Browsing by Author "Celik F."
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Item Cytokine expression profiles in Autism spectrum disorder: A multi-center study from Turkey(Academic Press, 2020) Kutuk M.O.; Tufan E.; Gokcen C.; Kilicaslan F.; Karadag M.; Mutluer T.; Yektas C.; Coban N.; Kandemir H.; Buber A.; Coskun S.; Acikbas U.; Guler G.; Topal Z.; Celik F.; Altintas E.; Giray A.; Aka Y.; Kutuk O.Autism Spectrum Disorder (ASD) is a complex neurodevelopmental disorder characterized by impairments in communication and social interaction as well as restricted interests and repetitive behaviors. The pathogenesis of ASD is not completely understood, but a growing body of research has demonstrated that the immune response may be a contributing factor in the etiology and/ or ontogeny of ASD. The aim of this study was to determine the expression levels of IL-1β, IL-1α, IL-4, IL-6, IL-17, TNF-α and TGF-β in peripheral blood mononuclear cells of children with ASD and healthy controls in order to determine the contributions of cytokines to ASD. Within the study timeframe, 195 children with ASDs (80.5% male) and 162 controls (73.6% male) were enrolled. Most children with ASD had a comorbid disorder (n = 114, 58.5%), with the most common diagnoses as Intellectual Developmental Disorder (IDD, n = 64, 32.8%) and ADHD (n = 64, 32.8%). The majority of children with ASD had severe autistic symptoms as evaluated via Childhood Autism Rating Scale (CARS, n = 130, 64.6%). The mean CARS score in the ASD sample was 40.8 (S.D. = 7.6). The patients with ASD were found to have significantly higher levels of IL-6 (p < 0.001) and significantly lower levels of IL-17 (p < 0.05, all Bonferroni corrected). Treatment tended to affect IL-4 levels. Lastly, discriminant function analysis (DFA) revealed that a combination of IL-6, IL-17 and IL-1α correctly classified 56.6% of cases. Despite extensive immunological evidence suggesting immune system aberrations, further research is required to clarify the relationship between immune profiles and ASD symptoms. © 2020 Elsevier LtdItem Novel inflammatory targets for immunotherapies in pediatric patients with trichotillomania(Elsevier GmbH, 2020) Kutuk M.O.; Tufan A.E.; Kilicaslan F.; Mutluer T.; Gokcen C.; Karadag M.; Yektas C.; Kandemir H.; Buber A.; Guler Aksu G.; Topal Z.; Giray A.; Celik F.; Acikbas U.; Kutuk O.Immune dysregulation may be important in the etiology of obsessive-compulsive and related disordersandbody-focusedrepetitivebehaviors, such as Trichotillomania (TTM). The role of inflammation and inflammatory markers in TTM has received relatively little attention. This study was aimed to determine the expression levels of inflammatory markers (i.e. IL-1β, IL-1α, IL-4, IL-6, IL-17, TNF-α and TGF-β) in peripheral blood mononuclear cells of children with TTM and healthy controls and to evaluate their association with clinical variables. Seventy-seven patients with TTM and 107 healthy controls were enrolled in the study. Peripheral blood was collected in standardized conditions. The mean age of patients and controls did not differ significantly (10.8 ± 4.4 and 12.0 ± 3.2 years; respectively). The majority of patients with TTM and controls were females (n = 55, 71.4 % and n = 55, 51.4 %; respectively); with a greater preponderance of females among TTM. Patients with TTM had significantly elevated expression levels of TNF-α, IL-6 and IL-17 compared to controls. However, the expression level of IL-4 was significantly reduced in TTM patients compared to controls. Accordingly, we found a pro-inflammatory state in TTM and those findings may suggest novel treatment options for TTM and further, cross-disciplinary studies focusing on neuro- inflammation in TTM conducted on larger samples are needed. © 2020 Elsevier GmbHItem Cytokine expression profiles in children and adolescents with tic disorders(Nature Research, 2024) Kutuk M.O.; Tufan A.E.; Kilicaslan F.; Gokcen C.; Aksu G.G.; Yektas C.; Kandemir H.; Celik F.; Mutluer T.; Buber A.; Karadag M.; Coban N.; Coskun S.; Hangul Z.; Altintas E.; Acikbas U.; Giray A.; Aka Y.; Basturk B.; Kutuk O.The etiology of tic disorders (TDs) is not precisely known, although several lines of evidence suggest involvement of the immune system in pathogenesis. Here, we aimed to determine the expression levels of pro-inflammatory and anti-inflammatory cytokines in children with TD and compare them with those of healthy controls. Furthermore, we also evaluated their association with clinical variables in the TD group. Within the study period, 88 children with tic disorders and 111 healthy control children were enrolled. Most children with tic disorders were diagnosed with Tourette’s disorder (n = 47, 53.4%) or persistent motor tic disorder (n = 39, 44.3%), while the remainder (n = 2, 2.3%) were diagnosed with persistent vocal tic disorder. We found that children with tic disorders had significantly elevated levels of IL-1β, TNF-α, IL-6 and IL-4 expression, while we detected lower expression levels of IL-17 in children with tic disorders. Our findings provide a molecular landscape of cytokine expression in children with TD, which may suggest a proinflammatory state not affected by the presence of comorbidity and symptom severity. Delineating the contribution of alterations in the immune system to the pathogenesis of tic disorders may pave the way for better therapeutic interventions. © The Author(s) 2024.Item Other primary headache disorders: Data from the HEAD-MENA-A study in Africa, Asia, and the Middle East(Elsevier B.V., 2024) Atalar A.Ç.; Genç H.; Ur Özçelik E.; Bolay H.; Uluduz D.; Unal-Cevik, I; Kissani N.; Luvsannorov O.; Togha M.; Ozge A.; Baykan B.; Cakan M.; Ak A.K.; Celik F.; Orun M.O.; Seker D.; Kucuk A.; Ozkan S.; Kiraz M.; Sirin T.C.; Ocal R.; Hakyemez H.A.; Yener M.O.; Serim V.A.; Cınar N.; Unal E.D.; Domac F.M.; Ates M.F.; Turkoglu B.G.; Gursoy G.; Cekic S.; Aslan S.K.; Agırcan D.; Oktar A.C.; Demirel E.A.; Gelener P.; Ibrahim E.A.A.E.; Evlice A.; Gorken G.; Sanlı Z.S.; Bayır B.R.H.; Tepe N.; Okluoglu T.; Demir T.G.; Badr M.Y.; Vurallı D.; Jafari E.; Polat B.; Ermis A.; Khanmammadov E.; Yolcu O.; Kul B.; Sakadi F.; Ulutas S.; Akturk T.; Ketema T.M.; Lala S.; Cedric A.P.S.A.; Velioglu S.K.; Kırbasoglu O.; Moustafa R.R.; Nowar A.G.; Kabay S.C.; Gumanovna V.K.; Yifru Y.M.; Nasergivehchi S.; Azizova I.; Kizek O.; Ekizoglu E.; Orhan E.K.; Melka D.; Alemayehu B.Objective: Other primary headache disorders (OPHD) are under-investigated compared to frequent primary headache types like migraine, tension-type headache, and trigeminal autonomic cephalalgias. Knowledge of the distribution and characteristics of OPHD subtypes is crucial for their recognition. We aimed to determine the prevalence at the hospital and headache clinics and clinical characteristics of OPHDs in patients from 13 countries. Methods: We analyzed a large dataset from the cross-sectional study Head-MENA-A (Middle East, North Africa, Asia). Consecutive patients over 10 years of age presenting with headaches were included from outpatient, inpatient, and emergency settings. A structured questionnaire addressing demographics, headache characteristics, accompanying symptoms, and triggers was administered. Headache subtypes were diagnosed according to the ICHD-3 criteria. Results: Among patients complaining of headaches (n = 3722), 106 (2.9%) were diagnosed with OPHD. Fifty-two patients (1.4% of all headache patients) had only OPHD, while 54 (1.5%) had both OPHD and a co-existing primary headache (mostly migraine). All OPHDs were more common in females. The most frequent subtypes were new daily persistent headache and primary stabbing headache (0.2% each among all admitted patients). Photophobia and phonophobia were the most frequent accompanying symptoms, while physical activity (28.8%), stress (15.4%), and the Valsalva maneuver (15.4%) were the most common triggering factors. The majority of triggering factors were more pronounced in patients with both migraine and OPHD. Conclusions: Other primary headaches are rare and heterogeneous. Their high co-existence with migraine suggests shared predisposing factors, hinting at a “headache continuum” concept for primary headaches. © 2024 Elsevier B.V.