Browsing by Author "Calli, C"

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    Intrauterine-diagnosed diastematomyelia
    Uyar, Y; Baytur, YB; Calli, C; Cetinkaya, B; Caglar, H
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    Efficacy of nasal corticosteroids alone or combined with antihistamines or montelukast in treatment of allergic rhinitis
    Pinar, E; Eryigit, O; Oncel, S; Calli, C; Yirnaz, O; Yukselb, H
    Objective: Topical corticosteroids are recommended as initial therapy in allergic rhinitis (AR) patients. We investigated clinical efficacy of monotherapy with topical steroid and combined therapy in AR patients. Methods: Ninety-five AR patients sensitive to grass pollens according to skin prick test results were enrolled in this placebo-controlled and open study. Patients were divided to four groups. Group-1 received only intranasal mometasone furoate (MF) 200 mu g (n = 25), group-2 received intranasal MF and oral desloratadine (DLR) 5 mg (n = 25), group-3 received intranasal MF and oral montelukast (MSK) 10 mg (n = 25), group-4 received only placebo (n = 20). Efficacy was assessed on the basis of total nasal symptom scores, rhinoconjunctivitis quality of life questionnaire scores and nasal inspiratory peak flow rates. Results: All groups that received treatment had better results when compared to the placebo group. Significant improvement in total nasal symptom scores was first evident at the end of the 2nd week in group-2. Group-3 had better results than those of the other groups at the end of the 1st month (p < 0.05). Quality of life scores were significantly better in group-2 and -3 when compared to those in group-1 (p < 0.05). Conclusion: Although corticosteroids are the mainstay of treatment in allergic rhinitis, montelukast may be considered as an additional agent especially in treatment of patients with impaired quality of life and it may be used to reduce nasal symptom scores. (c) 2007 Elsevier Ireland Ltd. All rights reserved.
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    In vivo tissue response and durability of five novel synthetic polymers in a rabbit model
    Sahin, E; Cingi, C; Eskiizmir, G; Altintoprak, N; Calli, A; Calli, C; Yilgör, I; Yilgör, E
    Alloplastic materials are frequently used in facial plastic surgeries such as rhinoplasty and nasal reconstruction. Unfortunately, the ideal alloplastic material has not been found. This experimental study evaluates the tissue response and durability of five novel polymers developed as an alloplastic material. In this experimental study involving a tertiary university hospital, six subcuticular pockets were formed at the back of 10 rabbits for the implantation of each polymer and sham group. Each pocket was excised with its adjacent tissue after three months, and collected for histopathological examination. Semi-quantitative examination including neovascularisation, inflammation, fibrosis, abscess formation, multinucleated foreign body giant cells was performed, and integrity of polymer was evaluated. A statistical comparison was performed. No statically significant difference was detected in neovascularisation, inflammation, fibrosis, abscess formation and multinucleated foreign body giant cells when a paired comparison between sham and polymer II, II and IV groups was performed individually. Nevertheless, the degree of fibrosis was less than sham group in polymer I (p = .027) and V (p = .018), although the other variables were almost similar. The integrity of polymers II (9 intact, 1 fragmented) and IV (8 intact, 2 absent) was better than the other polymers. These novel synthetic polymers could be considered as good candidates for clinical applicability. All polymers provided satisfactory results in terms of tissue response; however, fibrovascular integration was higher in polymers II, II and IV. In addition, the durability of polymer II and IV was better than the others.