Browsing by Author "Baykal Selçuk L."

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    A multicentre prospective analysis of the incidence of pemphigoid diseases in Turkey
    (John Wiley and Sons Inc, 2021) Durdu M.; Bozca B.C.; Enli S.; Yazıcı Özgen Z.; Yaylı S.; Aktan Ş.; Mutlu D.; Erturan I.; Ayvaz Çelik H.H.; Melikoğlu M.; Pala E.; Gürsel Ürün Y.; Harman M.; Şavk E.; Işık S.; Duygulu Ş.; İmren I.G.; Fettahlıoğlu Karaman B.; Kaya Erdoğan H.; Kılıç A.; Özçelik S.; Inan K.; Yılmaz M.A.; Şanlı H.E.; Kalay Yıldızhan İ.; Mülayim M.K.; Çiçek D.; Demir B.; Yasak Güner R.; Baykal Selçuk L.; Gündüz K.; Daye M.; Borlu M.; Solak E.O.; Dizman D.; Güneş B.; Ozkur E.; Polat M.; Eskiocak A.H.; Uzun S.
    Background: The differentiation between the pemphigoid diseases is essential for treatment and prognosis. In Turkey, data on the incidence of these diseases are insufficient. Our aim in this study is to determine the incidence, demographics and clinical characteristics associated with diseases of the pemphigoid group. Methods: We prospectively analysed 295 patients with pemphigoid who visited dermatology clinics of tertiary referral hospitals in 12 different regions of Turkey within a year. The diagnosis was based on clinical, histopathological, direct immunofluorescence (DIF) and serological (multivariant enzyme-linked immunosorbent assay [ELISA], indirect immunofluorescence and mosaic-based BIOCHIP) examinations. Clinical and demographic findings, aetiological factors and concomitant diseases observed in the patients were recorded. Results: A total of 295 (female/male ratio: 1.7/1) patients with pemphigoid were diagnosed in 1-year period. The overall incidence rate of pemphigoid diseases was found to be 3.55 cases per million-years. The ratio of pemphigoid group diseases to pemphigus group diseases was 1.6. The most common pemphigoid type was bullous pemphigoid (BP, 93.2%). The others were epidermolysis bullosa acquisita (3.1%), pemphigoid gestationis (2.4%), linear IgA disease (1%) and mucous membrane pemphigoid (0.3%). The most common (26.8%) possible trigger of the bullous pemphigoid was gliptin derivative drugs. The most common concomitant diseases with pemphigoid were cardiovascular (27.8%) and neurological diseases (23.7%). Conclusions: This study showed that the increased frequency of bullous pemphigoid reversed the pemphigoid/pemphigus ratio in Turkey. Further studies are warranted regarding the reasons for this increase. © 2021 The Australasian College of Dermatologists
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    Clinical and demographic features of hidradenitis suppurativa: a multicentre study of 1221 patients with an analysis of risk factors associated with disease severity
    (Blackwell Publishing Ltd, 2021) Özkur E.; Karadağ A.S.; Üstüner P.; Aksoy B.; Eşme P.; Çalışkan E.; Akoğlu G.; Kalkan G.; Demirseren D.D.; Polat M.; Ozden M.G.; Kılınç F.; Yalçınkaya İyidal A.; Kıvanç Altunay İ.; Türkmen M.; Uğurer E.; Baysak S.; Fettahlıoğlu Karaman B.; Mammadlı K.; Baykal Selçuk L.; Türkoğlu Z.; Atcı T.; Didar Balcı D.; Adışen E.; Temel B.; Aktan Ş.; Kaçar N.; Gündüz K.; Türel Ermertcan A.; Özdemir M.; Ünal Çakıter A.; Çölgeçen E.; Uçmak D.; Kelekçi H.; Ataseven A.; Durmaz K.; Kaya Özden H.; Engin B.; Yazıcı S.; Alpsoy E.
    Background: Hidradenitis suppurativa (HS) is a chronic, relapsing and debilitating inflammatory disease associated with profound morbidity. Aim: In this multicentre study, we investigated the demographic and clinical features of HS, and determined risk factors of disease severity. Methods: In total, 1221 patients diagnosed with HS from 29 centres were enrolled, and the medical records of each patient were reviewed. Results: The mean age of disease onset was 26.2 ± 10.4 years, and almost 70% (n = 849) of patients were current or former smokers. Mean disease duration was 8.9 ± 8.4 years with a delay in diagnosis of 5.8 ± 3.91 years. Just over a fifth (21%; n = 256) of patients had a family history of HS. The axillary, genital and neck regions were more frequently affected in men than in women, and the inframammary region was more frequently affected in women than in men (P < 0.05 for all). Acne (40.8%), pilonidal sinus (23.6%) and diabetes mellitus (12.6%) were the most prevalent associated diseases. Of the various therapies used, antibiotics (76.4%) were most common followed by retinoids (41.7%), surgical interventions (32.0%) and biologic agents (15.4%). Logistic regression analysis revealed that the most important determinants of disease severity were male sex (OR = 2.21) and involvement of the genitals (OR = 3.39) and inguinal region (OR = 2.25). More severe disease was associated with comorbidity, longer disease duration, longer diagnosis delay and a higher number of smoking pack-years. Conclusions: Our nationwide cohort study found demographic and clinical variation in HS, which may help broaden the understanding of HS and factors associated with disease severity. © 2020 British Association of Dermatologists
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    Internalized Stigma in Hidradenitis Suppurativa: A Multicenter Cross-Sectional Study
    (S. Karger AG, 2023) Bilgic A.; Fettahlloglu Karaman B.; Demirseren D.D.; Clnar L.; Kacar N.; Türel Ermertcan A.; Bulbul Baskan E.; Güven M.; Yazici S.; Özkök Akbulut T.; Ucmak D.; Ataseven A.; Temiz S.A.; Engin B.; Şikar Aktürk A.; Sarlcaoǧlu H.; Güler Özden M.; Özdemir H.; Mammadli K.; Durmaz K.; Gülbaşaran F.; Klllnc F.; Kaya Özden H.; Gönülal M.; Didar Balcl D.; Çevirgen Cemil B.; Sarlkaya Solak S.; Baykal Selçuk L.; Özaydln Yavuz G.; Yavuz Ä.H.; Dönmez L.; Alpsoy E.
    Background: Hidradenitis suppurativa (HS) causes significant physical, social, and psychological burdens. Internalized stigma, acceptance of negative attitudes and stereotypes of society regarding a person's illness, has not been studied previously in HS. Objectives: The objective of this study was to investigate the internalized stigma state of HS patients and identify the factors affecting it. Methods: This multicenter, prospective, cross-sectional study included 731 patients. Internalized Stigma Scale (ISS), Hurley staging, Physician Global Assessment, Dermatology Life Quality Index (DLQI), Skindex-16, Beck Depression Inventory-II (BDI-II), and Visual Analog Scale (VAS)-pain score were used in the study. Results: The mean ISS value (57.50 ± 16.90) was comparable to the mean ISS values of studies in visible dermatological and various psychiatric diseases. A significant correlation was found between the mean values of ISS and all disease activity scores, quality of life measures, BDI-II, and VAS-pain scores. Obesity, family history, low education and income level, vulva/scrotum involvement and being actively treated are significant and independent predictive factors for high internalized stigma in multivariate analysis. Conclusions: HS patients internalize society's negative judgements, which may create a profound negative effect on access to health care. Therefore, in addition to suppressing disease activity, addressing internalized stigma is fundamental for improving health care quality. © 2023 S. Karger AG. All rights reserved.
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    Clinical Features and Natural Course of Hidradenitis Suppurativa in Turkey: A Multicenter Study
    (S. Karger AG, 2024) Alpsoy E.; Fettahlloglu Karaman B.; Demirseren D.D.; Clnar S.L.; Kacar N.; Türel Ermertcan A.; Bulbul Baskan E.; Ucmak D.; Mammadli K.; Klllnc F.; Yazici S.; Temiz S.A.; Özkök Akbulut T.; Ataseven A.; Şikar Aktürk A.; Sarlcaoǧlu H.; Türkmen M.; Gülbaşaran F.; Engin B.; Kaya Özden H.; Durmaz K.; Güler Özden M.; Özdemir H.; Çevirgen Cemil B.; Sarlkaya Solak S.; Bilgili S.G.; Yavuz I.H.; Özaydln Yavuz G.; Güven M.; Polat Ekinci A.; Atcl T.; Didar Balci D.; Oztürk A.; Klvanç Altunay I.; Özkur E.; Ugurer E.; Karadag A.S.; Kalkan G.; Klllc S.; Erdoǧan B.; Yayli S.; Baykal Selçuk L.; Dönmez L.; Bilgic A.
    Introduction: The natural history, the progression of a disease process in an individual over time, has not yet been fully elucidated in hidradenitis suppurativa (HS). In this large multicenter study, we aimed to investigate the natural history of HS and its gender differences. Methods: This cross-sectional study included 827 patients. The chronological order of the clinical manifestations for each patient was recorded retrospectively. Sociodemographic characteristics, triggering factors, clinical, treatment, and prognostic featureswere also evaluated. Results: The mean age of disease onset was significantly younger in women than in men (22.42 ± 9.28 vs. 27.06 ± 20.56, p < 0.001) and those with a family history (p < 0.0001). The mean disease duration was 91.17 ± 83.64 months. The most common symptom was purulent discharge (81%). The mean duration of abscess was shorter in women than in men (3.11 ± 2.65 vs. 3.75 ± 3.75, p = 0.01). The axilla was the most common onset area followed by the inguinal and gluteal regions. The disease ran a more severe course in men. Abscess/inflammatory nodule was defined in the last 6 months in 88.6% of the patients; however, the first 5 years of the disease were the most active disease period in 67.5% of the patients. Multivariate analysis revealed being male, older age, family history, involvement of the axillary, inguinal, and perianal regions independently associated with HS severity. While antibiotic use was the most important factor in improving the disease symptoms, stress was themost common aggravating factor. Biological therapy in men, laser epilation and pregnancy in women were significant alleviating factors, whereas weight gain was a more common aggravating factor for women. Conclusion: HS shows a relentlessly progressive course with inflammatory attacks, but the first years of the disease are the most active period. This study confirms that environmental and hormonal factors may play an important role in the disease course, probably with other endogenous or exogenous factors. © 2024 S. Karger AG, Basel.