Browsing by Author "Büyükyazi, G"

Now showing 1 - 6 of 6
  • No Thumbnail Available
    Item
    Effects of Different Intensity Resistance Exercise Programs on Bone Turnover Markers, Osteoprotegerin and Receptor Activator of Nuclear Factor Kappa B Ligand in Post-Menopausal Women
    Karaarslan, S; Büyükyazi, G; Taneli, F; Ulman, C; Tikiz, C; Gümüser, G; Sahan, P
    Objective: To investigate the effects of 12-week two-different intensity resistance training programs on bone turnover markers, bone mineral density (BMD), osteoprotogerin (OPG), and soluble receptor activator of nuclear factor kappa p ligand (sRANKL) in postmenopausal women. Material and Methods: Forty healthy women (aged 45-60 years) participated in the study. High-intensity group (HIG; n=14) worked 4 days a week and performed two sets of 8-10 repetitions at similar to 70-80% of I repeat maximum (RM). Low-intensity group (LIG; n=13) worked in the same duration, with 13-17 repetitions, at similar to 40-50% of IRM. Control group (CG; n=13) did not perform any exercises. Body composition, I RM value for 10 exercises, repetitions of sit-ups for 30 seconds, bone formation and resorption markers, serum osteocalcine (OC). bone alkaline phosphatase (BAP), beta CrossLabs. OPG, and sRANKL levels were measured before and after the training program. BMD was measured via dual energy X-ray absorptiometry. Results: Resistance training caused increases in spine BMD in HIG and LIG (p<0.05). and OC levels increased in the HIG (p<0.05). We observed a significant difference between the percent change in HIG versus the percent change in CC in the spine BMD values (p<0.01). sRANKL levels decreased significantly in all three groups. Strength measures increased in both exercise groups (p<0.001), favoring the HIG. Conclusion: High-intensity resistance training may be more effective for increasing muscle strength and protecting against osteoporosis and fractures. Due to insignificant changes in OPG levels and significant reductions in sRANKL in all groups, measures of circulating OPG and sRANKL levels seem not to be so useful to predict BMD or bone turnover status after resistance training programs. Therefore, these parameters remain to be determined directly in the bone microenyironments together with BMD measures and bone turnover markers.
  • No Thumbnail Available
    Item
    Examining Acute Changes in Some Serum Biochemical Markers of Brain Tissue Damage After Free and Greco-Roman Style Wrestling
    Arslan, F; Büyükyazi, G; Ulman, C; Taneli, F; Gözlükaya, F; Çalkan, M
    Purpose: This study aimed to examine the acute changes in some serum biochemical markers due to overloading in one match of Greco-Roman and free style wrestling competitions. Method: In a repeated measures design, serum samples were collected before and 20 minutes after the first matches of the wrestlers during local wrestling competitions; subsequently analyzed for S-100B and heart-type fatty acid-binding protein. Study groups composed of Greco-Roman (n=15) and free style (n=16) wrestling groups of >= 19 year-old, healthy, male wrestlers. All matches were video-recorded for trauma analyses for each player. Results: Study results showed increments of 109% (p=.007) and 145% (p=.001) in serum S-100B; 63% (p=.023) and 198% (p=.002) in heart-type fatty acid-binding protein levels from pre to post match in the free and Greco-Roman style groups, respectively. The comparison of the increases obtained in the measured parameters did not reveal significant differences between the groups. Conclusion: Due to the significant increases in serum markers, there may be a possible additive effect of traumas in causing brain injuries/head traumas in free and Greco-Roman style wrestling. However, different style wrestling did not affect serum markers indicating brain tissue damage differently.
  • No Thumbnail Available
    Item
    The Effect of an Eight-Week Walking Program on Bone Turnover Markers and sRANKL/Osteoprotegerin Levels in Post-Menopausal Women
    Büyükyazi, G
    Objective: To examine the effect of an eight-week moderate intensity walking program on bone turnover markers, serum osteoprotegerin (OPG) and soluble receptor-activator of nuclear factor- kappa beta ligand (sRANKL) in post-menopausal women. Material and Methods: Twelve post-menopausal women (45-62 years) completed an eight-week walking program at moderate intensity (60-65% maximum heart rate reserve). Non-walking women served as the control group (CG; n= 11). Body weight, percent body fat, body mass index (BMI), estimated maximal oxygen consumption (estimated VO2(max)), bone turnover markers, sRANKL, serum OPG and sRANKL/OPG ratio were measured before and after the intervention. Results: Eight-week walking program produced significant increases in VO2(max) and reductions in body weight and BMI. Serum intact parathyroid hormone (iPTH), and beta- crosslaps (CTx) reduced (p< 0.01, for both), sRANKL/OPG ratio (p< 0.01) and sRANKL values (p< 0.05) increased in the exercise group (EG). We detected significant reductions in the serum OPG levels of EG and CG (p< 0.01). No significant differences were observed between the changes in EG and CG in terms of bone turnover markers, OPG and sRANKL values. Conclusion: Eight-week moderate intensity walking program is beneficial for improving cardiorespiratory function in post-menopausal women to enable them to lead a less risky and a more independent life; however, it seems not so effective in changing the bone turnover markers and the OPG/sRANKL system.
  • No Thumbnail Available
    Item
    The Effects of an 8-week Walking Program on Serum Lipids, Circulation Matrix Metalloproteinase-9 and Tissue Inhibitor of Metalloproteinase-1 in Post-menopausal Women
    Büyükyazi, G; Ulman, C; Taneli, F; Aksoy, D; Tikiz, H; Ari, Z
    Purpose: To examine the effects of an 8-week walking program on serum lipids, circulation matrix metalloproteinase-9 and tissue inhibitor of metalloproteinase-1 in post-menopausal women. Method: Body weight, percent body fat, body mass index, estimated maximal oxygen consumption, blood lipids, matrix metalloproteinase-9, tissue inhibitor of metalloproteinase-1 concentrations were assessed and their matrix metalloproteinase-9/tissue inhibitor of metalloproteinase-1 molar ratios were calculated in exercise (n=12) and control (n=12) groups. Exercise group completed an eight-week walking program at moderate (similar to 6.29 +/- 0.15km/h; similar to 62% maximum heart rate reserve) intensity. Results: Significant changes in estimated maximal oxygen consumption, systolic and diastolic blood pressures, body weight, and body mass index (p<.05) were determined in exercise group. However, there were no significant changes in the measured blood lipids (triglyceride, cholesterol, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol), matrix metalloproteinase-9, and tissue inhibitor of metalloproteinase-1 concentrations, and matrix metalloproteinase-9/tissue inhibitor of metalloproteinase-1 molar ratio of exercise group, except for a nearly significant change in tissue inhibitor of metalloproteinase-1 level (p=.092). We determined no significant changes in any of the measured parameters in control group. Conclusion: Despite its protective effects against coronary heart disease risks, the duration and intensity of this program is not sufficient to cause significant changes in blood lipids, matrix metalloproteinase-9, and tissue inhibitor of metalloproteinase-1 concentrations. A higher-intensity, longer-duration program accompanied with diet is proposed.
  • No Thumbnail Available
    Item
    Do Walking Programs Affect C-Reactive Protein, Osteoprotegerin and Soluble Receptor Activator of Nuclear Factor-Kappaβ Ligand?
    Esen, H; Büyükyazi, G; Ulman, C; Taneli, F; Ari, Z; Gözlükaya, F; Tikiz, H
    Aim: To examine the effects of 10-week walking programs on maximal oxygen consumption, body composition, serum lipids, highly-sensitive C-reactive protein, osteoprotegerin and soluble receptor activator of nuclear factor-kappa beta ligand. Method: Twenty-seven middle-aged men (40-60years) walked for ten weeks, five days per week, 40-52min per day at either moderate or high intensity (similar to 5.95 +/- 0.26km/h and similar to 7.64 +/- 0.36km/h; 50-55% and 70-75% maximum heart rate reserve, respectively). Non-walking, sedentary men served as controls (n=13). Estimated maximal oxygen consumption, body composition, lipid profile, highly-sensitive C-reactive protein, osteoprotegerin and soluble receptor activator of nuclear factor-kappa beta ligand were determined before and after the study. Results: After 10 weeks, estimated maximal oxygen consumption improved in both exercise groups (p<.05), favoring high-intensity group (p<.05). Body weight, percent body fat, and body mass index reduced significantly in both exercise groups (p<.05). Walking programs did not cause any significant changes in blood lipids, highly-sensitive C-reactive protein, and osteoprotegerin levels; however, soluble receptor activator of nuclear factor-kappa beta ligand levels were found to decrease in high-intensity group (p<.05) and the change observed in both exercise groups was different from the change in control group (p<.05). Conclusion: For protective effects against cardiac risk factors and arterial calcification, high-intensity walking programs are advisable due to the greater improvements in soluble receptor activator of nuclear factor-kappa beta ligand and estimated maximal oxygen consumption.
  • No Thumbnail Available
    Item
    Effects of two different eight-week walking programs on insulin resistance and ER stress-related markers in pre-menopausal women
    Dogru, Y; Büyükyazi, G; Ulman, C; Taneli, F; Tikiz, H; Göral, M; Esen, H
    Objective: The relationship between exercise and endoplasmic reticulum (ER) stress, insulin resistance, and obesity is a new field of research. To our knowledge, there are no studies examining the effects of walking exercises on ER stress related markers and insulin resistance in pre-menopausal women. To examine the effect of two different eight-week walking programs on the tumor necrosis factor-alpha (TNF-alpha), Fetuin-A (alpha 2 - Heremans Schmid glycoprotein), c-Jun N-terminal kinase-1 (JNK-1) and retinol-binding protein-4 (RBP-4), the related markers of ER stress and insulin resistance in pre-menopausal women. Methods: Exercise groups (moderate tempo walking group; MTWG; n=11; brisk walking group BWG; n= 12) walked five days a week, starting from 30 minutes, gradually increasing up to 51 minutes. BWG walked at similar to 70-75% and MTWG at similar to 50-55 of HRRmax. Body mass index (BMI), body fat percentage (%), VO2max, serum TNF-alpha, Fetuin-A, JNK-1, RPB-4, blood lipids, and insulin resistance levels were determined before and after the intervention. Results: VO2max increased in both exercise groups favoring BWG; RBP-4 decreased in both exercise groups (p<0.05). Serum TNF-alpha and, TG (p<0.05), BMI and percent body fat (p<0.01), and insulin levels reduced significantly in BWG (p<0.05). The reductions observed in both exercise groups in insulin resistance, and the increases determined in the negative levels of JNK-1 in BWG may be clinically important. Conclusion: Both type of walking resulted in similar positive effects on RBP-4. The reduction observed in TNF-alpha, RBP-4, and the increases in the negative levels of JNK-1 in BWG show the positive effects of brisk walking on ER stress. The reduction in insulin resistance in relation to the possible reductions in ER stress and apoptosis in BWG may be more effective to prevent metabolic diseases.