Browsing by Author "Bilgin, ES"
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Item Predicting Treatment Response in Esophageal Cancer Patients Using 18F FDG PET/CT Texturel Features ParametersMutevelizade, G; Duran, O; Aydin, N; Erdugan, M; Suner, A; Bilgin, ESItem Comparison of bone scintigraphy and whole-body diffusion-weighted magnetic resonance imaging in the detection of bone metastasesSözütok, S; Tarhan, S; Düzgün, F; Bilgin, ESPurpose: The aim of this study was o evaluate the efficacy and success of whole-body diffusion-weighted magnetic resonance imaging (WB-DW-MRI) as a new method for the detection of bone metastasis commonly seen in malignancies, compared to bone scintigraphy. Materials and Methods: The WB-DW-MRI findings of 21 patients with primary malignancies and bone metastases were retrospectively evaluated and compared to scintigraphy findings. Results: Twenty-one patients had 143 metastatic lesions detected by scintigraphy, and 96 of these bone metastases were also detected on WB-DW-MRI. The area where the success of WB-DW-MRI was highest was the lower extremities, for which 12 (92.3%) of 13 metastases were identified. This was followed by vertebrae, for which WB-DW-MRI detected 39 (86.6%) of 45 metastases. The metastasis detection rates for the upper extremities, pelvis, and cranium were calculated as 73.6%, 63.1%, and 60%, respectively. WB-DW-MRI was least successful in identifying metastases in ribs, with only 16 (38.1%) of 42 metastases being detected by this modality. Conclusion: In line with the findings obtained from this study, it is considered that WB-DW-MRI may be successful in the detection of bone metastases, especially in the axial skeleton. The failure observed for the ribs can be remedied by newly developed magnetic sensitivity technologies, increasing geometric resolution, and fast sequences that will prevent motion artifacts.Item Gastric emptying rate and its relation with microalbuminuria in children with type 1 diabetes mellitusErsoy, B; Bilgin, ES; Can, S; Urk, V; Batok, D; Yilmaz, O; Polat, MItem Synthesis, radiolabeling and in vivo biodistribution of diethylstilbestrol phosphate derivative (DES-P)Ünak, P; Müftüler, FZB; Içhedef, Ç; Medine, EI; Özmen, K; Ünak, T; Kilçar, AY; Gümüser, FG; Parlak, Y; Bilgin, ESDiethylstilbestrol (DES) is a well known, nonsteroidal estrogen with high affinity for the estrogen receptor (ER). Today DES is used to treat breast and prostate cancers. A phosphate derivative of DES [Diethylstilbestrol diphosphate (DES-P)] which is specific to tumor cells consisting alkaline phosphatase enzyme was synthesized and labeled with Tc-99m using tin chloride as reducing agent. In vivo biological activity of Tc-99m labeled diethylstilbestrol phosphate compound (Tc-99m-DES-P) was examined by biodistribution studies on Wistar Albino rats. Statistical evaluation was performed using SPSS 13 program. The percentage (%) radiolabeling yield of Tc-99m-DES-P and quality control studies were done by Thin Layer Radio Chromatography (TLRC). Results showed that, Tc-99m-DES-P may be proposed as an imaging agent for ER enriched tumors such as uterus and prostate and their metastases in bones.Item Multifunctional molecular imaging probes for estrogen receptors: 99mTc labeled diethylstilbestrol (DES) conjugated, cuinp quantum dot nanoparticles (DESCIP)Moharrami, P; Unak, P; Guldu, OK; Medine, EI; Gumuser, G; Bilgin, ES; Aras, OA theranostic nanoparticle was synthesized based on diethylstilbestrol conjugated with phosphate, copper, and indium (DESCIP) and labelled with Tc-99m which can be used for SPECT imaging of ER-enriched cancers. In vitro biological activity of Tc-99m-DESCIP was examined in breast adenocarcinoma cells (MCF-7), prostatic carcinoma cells (PC-3), and pulmonary epithelial cells (A-549). In vivo lymph node imaging was performed in normal and receptor blocked female New Zealand rabbits. Results demonstrated that Tc-99m-DESCIP and DESCIP has potential for imaging ER-enriched tumors such as breast and prostate tumors, and their metastases in the lung, as well as improving management for their therapies.Item Evaluation of New 99mTc(CO)3+ Radiolabeled Glycylglycine In VivoSenisik, AM; Içhedef, C; Kilçar, AY; Uçar, E; Ari, K; Parlak, Y; Bilgin, ES; Teksöz, SBackground: Peptide-based agents are used in molecular imaging due to their unique properties, such as rapid clearance from the circulation, high affinity and target selectivity. Many of the radiolabeled peptides have been clinically experienced with diagnostic accuracy. The aim of this study was to investigate in vivo biological behavior of [Tc-99m(CO)(3)(H2O)(3)](+) radiolabeled glycylglycine (GlyGly). Methods: Glycylglycine was radiolabeled with a high radiolabeling yield of 94.69 +/- 2%, and quality control of the radiolabeling process was performed by thin layer radiochromatography (TLRC) and High-Performance Liquid Radiochromatography (iIPLRC). Lipophilicity study for radiolabeled complex (Tc-99m(CO)(3)-Gly-Gly) was carried out using solvent extraction. The in vivo evaluation was performed by both biodistribution and SPECT imaging. Results: The high mdiolabelling yield of Tc-99m(CO)(3)-GlyGly was obtained and verified by TLRC and HPLRC as well. According to the in vivo results, SPECT images and biodistribution data are in good accordance. The excretion route from the body was both hepatobiliary and renal. Conclusion: This study shows that Tc-99m(CO)(3)-GlyGly has the potential to be used as a peptide-based imaging agent. Further studies, Tc-99m(CO)(3)-GlyGly can be performed on tumor-bearing animals.Item Glomerular filtration rate in type 1 diabetic adolescent by using single plasma sample and gamma camera methodsAras, F; Bilgin, ESAim: Type-1 diabetes mellitus (DM) has indicated that glomerular hyperfiltration (GFR) is a risk factor for nephropathy. Renal pathological changes develop before features of clinical renal disease including proteinuria and declining GFR are evident. We investigated changes in GFR in children and adolescents with type 1 DM by means of single plasma sample (SPS) and gamma camera Gate's methods using Tc-99m DTPA. Additionally, we determined the specificity, sensitivity, and consistency of the two methods. Material and Methods: Thirty-six patients (mean age: 15.01 +/- 4.03 years) with Type-1 DM (19 males, 17 females) were studied. Impairment of renal function was not detected in any of the patients with routine biochemical tests. Standard Tc-99m DTPA renal images were obtained for 40 minutes and GFR is calculated by Gate's method and values>130/1.73m(2) b.s. were considered hyperfiltration. SPS was obtained at 120 min-post injection and the Cristensen-Groth equation (CG) was used. The patients were divided into two groups according to the duration of diabetes as less than 5 years (Group A) and longer than 5 years (Group B). Results: In Group A, hyperfiltration was detected in 11 of 14 patients with SPS, whereas in 7 of 14 patients with Gate's method. In Group B, hyperfiltration was detected in 17 of 22 patients with SPS, whereas in 13 of 22 patients with Gate's method. Sensitivity of Gate's method was 67.9 % in all patients for diagnosis (Sensitivity: 67.9%, Specificity: 87.5 %, positive predictive value (PPV): 95 %, negative predictive value (NPV): 43.8%). The consistency of these two methods was found as 72.6% (p=0.005). Discussion: Gate's method is useful for clinical practice due to ease of use and high consistency with SPS, especially in the children. SPS remains the first-line method of GFR measurement in suspected diabetic nephropathy patients.Item Changes of Tc-99m MIBI uptake in salivary glands of patients with Graves' and Hashimato's DiseasesSöylemez, D; Gumuser, G; Parlak, Y; Bilgin, ESItem An Innovative Approach with Ga-68 PSMA PET/CT: The PRIMARY Scoring SystemAydin, N; Mutevelizade, G; Bozdemir, BC; Bilgin, ESItem Innovative Approaches in Prostate Cancer Management: The Efficacy of Ga-68 PSMA PET/CT in Detecting Bone MetastasesBozdemir, B; Mutevelizade, G; Aydin, N; Gumuser, G; Bilgin, ESItem Effect of 99mTc- MDP Administration onDual-Energy X-Ray Absorptiometry Bone Mineral Density MeasurementsGumuser, G; Parlak, Y; Topal, G; Aras, F; Ruksen, E; Bilgin, ESItem Prognostic value of fluorodeoxyglucose positron emission tomography derived metabolic parameters and textural features in soft tissue and bone sarcomasAydin, N; Mütevelizade, G; Gümüser, G; Bilgin, ESItem The Relationship Between Biometric Data And Lymphoscintigraphic Findings In Patients With Lower Extremity LymphedemaMutevelizade, G; Aymandir, G; Kilic, R; Aydin, N; Bozdemir, B; Parlak, Y; Gumuser, F; Bilgin, ESItem A Case Report: Primary Renal Lymphoma Presenting with a Pathological Femur FractureAydin, N; Mutevelizade, G; Bozdemir, BC; Bilgin, ESItem Lung Uptake of Tc-99m HMPAO in patients with Behcet DiseaseGumuser, G; Pirildar, T; Batok, D; Ruksen, E; Sakar, A; Bilgin, ESItem F-18 fluorodeoxyglucose positron emission tomography in testicular cancerGümüser, G; Aras, F; Bilgin, ESF-18 fluorodeoxyglucose positron emission tomography (F-18 FDG PET) is becoming a standard imaging modality in the diagnosis, staging and evaluation of therapy response for most malignant diseases. The purpose of the present review is to update existing knowledge about the value of FDG PET in testicular cancer together with a summary of the literature.Item Aneurysmal Bone Cyst in a patient with McCune-Albright SyndromeAydin, N; Mütevelizade, G; Gümüser, G; Bilgin, ESItem Effects of eight-week single versus multiple sets of resistance training on bone mineral density in young malesBuyukyazi, G; Colakoglu, M; Bilgin, ES; Sahin, C; Colakoglu, SItem The effect of sex steroids and body composition on bone mineral density in pubertal childrenYilmaz, D; Ersoy, B; Bilgin, ES; Gumuser, FG; Onur, EItem The Relationship Between Staging F-18 FDG PET/CT Parameters and Survival in Patients Diagnosed with Soft Tissue SarcomaAydin, N; Mütevelizade, G; Gümüser, G; Bilgin, ES