Browsing by Author "Can, C"

Now showing 1 - 6 of 6
  • No Thumbnail Available
    Item
    Effect of vitamin E on vascular responses of thoracic aorta in rat experimental arthritis
    Çinar, MG; Can, C; Ülker, S; Gök, S; Çoker, C; Soykan, N; Kosay, S; Evinç, A
    1. Vascular contractile and relaxant responses were evaluated in isolated aortic rings of adjuvant induced arthritic rats in comparison with control rats, and the effect of an antioxidant treatment on the development of the arthritis was investigated by vitamin E administration (100 mg/kg/day, IM, for 26 days). 2. Arthritis was induced by an intradermal injection of Freund's complete adjuvant into rat paw. Vascular responses, arthritic lesions and serum copper levels were evaluated after 26 days from adjuvant inoculation. 3. Serum copper levels were significantly lower in arthritic rats than in the control. 4. The contractile response of aortic rings to phenylephrine (PE), but not to KCl, was increased in preparations from arthritic rats, which could be explained by an enhancement of intracellular calcium contents. 5. Acetylcholine (Ach)-mediated endothelium-dependent and sodium nitroprusside (SNP)-mediated endothelium-independent relaxations were not changed significantly in vascular preparations from arthritic rats. 6. In arthritic rats, vitamin E treatment improved arthritic lesions with an increase in copper levels. Despite this ameliorating effect, vitamin E treatment caused an increase in contractile response to PE and a decrease in the relaxant response to Ach and SNP in arthritic rats. 7. These data show that vitamin E provides ameliorating effects in improving systemic signs of experimental arthritis, but it fails to restore abnormalities in vascular function, indicating that adjuvant-induced alterations in vascular function may include mechanisms other than oxygen-free radical formation. (C) 1998 Elsevier Science Inc.
  • No Thumbnail Available
    Item
    Antineovascular effect of α-interferon on corneal neovascularization in rats
    Öztürk, F; Sobaci, G; Ilker, SS; Can, C
    Clinical and histologic effects of topical recombinant a-interferon (IFN) systemic IFN topical dexamethasone, and dexamethasone plus topical IFN on corneal neovascularization in response to silver nitrate cauterization were investigated in 110 eyes of 60 Wistar rats. The eyes were evaluated according to tire burn stimulus, neovascularization, and histologic inflammation grades 5 days after cauterization. Antineovascular effects of topical and systemic IFN were significantly greater than a placebo but less than dexamethasone alone or in combination with IFN.
  • No Thumbnail Available
    Item
    Can We Predict the Surgical Margin Positivity in Patients Treated with Radical Prostatectomy? A Multicenter Cohort of Turkish Association of Uro-Oncology
    Bolat, D; Eskicorapci, S; Karabulut, E; Baltaci, S; Yildirim, A; Sözen, S; Ates, F; Sekerci, ÇA; Kurtulus, F; Dirim, A; Muezzioglu, T; Can, C; Bozlu, M; Gemalmaz, H; Ekici, S; Özen, H; Turkeri, L
    Objective To analyze the parameters that predict the surgical margin positivity after radical prostatectomy for localized prostate cancer. Materials and Methods In this multicenter study, the data of 1607 consecutive patients undergoing radical prostatectomy for localized prostate cancer in 12 different clinics in Turkey between 1993-2011 were assessed. Patients who had neoadjuvant treatment were excluded. We assessed the relationship between potential predictive factors and surgical margin status after radical prostatectomy such as age, cancer characteristics, history of transurethral prostate resection, surgical experience and nerve-sparing technique by using univariate and multivariate Cox regression analyses and t test. Results The overall surgical margin positivity rate was 22.6% (359 patients). In univariate analyses, preoperative prostate specific antigen level, clinical stage, biopsy Gleason score, percentage of tumor involvement per biopsy specimen, transurethral prostate resection history, surgical experience and nerve-sparing technique were significantly associated with positive surgical margin rate. In multivariate analyses, preoperative prostate specific antigen level (OR: 1.03, p=0.06), percentage of tumor involvement per biopsy specimen (OR: 7,14, p<0,001), surgical experience (OR: 2.35, p=0.011) and unilateral nerve-sparing technique (OR: 1.81, p=0.018) were independent predictive factors for surgical margin positivity. Conclusion Preoperative prostate specific antigen level, percentage of tumor involvement per biopsy specimen, surgical experience and nerve-sparing technique are the most important predictive factors of surgical margin positivity in patients undergoing radical prostatectomy for localized prostate cancer.
  • No Thumbnail Available
    Item
    The knowledge and considerations of the physicians regarding the inhaler devices in asthma and COPD: the INTEDA-1 study
    Caliskaner, AZ; Öztürk, C; Ceylan, E; Pekcan, S; Yilmaz, Ö; Öztürk, S; Can, C; Sener, O; Turay, ÜY; Koç, N; Ersoy, R
    Introduction: The present paper was aimed at indicating and discussing the possible problems related to inhaler devices by considering the knowledge and practices of the physicians regarding the inhalation therapies. Materials and Methods: The present study is a prospective, cross-sectional survey carried out by Turkish Respiratory Society Inhalation Therapy Group between February 2010 and February 2011 with a participation of ten individual centres. Seven inhaler devices that were available on the market in the country were assessed. The data on the problems that 684 clinicians actively attending patients with respiratory disorders experienced in daily clinical practice or their evaluations of their patients were obtained through the questionnaire. Results: The respondents, most of whom were pulmonologist (37.5%), and pediatrist (38.1%), had been, on average, 11.6 years in profession. The source of information on inhalers and administration techniques were reported to be mainly the internet and patient leaflets. Of the participants only 18.5% reported to have had adequate knowledge of inhaler devices and proper administration techniques. Most of the participants stated that they themselves provided the instructions of administration and that the method was often verbal explanation. The physicians believed that although approximately 60% of the patients used the drug correctly, 40.7% made critical mistakes to have adverse effects on the therapeutic outcome. The most important criteria on which the physians lay greater emphasis in choosing the inhaler devices were the physical capability, skills and age of the patients. Conclusion: The awareness of proper use of inhaler devices is a fundamental prerequisite for effective inhalation therapy has been improved in physicians. The results of the present study have shown that more effort is required for professional training. Assisting the physicans with medical personnel for training of the patients and educational motivation are required.
  • No Thumbnail Available
    Item
    Physicians' knowledge of and opinions about inhaler treatments in asthma and COPD: the INTEDA-1 study
    Caliskaner, Z; Ozturk, C; Pekcan, S; Yilmaz, O; Ozturk, S; Ceylan, E; Can, C; Sener, O; Turay, U; Ersoy, R
  • No Thumbnail Available
    Item
    The extreme errors in inhaler device use: data from the INTEDA-1 study
    Caliskaner, Z; Ozturk, C; Pekcan, S; Yilmaz, O; Ozturk, S; Ceylan, E; Can, C; Sener, O; Turay, U; Ersoy, R