Browsing by Author "Bayraktar O."

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    Electrospraying of zein for the preparation of micro/nano-particles loaded with sarcopoterium spinosum extract
    (AMG Transcend Association, 2019) Süngüc C.; Erdogan İ.; Uslu M.E.; Bayraktar O.
    Natural compounds that are isolated from various plant species have been the focus of folk medicine due to their bioactivities. Pharmaceutical, food and cosmetic industries also utilize these natural compounds with antioxidant and antimicrobial properties. Harsh processing and storage conditions causing loss of their bioactivities limit their applications. Therefore, biopolymeric carrier systems are required to preserve the natural bioactive compounds stability. Sarcopoterium spinosum is used in folkloric medicine for curing diabetes, gastrointestinal illnesses, cancer and pain. In this study, both solution and process parameters for electrospraying technique were investigated to encapsulate S. spinosum extract including natural bioactive compounds in zein particles. The best results were observed in 5% (w/v) of zein concentration in 70% aqueous ethanol. 0.3 ml/hour flow rate and 14 kV applied voltage were used in order to obtain narrow size distributionorbicular and smooth particle structure. The best mixture of S. spinosum extract and zein was achieved at weight ratio of 1:5. The zein microparticles with extract showed remarkable antioxidant activity. © 2019, AMG Transcend Association. All rights reserved.
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    Evaluation of the hemostatic activity of Equisetum arvense extract: The role of varying phenolic composition and antioxidant activity due to different extraction conditions
    (AMG Transcend Association, 2019) Uslu M.E.; Mele A.; Bayraktar O.
    Hemostasis is a procedure that causes bleeding to stop and is very important in injuries. Recent researches were focused on the discovery of plant hemostatic agents. Therefore, plant extracts were investigated as a major source as a hemostatic agent. In this research, Equisetum arvense extract was investigated as a candidate coagulatory agent. Effect of extraction parameters on coagulation was investigated. Although it has been stated in the literature that the extract of Equisetum arvense has anticoagulatory activity, it has been shown in this study that alteration of the extraction parameters changes the extract bioactivity from the anticoagulant to the coagulant. © 2019 by the authors.
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    Antioxidant, Antimicrobial, and Cytotoxic Activities of Condensate from Rf-Vacuum Timber Drying Process in the Forestry Industry
    (Springer Science and Business Media B.V., 2021) Köse M.D.; Uslu M.E.; Bayraktar O.
    As the demand for dried timber has been increasing worldwide, drying of timbers is required to supply the demand in the manufacturing industries of furniture and other interior woodwork. During the drying process, some condensation will occur, resulting in liquids' emission, which requires disposal. In the liquid condensate, there are many substances at low concentrations that make their recovery uneconomic. After revealing the potential of the substances available in these condensates, biotechnological processes can be employed to produce high value-added products. This condensate contains tree sap, including proteins, enzymes, and many natural compounds such as terpenoids, alkaloids, phenolic compounds. Thus, it is considered that these natural compounds might be beneficial in pharmaceutical applications. Natural compounds such as phenolic compounds are bioactive substances that have antioxidant, antimicrobial, and cytotoxic activities. This study was aimed to characterize the condensate from the Rf-vacuum drying process of beech (Fagus sylvatica L.), walnut (Juglans regia L.), and restharrow (Onosis arvensis L.) in terms of antioxidant capacity, total phenol content, antimicrobial activity, and cytotoxicity. Obtained data revealed that condensates from the Rf-vacuum drying process inhibited the growth of both S. epidermidis and E. coli significantly. Graphic Abstract: [Figure not available: see fulltext.] © 2021, The Author(s), under exclusive licence to Springer Nature B.V. part of Springer Nature.
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    Utilization of eggshell membrane and olive leaf extract for the preparation of functional materials
    (MDPI AG, 2021) Bayraktar O.; Galanakis C.M.; Aldawoud T.M.S.; Ibrahim S.A.; Köse M.D.; Uslu M.E.
    Eggshell membrane (ESM) is a natural proteinaceous by-product of the food industry, especially in the pasteurized egg industry, resulting in the availability of much discarded egg waste. In the literature, eggshell (ES) and ESM usage for their adsorbent properties to remove various organic and inorganic hazardous chemicals, especially from wastewater, has gained interest. In addition, agricultural (olive leaf) and food industry (eggshell and eggshell membrane) waste can together be valorized to produce value-added functional products. This study’s objective was to evaluate the eggshell membrane’s loading capacity for bioactive compounds obtained from olive leaf extract (OLE) in order to prepare functional biomaterial. In this study, waste eggshell membranes were used to adsorb the phenolic compounds from olive leaf extract to design functional biomaterials. Using the foam separation method, both separation of the eggshell membrane and adsorption of bioactive compounds to the eggshell membrane were achieved simultaneously. The characterization studies showed that OLE was successfully adsorbed to the eggshell membrane. Cytotoxicity and antimicrobial studies showed that prepared OLE-loaded membranes were functional materials with bioactive properties. In conclusion, ESM was determined as a promising protein in the production of functional antioxidative and antimicrobial food or dietary supplement after the adsorption of bioactive olive leaf polyphenols. © 2021 by the authors. Licensee MDPI, Basel, Switzerland.
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    Development and Characterization of Silk Fibroin-based Oral Films Containing Turmeric Extract as Dietary Supplement
    (AMG Transcend Association, 2023) Uslu M.E.; Bayraktar O.
    Dietary supplements have extreme importance. Due to the easily degradable nature of these supplements, the development and application of carrier systems in food technologies seem to be extremely important. Today, oral film technologies have gained importance due to their rapid and high absorption properties. This study chose silk fibroin (SF) as the main component due to its high biocompatibility. Turmeric extract has been added to the oral films as an active agent. The prepared films were analyzed with atomic force microscopy (AFM) and scanning electron microscopy (SEM) to reveal their morphological properties, and at the same time, the film thickness was measured. It has been found that the increase in extract amount is a factor that causes an increase in film roughness while causing a decrease in phase separation. It was observed that the film roughness increased twice with the addition of extract. The roughness of the films formed with 15% extract was measured as 28.5. The average roughness of the films formed without the use of extracts was observed as 15.7 mm. It was also observed that the Trolox equivalent antioxidant capacity (TEAC) was doubled for films containing 15% turmeric extract after one hour of release. The films exhibited different weight loss profiles after release as the amount of turmeric extract was changed. Disc diffusion experiments revealed that films containing turmeric extract exhibited antimicrobial effects. © 2022 by the authors.
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    Nationwide prospective audit for the evaluation of appendicitis risk prediction models in adults: Right iliac fossa treatment (RIFT) - Turkey
    (Oxford University Press, 2024) Yalcinkaya A.; Yalcinkaya A.; Balci B.; Keskin C.; Erkan I.; Yildiz A.; Kamer E.; Leventoglu S.; Caglikulekci M.; Zarbaliyev E.; Sevmis M.; Ulgen Y.; Altinel Y.; Meric S.; Akbas A.; Hacim N.A.; Vartanoglu Aktokmanyan T.; Aktimur Y.E.; Calikoglu F.; Gullu H.F.; Durma A.G.; Acar S.; Ciftci E.; Balik E.; Kulle C.B.; Ozata I.H.; Tufekci T.; Tatar C.; Sevinc M.M.; Sevik H.; Ertürk C.; Kiraz I.N.; Ozben V.; Aytac E.; Aliyeva Z.; Mutlu A.U.; Tanal M.; Celayir M.F.; Bozkurt E.; Yetkin S.G.; Ergin E.; Attaallah W.; Uprak T.K.; Omak A.; Simsek O.; Bozkurt M.A.; Kara Y.; Bozdag E.; Yirgin H.; Ozcan A.; Okkabaz N.; Ozdenkaya Y.; Haksal M.C.; Pekuz C.K.; Duru S.; Sivrikoz E.; Ozdemir Y.; Tan N.; Yarbug Karayali F.; Taghiyeva A.; Tirnova I.; Erenler Bayraktar I.; Bayraktar O.; Emsal E.Z.; Dalkilic M.I.; Yesiltas M.; Tok H.; Karakas D.O.; Pusane A.; Demirer A.I.; Sahin H.B.; Gok A.F.K.; Bozkurt H.A.; Yildirim M.; Uzunyolcu G.; Yanar H.T.; Ergun S.; Kutluk F.; Uludag S.S.; Zengin A.K.; Ozcelik M.F.; Sanli A.N.; Altuntas Y.E.; Memisoglu E.; Sari R.; Akdogan O.; Kucuk H.F.; Ozkan O.F.; Ulgur H.S.; Kirkan E.F.; Yuksekdag S.; Rencuzogullari A.; Aktas M.K.; Aba M.; Demirel A.O.; Eray I.C.; Aydogan B.; Cetinkunar S.; Yener K.; Sozutek A.; Irkorucu O.; Bayrak M.; Altintas Y.; Alabaz O.; Atasever A.; Erdogrul G.; Kupeli A.H.; Muhammedoglu B.; Kokdas S.; Kaya M.; Uysal E.; Yildirim A.C.; Zeren S.; Ekici M.F.; Algin M.C.; Kucuk G.O.; Eraslan H.; Aybar E.; Polat S.; Ceylan A.; Isik O.; Kural S.; Aktas A.; Bakar B.; Uzunoglu M.Y.; Gulcu B.; Ozturk E.; Devay A.O.; Taspinar E.; Balcin O.; Aksoy F.; Garip G.; Yalkin O.; Iflazoglu N.; Yigit D.; Kaya R.B.; Ugur M.; Kilic E.; Dedemoglu A.; Arslan R.E.; Temiz M.; Aydin C.; Demirli Atici S.; Kaya T.; Ozturk S.; Calik B.; Kilinc G.; Acar T.; Acar N.; Cengiz F.; Ureyen O.; Tan S.; Ilhan E.; Turk Y.; Durak A.T.; Yilmaz M.; Mercan M.; Atci R.; Sokmen S.; Bisgin T.; Egeli T.; Yildirim Y.; Safak T.; Celik K.; Yilmaz E.M.; Kirnap M.; Demirkiran A.E.; Sekerci U.U.; Karacan E.; Bilgic E.; Ozmen M.M.; Guldogan C.E.; Gundogdu E.; Moran M.; Erol T.; Dincer H.A.; Kirimtay B.; Yilmaz S.; Cennet O.; Yildiz A.; Sahin C.; Akyol C.; Koc M.A.; Ersoz S.; Turhan A.; Konca C.; Tezcaner T.; Erkent M.; Aydin O.; Avci T.; Altiner S.; Osmanov I.; Emral A.C.; Cetinkaya G.; Lapsekili E.; Sakca M.; Cimen S.; Ozen D.; Kozan E.B.; Dogan L.; Haberal E.; Kayhan O.; Aksel B.; Karabacak H.; Azili C.; Yazici F.; Apaydin M.; Kaya I.O.; Cetinkaya E.; Akin T.; Gunes G.; Turap H.; Aslan D.; Demirbag A.E.; Bolukbasi B.; Karaca B.E.; Ozturk E.; Ozeller E.; Kayacan G.S.; Borcek A.O.; Ece I.; Yormaz S.; Colak B.; Calisir A.; Sahin M.; Arslan K.; Hasirci I.; Ulutas M.E.; Metin S.H.; Gultekin F.A.; Ozkan Z.; Ilhan O.; Gundogdu T.; Liman R.K.; Kanat B.H.; Aydin A.; Sungurtekin U.; Ozgen U.; Aykota M.R.; Altintoprak F.; Gonullu E.; Cakmak G.; Dulger U.C.; Mantoglu B.; Demir H.; Akin E.; Eroz E.; Nazli O.; Dere O.; Dadasoglu M.A.; Kara E.; Tutcu S.; Solak I.; Gencer I.; Dalkiran A.; Sevinc B.; Karahan O.; Damburaci N.; Sari E.; Akay T.; Calta A.F.; Ozdemir A.; Ohri N.; Ermis I.; Bozbiyik O.; Ozdemir M.; Goktepe B.; Demir B.; Kilincarslan O.; Gunduz U.R.; Olcum M.; Dincer O.I.; Cakir R.C.; Dinc B.; Sahin E.; Uludag E.; Arslan Y.; Posteki G.; Oktay A.; Tatar O.C.; Guler S.A.; Utkan N.Z.; Tayar S.; Copelci Y.; Kartal M.; Kalayci T.; Yeni M.; Buyukkasap A.C.; Vural S.; Kesicioglu T.; Aydin I.; Gulmez M.; Saracoglu C.; Topcu O.; Kurt A.; Soylu S.; Kurt B.; Serin M.; Basceken S.I.; Gundes E.; Savda M.; Balkan A.Z.A.; Yildiz M.N.; Uzunkoy A.; Karaca E.; Berkan A.; Isik A.; Yildiz Y.A.; Ergul Z.; Yasar N.F.; Badak B.; Ozen A.; Velipasaoglu M.; Ure I.
    Background: Appendicitis is the most prevalent surgical emergency. The negative appendicectomy rate and diagnostic uncertainty are important concerns. This study aimed to assess the effectiveness of current appendicitis risk prediction models in patients with acute right iliac fossa pain. Methods: A nationwide prospective observational study was conducted, including all consecutive adult patients who presented with right iliac fossa pain. Diagnostic, clinical and negative appendicectomy rate data were recorded. The Alvarado score, Appendicitis Inflammatory Response (AIR), Raja Isteri Pengiran Anak Saleha Appendicitis (RIPASA) and Adult Appendicitis Score systems were calculated with collected data to classify patients into risk categories. Diagnostic value and categorization performance were evaluated, with use of risk category-based metrics including 'true positive rate' (percentage of appendicitis patients in the highest risk category), 'failure rate' (percentage of patients with appendicitis in the lowest risk category) and 'categorization resolution' (true positive rate/failure rate). Results: A total of 3358 patients from 84 centres were included. Female patients were less likely to undergo surgery than men (71.5% versus 82.5% respectively; relative risk 0.866, 95% c.i. 0.834 to 0.901, P < 0.001); with a three-fold higher negative appendicectomy rate (11.3% versus 4.1% respectively; relative risk 2.744, 95% c.i. 2.047 to 3.677, P < 0.001). Ultrasonography was utilized in 56.8% and computed tomography in 75.2% of all patients. The Adult Appendicitis Score had the best diagnostic performance for the whole population; however, only RIPASA was significant in men. All scoring systems were successful in females patients, but Adult Appendicitis Score had the highest area under the receiver operating characteristic curve value. The RIPASA and the Adult Appendicitis Score had the best categorization resolution values, complemented by their exceedingly low failure rates in both male and female patients. Alvarado and AIR had extremely high failure rates in men. Conclusion: The negative appendicectomy rate was low overall, but women had an almost three-fold higher negative appendicectomy rate despite lower likelihood to undergo surgery. The overuse of imaging tests, best exemplified by the 75.2% frequency of patients undergoing computed tomography, may lead to increased costs. Risk-scoring systems such as RIPASA and Adult Appendicitis Score appear to be superior to Alvarado and AIR. © 2024 The Author(s). Published by Oxford University Press on behalf of BJS Foundation Ltd.