Browsing by Author "Bakan, B"

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    Preparation of a 99mTc-labeled graft polymer and its in vitro and in vivo evaluation
    Avcibasi, U; Türkyarar, T; Karadag, A; Bakan, B; Yavasoglu, NÜK; Kusat, K; Akgöl, S; Gülcemal, D; Tekin, V; Müftüler, FZB; Topal, G; Parlak, Y; Gümüser, FG
    The aim of this study is the synthesis of a novel Tc-99m-labeld graft polymer and the biological evaluation of its in vitro and in vivo properties. To this end, a L-proline-graft-poly(HEMA) was prepared and labeled with Tc-99m. The radiochemical yield of approximately the Tc-99m-labeled compound amounted to 97 +/- 2.3%. The cytotoxicity test revealed no cytotoxic effect after a 24- and 48-h incubation. The results of the hemolysis test showed that hemolysis was non-toxic with an effect level of less than 2%. Subsequently, the biodistribution in healthy rats was determined. High accumulation of the polymer was observed in the pancreas, thyroid and prostate.