Browsing by Author "Buyukyazi, G"

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    Differences in the cellular and humoral immune system between middle-aged men with different intensity and duration of physically training
    Buyukyazi, G; Kutukculer, N; Kutlu, N; Genel, F; Karadeniz, G; Ozkutuk, N
    Aim. The effects of acute exercise on immune system and serum magnesium and iron have been investigated in recent years. However, data related to the comparisons of long-term physical training with different intensity and duration are limited. Methods. The association between long-term physical training and cellular (lymphocyte phenotyping) and humoral immune parameters (serum immunoglobulins) and serum magnesium and iron values in the middle-aged men was investigated. Eleven male master athletes (MA) performing high intensity and long duration training, 11 male recreational athletes (RA) performing moderate intensity and duration training (>10 years) participated. Eleven male sedentary individuals were enrolled as control group (CG). Results. The percentages of total CD3+ T cells, CD4+ T helper, CD8+ T suppressor/cytotoxic, CD19+ B cells, natural killer cells, HLA-DR+ active T cells and CD4/CD8 ratios did not show any significant difference among 3 groups. In MA, VO2max values showed a significant negative correlation with CD4+ T helper cells. There were no significant differences among MA, RA and CG in terms of IgG, IgA, and IgM concentrations. There was a significant correlation between VO2max and IgG in RA. Iron, iron binding capacity and ferritin were found similar in all groups, but serum magnesium level in MA was significantly lower than RA and CG. Conclusion. No exact data to support immunosuppression or immunostimulation could be obtained except a significant negative correlation between CD4+ T helper cells and VO2max values in MA and a positive correlation between serum IgG and VO2max ivalues in RA. These findings may be the indirect markers of cellular immune system suppression by intensive exercises and stimulation of IgG production by moderate exercises.
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    The effects of different intensity walking programs on serum blood lipids, high-sensitive C-reactive protein, and lipoprotein-associated phospholipase A2 in premenopausal women
    Buyukyazi, G; Ulman, C; Taneli, F; Esen, H; Gozlukaya, F; Ozcan, I; Tikiz, H
    Aim. - This study examined the effects of 12 weeks of walking programs on serum lipids, high-sensitive C-reactive protein, and lipoprotein-associated phospholipase A2. Methods. - Twenty-six pre-menopausal women (30-49 years) completed 12 weeks of walking programs either at moderate or high intensity (50-55%, 70-75% maximum heart rate reserve, respectively). Estimated maximal oxygen consumption was assessed with a 2-km walking test; body composition, blood lipids, high-sensitive C-reactive protein, and lipoprotein-associated phospholipase A2 were measured before and after the study. Results. - Maximal oxygen consumption increased, favoring high-intensity group; body weights, percent body fat (p<0.01) and body mass index (p<0.05) decreased in both exercise groups. There were no significant changes in the measured blood lipids in any of the groups, except for a significant reduction in low-density lipoprotein-cholesterol in high-intensity group (p<0.05). High-sensitive C-reactive protein and lipoprotein-associated phospholipase A2 levels reduced significantly in high-intensity (p<0.01) and moderate-intensity (p<0.05) groups, which were also different from the changes in the control group. Conclusion. - Walking programs with different intensity result in favorable changes; however, for protective effects against cardiovascular diseases, high-intensity walking may be advised due to greater reductions in low-density lipoprotein-cholesterol, and high-sensitive C-reactive protein and lipoprotein-associated phospholipase A2. (C) 2010 Elsevier Masson SAS. All rights reserved.
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    Serum testosterone, growth hormone, and insulin-like growth factor-1 levels, mental reaction time, and maximal aerobic exercise in sedentary and long-term physically trained elderly males
    Ari, Z; Kutlu, N; Uyanik, BS; Taneli, F; Buyukyazi, G; Tavli, T
    The aim of the study was to investigate the effect of regular exercise on maximum oxygen uptake capacity (VO2max), reaction time (RT), testosterone (T), growth hormone (GH), insulin-like growth Jactor-I (IGF-I) in athletes compared to sedentary controls. VO2max RT, T, GH, and IGF-I levels were 31.2 +/- 6.2 ml/min/kg, 106.7 +/- 23.2 s, 8.3 +/- 1.3 ng/mL, 1.6 +/- 0.7 ng/mL, 106.5 +/- 27.0 ng/mL in master athlete group and 18.8 +/- 5.1 ml/min/kg, 148.3 +/- 39.3 s, 5.4 +/- 1.7 ng/mL, 0.8 +/- 0.3 ng/mL, 90.2 +/- 23.8 ng/mL in sedentary control group, respectively. The differences between regularly exercising males and the control group of sedentary males were found to be statistically significant. The results showed that long-term exercise decreased RT and increased VO2max T, and GH in elderly males; elevated serum T and GH levels may be advantageous for brain functions.
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    Does chronic exercise alter immune parameters in postmenopausal women?
    Karadeniz, G; Buyukyazi, G; Gunduz, T; Kutlu, N; Ozbakkaloglu, B
    The aim of this study was to determine the effect of chronic exercise on immune functions. Eighteen postmenopausal women were included in the study: nine were undertaking chronic exercise (exercise group) and the other nine were sedentary (control group). The exercise group had been training for 7.2 h per week for 19.9 years, The subjects were chosen among postmenopausal women to eliminate any effects of menstrual cycle on the immune system. The subjects were paired and reported to the Human Performance Laboratory twice a week between 8:00 and 10:00 a.m. In the first visit, body composition and aerobic capacity were measured. In the second visit, their blood samples were drawn and screened immediately. VO(2)max was significantly higher in the exercise group. The leukocyte and lymphocyte subset data comparions demonstrated no significant difference between the exercise group and the control group. Only IgA was significantly higher in the exercise group than in the control group (p = 0.005). The results of this investigation indicate that chronic exercise training does not significantly alter concentrations of T and B lymphocytes or T lymphocyte subsets. However, a significant increase in IgA levels may occur, leading to changes in immune response.
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    Activity does not affect free and total prostate-specific antigen levels but lowers the free-to-total prostate-specific antigen ratio
    Ulman, C; Buyukyazi, G; Taneli, F; Uyanik, BS
    Prostate-specific antigen (PSA) and the ratio of free-to-total PSA are widely used tumour markers, but the effect of exercise on these parameters is unclear. We aimed to determine whether long-term physical training was associated with changes in serum PSA by comparing PSA concentrations in middle-aged master athletes (n = 12), recreational athletes (n = 12) and sedentary controls (n = 12). Serum total PSA and free PSA concentrations were assessed using an electrochemiluminescence immunoassay; there were no significant differences among the groups. The free-to-total PSA ratio was significantly lower statistically in master athletes compared with recreational athletes, but this is not clinically significant as both values (0.22 versus 0.31, respectively) were within the normal range. These results indicate that the free-to-total PSA ratio may be affected by long-term athletic training, and could be important when evaluating athletes with prostate-related disorders.
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    The effects of eight-week walking programs of two different intensities on serum lipids and circulating markers of collagen remodelling in humans
    Buyukyazi, G
    Aim. - This study examined the effects of eight weeks of walking programs on serum lipids, circulation matrix metalloproteinase-9 (MMP-9) and tissue inhibitor of metal loproteinase-1 (TIMP-1). Methods. - Thirty-seven premenopausal women (30-55 years) completed eight weeks of walking programs either at moderate (similar to 5.25 +/- 0.28 km/h; similar to 53% maximum heart rate reserve (HRRmax) or high-intensity (similar to 7.33 +/- 0.24 km/h; similar to 73% HRRmax). Non-walking, sedentary women served as controls. Estimated Vo(2max) was assessed with a 2 km walking test; body composition was measured using body composition analyzer; lipid, MMP-9, and TIMP-1 concentrations were measured in serum. Results. - After eight weeks, estimated Vo(2max) improved in high-intensity walking group (HIWG; p < 0.01) and in moderate-intensity walking group (MIWG; p < 0.05); BMI, and percent body fat decreased (p < 0.05) in both exercise groups. Only HIW caused significant reductions in total cholesterol (TC), low-density lipoprotein-cholesterol (LDL-C), and MMP-9 levels (p<0.05); we found no significant changes in high-density lipoprotein-cholesterol and triglyceride levels in any of the groups. Exercise did not cause any significant changes in TIMP-1 levels apart from a nearly significant reduction in HIWG (p = 0.084). Conclusion. - Walking programs with different intensity bring about favorable changes; but significant improvements for protective effects against cardiovascular diseases may be attained only with high-intensity walking programs due to the reduction in TC, LDL-C and MMP-9 levels. (C) 2008 Elsevier Masson SAS. All rights reserved.
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    Differences in blood lipids and apolipoproteins between master athletes, recreational athletes and sedentary men
    Buyukyazi, G
    Aim. Studies related with the role of intensive and moderate training on reducing coronary heart disease (CHID) risks have revealed conflicting results. Thus, the aim of this study was to clarify the association between long-term physical training with competitive and recreational purposes and blood lipids and apolipoproteins in the middle-aged master athletes, recreational athletes and sedentary controls. Methods. The association between long-term physical training and serum concentrations of lipids, lipoproteins, and apolipoproteins in the middle-aged men was investigated. Twelve male master athletes (NM), 12 male recreational athletes (RA) (> 10 y), and 12 male sedentary controls (CG) participated in the study. Serum concentrations of lipids and lipoproteins were measured by enzymatic methods; apolipoproteins (ApoA1 and ApoB) and serum lipoprotein(a) [Lp(a)] were measured by immonoprecipitation assays. Results. TC, LDL-C, ApoA1, Lp(a) levels and LDL-C/HDL-C ratio of the 3 groups did not show any significant differences. MA and RA had significantly higher levels <(V)over dot > O-2max, HDL-C, ApoA1/ApoB ratio; and lower values of percent body fat, resting heart rate, systolic and diastolic blood pressures, TG, ApoB and TC/HDL-C ratio than CG. We did not find any significant differences between MA and RA in any variables except for BMI and TC/HDL-C ratio. Conclusion. Habitual physical training favorably altered serum lipid and apolipoprotein profiles. Although there was no statistical significance (except for BMI and TC/HDL-C) between MA and RA, a tendency to reduce the CHID risks was observed almost in all variables in favor of MA.
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    Differences in the cellular and humoral immune system between sedentary and endurance-trained elderly males
    Buyukyazi, G
    Aim. - This study aimed to examine the association between active vs. inactive lifestyle and cellular and humoral immune system in the elderly. Methods. - Eleven elderly male athletes (mean age +/- S.D.: 67.1 +/- 6.0 year) performing regular aerobic exercise for about 38.8 +/- 18.5 yeasr (4.4 +/- 1.4 d week(-1); 10.0 +/- 8.1 h week(-1)) and eleven male individuals at similar ages (mean age S.D.: 64.9 +/- 4.6 year) leading a sedentary life were taken as control group. Immunological assessments were total leukocyte count, lymphocyte subpopulation, natural killer percentages, and IgA, IgG, and IgM concentrations. Results. - Baseline NK cell percentage, and serum IgA and IgM concentrations of master athletes were significantly higher than those of control group (29.3 +/- 12.8% vs. 20.0 +/- 7.5%; 2.4 +/- 0.66 g/l vs. 1.6 +/- 0.63 g/l; 1.0 +/- 0.47 g/l vs. 0.58 +/- 0.31 g/l, respectively; P < 0.05). No statistical differences were obtained in the total leukocyte counts and neutrophils, eosinophils, lymphocytes, monocytes, and the percentages of total T cells, B cells and T cell subsets (CD4+ T cells, CD8+ T cells), and IgG levels of the two groups. Conclusion. - Habitual exercise training may cause a slow down in the age-related decline in NK cell percentages and serum IgA and IgM levels of the elderly. (C) 2003 Elsevier SAS. All rights reserved.
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    Effects of aerobic plus explosive power exercises on bone remodeling and bone mineral density in young men
    Çay, V; Buyukyazi, G; Ulman, C; Taneli, F; Dogru, Y; Tikiz, H; Gümüser, G; Oran, A; Keskinoglu, P
    Objectives: This study aims to examine effects of aerobic jogging and explosive power exercises on body composition, maximal oxygen consumption (MaxVO(2)), bone mineral density (BMD) and bone turn-over markers: serum bone alkaline phosphatase (BAP), C terminal telopeptide (CTx), Procollagen type I N-terminal propeptide (PINP), in men aged between 20 and 40. Materials and methods: Thirty seven healthy males were divided into exercise group (EG, n = 19) and control group (CG, n = 18). EG completed 10 weeks of outdoor aerobic (jogging at 60-70% maximal heart rate reserve starting from 20 min steadily increasing up to 28 min) and explosive power exercises (in 2-3 sets, with maximum repetitions lasting 15 s), 3 times per week. All measurements were taken before and after the exercise program. BMD was measured via dual energy X-ray absorptiometry (DEXA). Results: Body mass index (p < 0.001) significantly decreased; MaxVO(2) (p < 0.001), femur neck (p = 0.036) and total score BMD significantly increased in EG (p = 0.034). BAP and vitamin D increased in both groups (p < 0.001). Conclusion: Performing our outdoor exercise program in spring months might have an important role in the significant increase (9 vs. 22 ng/mL) in mean vitamin D level, which reached above the fracture risk level of 20 ng/mL.
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    The effect of 8-week different-intensity walking exercises on serum hepcidin, IL-6, and iron metabolism in pre-menopausal women
    Buyukyazi, G; Ulman, C; Çelik, A; Çetinkaya, C; Sisman, AR; Çimrin, D; Dogru, Y; Kaya, D
    Objective: Hepcidin may be an important mediator in exercise-induced iron deficiency. Despite the studies investigating acute exercise effects on hepcidin and markers of iron metabolism, we found no studies examining the chronic effects of walking exercises (WE) on hepcidin and markers of iron metabolism in premenopausal women. The chronic effects of two 8-week different-intensity WE on hepcidin, interleukin 6 (IL-6), and markers of iron metabolism in pre-menopausal women were examined. Methods: Exercise groups (EG) [moderate tempo walking group (MTWG), n = 11; brisk walking group (BWG), n = 11] walked 3 days/week, starting from 30 to 51 min. Control group (CG; n = 8) did not perform any exercises. BWG walked at similar to 70%-75%; MTWG at similar to 50%-55% of HRRmax. VO2max, hepcidin, IL-6, and iron metabolism markers were determined before and after the intervention. Results: VO2max increased in both EGs, favoring the BWG. Hepcidin increased in the BWG (p < 0.01) and CG (p < 0.05). IL-6 decreased in the BWG and the MTWG (p < 0.05; p < 0.01). While iron, ferritin, transferrin, and transferrin saturation levels did not change in any group, total iron binding capacity (p < 0.05), red blood cells (p < 0.05), and hematocrit (p < 0.01) increased only in the BWG. Conclusion: Both WE types may be useful to prevent inflammation. However, brisk walking is advisable due to the positive changes in VO2max and some iron metabolism parameters, which may contribute to prevent iron deficiency. The increase in hepcidin levels remains unclear and necessitates further studies.