Browsing by Author "Ayse Cefle"

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    A real-life analysis of patients with rheumatologic\rdiseases on biological treatments: Data from TURKBIO\rRegistry
    (2022) gercek can; Fatos Onen; Dilek Solmaz; YAVUZ PEHLIVAN; Cemal Bes; Sema Yilmaz; Merih Birlik; Sedat Çapar; SONER ŞENEL; Suleyman Serdar Koca; mehmet akif öztürk; Özgül Soysal Gündüz; Ayse Cefle; Servet Akar; Ismail Sari; Ayten Yazici; ABDURRAHMAN TUFAN; SEMINUR HAZNEDAROGLU; Gozde Yildirim-Cetin; Servet Yolbas; Berna Goker; Ediz Dalkılıç; Nurullah Akkoç; Şükran Erten; Nevsun Inanc; Haner Direskeneli; Niels Steen Krogh; Sule Yavuz; Fatih Yıldız; Neslihan Yilmaz
    Objective: TURKBIO registry, established in 2011, is the first nationwide biological database in Turkey.\rThis study aimed to provide an overview of TURKBIO data collected by June 2018.\rMethods: The registry included adult patients with rheumatoid arthritis (RA), ankylosing spondylitis\r(AS), nonradiographic axial spondyloarthritis (nr-AxSpA), and psoriatic arthritis (PsA). Demographic and\rclinical features, disease activity markers, and other follow-up parameters, current and previous treatments,\rand adverse events were registered electronically at each visit using open-source software. The\rregistration of patient-reported outcome measures was carried out electronically by the patients using\rtouch screens.\rResults: TURKBIO registry included a total of 41,145 treatment series with biologicals. There were 2,588\rpatients with axSpA (2,459 AS and 129 nr-axSpA), 2,036 with RA, and 428 with PsA. The total number\rof patients, including those with other diagnoses, was 5,718. In the follow-up period, the number of\rpatients and also visits steadily increased by years. The yearly mean number of visits per patient was\rfound to be 2.3. Significant improvements in disease activity and health assessment parameters were\robserved following the biological treatments. Biologics were often given in combination with a conventional\rsynthetic disease-modifying antirheumatic drug in patients with RA. Infections were the\rmost commonly seen adverse events, followed by allergic reactions. Tuberculosis was observed in 12\rpatients, malignancy in 18, and treatment-related mortality in 31.\rConclusion: TURKBIO provided a valuable real-life experience with the use of biologics in rheumatic\rdiseases in Turkey.
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    Body mass index does not affect response of rituximab in patients with rheumatoid arthritis: results from the TURKBİO registry
    (2023) AHMET KARATAŞ; Rabia Pişkin Sağır; Suleyman Serdar Koca; Ediz Dalkılıç; gercek can; YAVUZ PEHLIVAN; Ayten Yazici; Nevsun Inanc; Ayse Cefle; Zeynep Ertürk; Servet Akar; ABDURRAHMAN SONER SENEL; Merih Birlik; Nurullah Akkoç; Fatos Onen
    Background/aim: Adipose tissue produces several inflammatory mediators. Thus, obesity affects the disease course and the responses to the antirheumatic agents in inflammatory diseases. The aim of the study was to determine whether the body mass index (BMI) is involved in the response to rituximab in rheumatoid arthritis (RA). Materials and methods: This multicenter retrospective study included 206 RA patients who received rituximab from the Turkish Biologic (TURKBIO) registry between 2011 and the end of May 2017. Demographic and clinical data including age, sex, disease type, disease duration, and previous or current treatment with disease-modifying antirheumatic drugs (DMARDs) and biological drug durations are stored in the database. Patients with a BMI ≥30 kg/m2 were classified as obese, and patients with a BMI <30 kg/m2 were classified as nonobese. Kaplan-Meier survival analysis was performed to estimate the drug survival. The subgroups were compared using the log-rank test. Results: The mean BMI of 206 patients included in the study was 27.05 (17.2–43.4) kg/m2. There were 59 (28.6%) patients in the obese group and 147 (71.4%) patients in the nonobese group. The mean age, female percentage, and baseline disease activity score 28 (DAS28) were higher in the obese group than in the nonobese group. However, the ΔDAS28 at both 6 and 12 months were not significantly different between the groups (p = 0.785 and p = 0.512, respectively). Patient pain Visual Analogue Scale (VAS), patient fatigue VAS, and patient global VAS scores were also significantly higher at baseline in the obese group (p = 0.003, p = 0.006, and p = 0.006, respectively). However, no significant difference was found in terms of changes in patient pain VAS, patient fatigue VAS, patient global VAS and physician global VAS scores at 6 and 12 months compared to those at baseline. Rituximab treatment was ongoing for 71.2% of the obese and 63.3% of the nonobese patients (p = 0.279). The median drug survival duration was 77 months in the obese group and 62 months in the nonobese group (p = 0.053). The estimated drug survival rates for rituximab were not statistically significantly different in the obese and nonobese groups. Rituximab-related side effects were also similar between the groups. Conclusion: In obese and nonobese patients with RA, rituximab treatment exhibits similar side effects and similar long-term efficacy. These results suggest that obesity does not alter drug survival for rituximab and response rates, in RA and rituximab may be a favorable treatment agent in patients with RA and obesity.
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    Biological treatment in elderly and young patients with ankylosing spondylitis: TURKBIO real-life data results
    (2024) Sadettin Uslu; Semih Gulle; Özkan Urak; gercek can; Ediz Dalkılıç; ABDURRAHMAN SONER SENEL; Servet Akar; Nevsun Inanc; Ayse Cefle; Aydan Koken Avsar; Servet Yolbas; SEMA YILMAZ; Özgül Soysal Gündüz; Ismail Sari; Merih Birlik; Nurullah Akkoç; Fatos Onen
    Objectives: This study aims to investigate the effect of age on disease activity and biological treatment in patients with ankylosing spondylitis (AS). Patients and methods: A total of 811 AS patients registered in the TURKBIO registry database between 2011 and 2019 were categorized according to their age at the time of entry into the registry and assigned to one of two groups: young patients, defined as <60 years of age (n=610), and those aged ≥60 years (n=201) were recorded as elderly patients. Demographic, clinical, and laboratory characteristics, along with disease activity markers and other follow-up parameters, as well as current and prior treatments, were electronically recorded during each visit using open-source software. Results: The mean age of the elderly patients was 67±5.8 years, while the mean age of the younger patients was 49.2±10.9 years. Male predominance was lower in the older AS group compared to the younger AS group (p=0.002). During follow-up period, 397 patients (comprising 318 young and 79 elderly individuals) had a history of using at least one biological disease-modifying agent (bDMARD). There was no significant difference between the groups in terms of DMARD and bDMARD-use distributions. First tumor necrosis factor inhibitor (TNFi) retention rates were found to be similar in both groups over 10 years of follow-up. Adverse events were found to be similar in young (19.9%) and elderly (26.8%) AS patients. Conclusion: Research in the TURKBIO cohort reveals that both older and younger patients with AS exhibited similar disease activity levels with comparable treatment approaches. Moreover, the results of TNFi treatments in elderly patients were the same as those observed in younger patients, with no notable increase in safety concerns.