Browsing by Author "Bulut S."
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Item A whole genome screen for linkage in Turkish multiple sclerosis(Elsevier, 2003) Eraksoy M.; Kurtuncu M.; Akman-Demir G.; Kilinc M.; Gedizlioglu M.; Mirza M.; Anlar Ö.; Kutlu C.; Demirkiran M.; Idrisoglu H.A.; Compston A.; Sawcer S.; Tombul T.; Asker Ö.; Balkan S.; Seçkin D.; Aydin H.; Akman-Demir G.; Kiyat A.; Yapici Z.; Epçeliden T.; Çe P.; Goldenberg E.; Gültiken B.; Güvenç A.; Işik N.; Seleker T.; Idiman E.; Özakbaş S.; Irkeç C.; Nazlier B.; Forta H.; Seleker F.; Güner K.; Karabudak R.; Kilinç M.; Komsuoǧlu S.; Efendi H.; Mert M.; Mirza M.; Erdoǧan F.; Müngen B.; Bulut S.; Özer F.; Yayla V.; Petek-Balci B.; Saǧduyu A.; Sarica Y.; Demirkiran M.; Selçuki D.; Mavioǧlu H.; Siva A.; Altintaş A.; Saip S.; Sütlaş N.; Kuşçu Yandim D.; Tireli H.; Özalp K.; Türkoǧlu R.; Örken C.; Özmanoǧlu M.; Velioǧlu S.; Özdemir G.; Gücüyener D.; Özkan S.; Tunali G.; Turan F.; Utku U.; Turgut N.; Ümit S.; Us Ö.; Ince Günal D.; Ütkür Y.; Aluçlu U.; Yavaşoǧlu Ö.; Yücemen N.; Yücesan C.; Zadikoǧlu A.; Zorlu Y.Factors exerting recessive effects on susceptibility to complex traits are expected to be over-represented in communities having a higher frequency of consanguineous marriage. Multiple sclerosis, a typical complex trait, is relatively common in Turkey where cultural factors also determine a high rate of consanguineous marriage. Previous genetic studies of multiple sclerosis in Turkey have been confined to the search for associations with candidate genes. In order to exploit the special genetic features of the Turkish population, we performed a whole genome screen for linkage in 43 Turkish multiplex families employing 392 microsatellite markers. Two genomic regions where maximum lod score (MLS) values were suggestive of linkage were identified (chromosomes 13q and 18q23) along with a further 14 regions of potential linkage. Parametric analysis of these data using a recessive model, appropriate for populations with a high frequency of consanguinity, increased the LOD scores in four regions. © 2003 Elsevier B.V. All rights reserved.Item Hepatobiliary insufficiency-candidate of transplantation newborns and anesthesia (two cases); [Hepatobilier yetmezlikli-transplantasyon adayi neonatal olgular ve anestezi](2008) Öztürk T.; Bulut S.; Toprak V.; Tezcan Keleş G.Biliary atresia (BA) is the most common and important neonatal hepatobiliary disorder and is seen in 1 in 8.000 to 1 in 18.000. Consequently, 70-80 % of BA patients will eventually require liver transplantation, approximately half in the first 2 y of life. Early diagnosis and therapy is essential especially for the survival of patients with biliary atresia.Item Anesthetic management in a case severe thoracolumbar kyphoscoliosis and difficult airway; [Ciddi torakolomber kifoskolyozu ve zor hava yolu olan olguda anestezi yönetimi](2009) Topçu I.; Öztürk T.; Bulut S.; Tezcan Keleş G.Anesthetic management in a case severe thoracolumbar kyphoscoliosis and difficult airway Spinal deformities may cause difficulties with both tracheal intubation and regional anesthesia. This report describes the anesthetic management that was performed in 48 years old patient with extremely severe thoracolumbar kyphoscoliosis and mallampati class IV. After examining the risk factors, spinal block by injecting single dose 12, 5 mg bupivacaine solution to the intratechal space was chosen to provide anaesthesia. Motor and sensory blockade at the level of Thl2 was achieved. Spinal anesthesia can be successfull even in cases of severe thoracolumbar kyphoscoliosis and difficult airway manage-ment.Item Effect of ground poppy seed as a fat replacer on meat burgers(2011) Gök V.; Akkaya L.; Obuz E.; Bulut S.Poppy seed paste was used in koefte production as an animal fat replacer and efficacy of using poppy seed was investigated. The use of ground poppy seed in formulation of meat burgers had no effect on the moisture content of uncooked meat burgers; however, it did have a significant effect (p < 0.05) on the fat content of meat burgers. Ground poppy seed addition significantly affected (p < 0.05) cooking yield, moisture retention, and fat retention of meat burgers. Ground poppy seed addition significantly decreased (p < 0.05) saturated fatty acid contents as the amount of ground poppy seed increased in meat burgers. A strong significant decrease (p < 0.05) on the cholesterol content of meat burgers with ground poppy seed addition was observed. Samples having 20% ground poppy seed had significantly better texture and juiciness score (p < 0.05) than any other sample which could be explained by increased moisture retention. Replacing animal fat with ground poppy seed paste is effective and may pave the way for an innovative meat product. © 2011 Elsevier Ltd.Item Validity and reliability of the turkish version of the adult adhd self-report screening scale for dsm-5(Galenos Publishing House, 2021) Genç H.A.; Yorguner N.; Bulut S.; Bulut G.C.; Aydemir Ö.; Yazgan Y.Background: Approximately half of the children with attention-deficit hyperactivity disorder continue to meet diagnostic criteria in adulthood. The prevalence of adult attention-deficit hyperactivity disorder is reported between 2.5% and 4.4% and is associated with significant impairment in quality of life and increased psychiatric comorbidity. Attention-deficit hyperactivity disorder in adults remains mostly undiagnosed and/or untreated despite the availability of effective treatments. The majority of people who do not receive necessary treatment are in the nonclinical or nonpsychiatric clinical population. Screening is an important step for diagnosing adults with attention-deficit hyperactivity disorder. Yet, there are no valid and reliable screening questionnaires calibrated for the Diagnostic and Statistical Manual for Mental Disorders-5 in Turkish. Aims: We aimed to test the reliability and the validity of the Adult Attention-Deficit Hyperactivity Disorder Self-Report Scale-5 screening questionnaire designed according to DSM-5 in the Turkish population. Study Design: Methodological and cross-sectional study. Methods: The translation was carried out according to the World Health Organization Composite International Diagnostic Interview translation guide using a linguistic adaptation approach. We used a convenience sampling method to recruit an individual with adult attention-deficit hyperactivity disorder (n = 68) and a control group (n = 68). The participants completed a sociodemographic form, 6-items Adult Attention-Deficit Hyperactivity Disorder Self-Report Scale-5, and the previous version 18-items Adult Attention-Deficit Hyperactivity Disorder Self-Report Scale-v1.1 for the concurrent validity analysis. For the diagnostic validity, clinical diagnosis made by psychiatrists according to the Diagnostic and Statistical Manual for Mental Disorders-5 criteria was used. Internal consistency and item-total correlation coefficients, exploratory factor analyses, correlation with Adult Attention-Deficit Hyperactivity Disorder Self-Report Scale-v1.1, and receiver operating characteristic curve analysis were conducted. Results: The internal consistency measured by Cronbach alpha was 0.869. Item-total correlation coefficients were calculated to be between 0.602 and 0.717, and the correlations were statistically significant (P < 0.0001). The Adult Attention-Deficit Hyperactivity Disorder Self-Report Scale-5 showed to have a unidimensional factor structure explaining 60.54% of the variance. The correlation between Adult Attention-Deficit Hyperactivity Disorder Self-Report Scale-5 and Adult Attention-Deficit Hyperactivity Disorder Self-Report Scale-v1.1 total score was calculated as 0.992 (P < 0.0001), and that between Adult Attention-Deficit Hyperactivity Disorder Self-Report Scale-5 and Adult Attention-Deficit Hyperactivity Disorder Self-Report Scale-v1.1 attention-deficit subdimension was 0.868 (P < 0.0001). In the receiver operating characteristic analysis of Adult Attention-Deficit Hyperactivity Disorder Self-Report Scale-5, the area under the curve was found to be 0.916. The cut-off score was calculated as 9 of 10 with a sensitivity of 85.2% and specificity of 89.7%. Conclusion: Adult Attention-Deficit Hyperactivity Disorder Self-Report Scale-5 is a valid and reliable self-report measure to assess and screen attention-deficit hyperactivity disorder in the Turkish population. It may be useful for both clinical and population studies. © @Author(s).