M.; Yaylali G.F.; Topsakal S.; Hekimsoy Z.; Akbaba G.; Aslan I.; Balci M.K.; Dalkiran S.; Akbay E.; Gul K.; Agbaht K.; Yilmaz M.O.; Bozkirli E.; Tetiker B.T.; Cetinkaya Altuntas S.; Atmaca A.; Durmuş E.T.; Mete T.; Kutluturk F.; Kucukler F.K.; Dikbas O.; Akin S.; Nuhoglu I.; Ersoz H.O.; Bayraktaroglu T.; Sisman P.; Sahin I.; Cetin S.; Capoglu I.; Akbas E.M.; Ucler R.; Eren M.A.; Tuzcu A.K.; Pekkolay Z.; Ozkaya M.; Araz M.Aims: Turkey has the highest prevalence of diabetes in Europe. It is therefore essential to know the overall cardiovascular risk and reveal the predictors of metabolic control in Turkish adults with diabetes mellitus. Methods: A nationwide, multicenter survey consecutively enrolled patients who were under follow up for at least a year. Optimal control was defined as HbA1c < 7%, home arterial blood pressure (ABP) < 135/85 mmHg, or LDL-C < 100 mg/dL. Achieving all parameters indicated triple metabolic control. Results: HbA1c levels of patients (n = 5211) were 8.6 ± 1.9% (71 ± 22 mmol/mol) and 7.7 ± 1.7% (61 ± 19 mmol/mol), in Type 1 and Type 2 diabetes, respectively. Glycemic control was achieved in 15.3% and 40.2%, and triple metabolic control was achieved in 5.5% and 10.1%, respectively. Only 1.5% of patients met all the criteria of being non-obese, non-smoker, exercising, and under triple metabolic control. Low education level was a significant predictor of poor glycemic control in both groups. Conclusions: Few patients with Type 2, and even fewer with Type 1 diabetes have optimal metabolic control in Turkey. TEMD study will provide evidence-based information to policy makers to focus more on the quality and sustainability of diabetes care in order to reduce the national burden of the disease. © 2018 Elsevier B.V.Item The dinoflagellate cyst genera Achomosphaera Evitt 1963 and Spiniferites Mantell 1850 in Pliocene to modern sediments: a summary of round table discussions(Taylor and Francis Inc., 2018) Mertens K.N.; Van Nieuwenhove N.; Gurdebeke P.R.; Aydin H.; Bogus K.; Bringué M.; Dale B.; De Schepper S.; de Vernal A.; Ellegaard M.; Grothe A.; Gu H.; Head M.J.; Heikkilä M.; Limoges A.; Londeix L.; Louwye S.; Marret F.; Masure E.; Matsuoka K.; Mudie P.J.; Penaud A.; Pospelova V.; Price A.M.; Ribeiro S.; Rochon A.; Sangiorgi F.; Schreck M.; Torres V.; Uzar S.; Versteegh G.J.M.; Warny S.; Zonneveld K.We present a summary of two round-table discussions held during two subsequent workshops in Montreal (Canada) on 16 April 2014 and Ostend (Belgium) on 8 July 2015. Five species of the genus Achomosphaera Evitt 1963 and 33 of the genus Spiniferites Mantell 1850 emend. Sarjeant 1970 occuring in Pliocene to modern sediments are listed and briefly described along with remarks made by workshop participants. In addition, several holotypes and topotypes are reillustrated. Three species previously assigned to Spiniferites are here considered/accepted as belonging to other genera: Impagidinium inaequalis (Wall and Dale in Wall et al. 1973) Londeix et al. 2009, Spiniferites? rubinus (Rossignol 1962 ex Rossignol 1964) Sarjeant 1970, and Thalassiphora balcanica Balteş 1971. This summary forms the basis for a set of papers that follows, where points raised during the workshops are explored in greater detail. © 2018, © 2018 The Author(s). Published by AASP–The Palynological Society.Item Experimental and computational investigation of graphene/SAMs/n-Si Schottky diodes(Elsevier B.V., 2018) Aydin H.; Bacaksiz C.; Yagmurcukardes N.; Karakaya C.; Mermer O.; Can M.; Senger R.T.; Sahin H.; Selamet Y.We have investigated the effect of two different self-assembled monolayers (SAMs) on electrical characteristics of bilayer graphene (BLG)/n-Si Schottky diodes. Novel 4″bis(diphenylamino)-1, 1′:3″-terphenyl-5′ carboxylic acids (TPA) and 4,4-di-9H-carbazol-9-yl-1,1′:3′1′-terphenyl-5′ carboxylic acid (CAR) aromatic SAMs have been used to modify n-Si surfaces. Cyclic voltammetry (CV) and Kelvin probe force microscopy (KPFM) results have been evaluated to verify the modification of n-Si surface. The current–voltage (I–V) characteristics of bare and SAMs modified devices show rectification behaviour verifying a Schottky junction at the interface. The ideality factors (n) from ln(I)–V dependences were determined as 2.13, 1.96 and 2.07 for BLG/n-Si, BLG/TPA/n-Si and BLG/CAR/n-Si Schottky diodes, respectively. In addition, Schottky barrier height (SBH) and series resistance (R s ) of SAMs modified diodes were decreased compared to bare diode due to the formation of a compatible interface between graphene and Si as well as π–π interaction between aromatic SAMs and graphene. The CAR-based device exhibits better diode characteristic compared to the TPA-based device. Computational simulations show that the BLG/CAR system exhibits smaller energy-level-differences than the BLG/TPA, which supports the experimental findings of a lower Schottky barrier and series resistance in BLG/CAR diode. © 2017 Elsevier B.V.Item Utilization of statins and LDL-cholesterol target attainment in Turkish patients with type 2 diabetes - a nationwide cross-sectional study (TEMD dyslipidemia study)(BioMed Central Ltd, 2020) Bayram F.; Sonmez A.; Haymana C.; Sabuncu T.; Dizdar O.S.; Gurkan E.; Carlioglu A.K.; Agbaht K.; Ozdemir D.; Demirci I.; Barcin C.; Salman S.; Tetiker T.; Balci M.K.; Kebapci N.; Ersoy C.; Yumuk V.; Toth P.P.; Satman I.; Guldiken S.; Ayturk S.; Yilmaz M.; Asik M.; Dinccag N.; Cakmak R.; Turker F.; Idiz C.; Hacisahinogullari H.; Bagdemir E.; Yildiz B.; Haliloglu O.; Sancak S.; Ozsari L.; Cagiltay E.; Deyneli O.; Imre E.; Gonen S.; Boysan S.N.; Altuntas Y.; Ozturk F.Y.; Mert M.; Piskinpasa H.; Aydin H.; Imamoglu S.; Gul O.O.; Kiyici S.K.; Cetinarslan B.; Selek A.; Dogru T.; Kirik A.; Efe B.; Kaya A.; Cordan I.; Baldane S.; Kirac C.O.; Capa Z.; Cesur M.; Yetkin I.; Corapcioglu D.; Canlar S.; Yildiz O.B.; Sendur S.N.; Cakir B.; Corakci A.; Kutlu M.; Tutuncu N.B.; Bozkus Y.; Cakal E.; Demirbas B.; Ertek S.; Altay M.; Dagdeviren M.; Abedi A.H.; Cetinkalp S.; Ozisik H.; Oruk G.G.; Yener S.; Saydam B.O.; Guney E.; Unubol M.; Yaylali G.F.; Topsakal S.; Hekimsoy Z.; Akbaba G.; Aslan I.; Dalkiran S.; Akbay E.; Gul K.; Yilmaz M.O.; Bozkirli E.; Altuntas S.C.; Atmaca A.; Durmuş E.T.; Mete T.; Kutluturk F.; Kucukler F.K.; Dikbas O.; Akin S.; Nuhoglu I.; Ersoz H.O.; Bayraktaroglu T.; Sisman P.; Sahin I.; Cetin S.; Capoglu I.; Akbas E.M.; Ucler R.; Eren M.A.; Tuzcu A.K.; Pekkolay Z.; Ozkaya M.; Araz M.Background: Attaining acceptable levels of LDL Cholesterol (LDL-C) significantly improves cardiovascular (CV) outcomes in patients with type 2 diabetes mellitus (T2DM). The LDL-C target attainment and the characteristics of patients attaining these targets were investigated in this study. Furthermore, the reasons for not choosing statins and the physicians’ attitudes on the treatment of diabetic dyslipidemia were also examined. Methods: A nationwide, cross-sectional survey was conducted in tertiary centers for diabetes management. Adult patients with T2DM, who were under follow-up for at least a year in outpatient clinics, were consecutively enrolled for the study. LDL-C goals were defined as below 70 mg/dL for patients with macrovascular complications or diabetic nephropathy, and below 100 mg/dL for other patients. Data about lipid-lowering medications were self-reported. Results: A total of 4504 patients (female: 58.6%) were enrolled for the study. The mean HbA1c and diabetes duration was 7.73 ± 1.74% and 10.9 ± 7.5 years, respectively. The need for statin treatment was 94.9% (n = 4262); however, only 42.4% (n = 1807) of these patients were under treatment, and only 24.8% (n = 448) of these patients achieved LDL-C targets. The main reason for statin discontinuation was negative media coverage (87.5%), while only a minority of patients (12.5%) mentioned side effects. Physicians initiated lipid-lowering therapy in only 20.3% of patients with high LDL-C levels. It was observed that the female gender was a significant independent predictor of not attaining LDL-C goals (OR: 0.70, 95% CI: 0.59–0.83). Conclusions: Less than 50 % of patients with T2DM who need statins were under treatment, and only a quarter of them attained their LDL-C targets. There exists a significant gap between the guideline recommendations and the real-world evidence in the treatment of dyslipidemia in T2DM. © 2020, The Author(s).Item A review of rare, poorly known, and morphologically problematic extant marine organic-walled dinoflagellate cyst taxa of the orders Gymnodiniales and Peridiniales from the Northern Hemisphere(Elsevier B.V., 2020) Mertens K.N.; Gu H.; Gurdebeke P.R.; Takano Y.; Clarke D.; Aydin H.; Li Z.; Pospelova V.; Shin H.H.; Li Z.; Matsuoka K.; Head M.J.Dinoflagellates are a major component of the modern plankton. Of the 2192 species of marine free-living dinoflagellates presently described, an increasing number are being shown to produce resting cysts (probably hypnozygotes) within their life cycle. With rare exception, only the resting cysts fossilize, so they are of central importance in tracing the history of dinoflagellates through geological time. Cysts of many of the more common dinoflagellate species have distinctive morphologies allowing their geographic and stratigraphic occurrences to be traced. An ever-increasing number of taxa are also being shown to produce distinctive and geologically preservable cysts, potentially enhancing our knowledge of the diverse representation of dinoflagellates through time. Here the organic-walled cysts of 73 rare, poorly known or morphologically problematic marine dinoflagellate cyst species belonging to the orders Gymnodiniales (nine species) and Peridiniales (64 species) are reviewed, described and illustrated, and their stratigraphic ranges assessed. The names Echinidinium aculeatum and Echinidinium transparantum are validated. © 2019 Elsevier B.V.Item Enhancement of luminescence and thermal stability in Eu3+-doped K3Y(BO2)6 with Li+ and Na+ co-doping(Elsevier B.V., 2024) Kaynar U.H.; Aydin H.; Altowyan A.S.; Hakami J.; Coban M.B.; Ayvacikli M.; Ekdal Karali E.; Canimoglu A.; Can N.Eu3+-doped and Li+/Na+ co-doped K3Y(BO2)6 (KYBO) phosphors were synthesized through a microwave-assisted sol–gel method, and their structural and photoluminescent (PL) characteristics were examined. X-ray diffraction (XRD) and Rietveld refinement confirm effective dopant incorporation and preservation of the crystalline structure. Fourier Transform Infrared (FTIR) spectroscopy indicates the maintenance of the borate structure, confirming the structural integrity of the phosphors upon doping. The addition of Li+ and Na+ co-dopants notably enhances luminescent efficiency and thermal stability, making these phosphors promising candidates for solid-state lighting (SSL) applications. PL analysis reveals strong red emission peaks at 612 nm, attributed to the 5Do → 7F2 transition of Eu3+ ions. The study indicates that electric dipole-quadrupole interactions are the primary mechanism for energy migration, with a critical distance of approximately 22.68 Å. This mechanism contributes to concentration quenching at higher doping levels. High temperature PL measurements indicated an activation energy of 0.1389 eV for thermal quenching in the Li+ co-doped sample. Additionally, the Na+ co-doped sample exhibited an abnormal thermal stability behavior, with an even higher activation energy of 0.2536 eV. This suggests that Na+ co-doping significantly enhances the thermal resilience of the phosphor, making it more suitable for high-power light-emitting applications that operate under extreme conditions. CIE chromaticity diagrams highlight the potential for optimizing Eu3+ doping levels, combined with Li+ and Na+ co-doping, to improve luminescent performance and thermal stability for advanced SSL applications. © 2024 The Society of Powder Technology Japan