Browsing by Author "Aydin N."

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    Serotonin transporter gene polymorphisms in patients with chronic tension-type headache: A preliminary study
    (2008) Akcali A.; Tataroglu C.; Erdal E.; Aydin N.; Pehlivan S.
    Background and Objectives: This study is designed to understand the pathophysiology of one of the most serious health problems, chronic tension-type headache (CTTH). Two polymorphic sites in serotonin transporter protein gene attracted much interest. These are: the variable number of tandem repeats (VNTR) and 5′-flanking promoter region (5-HTTLPR). Materials and Methods: VNTR and 5-HTTLPR polymorphisms were investigated in 126 CTTH patients and 138 healthy control subjects. The patients were being treated with amitripytyline or citalopram or sertraline (SSRI). The polymerase chain reaction (PCR) method was used to investigate the polymorphisms in the serotonin transporter protein gene. Results: There were no statistically significant results based on the 5-HTTLPR gene alleles, however, STin 2.12/12 genotype and STin 2.12 allele were seen to predominate the control group. In order to investigate the combined effect of the two polymorphic loci on the 5-HTT gene expression, samples were separated into nine groups. Genotypes (S/S-12/10) and (L/S-12/10) displayed statistically significant frequency in the CTTH group than in the control group. No significant differences were noticed between the 5-HTTLPR and VNTR haplotype groups and success in treatment. Conclusion: It is possible to make reliable comparisons and hypothesis about the homozygous and/or heterozygous presence of S and STin 12/10 alleles which may be in interaction with CTTH. On the other hand, the presence of homozygous L and STin12 alleles may play a protective role against CTTH. It is also possible that heterogeneity among diseases showing the same clinical research will require a lot of effort for individual identification.
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    Case report of a late onset bowenoid papulosis progressing to squamous cell carcinoma: Letter to the editor
    (Turkiye Klinikleri, 2009) Aydin N.; Türel Ermertcan A.; Öztürkcan S.; Bilaç C.; Yoleri L.; Temiz P.
    [No abstract available]
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    EPIdemiology of Surgery-Associated Acute Kidney Injury (EPIS-AKI): Study protocol for a multicentre, observational trial
    (BMJ Publishing Group, 2021) Weiss R.; Saadat-Gilani K.; Kerschke L.; Wempe C.; Meersch M.; Zarbock A.; Makhloufi H.; Cherak A.; Ghanem L.L.; Gouaglia Z.; Guadouri D.N.; Hama F.N.; Kara M.; Saadi O.; Sakhraoui R.; Bourou F.; Cherifi A.; Sadaoui R.G.; Ouyahia A.; Ouahab I.; Bouaoud S.; Abdoun M.; Tidjane A.; Tabeti B.; Boudjenan-Serradj N.; Rivera C.J.P.; Cabrer P.; Corso J.; García J.P.; Idarraga S.; Montoya C.; Figueroa R.; Aldana E.; Torrado M.A.; Peng K.; Ma Z.-M.; Yang Y.-F.; Zhu Y.-J.; Sklienka P.; Frelich M.; Jarkulis V.; Sevcik P.; Vodicka V.; Elbahnasawy M.G.; Elsalhawy S.; Motawea S.; Othman Z.; Sahma M.; Nafea A.M.; Ahmed N.; Attia D.A.; Emara M.M.; Bonna M.M.; Gabr M.A.; Tarbay A.I.; Abdehaleem I.A.; Mohamed E.E.; Eldeeb A.M.; Abbas A.M.; Magdy J.A.; Hamed Z.H.; Osman H.M.E.; Abbas M.S.; Joannes-Boyau O.; Barraud N.; Berthelot C.; Camus T.; Dahmi A.; Defaye M.; Derville S.; El-Boustani Y.; Deloge E.; Jacob H.; Monziols S.; Priem F.; Robin J.-J.; Legros V.; Floch T.; Muccio S.; Geneve C.; Legouge M.L.; Mauny S.T.; Mfam W.; Pascot L.; Aveline C.; Chartier M.; Duteurtre B.; Gautier J.F.; Cousin A.L.; Vautier P.; Nadaud J.; Begel N.; Chekirine C.-A.; Derlon V.; Grein E.; Lehair M.-A.; Magazzeni L.; Magazzeni P.; Potter C.; Roth C.; Voivret F.; Rimmelé T.; Cerro V.; Suria S.; Elmawieh J.; Stoclin A.; Cirenei C.; Andrieu G.; Couloumy S.; Falcone J.; Fajardy M.; Gagneuil A.; Girardet E.; Mazereeuw A.; Ponsonnard S.; Egreteau P.-Y.; Bertel M.; Bocher S.; Carn V.; Guen L.L.; Loup G.L.; Lefevre M.; Ichai C.; Diop A.; Jean-Michel V.; Devlieger S.; Duthoit J.; El Kadiri M.; Léger M.; Cassisa V.; Lasocki S.; Masson C.; Rineau E.; Verrier P.; Coquerel A.; Montravers P.; Atchade E.; Rochon C.-E.; Delerue C.; Quentin V.; Latry V.; Queixalos N.; Cottenceau V.; Braun T.; Bouzoubaa S.; Christ B.; Geiger A.; Gomille J.; Kieffer V.; Mangeant S.; Prochilo C.; Schmitt C.; Skwirba S.; Grand H.; Boury F.; Mayeur N.; Pasquie M.; Garçon P.; Bruckert V.; Arnould V.; Bonciu M.; Chapelle T.; Facchino L.; Fagot-Gandet F.; Iachim A.; Mannu E.; Perus O.; Plattier R.; Rozier R.; Pradel G.; Boudinaud M.; Hausermann M.-H.; Nguyen M.H.; Ramorasata A.; Barreau A.; Boivin A.-H.; Ravry C.; Mottard N.; Beuvelot J.; Bossion F.P.; Desebbe O.; Dörr C.; von Groote T.C.; Küllmar M.; Massoth C.; Ziemann S.; Grüßer L.; Kowark A.; Wittig P.; Brandenburger T.; Dimski T.; Döhmen N.; Huthmann L.; Kaierle D.; Pelletier C.; Schleß M.; Hohn A.; Cleophas S.; Haunhorst S.; Jansen M.; Schmitt A.; Soisch J.; Sturm K.; Rosenberger P.; Bendig A.; Flohr L.; Häberle H.; Hofmann P.; Kuhle J.; Leser N.M.; Pfister K.; Prohaska S.; Sennholz F.; Stetz L.; Weber K.; Stehr S.; Klaus S.; Sadlo M.; Boschin M.; Sengelhoff C.; Göbel U.M.; Haaker J.G.; Göttker C.-K.; Gründel M.; Heringlake M.; Baumgärtel R.; Berggren A.; Gülzow M.; Muras L.; Paarmann H.; Thal S.; Bentley A.; El-Masri D.; Sebastiani A.; Arnaoutoglou E.; Ntalouka M.; Stratigopoulou P.; Analytis A.; Mavrommatis E.; Tzimas P.; Karakosta A.; Pantazi D.; Dimakopoulou A.; Dimitropoulou K.; Ioannidis O.; Jalaawiy H.; Anwar A.; Hashim H.T.; Aldawoody H.I.R.; Cortegiani A.; Catalisano G.; Ingoglia G.; Ippolito M.; De Rosa S.; Cattin L.; Bianchin A.; Barone M.; Paternoster G.; Cutuli S.L.; Russo A.; Sollazzi L.; Cascarano L.; Antonelli M.; Aceto P.; Romanò B.; Spadaro S.; Tripodi V.F.; Rossi M.; Scappatura R.; Vadalà M.C.; Fiume D.; Strano M.T.; Oddo G.; Santorsola C.; Hussain B.A.; Alnaser A.R.; Ghassan A.H.; Hasanein K.; Theab M.; Shin S.; Jung S.; Lee K.; Jung S.M.; Baek J.; Elhadi M.K.; Aldressi W.W.O.; Abuzeid I.; Albaraesi M.; Aldressi S.; Khalel W.; Abdulwahed E.; Abujrad A.A.A.; Almaghrabi A.; Alteleeb M.; Alshareea E.A.A.; Biala M.I.; Deeknah A.; Gheddim D.A.; Ghmagh R.; Ikhrays N.S.A.A.; Sinan M.; Soula E.; Bahroun S.G.; Derwish K.; Mohamed A.M.; Younes E.S.; Al Islam Benjouira R.; Aliwa M.; Altashani N.A.; Alteb M.O.; Msherghi A.; Alagelli F.; Albarouni S.; Albishti A.; Aljamal S.; Alsori M.; Ekhuja T.; Elzwai S.; Ghula M.; Mustafa T.; Tuwaib A.; Zriba H.; Agilla H.M.; Rafanomezantsoa T.A.; Podesta A.M.C.; Bonnici D.M.; Pirotta T.; López G.A.G.; Mijovska M.M.; Davitkovska T.; Gavrilovska A.; Lukikj S.; Vesova M.; Zafirova D.; Amro S.; Hajjaj B.N.F.; Alkhazendar M.; Barakat Y.; Elejla S.A.; Elhissi A.; Khader A.; Salem A.; de Freitas Regufe R.; de Oliveira Eloy A.F.; Perdigão L.M.N.C.; Grigoriev E.; Ivkin A.; Kornelyuk R.; Yaroustovsky M.; Abramyan M.; Komardina E.; Lesteva N.; Aybazova M.; Kumykova E.; Lesina S.; Rybakov G.; Shestov A.; Barmou A.A.A.; Ahmed B.L.A.; Eliyas A.M.; Emadeldin Y.; Kaserer A.; Castellucci C.; Rössler J.; Akbas S.; Petrun A.M.; Gregorcic I.; Sok V.; Cicak R.; Bárcena E.; Guisado A.; Wi I.; Melchor J.R.; Becerra-Bolaños Á.; Cabrera-Doreste S.; Domínguez-Arbelo A.; Delgado-Alonso M.C.; Muiño-Palomar V.; Rodríguez-Pérez A.; Estévez J.M.; Munoz M.B.C.; Matas J.M.; Palao S.P.; Quirós M.D.M.; Teslev A.C.; Argilaga M.; Campos M.; Bainac A.; Batalla A.; Alvarez M.G.; Giné M.; Herránz G.; Hinojal I.; Ejea M.L.; de la Rosa Ruiz N.; Abasolo M.G.; Acuna C.R.H.; Zaranton I.I.; Mendigurenmurua A.; Sanz M.J.M.; de la Fuente E.O.; Vaquero M.P.P.; Iglesias A.S.; Mieres A.U.; Urrestizala A.U.; Ferreira L.; Lobato F.; Sevilla M.A.; Erazo A.; Miró P.; Sabaté S.; Vernetta D.; Perez A.A.; Pagola M.A.; Paulis B.C.; del Val Peciña E.; Odriozola A.G.; Aizpurua A.L.; Piquer O.P.; Garcia P.P.; Rezola P.O.; Lopez A.O.; de la Calle Gil I.; Casado R.N.; Adamove P.; Domenge R.B.; Blasco F.M.B.; Villamizar A.A.R.; Llaneras M.A.P.; García-Sánchez J.I.; Téllez L.F.; Zamorano S.G.; Herreros N.G.; Esteve A.R.; Rodríguez P.M.; Trigo I.G.; Alcaraz A.; Jiménez A.L.; Rubio I.; García N.; Callejas R.; Toha A.M.C.; Claros E.; Cobeta P.; Crespo P.; Dorado T.; Elías E.; Felices J.; Gil D.; Gómez M.; Mané N.; Martín M.; Martínez A.; Pereira L.; Samaranch A.B.N.; Serrano A.; Tiscar C.; VillaHoz J.; Menéndez P.G.; Cardona E.; Conesa A.; Estepa V.; Galán P.; Espí L.L.; Aldeán Y.L.; Manrique S.; Ariza V.M.; Villa L.V.; Suliman E.S.M.A.; Hamid H.; Ibrahim A.M.; Saeed M.M.; Mukadder O.S.; Altun D.; Canbolat N.; Dinçer M.B.; Seyhan T.Ö.; Yildirim S.A.; Iyigün M.; Yapici D.; Özdemir L.; Sagun A.; Boztug N.; Cetintas Y.; Dinc B.; Gündüz E.; Ünlügenç H.; Tunay D.L.; Karakaya D.; Dost B.; Komurcu O.; Akcil E.F.; Dilmen Ö.K.; Tunali Y.; Ok G.; Alsina E.T.; Hakli Ö.; Polat C.; Turgut N.; Kizilcik N.; Köner Ö.; Sen Ö.; Aydin N.; Basaran B.; Bingul E.S.; Gürkan Y.; Darcin K.; Ugur S.; Saracoglu K.T.; Demir A.; Aysegül Ö.; Balci E.; Girgin B.; Guler A.; Karadeniz Ü.; Özaslan N.; Hülya Y.Ö.; Ozcan N.; Postaci A.; Sahap M.; Salman N.; Sagir Ö.; Atik B.; Bicakcioglu M.; Demir H.F.; Fatih U.; Kocaoglu N.; Toprak H.I.; Aslan D.D.; Colak Y.Z.; Ozcan M.S.; Yilmaz M.; Karaca U.; Sahin S.H.; Karka Ö.E.; Senoglu G.D.; Karadag S.E.; Alkis N.; Baytas V.; Akdogan A.; Besir A.; Erturk E.; Kutanis D.; Saylan S.; Tugcugil E.; Ayvat P.; Günaydin B.; Büyükgebiz B.M.; Boran O.F.; Calisir F.; Orak Y.; Balkan B.K.; Büyükcoban S.; Gökel E.; Günenc S.F.; Özbilgin S.; Göre S.; Akesen S.; Cansabuncu S.; Momot N.; Panchenko A.; Pittet J.-F.; Rutledge K.
    Introduction More than 300 million surgical procedures are performed each year. Acute kidney injury (AKI) is a common complication after major surgery and is associated with adverse short-term and long-term outcomes. However, there is a large variation in the incidence of reported AKI rates. The establishment of an accurate epidemiology of surgery-associated AKI is important for healthcare policy, quality initiatives, clinical trials, as well as for improving guidelines. The objective of the Epidemiology of Surgery-associated Acute Kidney Injury (EPIS-AKI) trial is to prospectively evaluate the epidemiology of AKI after major surgery using the latest Kidney Disease: Improving Global Outcomes (KDIGO) consensus definition of AKI. Methods and analysis EPIS-AKI is an international prospective, observational, multicentre cohort study including 10 000 patients undergoing major surgery who are subsequently admitted to the ICU or a similar high dependency unit. The primary endpoint is the incidence of AKI within 72 hours after surgery according to the KDIGO criteria. Secondary endpoints include use of renal replacement therapy (RRT), mortality during ICU and hospital stay, length of ICU and hospital stay and major adverse kidney events (combined endpoint consisting of persistent renal dysfunction, RRT and mortality) at day 90. Further, we will evaluate preoperative and intraoperative risk factors affecting the incidence of postoperative AKI. In an add-on analysis, we will assess urinary biomarkers for early detection of AKI. Ethics and dissemination EPIS-AKI has been approved by the leading Ethics Committee of the Medical Council North Rhine-Westphalia, of the Westphalian Wilhelms-University Münster and the corresponding Ethics Committee at each participating site. Results will be disseminated widely and published in peer-reviewed journals, presented at conferences and used to design further AKI-related trials. Trial registration number NCT04165369. ©
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    Push and Pull Factors of Why Medical Students Want to Leave Türkiye: A Countrywide Multicenter Study
    (Routledge, 2024) Eser E.; Cil E.; Sen Gundogan N.E.; Col M.; Yildirim Ozturk E.N.; Thomas D.T.; Sunter A.T.; Arslan H.N.; Citil R.; Onder Y.; Picakciefe M.; Dede B.; Demirel C.; Aydin N.; Caglayan C.; Aker A.A.; Borlu A.; Durmus H.; Can G.; Siddikoglu E.; Sumer E.H.; Uygun T.; Alkoy S.; Aktas Aycan K.; Koruk İ.; Kuzan R.; Demir L.S.; Hacilar E.; Sari H.; Kilinc Z.; Onal O.; Dogan E.; Emek M.; Terzioglu R.; Yapici G.; Erdal D.; Eser S.; Ayhan Akman E.; Kosan Z.; Yilmaz S.; Ayoglu F.N.; Acikgoz B.; Musal B.; Suner A.F.; Erdogan A.; Cilburunoglu İ.; Saygun M.; Daymaz D.; Arslantas D.; Onsuz M.F.; Beyhun N.E.; Ustundag M.G.; Ekuklu G.; Ozder Tas F.; Abacigil F.; Oncu S.; Hıdıroğlu S.; Ozaydin A.N.; Pirincci E.; Bulut I.; Tozun M.; Eskiocak M.; Gunel P.; Torun S.D.; Yavuz M.; Hasde M.; Camur D.; Gunes G.; Kurt B.; Guler Baysoy N.; Bakirci N.; Demir F.; Catak B.; Ozyurda F.; Turan M.
    Phenomenon: Physician immigration from other countries is increasing as developed countries continue to be desirable destinations for physicians; however, the determinants of Turkish physicians’ migration decisions are still unclear. Despite its wide coverage in the media and among physicians in Türkiye, and being the subject of much debate, there is insufficient data to justify this attention. With this study, we aimed to investigate the tendency of senior medical students in Türkiye to pursue their professional careers abroad and its related factors. Approach: This cross-sectional study involved 9881 senior medical students from 39 different medical schools in Türkiye in 2022. Besides participants’ migration decision, we evaluated the push and pull factors related to working, social environment and lifestyle in Türkiye and abroad, medical school education inadequacy, and personal insufficiencies, as well as the socioeconomic variables that may affect the decision to migrate abroad. The analyses were carried out with a participation rate of at least 50%. Findings: Of the medical students, 70.7% had emigration intentions. Approximately 60% of those want to stay abroad permanently, and 61.5% of them took initiatives such as learning a foreign language abroad (54.5%) and taking relevant exams (18.9%). Those who wanted to work in the field of Research & Development were 1.37 (95% CI: 1.22–1.54) times more likely to emigrate. The push factor that was related to emigration intention was the “working conditions in the country” (OR: 1.89, 95% CI: 1.56–2.28) whereas the “social environment/lifestyle abroad” was the mere pull factor for the tendency of emigration (OR: 1.73, 95% CI: 1.45–2.06). In addition, the quality problem in medical schools also had a significant impact on students’ decisions (OR: 2.20, 95% CI: 1.83–2.65). Insights: Although the percentage of those who want to emigrate “definitely” was at the same level as in the other developing countries, the tendency to migrate “permanently” was higher in Türkiye. Improving working conditions in the country and increasing the quality of medical faculties seem vital in preventing the migration of physicians. © 2023 Taylor & Francis Group, LLC.