Browsing by Author "Cengiz, T"

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    Serotonin transporter gene polymorphisms in patients with chronic tension-type headache: A preliminary study
    Aylin, A; Cengiz, T; Emin, E; Neriman, A; Sacide, P
    Background and Objectives: This study is designed to understand the pathophysiology of one of the most serious health problems, chronic tension-type headache (CTTH). Two polymorphic sites in serotonin transporter protein gene attracted much interest. These are: the variable number of tandem repeats (VNTR) and 5'-flanking promoter region (5-HTTLPR). Materials and Methods: VNTR and 5-HTTLPR polymorphisms were investigated in 126 CTTH patients and 138 healthy control subjects. The patients were being treated with amitripytyline or citalopram or sertraline (SSRI). The polymerase chain reaction (PCR) method was used to investigate the polymorphisms in the serotonin transporter protein gene. Results: There were no statistically significant results based on the 5-HTTLPR gene alleles, however, STin 2.12/12 genotype and STin 2.12 allele were seen to predominate the control group. In order to investigate the combined effect of the two polymorphic loci on the 5-HTT gene expression, samples were separated into nine groups. Genotypes (S/S-12/10) and (L/S-12/10) displayed statistically significant frequency in the CTTH group than in the control group. No significant differences were noticed between the 5-HTTLPR and VNTR haplotype groups and success in treatment. Conclusion: It is possible to make reliable comparisons and hypothesis about the homozygous and/or heterozygous presence of S and STin 12/10 alleles which may be in interaction with CTTH. On the other hand, the presence of homozygous L and STin12 alleles may play a protective role against CTTH. It is also possible that heterogeneity among diseases showing the same clinical research will require a lot of effort for individual identification.
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    A Qualitative Study on Being an Emergency Nurse in the COVID-19 Pandemic: Trying to Stay Balanced on the Life-Death Line
    Yilmaz, E; Çetinkaya, A; Helvaci, D; Cengiz, T
    Objective: The aim of this study is to describe the perceptions and experiences of emergency nurses during the COVID-19 pandemic. Methods: The research was conducted with content analysis based on a qualitative approach. The study was conducted in the emergency department of a training and research hospital in western Turkey between July and December 2021. Forty-nine nurses who were determined by the criterion sampling method, which is one of the purposeful sampling method, were interviewed. Nurses working in the emergency department, caring for patients with COVID-19, and volunteering to participate in the study were included in the study group. The data were collected using an information form consisting of 8 questions containing the socio-demographic characteristics of the nurses, and a data collection form consisting of 10 semi-structured open-ended questions was created in line with the literature. NVIVO 12 Pro program was used in the analysis of the data. The data were evaluated by thematic analysis. Results: Five categories were reached in this research based on qualitative question analysis conducted with nurses who worked as emergency nurses in the fight against COVID-19 pandemic. The category labels and citation numbers from the most cited to the least are as follows: negative affect reflection (f:275), difficult working conditions (f:273), fatigue in the struggle (f:205), the promise of the profession (f:112), and head efforts (f:103). Conclusion: As a result of the research, it was determined that emergency nurses were affected negatively physically and psychologically during the COVID-19 process, experienced various personal and professional problems, and used effective methods to cope with all these negativities. In order to improve and maintain the physical and mental health of nurses, their support needs should be closely monitored and support systems should be established.