Browsing by Author "Bayazit, TO"

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    Distribution of Paw Preference in Female and Male Rats: Assessed by A Modified Version Food-Reaching Test
    Kutlu, N; Bayazit, TO; Mutlu, F
    We re-studied the distribution of paw preference in male and female rats using a new food-reaching test. Paw preference was assessed using a modified new version of food reaching task in quadrupedal position. Of the total sample (N=165). Of 165 rats, 86 (52.12%) were right-handed, 72 (43.64%) were left-handed, and 7 (4.24%) were mixed-handed. Of the in male (N=74) 36(48.65%) were right-handed, 35 (47.30%) were left-handed, and 3 (4.05%) were mixed-handed. The right-minus left paw reaches fitted to gaussian data with two prominent peaks due to right and left preference. In female (N=91) 50(54.94%) were right-handed, 37(40.66%) were left-handed, and 4 (4.40%) were mixed-handed. The female right-preference showed a right-bais compared to males. The males left-preference were more than female left-preference. The distribution of right minus left paw reach was not U-shaped, it was J-shaped like in humans. The results indicate that the distribution of paw preference in rats is similar to that of other animals and to human handedness. It was concluded that there is a right-bias in paw rats, which is caused by the female right-preference under the influence of a biological factor. The right-pawed males were found to be least lateralized than the male left-preference, and female right-and left preference. The brain is in general more lateralized than the female brain.
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    Blood brain barrier in right- and left pawed female rats assessed by a new staining method
    Kutlu, N; Vatansever, HS; Bayazit, TO; Ekerbicer, N; Tan, U
    The asymmetrical breakdown of the blood-brain barrier (BBB) was studied in female rats. Paw preference was assessed by a food reaching test. Adrenaline-induced hypertension was used to destroy the BBB, which was evaluated using triphenyltetrazolium (TTC) staining of the brain slices just after giving adrenaline for 30 s. In normal rats, the whole brain sections exhibited complete staining with TTC. After adrenaline infusion for 30 s, there were large unstained areas in the left brain in right-pawed animals, and vice versa in left-pawed animals. Similar results were obtained in seizure-induced breakdown of BBB. These results were explained by an asymmetric cerebral blood flow depending upon the paw preference in rats. It was suggested that this new method and the results are consistent with contralateral motor control that may be important in determining the dominant cerebral hemisphere in animals.