Browsing by Author "Aydogdu, I"

Now showing 1 - 20 of 43
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    From Bone Marrow Necrosis to Gaucher Disease; A Long Way to Run
    Erdem, N; Çizmecioglu, A; Aydogdu, I
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    Langerhans cell histiocytosis: A rare cause of pathological rib fracture
    Yolcu, A; Tulay, CM; Temiz, P; Aydogdu, I
    Langerhans cell histiocytosis, formerly known as histiocytosis X, represents clonal proliferations of the antigen-presenting dendritic cells, which are normally found in many organs. It is a rare disease which tends to affect children and adolescents. In particular, adult-onset type is very rare. Herein, we present a female adult diagnosed with Langerhans cell histiocytosis of the rib without any systemic involvement which was successfully treated with surgery.
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    A comparative analysis of metaheuristic algorithms for optimizing curved roof structures
    Üstüner, B; Aydogdu, I; Özyürek, C; Dogan, E
    This article explores the optimal design of curved steel structures with a focus on minimizing their weight by determining the most suitable cross-sections. Customized optimization algorithms were developed to identify structural designs that meet safety and durability requirements, adhering to design constraints set by the ASDAISC specification. To ensure reliable results, the study employs a variety of metaheuristic optimization methods: Biogeography-Based Optimization (BBO), Dynamic Harmony Search (DHS), Wolf Colony Algorithm (WCA), and Honey Badger Algorithm (HBA). The Honey Badger Algorithm, a relatively new addition to the field, was used for the first time in the context of structural optimization for curved roof systems. This unique approach aims to evaluate its performance in civil engineering problems and compare it with other established algorithms. The major challenges of this study lie in the inherent complexity of dome structures, which involve a large number of elements and nonlinear constraints. The subdivision of the structure into smaller groups was necessary to manage the computational load, although this introduced additional complexities. Despite these challenges, the metaheuristic methods demonstrated their robustness in addressing such intricate engineering problems. Additionally, data retrieval is facilitated through Open Application Interface (OAPI) functions, enabling seamless data transfer between SAP 2000 and Visual Basic. The study's final design example involves a dome model with 2556 elements, which was both modeled and optimized. The results demonstrate the effectiveness of these optimization algorithms in achieving structurally sound and efficient designs. The insights gained from this study contribute to our understanding of optimized cross-sections in curved steel structures, offering valuable guidance for improving structural performance and minimizing material usage.
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    Arare parasitic infection: visceral leishmaniasis case after gastric cancer treatment
    Yolcu, A; Dirican, A; Ozturk, GG; Cetin, CB; Aydogdu, I
    We present acase of Visceral Leishmaniasis (VL) in apatient with gastric cancer treated with chemoradiotherapy. A69-year-old man with gastric carcinoma had been treated with total gastrectomy, lymphadenectomy and postoperative radiotherapy with chemotherapy. Then 3years after treatment, due to pancytopenia with progressive trombocytopenia and splenomegaly, bone marrow examination was performed and Leishmania spp. amastigotes were diagnosed. When antibiotherapy was completed, splenomegaly was eliminated and the laboratory results became normal. VL should be kept in mind in the differential diagnosis of patients, even adults, with splenomegaly, trombocytopenia and ahistory of contact with dogs in endemic countries such as Turkey.
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    Treatment of inflammatory bowel disease by leukocytapheresis
    Gerçeker, E; Yüceyar, H; Kasap, E; Demirci, U; Ekti, BC; Aydogdu, I; Miskioglu, M
    Studies about leukocytapheresis have emerged with the need of search for alternatives to conventional treatment in inflammatory bowel diseases (IBD). Leukocytapheresis is a novel non-pharmacologic approach for active ulcerative colitis (UC) and Crohn's disease (CD), in which leukocytes are mechanically removed from the circulatory system. Patients with active IBD treated with leukocytapheresis using a Cellsorba E column between 2012 and 2015, were enrolled in Turkey. In our experience, the results of leukocytapheresis therapy in 6 patients with CD and 20 patients with active UC were overviewed. Leukocytapheresis (10 sessions for remission induction therapy, 6 sessions for maintenance therapy) was applied to the patients with their concomitant medications. Intensive leukocytapheresis (>= 4 leukocytapheresis sessions within the first 2 weeks) was used in 30% patients with active severe UC. The overall clinical remission rate in patients with UC was 80%, and the mucosal healing rate was 65%. Patients were followed for an average of 24 months. It was observed that clinical remission has continued in 65% of patients with UC. Mild relapse was observed in 3 patients with UC during follow up period. In 5 patients with CD significant clinical remission was achieved except only one patient. Surgical needs were disappeared in 3 patients with obstructive type Crohn's disease, Adverse events were seen in only 4.3% of 416 sessions. Any concomitant medications did not increase the incidence of adverse events. Our results indicate that leukocytapheresis is efficacious in improving remission rates with excellent tolerability and safety in patients with IBD. (C) 2017 Elsevier Ltd. All rights reserved.
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    Peripheral Blood Smear Findings of COVID-19 Patients Provide Information about the Severity of the Disease and the Duration of Hospital Stay
    Berber, I; Cagasar, O; Sarici, A; Berber, NK; Aydogdu, I; Ulutas, O; Yildirim, A; Bag, HGG; Delen, LA
    Background: Data about the morphological changes in peripheral blood smears during COVID-19 infection and their clinical severity association are limited. We aimed to examine the characteristics of the cells detected in the pathological rate and/or appearance and whether these findings are related to the clinical course by evaluating the peripheral blood smear at the time of diagnosis in COVID-19 patients. Methods: Clinical features, laboratory data, peripheral blood smear of fifty patients diagnosed with COVID-19 by PCR was evaluated at diagnosis. Peripheral smear samples of the patients were compared with the age and sex-matched 30 healthy controls. Pictures were taken from the patient's peripheral blood smear. Patients were divided into two groups. Mild and severe stage patient groups were compared in terms of laboratory data and peripheral smear findings. The relationship between the laboratory values of all patients and the duration of hospitalization was analyzed. Results: The number of segmented neutrophils and eosinophils were low, pseudo-Pelger-Huet, pseudo-Pelger-Huet/mature lymphocyte ratio, atypical lymphocytes, monocytes with vacuoles, bands, and pyknotic neutrophils rates were higher in the peripheral blood smear of the patient group (p<0.05). Increased pseudo-Pelger-Huet anomaly, pseudo-Pelger Huet/mature lymphocyte ratio, a decreased number of mature lymphocytes, and eosinophils in peripheral blood smear were observed in the severe stage patients (p<0.05). A negative correlation was observed between hospitalization duration and mature lymphocyte and monocytes with vacuoles rates (p<0.05). Conclusion: A peripheral blood smear is an inexpensive, easily performed, and rapid test. Increased Pseudo-Pelger-Huet anomaly/mature lymphocyte rate suggests a severe stage disease, while high initial mature lymphocyte and monocytes with vacuoles rates at the time of diagnosis may be an indicator of shortened duration of hospitalization.
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    Enzyme Replacement Therapy in a Gaucher Family
    Erdem, N; Buran, T; Berber, I; Aydogdu, I
    Gaucher disease is a lipid storage disorder due to deficiency of beta glucocerebrosidase. It's an autosomal recessive disease and as a result of this enzyme deficiency, glucocerebroside accumulates in various types of tissues like liver, brain spleen and bone marrow. We aimed to describe the effects of enzyme replacement therapy in three members of a family with Gaucher disease and to emphasize screening of the family members of the patients with Gaucher disease. Furthermore, late diagnosis and treatment in these patients have a minimal effect on improvement of the quality of Fie, and early diagnosis and treatment are very important in Gaucher disease.
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    Cutaneous Anaplastic Large-Cell Lymphoma with Dramatic Response to Brentuximab Vedotin
    Sahin, M; Miskioglu, M; Inanir, I; Akar, H; Nese, N; Temiz, P; Aydogdu, I
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    Bilateral plasmacytoma of the breast
    Orguc, S; Akin, M; Aydogdu, I; Nese, N
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    Pathological Fracture in Odontoid Process in Multiple Myeloma
    Acar, EA; Demirci, U; Pabusçu, Y; Miskioglu, HM; Aydogdu, I
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    Actual reason for bone fractures in the case of a patient followed-up with the osteogenesis imperfecta: Gaucher's Disease
    Demirci, U; Çizmecioglu, A; Aydogdu, I
    Gaucher's disease (GD) is a rare disease characterized by a beta-glucocerebroside accumulation in the reticulo-endothelial system. Patients may refer to the clinic with complaints of bone pain, hepatosplenomegaly, anemia, thrombocytopenia, growth retardation, interstitial pulmonary disease, pulmonary hypertension, and skeletal disorders. Skeletal system involvement is observed commonly in Gaucher patients and a significant cause of morbidity. Our patient was followed for several years as a glass child - osteogenesis imperfecta and he had joint deformities due to skeletal fractures. We wanted to present this case to raise awareness of GD's skeletal involvement and effects of late diagnosis.
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    Amlodipine-induced gingival hypertrophy
    Yolcu, A; Aydogdu, I
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    Signet-Ring Plasma Cells
    Yolcu, A; Aydogdu, I
    A 72-year-old man was referred to the hematology service for management of multiple myeloma. A bone marrow biopsy confirmed 70% involvement of plasma cells, with some cells showing morphologic features of signet-ring cells.
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    The Prognostic Impact of Tumor Microenvironment and Checkpoint Blockade-Associated Molecules (PD-1, PD-L1, CD163 and CD14) in Nodal Diffuse Large B-cell Lymphoma, NOS
    Atmis, O; Nese, N; Aydogdu, I; Alaca, I; Mavili, HS; Isisag, A
    It is aimed to determine expression of programmed cell death-1 (PD-1), programmed cell death ligand-1 (PD-L1), CD163 and CD14 in diffuse large B-cell lymphomas (DLBCL), and whether these markers may predict prognosis in DLBCL cases. A total of 52 nodal DLBCL, NOS cases with no known extranodal involvement at the time of diagnosis were evaluated. PD-1, PD-L1, CD163, and CD14 were studied by immunohistochemistry. The relationships between the results and clinical and laboratory prognostic markers were investigated. It was observed that patients with PD-1 expression < 5 positive cells/HPF had worse overall survival. No significant relationship was found between survival and PD-L1, CD163 and CD14 expressions. In addition, cases that are > 60 years of age, that have Eastern Cooperative Oncology Group (ECOG) performance score >= 2, stage IV disease, high International Prognostic Index score score (>= 3), elevation of LDH, low albumin level, low hemoglobin level, low peripheral blood lymphocyte count, high peripheral blood neutrophil/lymphocyte ratio, high peripheral blood platelet/lymphocyte ratio were found to have worse overall survival. It was concluded that in patients with low number of PD-1 positive tumor-infiltrating lymphocytes have low survival rates and therefore PD-1 expression may be useful in indicating prognosis.
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    Clinicopathologic Spectrum of Dermatological Diseases in Patients with Acute Myeloid Leukemia (AML): A Retrospective Study in AML Patients with Cutaneous Manifestations
    Çetinarslan, T; Avci, BT; Pehlivan, FS; Aydogdu, I; Temiz, P; Ermertcan, AT
    Leukemia is one of the most common hematological malignancies. Cutaneous manifestations of leukemias consist of two groups: specific and non-specific. While the drug reactions, opportunistic infections due to myelosuppression are non-specific skin findings of leukemias, leukemia cutis is a specific sign of cutaneous involvement. In this retrospective study, we included patients over the age of 18 who were diagnosed with acute myeloid leukemia (AML) and underwent histopathological examination due to dermatological complaints. A total of 21 patients were included. Histopathological examination results were consistent with myeloid sarcoma, erythema nodosum, cutaneous drug eruption, necrosis due to vascular damage, cutaneous vasculitis, graft versus host disease, Sweet syndrome and viral infection. Dermatological examination plays an important role in AML patients. Skin biopsy and immunohistochemical examination should be performed to make early diagnosis of skin metastasis of leukemias and paraneoplastic syndromes to reduce the mortality and morbidity in AML patients.
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    Oral administration of ruxolitinib in psoriasis vulgaris: A case report of plaque psoriasis accompanied by myelofibrosis secondary to polisitemia vera successfully treated with oral ruxolitinib
    Çetinarslan, T; Aydogdu, I; Ermertcan, AT
    Psoriasis is a chronic inflammatory skin disease characterized by keratinocyte hyperproliferation and immune cell infiltration. Various therapies have been discovered for psoriasis, including topical treatments, phototherapy, conventional systemic agents such as methotrexate, retinoids and ciclosporine, as well as biologics. Janus kinase/signal transducer and activator of transcription (JAK/STAT) pathway inhibitors targeting Tumor Necrosis Factor alpha (TNF-alpha), interleukin (IL)-23 and IL-17 can be effective in psoriasis. Ruxolitinib is a US Food and Drug Administration-approved first-generation Janus kinase inhibitor for polycythemia vera, myelofibrosis, and acute graft-versus-host disease. Ruxolitinib cream has been investigated in various dermatologic diseases, including atopic dermatitis, vitiligo, psoriasis, and alopecia areata. However, there is limited data on the efficacy of oral ruxolitinib in patients with psoriasis vulgaris. Here, we report a patient diagnosed with myelofibrosis coexisting with psoriasis vulgaris, successfully treated with oral ruxolitinib.