Browsing by Author "Bilge U."

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    Community-acquired pneumonia in patients with chronic obstructive pulmonary disease requiring admission to the intensive care unit: Risk factors for mortality
    (2013) Cilli A.; Erdem H.; Karakurt Z.; Turkan H.; Yazicioglu-Mocin O.; Adiguzel N.; Gungor G.; Bilge U.; Tasci C.; Yilmaz G.; Oncul O.; Dogan-Celik A.; Erdemli O.; Oztoprak N.; Samur A.A.; Tomak Y.; Inan A.; Karaboga B.; Tok D.; Temur S.; Oksuz H.; Senturk O.; Buyukkocak U.; Yilmaz-Karadag F.; Ozcengiz D.; Karakas A.; Savasci U.; Ozgen-Alpaydin A.; Kilic E.; Elaldi N.; Bilgic H.
    Purpose: The aims of this study are to identify factors predicting mortality in patients with chronic obstructive pulmonary disease (COPD) and community-acquired pneumonia (CAP) requiring intensive care unit (ICU) admission and to examine whether noninvasive ventilation treatment reduces mortality. Materials and Methods: An analysis was performed on data from patients with CAP hospitalized in the ICUs of 19 different hospitals in Turkey between October 2008 and January 2011. Predictors of mortality were assessed by both univariate and multivariate statistical analyses. Results: Two hundred eleven patients with COPD and CAP were included. The overall ICU mortality was 23.9%. Noninvasive ventilation treatment (odds ratio [OR], 0.12; 95% confidence interval [CI], 0.03-0.49; P = .003), hypertension (OR, 0.13; 95% CI, 0.02-0.93; P = .042), bilateral infiltration (OR, 13.92; 95% CI, 2.94-65.84; P = .001), systemic corticosteroid treatment (OR, 0.19; 95% CI, 0.35-0.96; P = .045), length of ICU stay (OR, 0.65; 95% CI, 0.47-0.89; P = .007), and duration of invasive mechanical ventilation (OR, 1.11; 95% CI, 1.01-1.22; P = .032) were independent factors related to mortality. Conclusion: Noninvasive ventilation, hypertension, systemic corticosteroid treatment, and shorter ICU stay are associated with reduced mortality, whereas bilateral infiltration and longer duration of invasive mechanical ventilation are associated with increased risk of mortality in patients with COPD and CAP requiring ICU admission. © 2013 Elsevier Inc.
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    Mortality indicators in community-acquired pneumonia requiring intensive care in Turkey
    (2013) Erdem H.; Turkan H.; Cilli A.; Karakas A.; Karakurt Z.; Bilge U.; Yazicioglu-Mocin O.; Elaldi N.; Adiguzel N.; Gungor G.; Taşci C.; Yilmaz G.; Oncul O.; Dogan-Celik A.; Erdemli O.; Oztoprak N.; Tomak Y.; Inan A.; Karaboǧa B.; Tok D.; Temur S.; Oksuz H.; Senturk O.; Buyukkocak U.; Yilmaz-Karadag F.; Ozcengiz D.; Turker T.; Afyon M.; Samur A.A.; Ulcay A.; Savasci U.; Diktas H.; Ozgen-Alpaydin A.; Kilic E.; Bilgic H.; Leblebicioglu H.; Unal S.; Sonmez G.; Gorenek L.
    Background: Severe community-acquired pneumonia (SCAP) is a fatal disease. This study was conducted to describe an outcome analysis of the intensive care units (ICUs) of Turkey. Methods: This study evaluated SCAP cases hospitalized in the ICUs of 19 different hospitals between October 2008 and January 2011. The cases of 413 patients admitted to the ICUs were retrospectively analyzed. Results: Overall 413 patients were included in the study and 129 (31.2%) died. It was found that bilateral pulmonary involvement (odds ratio (OR) 2.5, 95% confidence interval (CI) 1.1-5.7) and CAP PIRO score (OR 2, 95% CI 1.3-2.9) were independent risk factors for a higher in-ICU mortality, while arterial hypertension (OR 0.3, 95% CI 0.1-0.9) and the application of non-invasive ventilation (OR 0.2, 95% CI 0.1-0.5) decreased mortality. No culture of any kind was obtained for 90 (22%) patients during the entire course of the hospitalization. Blood, bronchoalveolar lavage, and non-bronchoscopic lavage cultures yielded enteric Gram-negatives (n=12), followed by Staphylococcus aureus (n=10), pneumococci (n=6), and Pseudomonas aeruginosa (n=6). For 22% of the patients, none of the culture methods were applied. Conclusions: SCAP requiring ICU admission is associated with considerable mortality for ICU patients. Increased awareness appears essential for the microbiological diagnosis of this disease. © 2013 International Society for Infectious Diseases.
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    Antibiotic treatment outcomes in community-acquired pneumonia
    (Turkiye Klinikleri Journal of Medical Sciences, 2018) Çilli A.; Sayiner A.; Çelenk B.; Şakar Coşkun A.; Kilinç O.; Hazar A.; Aktaş Samur A.; Taşbakan S.; Waterer G.W.; Havlucu Y.; Kiliç Ö.; Tokgöz F.; Bilge U.
    Background/aim: The optimal empiric antibiotic regimen for patients with community-acquired pneumonia (CAP) remains unclear. This study aimed to evaluate the clinical cure rate, mortality, and length of stay among patients hospitalized with community-acquired pneumonia in nonintensive care unit (ICU) wards and treated with a β-lactam, β-lactam and macrolide combination, or a fluoroquinolone. Materials and methods: This prospective cohort study was performed using standardized web-based database sheets from January 2009 to September 2013 in nine tertiary care hospitals in Turkey. Results: Six hundred and twenty-one consecutive patients were enrolled. A pathogen was identified in 78 (12.6%) patients. The most frequently isolated bacteria were S. pneumoniae (21.8%) and P. aeruginosa (19.2%). The clinical cure rate and length of stay were not different among patients treated with β-lactam, β-lactam and macrolide combination, and fluoroquinolone. Forty-seven patients (9.2%) died during the hospitalization period. There was no difference in survival among the three treatment groups. Conclusion: In patients admitted to non-ICU hospital wards for CAP, there was no difference in clinical outcomes between β-lactam, β-lactam and macrolide combination, and fluoroquinolone regimens. © TÜBİTAK.