Browsing by Author "Can Sevinc"

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    Fırsatçı pulmoner infeksiyon ön tanısıyla yapılan bronkoalveoler lavajın mikrobiyolojik sonuçları
    (2006) Aylin GÜLCÜ; Nuray KÖMÜS; Arif Hikmet ÇIMRIN; Oya İTİL; Mine YÜCESOY; Can Sevinc; ATİLA AKKOÇLU; OGUZ KILINC; Eyüp Sabri Uçan; Zeynep Gulay; Nuran ESEN; Gülper ŞENER
    2001-2002 yıllarını kapsayan dönemde, fırsatçı pulmoner infeksiyon ön tanısı ile bronkoalveoler lavaj (BAL) yapılan, yaş ortalaması 51.4 ± 18.1 yıl olan, 33 (%53)’ü erkek, 29 (%47)’u kadın toplam 62 olgunun bakteriyolojik inceleme sonuçları değerlendirildi. Olguların 18 (%29)’inde hematolojik malignite, 13 (%21)’ünde solid organ tümörü, 31 (%50)’inde ise malign olmayan nedenlere bağlı immünsüpresyon söz konusu idi. Endoskopik olarak 11 (%18) olguda infeksiyon ile uyumlu bulgular, 2 (%3) olguda endobronşiyal lezyon, 2 (%3) olguda indirekt tümör bulguları saptanırken, 47 (%76) olguda ise fiberoptik bronkoskopik (FOB) bulgular normaldi. Aside dirençli basil (ARB) direkt bakısı 3 (%5) olguda pozitif bulundu. Dört (%6) olguda hem mikobakteriyel kültürde üreme hem de Mycobacterium tuberculosis-polimeraz zincir reaksiyonu (PCR)pozitifliği saptandı. Gram boyalı incelemede 14 (%23) olguda infeksiyon ile uyumlu bulgular vardı. On (%16) olgunun bakteriyolojik kültüründe tek etken, 7 (%11)’sinde ise birden fazla etken olmak üzere toplam 17 (%27) olguda üreme olduğu belirlendi. Tümü hematolojik maligniteli 3 (%5) olgunun fungal kültürlerinde üreme saptandı. Sonuçta dört olguda mikobakteriyel, 17 olguda bakteriyel, üç olguda da fungal olmak üzere toplam 24 (%39) olguda mikrobiyolojik olarak infeksiyon etkenine ulaşılmış oldu.
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    Relationship between functional status and fatigue after COVID-19 infection: a multicenter study from Türkiye
    (2024) ipek candemir; Pınar Ergün; DİCLE KAYMAZ; Mustafa Engin Şahin; ipek ozmen; Elif YILDIRIM; Asli Gorek Dilektasli; BÜŞRA KAHRAMAN; Ayten Odabaş; Deniz Kızılırmak; SEÇİL SARI; Celalettin Korkmaz; CANTÜRK TASÇI; YAKUP ARSLAN; Sema SAVCI; BUSE OZCAN KAHRAMAN; AYLIN TANRIVERDI; Can Sevinc; Melda Saglam; Deniz Inal-Ince; Naciye Vardar-Yagli; Ebru Calik Kutukcu; Dilber Durmaz; Neslihan Duruturk; gaye ulubay; lütfiye Kılıç; Benan Çağlayan; Aylin Aylin; GÜVEN ÖZKAYA; Sabri Serhan OLCAY
    Background/aim: Symptoms of COVID-19 may persist for months. One of the persistent symptoms of COVID-19 is fatigue, which reduces functional status. The relationship between fatigue, functional status, and various other factors has received little attention, which this study aims to address.. Materials and methods: Patients with COVID-19 infection were included in this multicenter cross-sectional study. Age, sex, body mass index (BMI), marital status, smoking status, presence and duration of chronic disease, comorbidity index, regular exercise habits, time since COVID-19 diagnosis, hospitalization status, length of hospital stay, intubation status, home oxygen therapy after discharge, participation in a pulmonary rehabilitation program, presence of dyspnea, presence of cough, presence of sputum, and modified Medical Research Council, Post-COVID Functional Status (PCFS), Fatigue Severity Scale (FSS), and EQ-5D-5L Questionnaire scores were recorded. Results: We enrolled 1095 patients, including 603 (55%) men and 492 (45%) women with a mean age of 50 ± 14 years. The most common chronic lung disease was COPD (11%) and 266 (29%) patients had nonpulmonary disease. The median time elapsed since COVID-19 diagnosis was 5 months; the hospitalization rate was 47%. The median PCFS grade was 1 (0–4) and the median FSS score was 4.4 (1–7). The PCFS and FSS were positively correlated (r = 0.49, p < 0.01; OR: 1.88, 95% CI: 1.68–2.10). Both functional status and fatigue were associated with quality of life, which was lower in older patients, those with higher BMI, those with systemic disease, those not exercising regularly, and those with more severe COVID-19 infection (defined by dyspnea, pneumonia as indicated by computed tomography, hospitalization, length of stay, ICU admission, intubation, and the need for home oxygen after discharge). Conclusion: Fatigue may cause poorer functional status regardless of the time since COVID-19 diagnosis. In this study, patients with FSS scores of >4.78 showed moderate to severe functional limitations. It is important to address modifiable patient risk factors and reduce the severity of COVID-19 infection.
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    Bronchiectasis in Türkiye: Data from a Multicenter Registry (Turkish Adult Bronchiectasis Database)
    (2024) EBRU ÇAKIR EDİS; Aykut Cilli; Deniz Kızılırmak; AYŞIN ŞAKAR COŞKUN; Nurcan Güler; Sedat Çiçek; Can Sevinc; Meltem Ağca; inci gülmez; Benan Çağlayan; mehmet kabak; Elif Yelda Ozgun Niksarlioglu; Nurdan Kokturk; Abdullah Sayiner; TEBVEB Researchers
    Background: Bronchiectasis is a chronic lung disease characterized by permanent bronchial wall dilatation. Although it has been known as an orphan disease, it has recently gained attention because of registry-based studies and drug research. Aims: We aimed to use a multicenter database to analyze and compare data regarding the etiology, associated comorbidities, microbiological characteristics, and preventive strategies of bronchiectasis in Türkiye to those of other countries. Study Design: A multicenter prospective cohort study. Methods: The multicenter, prospective cohort study was conducted between March 2019 and January 2022 using the Turkish Adult Bronchiectasis Database, in which 25 centers in Türkiye participated. Patients aged > 18 years who presented with respiratory symptoms such as cough, sputum, and dyspnea and were diagnosed with non-cystic fibrosis bronchiectasis using computed tomography were included in the study. Demographic information, etiologies, comorbidities, pulmonary functions, and microbiological, radiological, and clinical data were collected from the patients. Results: Of the 1,035 study participants, 518 (50%) were females. The mean age of the patients was 56.1 ± 16.1 years. The underlying etiology was detected in 565 (54.6%) patients. While postinfectious origin was the most common cause of bronchiectasis (39.5%), tuberculosis was identified in 11.3% of the patients. An additional comorbidity was detected in 688 (66.5%) patients. The most common comorbidity was cardiovascular disease, and chronic obstructive pulmonary disease (COPD) and bronchiectasis was identified in 19.5% of the patients. The most commonly detected microbiological agent was Pseudomonas aeruginosa (29.4%). Inhaled corticosteroids (ICS) were used in 70.1% of the patients, and the frequency of exacerbations in the last year was significantly higher in patients using ICS than in nonusers (p < 0.0001). Age [odds ratio (OR): 1.028; 95% confidence interval (CI): 1.005-1.051], cachexia (OR: 4.774; 95% CI: 2,054-11,097), high modified medical research council dyspnea scale score (OR: 1,952; 95% CI: 1,459-2,611), presence of chronic renal failure (OR: 4,172; 95% CI: 1,249-13,938) and use of inhaled steroids (OR: 2,587; 95% CI: 1,098-6,098) were significant risk factors for mortality. Mortality rates were higher in patients with COPD than in those with no COPD (21.7-9.1%, p = 0.016). Patients with bronchiectasis and COPD exhibited more frequent exacerbations, exacerbation-related hospitalizations, and hospitalization in the intensive care unit in the previous year than patients without COPD. Conclusion: This is the first multicenter study of bronchiectasis in Türkiye. The study results will provide important data that can guide the development of health policies in Türkiye on issues such as infection control, vaccination, and the unnecessary use of antibiotics and steroids.