Browsing by Author "Barutçuoglu, M"
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Item Anaplastic Ependymoma and Atypical Refractory Longitudinal Expansive Transverse Myelitis Due to Immune Reaction After COVID-19-A Case Discussion That Raises Many Unknown Questions About Covid-19Gemici, YI; Çelik, F; Göz, ZZ; Isisag, A; Ovali, GY; Zileli, M; Barutçuoglu, M; Mavioglu, HInflammatory neurologic manifestations, both infectious and noninfectious, have been reported secondary to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2/COVID-19). However, the relationship of spinal tumor and COVID-19 longitudinally extensive transverse myelitis (LETM) coexistence has never been reported in our knowledge. The clinical presentation and response to treatment of a 24-year-old female patient diagnosed with COVID-19 LETM and anaplastic ependymoma are described in this case report. The Patient's cerebrospinal fluid COVID-19 antibody level was higher than serum , she was resistant to immunosuppressive treatment. The interaction between COVID-19 and spinal tumor was discussed in the light of the literature. It is thought that COVID-19 infection could trigger tumor growth in this patient. Also, this is the first case of anaplastic ependymoma and COVID-19 myelitis coexistence in the literature.Item Comparison of Three Surgical Approaches for the Treatment of Lumbar Spinal Stenosis: Total Laminectomy, Unilateral Approach for Bilateral Decompression, and Total Laminectomy with Posterior Transpedicular Screw FixationBarutçuoglu, M; Mete, M; Unsal, UU; Gurgen, AI; Duransoy, YKIntroduction: Lumbar spinal stenosis (LSS) is one of the most common diseases for spinal surgery and many surgical techniques are used for treatment. Objective: The aim of this retrospective study was to observe the clinical and radiological results of total laminectomy (TL), unilateral approach for bilateral decompression, and posterior transpedicular fixation-interbody fusion with TL. Materials and Methods: The data of 112 patients who underwent surgical treatment for LSS with different surgical techniques were reviewed retrospectively. The patients were divided into 3 groups according to the surgical technique. In the first group, patients underwent TL, in the second group, patients underwent bilateral decompression via unilateral hemilaminectomy, and in the third group, patients underwent posterior transpedicular fixation-interbody fusion with TL. Preoperative and postoperative evaluations were done by visual analog scale (VAS) and functional back pain scales (FBPSs). Furthermore, three groups were compared in respect of operation time, bleeding, and complications. Results: The difference between preoperative and postoperative VAS and FBPS scores were statistically significant in all groups. Operation time, bleeding, and hospital stay were greater in fusion group than decompression-alone groups. The VAS improvement rate was 66%, 70%, and 62% in Group 1, Group 2, and Group 3, respectively. In addition, improvement of FBPS scores between preoperative and postoperative period was statistically significant for the three groups (P < 0.05). Conclusion: Decompression with fusion surgery had no significant difference compared with decompression alone in patient's clinical outcome and safety.Item Intracranial hydatid cyst is a rare cause of midbrain herniation: A case report and literature reviewDuransoy, YK; Mete, M; Barutçuoglu, M; Ünsal, ÜÜ; Selcuki, MHydatid disease is a parasitic infection affecting the brain in about 2% of the cases. Brain involvement is most commonly observed in children. Here, we report a 13-year-old male patient who presented with headache, nausea, and vomiting. Before cranial computed tomography (CT) was performed, the patient had generalized epileptic seizures. He was disoriented, and had anisocoria with dilatation of the right pupilla. CT showed a cystic lesion of 10-cm diameter in the right temporoparietal region that had caused a shift of the midline structures to the contralateral side; an urgent operation was performed as there were signs of midbrain herniation.Item Scoliosis may be the first symptom of the tethered spinal cordBarutçuoglu, M; Selçuki, M; Umur, AS; Mete, M; Gurgen, SG; Selcuki, DBackground: Tethered cord syndrome (TCS) is a progressive clinical entity that arises from abnormal spinal cord tension. Scoliosis may be a unique symptom in TCS. The aim of this study is to investigate prognosis after releasing the filum terminale in scoliosis due to TCS with/without findings in magnetic resonance imaging (MRI) and to draw attention to the importance of somatosensorial evoked potentials (SSEP) on the differential diagnosis of idiopathic scoliosis versus scoliosis due to TCS with normal appearance of filum terminale and conus medullaris. Materials and Methods: Eleven female and seven male patients with progressive scoliosis were included in the study. They were evaluated radiologically, SSEP and urodynamical studies. Preoperative and postoperative anteroposterior full spine X-rays were obtained for measuring the Cobb's angle. MRI was performed in all cases for probable additional spinal abnormalities. All patients underwent filum terminale sectioning through a L5 hemilaminectomy. The resected filum terminale were subjected to histopathological examination. Results: The mean Cobb angle was 31.6 degrees (range 18 degrees u45 degrees). Eight patients (44.45%) had a normal appearance of filum terminale and normal level conus medullaris in MRI, but conduction delay and/or block was seen on SSEP. In the histopathological examination of filum terminale dense collagen fibers, hyaline degeneration and loss of elastic fibers were observed. Postoperatively none of the patients showed worsening of the Cobb angle. Three patients showed improvement of scoliosis. Conclusion: In TCS presented with scoliosis, untethering must be performed prior to the corrective spinal surgery. Absence of MRI findings does not definitely exclude TCS. SSEP is an important additional guidance in the diagnosis of TCS. After untethering, a followup period of 6 months is essential to show it untethering helps in stopping the progress of the scoliotic curve. In spite of non progression (curve stopped lesser than 45 degrees) or even improvement of scoliosis, there may be no need for major orthopedic surgical intervention.Item Congenital Dermal Sinus Tract of the Spine: Experience of 16 PatientsMete, M; Umur, AS; Duransoy, YK; Barutçuoglu, M; Umur, N; Gurgen, SG; Selçuki, MCongenital dermal sinus tract is a rare entity which lined by epithelial cells and can end anywhere between subcutaneous planes to thecal sac. These tracts may be accompanied with other pathologies such as lipomyelomeningocele, myelomeningocele, split cord malformation, tethered cord, filum abnormality and inclusion tumors and treatment includes resection of tract with intradural exploration. The authors review their experience with 16 cases. Clinical, radiological appearance and treatment of these lesions discussed with literature review.Item The evaluation of muscle biopsy findings in children with neuromuscular disordersDiniz, G; Yildirim, HT; Ünalp, A; Barutçuoglu, M; Güzel, O; Polat, M; Türe, S; Özgönül, F; Serdaroglu, GObjective: The studies considering the clinical and histopathological features of childhood muscle disease are scarce in number worldwide. This study aims to examine the histopathological profile of the children's muscle biopsies evaluated at the Behcet Uz Children's Hospital (BUCH) and determine their correlation with clinical diagnosis. Methods: We retrospectively reviewed 323 children who underwent muscle biopsy examination between 2004 and 2011 at pathology laboratory of Izmir BUCH. All patients were clinically diagnosed as neuromuscular disorders and biopsy specimens were collected from 5 different centers of neurological disorders. Results: The mean age of the patients was 6.15 years (3 weeks-18 years). Only 22 cases (6.8%) were older than 14 and 39 (12.07%) were younger than twelve months. Spinal muscular atrophy (n=11; 28.2%) was the most common disease in the infantile group. Dystrophies were diagnosed in 148 (45.7%) patients and 102 of them were dystrophinopathies. Other disorders were 23 primary, 16 inflammatory and 19 metabolic/mitochondrial myopathies and 28 neuropathies. Seventy three (22.9%) patients had similarly affected family members. Consanguinity rate was 25.1%. Serum enzymes alterations, EMG pathologies and fiber type disproportion were determined in 109 (33.7%), 188 (58.2%) and 85 (26.3%) of the patients respectively. There were statistical significant correlations between the types of disease and serum enzyme levels (p=0.001), and age (p=0.015) of the patients. Conclusion: The present study revealed the panorama of the childhood muscle diseases in western Turkey. We conclude that if avoidance from unnecessary diagnostic and therapeutic interventions was desired, we must be aware of the limitation and diagnostic value of muscle biopsy evaluations in childhood muscle diseases.Item The Role of Transforming Growth Factor Beta and Smad Receptors in Determining Prognosis in High-Grade Primary Brain Tumors: Glioblastoma MultiformeGürsoy, G; Barutçuoglu, M; Sivrikoz, ON; Gökalp, S; Vatansever, SIntroduction High-grade primary brain tumors cause serious morbidity and mortality. This study aimed to investigate the role of transforming growth factor beta (TGF-beta) and suppressor of mothers against decapentaplegic (Smad) receptors in high-grade primary brain tumors. \Material and Method Thirteen patients with a pathological diagnosis of glioblastoma multiforme were included in the study. Pathological preparations of each patient were analyzed retrospectively in histochemistry and immunohistochemistry laboratories. Transforming growth factor beta 1, TGF-beta 2, TGF-beta 3, Smad 1/2/3, Smad 6, and Smad 7 stainings were evaluated, and the immunoreactivity densities were examined. Result We found out an increase in the expression of TGF-beta 1 and TGF-beta 3 protein. Regarding the inhibitin receptors, Smad 6 showed much more expression than Smad 7. Thus, we found that Smad 6 has a protective effect and role in the tissue. Immunhistochemically, TGF-beta family stains, which are activated by types I-and -II receptors, and the stainless staining of the Smad family might also be showing that the TGF-beta family is taking action with a secondary pathway other than the Smad family. Conclusion In addition to Smad family receptors, Shc-GBR2, SARA, and Ras-Erk1/2 receptors should be investigated in future research. After that, the prognosis, diagnosis, and patient-based chemotherapy strategies for the treatment of glioblastoma multiforme may take a more prominent role.