Browsing by Author "Balci C."

Now showing 1 - 2 of 2
  • No Thumbnail Available
    Item
    Comparison of propofol and sevoflurane anesthesia by means of blood loss during endoscopic sinus surgery
    (2004) Sivaci R.; Yilmaz M.D.; Balci C.; Erincler T.; Unlu H.
    Objective: The purpose of the present investigation is to examine whether induced hypotension with propofol or sevoflurane anesthesia improves the dryness of surgical field in endoscopic sinus surgery (ESS). Methods: The study was performed between 1999 and 2002 in Celal Bayar University and Afyon Kocatepe University Hospitals, Turkey. Thirty-two patients (American Society of Anesthesiologists physical status I and III) with chronic sinusitis undergoing outpatient endoscopic sinus surgery under general anesthesia were studied to determine if anesthetic technique had an impact on estimated blood loss. The patients were allocated randomly into 2 groups. None of the patients were premedicated. Anesthesia was induced with propofol in both groups and maintained with propofol/fentanyl in the first group and sevoflurane/fentanyl in the second group. In both groups, controlled hypotension was used to improve surgical condition. Results: There were no differences between the duration of surgery and intraoperative mean arterial blood pressure when comparing the 2 groups. The average estimated blood loss in the propofol group was 128.1 ± 37.3 ml compared with an average estimated blood loss of 296.9 ± 97.8 ml in the sevoflurane group (p<0.01). Conclusion: General anesthesia based on propofol infusion may have the advantage of decreased bleeding compared with conventional inhalation agents. Therefore, making endoscopic surgery technically easier and safer by improving endoscopic visualization of the surgical field.
  • No Thumbnail Available
    Item
    Biochemical changes representing oxidative stress on brain tissue due to intraabdominal hypertension in a rat model
    (2007) Karabekir H.S.; Guzey F.K.; Balci C.; Guvenc Y.; Onur E.; Akbulut G.; Serteser M.
    Introduction: Intraabdominal hypertension affects the central nervous system in addition to respiratory, renal and cardiovascular systems. This effect that, investigated in detail by clinical and experimental studies, is due to the increase of intracranial pressure and decrease of cerebral perfusion pressure caused by the increase of intrathoracic pressure and increase of pressure of great veins. However, no study has been found on biochemical changes on central nervous tissue due to intraabdomial hypertension. Material and methods: Thirty rats were divided into three groups containing 10 animals: sham group, study group I and study group II. In group I, intraabdominal pressure was elevated to 20 mmHg, and in group II, it was elevated to 30 mmHg for 60 minutes. Intracranial pressures (ICP) in all animals were monitored. Values of biochemical parameters including thiobarbituric acid, nitrite oxide, xanthine oxidase, protein carbonyls and protein sulfhydryl in cortical, subcortical, cerebellar and spinal cord tissues were compared with the corresponding values in sham rats. Results: Thiobarbituric acid (0.58±0.8 and 0.76±0.04 vs. 0.23±0.03, p<0.05 and p<0.001), nitrite oxide (3.11±0.10 and 8.46±0.54 vs. 1.52±0.18, p<0.05 and p<0.001), xantine oxidase (1.55±0.11 and 3.01±0.25 vs. 0.32±0.09, p<0.001) and carbonyl levels (1.41±0.01 and 1.69±0.01 vs. 1.22±0.03, p<0.001) of the various central nervous system regions and ICP were increased. SH levels (92.60±2.50 and 74.60±3.80 vs. 139.20±4.72, p<0.001) were decreased after intraabdominal hypertension, and higher IAP generally caused more detrimental effects on these parameters. The levels of spinal cord and cerebellum samples were significantly worse in the study groups for most of the markers. Conclusions: Intraabdominal hypertension may cause biochemical changes representing oxidative stress on various regions of central nervous system even 60 minutes after increase of intraabdominal pressure, and higher IAH causes more detrimental effects. Most prominent effects were seen in spinal cord and cerebellar tissue suggesting that compression of lumbar vertebral venous pressure might have a role in addition to increase of ICP due to increase of pressure of great veins caused by increase of intrathoracic pressure. Copyright © 2007 Termedia & Banach.