Browsing by Author "Bora, S"

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    Behavioural Representation of the Aorta by Utilizing Windkessel and Agent-Based Modelling
    Emek, S; Bora, S; Evren, V; Çakirlar, I
    The main objective of the present paper is to report two studies on mathematical and computational techniques used to model the behaviour of the aorta in the human cardiovascular system. In this paper, an account of the design and implementation of two distinct models is pre-sented: a Windkessel model and an agent-based model. Windkessel model represents the left heart and arterial system of the cardiovascular system in the physiological domain. The agent-based model offers a simplified account of arterial behaviour by randomly generating arterial parameter values. This study has described the mechanism how and when the left heart contracts and pumps the blood out of the aorta, and it has taken the Windkessel model one step further. The results of this study show that the dynamics of the aorta can be explored in each modelling approaches as proposed and implemented by our research group. It is thought that this study will contribute to the literature in terms of development of the Windkessel model by considering its timing and redesigning it with digital electronics perspective.
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    Biological effects of tolerable level chronic boron intake on transcription factors
    Boyacioglu, SO; Korkmaz, M; Kahraman, E; Yildirim, H; Bora, S; Ataman, OY
    The mechanism of boron effect on human transcription and translation has not been fully understood. In the current study it was aimed to reveal the role of boron on the expression of certain transcription factors that play key roles in many cellular pathways on human subjects chronically exposed to low amounts of boron. The boron concentrations in drinking water samples were 1.57 +/- 0.06 mg/l for boron group while the corresponding value for the control group was 0.016 +/- 0.002 mg/l. RNA isolation was performed using PAX gene RNA kit on the blood samples from the subjects. The RNA was then reverse transcribed into cDNA and analyzed using the Human Transcription Factors RT2 Profiler (TM) PCR Arrays. While the boron amount in urine was detected as 3.56 +/- 1.47 mg/day in the boron group, it was 0.72 +/- 0.30 mg/day in the control group. Daily boron intake of the boron and control groups were calculated to be 6.98 +/- 3.39 and 1.18 +/- 0.41 mg/day, respectively. The expression levels of the transcription factor genes were compared between the boron and control groups and no statistically significant difference was detected (P > 0.05). The data suggest that boron, intake at 6.98 +/- 3.39 mg/day, which is the dose at which beneficial effects might be seen, does not result in toxicity at molecular level since the expression levels of transcription factors are not changed. Although boron intake over this level will seem to increase RNA synthesis, further examination of the topic is needed using new molecular epidemiological data. (C) 2016 Elsevier GmbH. All rights reserved.