Browsing by Author "Celkan, T"

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    Sirolimus is effective and safe in childhood relapsed-refractory autoimmune cytopenias: A multicentre study
    Acar, SO; Tahta, N; Al, IO; Erdem, M; Gözmen, S; Karapinar, TH; Kilinç, B; Celkan, T; Kirkiz, S; Koçak,Ü; Ören, H; Yildirim, AT; Arslantas, E; Ayhan, AC; Oymak, Y
    Autoimmune cytopenias are a heterogeneous group of disorders characterized by immune-mediated destruction of haematopoietic cell lines. Effective and well-tolerated treatment options for relapsed-refractory immune cytopenias are limited. In this study, the aim was to evaluate the efficacy and safety of sirolimus in this disease group within the paediatric age group. The study enrolled patients in the paediatric age group who used sirolimus with a diagnosis of immune cytopenia between December 2010 and December 2020, followed at six centres in Turkey. Of the 17 patients, five (29.4%) were treated for autoimmune haemolytic anaemia (AIHA), six (35.2%) for immune thrombocytopenic purpura (ITP) and six (35.2%) for Evans syndrome (ES). The mean response time was 2.7 months (range, 0-9 months). Complete response (CR) and partial response (PR) were obtained in 13 of 17 patients (76.4%) and nonresponse (NR) in four patients (23.5%). Among the 13 patients who achieved CR, three of them were NR in the follow-up and two of them had remission with low-dose steroid and sirolimus. Thus, overall response rate (ORR) was achieved in 12 of 17 patients (70.5%). In conclusion, sirolimus may be an effective and safe option in paediatric patients with relapsed-refractory immune cytopenia. In a retrospective multicentre study of 17 cases (11 boys and 6 girls) who were receiving sirolimus for immune cytopenia were analysed. We found that complete response (CR) and partial response (PR) were obtained in 13 of 17 patients (76.4%) and nonresponse (NR) in 4 patients (23.5%). Overall response rate (ORR) was achieved in 12 of 17 patients (70.5%).image
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    Influence of Paroxysmal Nocturnal Hemoglobinuria Clone Positivity on Outcome of Childhood Acquired Aplastic Anemia: A Multicenter Center Study
    Cangul, SU; Karapinar, DY; Erdem, AY; Yarali, HN; Ozdemir, HH; Gumruk, F; Cakmakli, HF; Ince, EU; Ozdemir, GNN; Gokce, M; Celkan, T; Bahadir, A; Bayhan, T; Oren, H; Gulen, H; Kupesiz, FT; Cetin, M; Ozbek, N
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    Cross-sectional study: long term follow-up care for pediatric cancer survivors in a developing country, Turkey: current status, challenges, and future perspectives
    Incesoy Özdemir, S; Taçyildiz, N; Varan, A; Kebudi, R; Zülfikar, B; Celkan, T; Sahin, G; Çorapçioglu, F; Keskin Yildirim, Z; Pinarli, FG; Olgun, N; Sari, N; Dagdemir, A; Özyörük, D; Eren, T; Çakir, FB; Adakli Aksoy, B; Bozkurt, C; Güler, E; Özgüven, AA; Erbey, F; Berber, M; Dinçaslan, H; Ünal, E; Kantar, M
    Aim: The main purpose of this study is to determine the current status of long-term follow-up (LTFU) for childhood cancer survivors and the challenges of LTFU for pediatric cancer survivors at pediatric oncology institutions in Turkey. Material and methods: A questionnaire was e-mailed to the directors of 33 pediatric oncology centers (POCs) registered in the Turkish Pediatric Oncology Group (TPOG). Of these 33 active TPOG institutions, 21 participated in the study and returned their completed questionnaires. Results: Only 1 of the 21 participating centers had a separate LTFU clinic. The remaining centers provided LTFU care for childhood cancer survivors at the pediatric oncology outpatient clinic. Of these centers, 17 (80.9%) reported difficulty in transition from the pediatric clinic to the adult clinic, 14 (66.6%) reported insufficient care providers, and 12 (57.1%) reported insufficient time and transportation problems. As neglected late effects, 16 (76.1%) centers reported psychosocial and getty job problems and 11 (52.3%) reported sexual and cognitive problems. None of the centers had their own LTFU guidelines for their daily LTFU practice. Conclusion: This study was the first to gain an overview of the needs of POCs and the gaps in survivorship services in Turkey. The results from this study will help to develop a national health care system and national guidelines for pediatric cancer survivors.