Browsing by Author "Berksoy, E"

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    Possible complications of martial arts technique
    Gokalp, G; Berksoy, E; Bardak, S; Demir, S; Demir, G; Bicilioglu, Y; Zengin, N
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    How important is the damage to the liver after lower limb ischemia-reperfusion? An experimental study in a rat model
    Gökalp, G; Eygi, B; Kiray, M; Açikgöz, B; Berksoy, E; Bicilioglu, Y; Zengin, N; Iscan, S; Gökalp, O; Gürbüz, A
    Background: The aim of this study was to compare the effect of lower extremity ischemia reperfusion on the liver and the effect of ischemia-reperfusion on the liver itself in a rat model. Methods: Thirty Sprague-Dawley male rats were randomly divided into three groups including 10 in each group: sham (Group 1), lower limb ischemia-reperfusion (Group 2), and liver ischemia-reperfusion (Group 3). In Group 2, one hour of left lower limb ischemia was performed. In Group 3, one hour of ischemia in the liver was performed, followed by 24 hours of reperfusion. After reperfusion, the liver tissues were removed, and the groups were evaluated biochemically and histologically. Results: The liver malondialdehyde levels were significantly higher in Groups 2 and 3 than in the sham group (p<0.001). In Group 2, the malondialdehyde levels were significantly higher than in Group 3 (p=0.019). The glutathione levels in the liver were significantly lower in Groups 2 and 3 than in the sham group (p<0.001). However, the glutathione levels were significantly higher in Group 2 than in Group 3 (p=0.005). In the histological evaluation, although the liver damage score was higher in Group 3 than in Group 2 (p=0.015), there was no significant difference between the two groups in TUNEL(+) cell number (p>0.05). Conclusion: Reperfusion injury in the liver after lower limb ischemia-reperfusion is as important as ischemia-reperfusion injury which is specifically induced in the liver. This should be taken into account, particularly in reperfusion surgeries following vascular trauma or in cases of leg tourniquets to stop bleeding after lower limb vascular trauma.
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    COVID-19 disease in children presenting to the pediatric emergency department: A multicenter study with 8886 cases from Turkey
    Duman, M; Sik, N; Teksam, O; Akca, H; Kurt, F; Caglar, AA; Yildiz, LA; Tasar, MA; Fidanci, I; Yayla, BCC; Yilmaz, D; Gungor, E; Demir, S; Cokugras, H; Cebeci, SO; Onal, P; Saz, EU; Yurtseven, A; Uysalol, M; Yildiz, R; Gumus, S; Bal, A; Sen Bayturan, S; Zengin, N; Atik, S; Ciftdogan, DY; Berksoy, E; Cicek, A; Sahin, S; Kizil, MC; Kara, Y; Apa, H; Ulusoy, E; Kara, AA; Yesil, E; Erdem, M; Turan, C; Arslanoglu, S; Duyu, M; Besli, GE; Arslan, G; Oflu, AT; Celegen, M; Buldu, E; Piskin, IE; Kardes, H; Yilmaz, HL; Yildizdas, D; Gokulu, G; Cay, P; Ozer, U; Guleryuz, OD; Colak, O; Guneysu, ST
    Background: The aim was to evaluate the epidemiological, clinical, laboratory, and radiologic data of children with SARS-CoV-2 positivity by polymerase chain reaction (PCR) together with treatment strategies and clinical out-comes and to evaluate cases of multisystem inflammatory syndrome in children (MIS-C) in this population.Methods: This was a multicenter retrospective observational cohort study performed in the pediatric emergency departments of 19 tertiary hospitals. From March 11, 2020, to May 31, 2021, children who were diagnosed with confirmed nasopharyngeal/tracheal specimen SARS-CoV-2 PCR positivity or positivity for serum-specific anti-bodies against SARS-CoV-2 were included. Demographics, presence of chronic illness, symptoms, history of con-tact with SARS-CoV-2 PCR-positive individuals, laboratory and radiologic investigations, clinical severity, hospital admissions, and prognosis were recorded.Results: A total of 8886 cases were included. While 8799 (99.0%) cases resulted in a diagnosis of SARS-CoV-2 with PCR positivity, 87 (1.0%) patients were diagnosed with MIS-C. Among SARS-CoV-2 PCR-positive patients, 51.0% were male and 8.5% had chronic illnesses. The median age was 11.6 years (IQR: 5.0-15.4) and 737 (8.4%) patients were aged <1 year. Of the patients, 15.5% were asymptomatic. The most common symptoms were fever (48.5%) and cough (30.7%) for all age groups. There was a decrease in the rate of fever as age increased (p < 0.001); the most common age group for this symptom was <1 year with the rate of 69.6%. There was known contact with a SARS-CoV-2 PCR-positive individual in 67.3% of the cases, with household contacts in 71.3% of those cases. In terms of clinical severity, 83 (0.9%) patients were in the severe-critical group. There was hospital admission in 1269 (14.4%) cases, with 106 (1.2%) of those patients being admitted to the pediatric intensive care unit (PICU). Among patients with MIS-C, 60.9% were male and the median age was 6.4 years (IQR: 3.9-10.4). Twelve (13.7%) patients presented with shock. There was hospital admission in 89.7% of these cases, with 29.9% of the patients with MIS-C being admitted to the PICU.Conclusion: Most SARS-CoV-2 PCR-positive patients presented with a mild clinical course. Although rare, MIS-C emerges as a serious consequence with frequent PICU admission. Further understanding of the characteristics of COVID-19 disease could provide insights and guide the development of therapeutic strategies for target groups.(c) 2022 Elsevier Inc. All rights reserved.