Browsing by Author "Bozkurt B."

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    Drug allergy in tertiary care in Turkey: Results of a national survey. The ADAPT study: Adult drug allergy perception in Turkey
    (Elsevier Doyma, 2014) Çelik G.E.; Karakaya G.; Öztürk A.B.; Gelincik A.; Abadoğlu T.; Sin A.; Damadoğlu E.; Yilmaz T.I.; Demirtürk M.; Dursun B.; Özdemir S.K.; Çelikel S.; Değirmenci P.; Bozkurt B.; Göksel T.; Erkekol F.; Aydin T.; Kavut A.B.; Kirmaz C.; Kalpaklioğlu F.; Büyüköztürk S.; Kalyoncu F.
    Background: No data are available on the incidence of drug hypersensitivity (DH) reactions in outpatient settings of tertiary allergy/immunology clinics. Our aims were to document the frequency of outpatient hospital admissions due to DH reactions to allergy/immunology clinics in adults and the management of these reactions in real life. We also investigated whether drug allergy affected social and medical behaviours of the patients. Methods: This multi-centre study was performed for one year with the participation of 11 out of 16 tertiary allergy/clinical immunology clinics in Turkey. The study group consisted of the patients with DH reactions. Results of a questionnaire including drug reactions and management were recorded. Results: Among 54,863 patients, 1000 patients with DH were enrolled with a median of 2.1% of all admissions. In real life conditions, the majority of approaches were performed for finding safe alternatives (65.5%; 1102 out of 1683) with 11.7% positivity. Diagnostic procedures were positive in 27% (154/581) of the patients. The majority of the patients had higher VAS scores for anxiety. A total of 250 subjects (25%) reported that they delayed some medical procedures because of DH. Conclusion: Our results documented the frequency of admissions due to DH reactions to allergy/clinical immunology clinics for the first time. Although physicians mostly preferred to perform drug tests in order to find safe alternatives, considering the fact that DH was confirmed in 27% of the patients, use of diagnostic tests should be encouraged, if no contraindication exists in order to avoid mislabelling patients as DH. © 2013 SEICAP.
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    In vitro anti-leishmanial activity of Sarcopoterium spinosum against Leishmania tropica; [Sarcopoterium spinosum’un Leishmania tropica’ya karşı in vitro anti-leishmanial etkisi]
    (Chartered Inst. of Building Services Engineers, 2018) Can H.; Kayalar H.; Bozkurt B.; Can Ş.; Döşkaya M.; Töz S.
    Complex clinical symptoms such as ulcerative skin lesions, destructive mucosal inflammation, and disseminated visceral infection can reveal in leishmaniasis. The conventional drugs are toxic and expensive. In addition, patients receive a long treatment with these drugs which have adverse effects and unfortunately there are some limitations during the treatment. The aim of this study is to investigate the in vitro anti-leishmanial activities of four different extracts of Sarcopoterium spinosum against Leishmania tropica. Initially, different concentrations of ethanol, methanol, n-hexane, and water extracts of S. spinosum were incubated with L. tropica promastigotes. After 72 hours of incubation, the growth of L. tropica promastigotes was significantly inhibited and the percentage of inhibition ranged between 42.8 and 100 %. Among these extracts, the most efficient growth inhibition (100 %) was obtained with methanol extract (at a dose of 50 µg/ml). In conclusion, S. spinosum may be a potential source for the development of novel therapeutic agents to treat L. tropica infection. © 2018, Chartered Inst. of Building Services Engineers. All rights reserved.
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    Relationship between ghrelin and obestatin levels and ghrelin/obestatin ratio in patients with asthma; [Serum ghrelin, obestatin düzeyleri ve ghrelin/obestatin oranının astım ile ilişkisi]
    (Ankara University, 2020) Kizilirmak D.; Bozkurt B.; Karamanli H.
    Methods: 51 patients with stable persistent asthma and 36 healthy controls were included to the study. Pulmonary function tests were conducted in all case. Skin prick test and an asthma control test were conducted in patients with asthma. All patients and controls were compared in terms of ghrelin and obestatin levels, as well as the ghrelin/obestatin ratio. Plasma concentrations of ghrelin and obestatin were detected by enzymelinked immunosorbent assay. Homeostasis model assessment-insulin resistance (HOMA-IR) scores were calculated as an index of insulin resistance. Results: No differences in ghrelin or obestatin levels or the ghrelin/obestatin ratio were detected between patients with asthma and the control group. Ghrelin levels were significantly lower in obese patients. The HOMA-IR score was significantly higher in patients with asthma than in controls. Conclusion: Ghrelin and obestatin levels, and the ghrelin/obestatin ratio, were similar in controls and patients with stable asthma. Although the groups were similar in terms of body mass index and waist circumference, the HOMA-IR score was significantly higher in patients with asthma. © 2020 by Tuberculosis and Thorax.