Browsing by Author "Bor, S"

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    PREVALANCE OF FECAL INCONTINENCE AND ITS EFFECT ON QUALITY OF LIFE IN ELDERLY INDIVIDUALS LIVING IN NURSING HOMES IN THE CITY OF IZMIR
    Dedeli, Ö; Fadiloglu, Ç; Turan, I; Bor, S
    Introduction: In this study, it was aimed to determine fecal incontinence prevalance and its effect on quality of life of elderly. Materials and Method: The research was carried out in a sample of a total of 304 elderly individuals who were selected senior citizens residing in three nursing homes within the city of Directorate of Social Services, izmir between the dates of September 2006-November 2006. Research data was collected by sociodemographic and bowel habit data form, reliable and valid Turkish Adaptation of Fecal Incontinence Quality of Life Scale (FIQOLS) and Fecal Incontinence Severity Index (FISI). Results: 9,5% of elderly in households stated fecal incontinence. The score of elderly's FIQOLS the reason of depression/self perception (12.5 +/- 4.6) and embrassment (4.2 +/- 2.6) domains were low, their psychosocial statement the most affected, Significant correlation between the FISI and FIQOLQ's domains depression/self perception (r=-0.8 p<0.05) and embrassment was found (r=-0.9 p<0.05). Conclusion: Fecal incontinence in elderly has negative effect on health and quality of life. Indepently from the severity of fecal incontinence type and prevalance, it is necessary to support to the elderly for their feeling well for physical, social, hygenic and psyhologic.
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    Is administration of n-3 fatty acids by mucosal enema protective against trinitrobenzene-induced colitis in rats?
    Yuceyar, H; Ozutemiz, O; Huseyinov, A; Saruç, M; Alkanat, M; Bor, S; Coker, I; Batur, Y
    We investigated the protective role of fish oil (FO-source of n-3 FA) enriched diet tin the first protocol in 20 rats and FO administration intrarectally (in the second protocol) in 40 rats with trinitrobennzene (TNB) colitis. All colonic specimens were pathologically evaluated, myeloperoxidase enzyme activities were measured, leukotriene B4 (LTB4) and LTC4 levels were determined by radioimmunoassay. In the first protocol 10 rats (group Al) were fed with 8% sunflower and cotton oil enriched diet and (group A2) with 8% FO enriched diet for 6 weeks. At the end of this period, TNB (30 mg in 0.25 mi of 30% ethanol) were intrarectally administered. After 2 weeks, rats were sacrificed. MPO activities (2.47 versus 30.17), LTB4 (34.5 versus 903.3) and LTC4 (77.7 versus 456.0) levels were significantly reduced in group A2 compared with group Al (P < 0.005). There was also a significant difference in pathologic scores (1.55 versus 2.12, P < 0.0002) between two groups. In the first part of the second protocol, 20 male rats were randomized into two equal groups (B1 and B2) and TNB colitis was induced. After 1 day, 1 mi of saline (group B1) or n-3 FA enemas (group B2) were administered every day for 2 weeks. At the end of this period, rats were sacrificed and evaluated as done for previous groups. Although there was no significant difference between the two groups in comparison with MPO enzyme activities and pathologic scores, the LTB4 (130.1 versus 971.0) and LTC4 (126.0 versus 532.0) levels of FO group were significantly reduced (P < 0.005). In the second part of the second protocol, 20 male rats were randomized into two groups. One millilitre of saline (group B3) or FO enemas (group B4) were administered to rats every day for 3 days. At the fourth day, TNB-colitis was induced and after 24 h rats were sacrificed. We could not find any significant difference in MPO activities, pathologic scores, LTB4 and LTC4 levels between groups B3 and B4. In conclusion; FO enriched diet decreased both pathologic damage and tissue LT levels. The second protocol of our study revealed that the long-term FO enemas decreased the LTB4 and LTC4 levels; however, did not have any beneficial effect on the tissue lesions. Short periods of FO enemas did not have a protective role in the occurrence of experimental colitis. The present study showed that FO enemas significantly decreased LT levels. The protective effect of FO (oral and enema) in TNB colitis may open a new insight into the treatment of inflammatory bowel disease. (C) 1999 Harcourt Publishers Ltd.
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    The frequency of sexual-physical abuse history in irritabl bowel syndrome patients and diagnostic relation with major depressive disorder history
    Eker, MÇ; Kasap, E; Elbi, H; Bor, S
    Objective: IBS is a functional disorder which is one of the most common causes of gastroentrology doctor visits. Besides multiple factors suggested for the etiology of IBS, the co-morbidity of psychiatric illnesses, of which MDD is most the frequent, is also noted. Being exposed to sexual or physical abuse is also considered as a risk factor for the development of IBS. Methods: In this study the differences between IBS patients and non-IBS control cases are evaluated regarding the history of major depressive disorder and sexual or physical abuse. Fiftyfour IBS and thirty control cases (mean age for IBS patients 41 +/- 11; for control group 34 +/- 12 years; p<0.05) were recruited for the study. Results: IBS patients had a history of MDD more frequently than the control cases (69% for the IBS group, n=37; 30% for the control group, n=9; p<0.001]. However, two groups did not differ regarding the history of sexual abuse (20% for the IBS group, n=11; (13% for the control group, n=4; p>0.05) or physical abuse (19% for the IBS group, n=10; 13% for the control group, n=4; p>0.05). Discussion: IBS and MDD are frequently co-morbid and this co-morbidity suggests a possible common point for the etiopathogenesis for both disorders. Nevertheless, the contribution of sexual or physical abuse to the co-morbidity of these disorders seems to be inconclusive. It can be suggested that sexual and physical abuse history do not have fundemental importance for the development of IBS in our patients. (Anatolian Journal of Psychiatry 2010; 11:120-126)
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    Effects of a kefir supplement on symptoms, colonic transit, and bowel satisfaction score in patients with chronic constipation: A pilot study
    Turan, I; Dedeli, Ö; Bor, S; Ilter, T
    Background/Aims: Although probiotics have been extensively studied in irritable bowel syndrome, data on the impact of probiotics on chronic constipation are scarce. We aimed to evaluate the effects of kefir, which is a probiotic fermented milk product, on the symptoms, colonic transit, and bowel satisfaction scores of patients with chronic constipation. Materials and Methods: Twenty consecutive patients with functional constipation according to the Rome II criteria were divided into two groups based on their colon transit studies: 1. The normal transit (NT) group (n=10); and 2. The slow transit (ST) group (n=10). After a baseline period, 500 mL/day of a probiotic kefir beverage was administered to all patients for 4 weeks. Defecation parameters (stool frequency, stool consistency, degree of straining, laxative consumption) were recorded in diaries daily by the patients. Bowel satisfaction scores were assessed using a visual analog scale. The colon transit study was repeated in the ST group at the end of the study. Results: At the end of the study, the patients showed an increased stool frequency (p<0.001), improved stool consistency (p=0.014), and decreased laxative consumption (p=0.031). The degree of straining during evacuation showed a tendency to improve after kefir administration; however, this was not statistically significant (p=0.18). A repeat transit study showed an acceleration of colonic transit in the ST group (p=0.013). Bowel satisfaction scores also improved (p<0.001). Conclusion: This pilot study shows that kefir has positive effects on the symptoms of constipation. Our results also suggest that kefir improves bowel satisfaction scores and accelerates colonic transit. Controlled trials are warranted to confirm these findings.
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    Prevalence of gastroesophageal reflux disease in a country with a high occurrence of Helicobacter pylori
    Bor, S; Kitapcioglu, G; Kasap, E
    AIM To evaluate the prevalence of gastroesophageal reflux disease (GERD) with additional symptoms, relationship with Helicobacter pylori (H. pylori) of this country-wide study. METHODS Data from 3214 adults were obtained with validated questionnaire. Eight hundred and forty-one subjects were randomized to be tested for H. pylori via the urea breath test. Frequent symptoms were defined heartburn and/or regurgitation occurring at least weekly. RESULTS The prevalence of GERD was 22.8%, frequent and occasional heartburn were 9.3%-12.7%, regurgitation were 16.6%-18.7%, respectively. Body mass index (BMI) <= 18.5 showed a prevalence of 15%, BMI > 30 was 28.5%. The GERD prevalence was higher in women (26.2%) than men (18.9%) (P < 0001). Overall prevalence of H. pylori was 75.7%. The prevalence was 77.1% in subjects without symptoms vs 71.4% in subjects with GERD (chi(2) = 2.6, P = 0.27). Underprivileged with the lowest income people exhibit a higher risk. CONCLUSION GERD is common in Turkey which reflects both Western and Eastern lifestyles with high rate of H. pylori. The presence of H. pylori had no effect on either the prevalence or the symptom profile of GERD. Subjects showing classical symptoms occasionally exhibit more additional symptoms compared with those without classical symptoms.
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    Normative values of the balloon expulsion test in healthy adults
    Dedeli, Ö; Turan, I; Öztürk, R; Bor, S
    Background/aims: Constipation is the most frequent complaint of the digestive tract. It has been reported that approximately half of the patients with constipation have functional defecation disorders (dyssynergic defecation). An important diagnostic tool for the diagnosis of functional defecation disorders is the balloon expulsion test. Normative values have not been widely determined in different populations. We aimed to determine the data which could be indicative of normative values of the balloon expulsion test for healthy individuals in our society. Methods: A total of 116 healthy volunteers were evaluated in. the study (55 men). Subjects were classified into three subgroups according to age (20-39 yrs, 40-59 yrs, >= 60 yrs). Catheters with balloon and application room were standardized, and then a balloon expulsion test was performed in all groups. The results of the balloon expulsion test were statistically compared between groups. Results: The distribution of males/females according to age groups was: 20-39 yrs: 20/22, 40-59 yrs: 20/23, >= 60 yrs: 15/16. The balloon expulsion time was determined as 44.1 +/- 19.0 seconds in male subjects and 56.4 +/- 21.4 seconds in females (p=0.001). An increase in the balloon expulsion time was observed to be related with age in males (p=0.00001); however, no statistically significant difference was shown by age in female subjects (p=0.80). If the entire study group was considered, there was a significant correlation between age and balloon expulsion time (p=0.0001). Conclusions: The balloon expulsion test is a simple procedure to identify impaired evacuation in constipated patients. This study represents the first assessment of the balloon expulsion test in a healthy Turkish population. It has been demonstrated that expulsion should take less than 30 seconds for men younger than 40 years of age and less than 1 minute above 40 years. For women, expulsion should occur in I minute regardless of age. Our results could serve as a valuable resource of normative data.
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    Validity and Reliability of a Turkish Version of the Fecal Incontinence Quality of Life Scale
    Dedeli, O; Fadiloglu, C; Bor, S
    PURPOSE: Anorectal disorders, including fecal incontinence, are a significant healthcare problem that produce bothersome symptoms and adversely affect quality of life. We sought to establish the validity and reliability of a Turkish language version of the Fecal Incontinence Quality of Life Scale (FIQOLS). SUBJECTS AND SETTING: Data were collected at the Fecal Incontinence-Constipation-Biofeedback Clinic, located in the Gastroenterology Department at Ege University School of Medicine Hospital in Izmir, Turkey. The study sample comprised patients with fecal incontinence who attended the clinical assessment and agreed to participate in the study. INSTRUMENTS: A sociodemographic questionnaire form, the 29-item FIQOLS, and the Fecal Incontinence Severity Index (FISI), as well as the 36-Item Short Form Health Survey (SF-36) were administered to subjects. Both the FIQOLS and FISI were translated from English to Turkish by using a back-translation technique. METHODS: Subjects initially completed the FIQOLS, FISI, and the SF-36 at baseline and again after a 2-week interval to allow test-retest reliability measurement. Internal consistency was also measured, using the Cronbach alpha and Spearman-Brown split-half coefficients. Test-retest reliability was evaluated using interclass correlation coefficient testing. The validity of FIQOLS with respect to the SF-36 and FISI was analyzed using Pearson correlation coefficients. RESULTS: Fifty subjects with fecal incontinence participated in the study; their mean age (SD) was 57.1 (+/-15.7) years. Almost two-thirds (66%) were female, and 38% did not complete primary school education. Test-retest reliability analysis revealed an intraclass correlation of r value higher than 0.70 (P < .05). The overall Cronbach alpha coefficient of instrument was .88; the Spearman-Brown split-half value was 0.84 for the first half of the tool and 0.76 for the second half. The Cronbach alpha coefficient for subfactors varied from .56 to .82. The FIQOLS score was found to have a statistically significant (P < .05) correlation with both the FISI and SF-36. CONCLUSION: These findings support the Turkish language version of the FIQOLS as a valid and reliable instrument.