Browsing by Author "Cakir, ADU"

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    Cognitive functioning of adolescents using Methamphetamine: The impact of inflammatory and oxidative processes
    Cakir, B; Cakir, ADU; Sapmaz, SY; Bilac, O; Taneli, F; Kandemir, H
    BackgroundMethamphetamine is a substance that causes neurotoxicity and its use is increasing in recent years. Literature highlights cognitive impairment resulting from Methamphetamine use. The aim of the present study is to evaluate the relationship between cognitive impairment and inflammatory processes in adolescents with Methamphetamine use disorder.MethodsThe study included 69 adolescents aged 15-19 years, comprising 37 participants with Methamphetamine Use Disorder and 32 healthy controls. Central Nervous System Vital Signs was used to detect cognitive impairment. Childhood Trauma Questionnaire-33 and The Children's Depression Inventory scales were used. In addition, venous blood was collected from the volunteers. Biochemical parameters (IL-1beta, IL-6, TNF-a, BDNF, FAM19A5, TAS, TOS) were analyzed.ResultsOur study showed that (I) IL-6 and TNF-a levels of Methamphetamine users were lower than the healthy group; (II) BDNF levels of Methamphetamine users were higher than the healthy group; (III) mean Neurocognitive Index in cognitive tests of Methamphetamine using adolescents was negatively correlated with duration of Methamphetamine use and BDNF levels.ConclusionsOur study suggests that Methamphetamine use may have a negative effect on cognitive functions.
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    Nonsuicidal self-injury in adolescents: Role of sociodemographic and clinical factors, emotion regulation, and maladaptive personality traits
    Canol, T; Sapmaz, SY; Barut, EA; Cakir, ADU; Bilac, O; Kandemir, H
    Objective: This study aims to assess the individual and psychosocial factors related to nonsuicidal self-injury (NSSI).Method: This study included patients with NSSI (n=44), non-NSSI patients (n=37), and a healthy control group (n=38) between 12 and 18 years of age. The clinical interviews were conducted with all participants. The participants completed an information form, the Difficulties in Emotion Regulation Scale (DERS), and the Personality Inventory for DSM-5-Brief Form.Results: In our findings, NSSI was associated with difficulties in peer relationships, disruption in family unity, domestic violence, smoking, sexual abuse, physical abuse, and suicidal ideation history. Patients in the NSSI group showed higher scores on the DERS than those in other groups. They also showed a higher level of maladaptive personality traits compared with adolescents in other groups. Our findings showed that NSSI was associated with suicidal ideation history and maladaptive personality traits.Conclusion: The existing literature and our findings indicate that previous suicidal ideation and maladaptive personality traits might be suggestive of NSSI. Considering these potential risk factors would allow clinicians to develop more suitable early intervention, follow-up, and treatment strategies for NSSI in the adolescent population.