Browsing by Author "Cetin M."

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    Effects of different postmenopausal hormone therapy regimens on cerebral blood flow and cognitive functions
    (2009) Guvenal T.; Durna A.; Erden O.; Guvenal F.; Cetin M.; Cetin A.
    Introduction: The purpose of this study was to compare the effects of different postmenopausal hormone therapy regimens, namely conjugated equine estrogens (CEE), CEE plus medroxyprogesterone acetate (MPA), tibolone, and raloxifene on cerebral blood flow and cognitive functions. Methods: A total of 64 healthy postmenopausal women admitted to the Department of Obstetrics and Gynecology, Cumhuriyet University, Turkey were included in this study. Patients were divided into five groups with respect to the treatment protocols: CEE 0.625 mg/day (n=13); CEE 0.625 mg/day + MPA 2.5 mg/day (n=14); tibolone 2.5 mg/day (n=11); raloxifene 60 mg/day (n=9); and control (n=17). The CEE group included only women with surgical menopause. Those who were on hormonal therapy, who had previously used hormonal therapy, who had neurological disorders, or who did not accept the longterm follow-up were excluded from the study. Demographic and clinic characteristics were recorded. Before starting the therapy regimens, cerebral blood flow was evaluated by internal carotid artery and middle cerebral artery peak systolic velocity, and pulsatility index measurements via Doppler ultrasonography. Cognitive functions were evaluated by the Standardized Mini-Mental Test. The mean follow-up period was 10.9±2.4 months, ranging between 8 and 16 months. After the follow-up period, the cerebral blood flow, and cognitive function of each woman was re-evaluated. Results: Demographic and clinical characteristics of the women were not significantly different between the study groups (P>0.05). There were no significant differences between the pretreatment and posttreatment values for cerebral blood flow indices and cognitive function scores in any of the study groups (P>0.05). Conclusion: Different postmenopausal hormone therapy regimens have not revealed any significant effects on either cerebral blood flow or cognitive function. © 2009 Springer Healthcare Communications.
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    Effects of selective and non-selective cyclooxygenase (COX) inhibitors on postoperative adhesion formation in a rat uterine horn model
    (2010) Guvenal T.; Yanar O.; Timuroglu Y.; Cetin M.; Cetin A.
    Objective: To investigate the effects of cyclooxygenase (COX) inhibitors including celecoxib, indomethacin, and nimesulide on postoperative adhesion formation. Material and Methods: Forty-eight female Wistar-Albino rats were randomly divided into four groups: control (saline solution), celecoxib, indomethacin, and nimesulide groups. The uterine horns of rats were traumatized with unipolar electrocautery. Drugs of each group and saline in the control group were insillated on travmatized areas of horns as intraperitoneally. After three weeks, the extent and severity of adhesions with a standardized scoring system were evaluated. Results: The extent and severity of postoperative adhesions were significantly reduced in nimesulide group compared with the control group. The extent but not severity of adhesions in rats given indomethacin was significantly reduced. Celecoxib showed no significant reduction in the extent and severity of adhesions. Conclusion: Nimesulide is more effective than the other COX inhibitors in the prevention of postoperative adhesions in rats.
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    Clarithromycin-induced long QT syndrome: A case report
    (Hindawi Limited, 2012) Cetin M.; Yilidrimer M.; Özen S.; Tanrverdi S.; Coskun S.
    Long QT syndrome develops for a number of reasons. The number of non-antiarrhythmic drugs reported to induce QT interval prolongation with or without torsade de pointes continues to increase. Clarithromycin is a macrolide antibiotic being increasingly used for the treatment of atypical pneumonia. In this paper, we describe a patient who developed long QT prolongation syndrome after receiving clarithromycin for the treatment of atypical pneumonia. © Copyright 2012 Mecnun Cetin et al.
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    Removal of the broken part of implantable cardioverter-defibrillator's electrode causing pulmonary embolism via femoral vein
    (Elsevier B.V., 2015) Zencir C.; Selvi M.; Elbi H.; Cetin M.; Gungor H.; Akgullu C.; Badak M.I.
    A 66-year-old patient with idiopathic dilated cardiomyopathy underwent transvenous extraction of an implantable cardioverter-defibrillator. The distal part of the electrode was broken during manual traction through the left subclavian vein. In the present case, we showed a rare complication of transvenous lead extraction and its management. © 2015 Cardiological Society of India.
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    Association between hematologic parameters and in-hospital mortality in patients with infective endocarditis
    (Elsevier (Singapore) Pte Ltd, 2015) Zencir C.; Akpek M.; Senol S.; Selvi M.; Onay S.; Cetin M.; Akgullu C.; Elbi H.; Gungor H.
    Early and accurate risk prediction is an important clinical demand in patients with infective endocarditis (IE). The platelet-to-lymphocyte ratio (PLR) is an independent predictor of worse prognosis in various cardiovascular diseases. The aim of this study was to determine the value of PLR in the prediction of in-hospital mortality among IE patients. We retrospectively analyzed the clinical, laboratory, and echocardiographic data of 59 adult patients with definite IE and in 40 adult controls. In-hospital mortality occurred in 16 (27%) patients. Vegetation size, levels of high-sensitive C-reactive protein and procalcitonin, neutrophil-to-lymphocyte ratio, and PLR were significantly higher in the in-hospital-mortality-positive group than in the in-hospital-mortality-negative group (p = 0.004, p = 0.009, p = 0.030, p = 0.001, and p = 0.008, respectively). Lymphocyte count was, however, significantly lower in the in-hospital-mortality-positive group (p = 0.004). In the receiver-operating characteristic analysis, PLRs over 191.01 predicted in-hospital mortality with 56.3% sensitivity and 81.4% specificity [area under the curve 0.725, 95% confidence interval (CI) 0.594-0.833; p = 0.0027]. In the multivariate analysis, PLR was found to be an independent predictor of in-hospital mortality in patients with IE (odds ratio 1.022, 95% CI 1.003-1.042; p = 0.021). In conclusion, higher PLR may predict in-hospital mortality in patients with IE. © 2015, Kaohsiung Medical University. Published by Elsevier Taiwan LLC. All rights reserved.
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    Relation between vascular endothelial markers and right ventricular function in the children with asthma
    (Tehran University of Medical Sciences, 2017) Cetin M.; Karaboga B.; Yilmaz O.; Yilmaz M.; Yuksel H.; Coskun S.
    Objectives: The aim of the study was to evaluate the possible relationship of clinical severity during asthmatic exacerbation with the ventricular functions and the levels of vascular endothelial-related biomarkers endothelin-1 (ET-1) and platelet-derived growth factor-BB (PDGF-BB) in the condensed breathing air in the children with asthma. Methods: The study included a total of 80 children with acute asthmatic episode; of these, 28 had a mild, 26 had a moderate, and 26 had a severe attack. Samples of condensed breathing air were obtained for being analyzed for ET-1 and PDGF-BB levels during the study. All patients were evaluated by echocardiography at the beginning of the study and two weeks after the treatment of asthmatic episode. Results: Before treatment, mPAP in moderate and severe asthma groups was significantly higher than in mild asthma group (21.6 ± 7.3, 30.1 ± 9.8 and 32.7 ± 7.8; P < 0.01, P < 0.001, respectively). After treatment, no significant difference was detected between the asthma groups (P > 0.05). Am and Em waves, and IVRT, IVCT, ET and RV MPI during the asthmatic attack and after treatment did not change significantly between the groups; pre- and post-treatment values of these parameters also did not show significant differences. In exhaled air samples of the group with severe asthma exacerbation ET-1 and PDGF-BB were higher than those in the moderate and mild group (0.80 ± 0.42, 0.58 ± 0.30, 0.50 ± 0.15; P = 0.002 and 281.7 ± 253.2, 167.3 ± 148.1, 135.9 ± 74.9; P = 0.008 respectively). Conclusions: Ourstudy resultsshowedthatmPAPin direct proportion with the increasedinflammatory cytokineswassignificantly higher in asthma attacks and levels of ET-1 and PDGF-BB were significantly increased with severity of asthma, indicating a vascular response. © 2017, Iranian Journal of Pediatrics.
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    Evaluation of cardiac autonomic functions in children with thalassemia trait, iron deficiency anemia and iron deficiency
    (Yuzuncu Yil Universitesi Tip Fakultesi, 2018) Cetin M.; Moumin N.; Karaboga B.; Coskun S.; Gulen H.
    Distruption of cardiac autonomic functions during diseases associated with anemia were reported in multiple studies previously. Objective in this study is to investigate heart rate variability (HRV) for evaluation of cardiac autonomic functions in children patients with Thalassemia trait (TT), iron deficiency anemia (IDA) and iron deficiency (ID) without anemia. Twenty-five patients with TT, 25 patients with IDA, 25 patients with ID, and 25 healthy controls were assessed with 24-hour ambulatory electrocardiography recordings. The following time-domain indices were calculated; standard deviation values of all normal sinus R-R intervals for 24 hours (SDNN), standard deviation levels of all mean normal sinus R-R interspaces over each 5-minute strip in the 24-hour enrollments (SDANN), the square root of the mean of the sum of squares of differences between adjacent RR intervals (RMSSD), percentage of difference between adjacent normal R -R intervals that are greater than 50 ms computed for the overall 24-hour ECG recording (pNN50). Re-evaluation regarding HRV were done in children with IDA after 4 months of treatment. Although reduction in HRV parameters was detected in IDA group compared to ID, TT, and control groups, it wa s statistically not significant. The pNN50 was significantly low only in the IDA group (p=0.042). When ID group and TT group were compared with control group, it was found that HRV parameters were not affected. In IDA group, SDNN, SDANN, RMSSD and pNN50 index were significantly higher after trea tment (p=0.002, p=0.005, p=0.005, p=0.010, respectively). Our results indicate that cardiac autonomic activity are affected in IDA and improvement occurs after treatment. HRV parameters were found to be especially associated with hemoglobin and hematocrit values. © 2018, Yuzuncu Yil Universitesi Tip Fakultesi. All rights reserved.