MCBÜ Açıkerişim Sistemi :: Browsing by Author "Cingi C."

Browsing by Author "Cingi C."

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Seawater gel in allergic rhinitis: Entrapment effect and mucociliary clearance compared with saline
(2010) Cingi C.; Halis Unlu H.; Songu M.; Yalcin S.; Topcu I.; Cakli H.; Bal C.
Objective: We performed a prospective study to investigate the the efficacy of seawater gel in reducing symptoms in patients with mild allergic rhinitis. We also aimed to investigate the impact of nasal irrigation on mucociliary clearance with seawater gel compared with saline in this patient group. Methods: The study was performed in 100 consecutive adult individuals with a history of allergic rhinitis that was not controlled by anti-allergic drugs. Patients were assigned to receive seawater gel nasal spray for 10 days. The efficacy of treatment was assessed by means of total nasal symptom score and clinical findings. Results: A statistically significant difference was found between scores of ‘nasal discharge, nasal obstruction, sneezing, nasal itching—before and after treatment (p < 0.001). Clinical findings evaluation revealed a statistically significant decrease in lower turbinate colour rating and turbinate congestion at the end of treatment (p< 0.001). Saccharin transit time decreased from baseline in the seawater trials by 12% compared with a 4% decrease for saline. The difference between the percent changes was statistically significant (t = 2.177; p < 0.05). Conclusions: The present study provides evidence that a four times daily regimen of seawater gel can be an adjunctive therapy in the patient with allergic rhinitis. © 2010, SAGE Publications. All rights reserved.
Efficacy of leukotriene antagonists as concomitant stherapy in allergic rhinitis
(2010) Cingi C.; Gunhan K.; Gage-White L.; Unlu H.
Objectives/Hypothesis: The symptoms of allergic rhinitis result from an immunoglobulin E-dependent mast cell activation cascade, marked by the release of inflammatory mediators, including histamine. Patients with perennial allergic rhinitis also have elevated levels of cysteinyl leukotrienes (CysLTs) in nasal lavage fluid. Histamine and CysLTs produce different responses in the pathogenesis of allergic rhinitis, and this study tested the hypothesis that the effects of combined antihistamine and leukotriene antagonist therapy would be more effective than antihistamine alone. Study Design: Multicentered, prospective, randomized, placebo-controlled, parallel-group. Methods: Three groups totaling 275 patients using: 1) fexofenadine alone, 2) fexofenadine with montelukast, or 3) fexofenadine with placebo, participated in a 21-day trial conducted during the spring pollen season. Objective analysis included pre- and poststudy physical examination findings and nasal resistance measurements. Subjective data gathered included a daily patient diary and pre- and poststudy patient satisfaction measurements. Results: The group using both fexofenadine and montelukast showed significantly better control of nasal congestion both subjectively, using patient diary and visual analog scale evaluations, and objectively, using rhinomanometry and physical examination, compared to groups using antihistamine alone or with placebo. Conclusions: Our data provided both objective and subjective evidence that leukotriene receptor antagonist- antihistamine combination therapy is more effective than antihistamine alone in the control of allergic rhinitis symptoms. © 2010 The American Laryngological, Rhinological and Otological Society, Inc.
The histopathological effect of thymoquinone on experimentally induced rhinosinusitis in rats
(2011) Cingi C.; Eskiizmir G.; Burukoǧlu D.; Erdoǧmuş N.; Ural A.; Ünlü H.
Background: Rhinosinusitis is a common disorder and its treatment includes a variety of topical and systemic drugs. This study was designed to determine the histopathological effect of thymoquinone on experimentally induced rhinosinusitis in rats. Methods: Sixty rats were randomly allocated into 3 test and 2 control groups, each of which consisted of 12 animals. The rhinosinusitis model was induced using intranasal application of platelet-activating factor. In test groups, the animals were separated into groups: (1) rhinosinusitis- antibiotherapy, (2) rhinosinusitis-thymoquinone, (3) rhinosinusitis-combination therapy. The positive and negative control groups were defined: rhinosinusitis group without any treatment and the group without rhinosinusitis, respectively. The histopathological features (vascular congestion, inflammation, and epithelial injury) in nasal respiratory and olfactory mucosa of animals were examined and graded according to their severity. A quantitative and statistical analysis of histopathological features was performed. Results: All histopathological features showed statistically significant differences between negative and positive control groups, respectively. Conversely, neither the group with rhinosinusitis-antibiotherapy nor the group with rhinosinusitis- thymoquinone had a statistically significant difference with the negative control group. Moreover, none of the histopathological features showed a statistically significant difference, when the group with rhinosinusitis- antibiotherapy and the group with rhinosinusitis-thymoquinone were compared. A statistically significant difference was not determined when the group with rhinosinusitiscombination therapy was compared with the group with rhinosinusitis-thymoquinone. The histopathological features did not show a statistically significant difference between the group with combination therapy and the negative control Conclusion: Thymoquinone is a promising bioactive agent for the treatment of rhinosinusitis, and its histopathological effect is as equivalent as an antibiotic. Copyright © 2011, OceanSide Publications, Inc.
New modification of cephalic resection of lateral crus in endonasal rhinoplasty
(2012) Cingi C.; Eskiizmir G.; Toros S.Z.
A successful rhinoplasty mainly depends on maintaining adequate nasal tip projection and achieving the desired tip refinement. In endonasal rhinoplasty, the surgeon canmodify the tip anatomy while still preserving the key structural support mechanisms. Herein, we describe a new modification of retrograde technique for the resection of the cephalic margin of the lateral crus in endonasal rhinoplasty in which a combined resection of the cephalic margin of the lateral crus and its underlying mucoperichondrium are performed. Copyright © 2012 by Mutaz B. Habal, MD.
Nonmelanoma Skin Cancer of the Head and Neck: Reconstruction
(2012) Eskiizmir G.; Baker S.; Cingi C.
Reconstruction of facial defects formed after resection of skin cancers is a challenging procedure. Achieving the best functional and aesthetic outcome depends on accurate preoperative planning. Reconstructive surgeons should perform a detailed analysis of the facial defect based on location, size, and depth and choose the most appropriate technique according to their experiences and patient preferences and expectations. This article reviews the preoperative analysis of facial defects, and the major principles and techniques of facial reconstruction. Discussed are reconstruction of the nose, lip, cheek, forehead, and eyelid, presenting for each technique the goals of the reconstruction, types of flaps and grafts, and surgical technique. © 2012 Elsevier Inc.
Nonmelanoma Skin Cancer of the Head and Neck: Prevention
(2012) Oghan F.; Eskiizmir G.; Unlu H.; Cingi C.
The importance and effectiveness of prevention efforts and strategies for skin cancers are reviewed. Topical sunscreens and their proper use are presented. Topical and ingested forms of natural, synthetic, or biologic chemical agents that are potentially efficacious for chemoprevention are listtdldted and discussed. © 2012 Elsevier Inc.
Nonmelanoma Skin Cancer of the Head and Neck: Nonsurgical Treatment
(2012) Ermertcan A.T.; Hellings P.W.; Cingi C.
Nonmelanoma skin cancer (NMSC) is one of the most prevalent types of cancer worldwide, with basal cell carcinoma and squamous cell carcinoma being the most frequent histologic types. Surgical excision remains the mainstay of treatment, but nonsurgical treatment options may be indicated in specific cases. Nonsurgical treatment options for NMSC may be preferred as good alternatives under certain circumstances. This review provides a comprehensive overview of the nonsurgical treatment modalities for NMSCs, such as curettage and electrodesiccation, cryotherapy, radiotherapy, laser, photodynamic therapy, immunotherapy, and retinoid therapy. © 2012 Elsevier Inc.
Nonmelanoma Skin Cancer of the Head and Neck: Current Diagnosis and Treatment
(2012) Eskiizmir G.; Cingi C.
An overview of where nonmelanoma cancers appear in the hierarchy of cancers is succinctly presented, as well as their incidence, etiology, and costs. The examination and treatment of these cancers are summarized. © 2012 Elsevier Inc.
Suction tube facilitates the transfer of nasal tip sutures in endonasal rhinoplasty
(Lippincott Williams and Wilkins, 2012) Cingi C.; Toros S.Z.; Eskiizmir G.
Nasal tip sculpturing is the most challenging aspect of rhinoplasty. It is principally performed by the reduction or increment of the nasal tip characteristics with sutures or grafts using endonasal or external approach. In endonasal approach, although most of the key structural mechanisms of the nasal tip can be preserved, the transfer of nasal tip sutures, which are used for contouring the alar cartilages and/or graft stabilization, from 1 nasal cavity to another has several difficulties such as time loss, need for extensive dissection, or injuring the soft tissue and alar cartilages. In the current article, we aimed to represent our surgical technique that facilitates suture contouring using a suction tube during the transfer of nasal tip sutures in endonasal rhinoplasty. Copyright © 2012 by Mutaz B. Habal, MD.
Effectiveness of montelukast in pediatric patients with allergic rhinitis
(Elsevier Ireland Ltd, 2013) Yilmaz O.; Altintas D.; Rondon C.; Cingi C.; Oghan F.
Allergic rhinitis (AR) is one of the most common chronic diseases of childhood and carries significant morbidity as well as physical and psychosocial consequences. Therapy aims to alleviate clinical symptoms, prevent complications and improve psychosocial consequences. Leukotrienes which are amongst the main mediators in pathogenesis of AR have chemotactic properties and lead to increased vascular permeability. Thus, leukotriene antagonism may be an effective therapeutic option in treatment of allergic diseases, specifically AR. Montelukast which is a leukotriene receptor type I inhibitor has variable efficacy in children with AR and the guidelines recommend its use in children with seasonal AR aged six years and above. Although its efficacy is inferior to anti-histamines and intranasal corticosteroids, combination treatment may warrant clinical efficacy. Therefore, montelukast may be considered to be a well-tolerated therapeutic option for children with AR with minor side effects though long term results need to be assessed.In conclusion, larger scale research enrolling pediatric cases with seasonal and persistent AR are required before concise recommendations about montelukast use in pediatric AR can be made. © 2013 Elsevier Ireland Ltd.
Desloratadine-montelukast combination improves quality of life and decreases nasal obstruction in patients with perennial allergic rhinitis
(2013) Cingi C.; Oghan F.; Eskiizmir G.; Yaz A.; Ural A.; Erdogmus N.
Background: The effects of desloratadine-montelukast combination on quality of life (QoL) and nasal airflow of patients with perennial allergic rhinitis (PAR) has not been reported. The objective of this work was investigate the efficacy of desloratadine-montelukast combination on nasal obstruction and health-related quality of life (HRQL) of patients with PAR. Methods: The patients with PAR (n = 40) were assessed using acoustic rhinometry (AcR) and Rhinoconjunctivitis QoL Questionnaire (RQLQ) before therapy. Desloratadine-montelukast fixed-dose combination treatment was applied to every patient once daily. The AcR and RQLQ score were reevaluated at the first and third months; and statistical comparison of pretreatment and posttreatment results was performed. Results: Nasal symptoms and signs such as itching, sneezing, discharge, congestion, and edema, and color change of turbinates have been decreased after treatment. In AcR, minimum cross-sectional area (MCA) measurements and volume results were increased after the treatment. Correlation was found between the volume results and nasal discharge and/or congestion in right nasal passages. In left nasal passages, statistical relation was observed between the MCA and itching and/or change of turbinate color (p < 0.05). A significant decrease in the overall RQLQ score was determined at the first and third months of therapy. The difference between scores at baseline and end of the first and third months for all domains was statically significant (p < 0.001). The treatment difference in change from the first month to the end of the third month was statistically significant (p < 0.05). Conclusion: Desloratadine-montelukast combination therapy causes subjective and objective decrease in nasal obstruction, reduces the other symptoms of PAR and improves the disease-specific QoL. © 2013 ARS-AAOA, LLC.
Deviated nose attenuates the degree of patient satisfaction and quality of life in rhinoplasty: A prospective controlled study
(2013) Cingi C.; Eskiizmir G.
Objective: To analyse and compare the patient satisfaction and quality of life in patients with and without deviated nose deformity who underwent rhinoplasty. Design: Prospective, before-after trial. Setting: Tertiary referral centre. Participants: A total of 191 patients who underwent primary rhinoplasty between 2006 and 2009 were included. The study population was separated into two groups: non-deviated (patients with an external nasal deformity of less than 50) and deviated nose (patients with an external nasal deformity of more than 50). Main Outcome Measures: The angles of deviations were measured from the pre- and postoperative photographs by an image analysis software program. Patient satisfaction and quality of life were measured by Rhinoplasty outcome evaluation and European Quality of Life-5 Dimension questionnaires before and after surgery. Results: Eighty-one cases had deviated nose deformity; on the other hand, 110 cases had nasal deformities other than deviated nose deformity. The objective analysis of surgical outcome demonstrated a statistically significant improvement in the favour of postoperative results in both non-deviated (P = 0.0004) and deviated (P = 0.0002) nose groups. In addition, Rhinoplasty outcome evaluation and European Quality of Life-5 Dimension questionnaires demonstrated remarkable improvement in both non-deviated and deviated nose groups after rhinoplasty. However, the comparison of pre- and postoperative change between non-deviated and deviated nose groups demonstrated statistically significant differences in almost all questions (except family and friends' satisfaction with appearance P = 0.069) and total score (P < 0.001) of Rhinoplasty outcome evaluation questionnaire, European Quality of Life-5 Dimension index (P < 0.001), European Quality of Life-5 Dimension visual analogue scale (P = 0.036) and living quality index (P < 0.001) with lower scores in deviated nose group. Conclusion: Rhinoplasty can provide an objective improvement, high satisfaction and positive impact on quality of life. However, the degree of satisfaction and improvement in quality of life in patients with deviated nose deformity are less than patients with non-deviated nose deformity. © 2013 Blackwell Publishing Ltd.
Effects of high altitude on sleep and respiratory system and theirs adaptations
(2013) San T.; Polat S.; Cingi C.; Eskiizmir G.; Oghan F.; Cakir B.
High-altitude (HA) environments have adverse effects on the normal functioning body of people accustomed to living at low altitudes because of the change in barometric pressure which causes decrease in the amount of oxygen leading to hypobaric hypoxia. Sustained exposure to hypoxia has adverse effects on body weight, muscle structure and exercise capacity, mental functioning, and sleep quality. The most important step of acclimatization is the hyperventilation which is achieved by hypoxic ventilatory response of the peripheral chemoreceptors. Hyperventilation results in increase in arterial carbondioxide concentration. Altitude also affects sleep and cardiac output, which is the other determinant of oxygen delivery. Upon initial exposure to HA, the resting pulse rate increases rapidly, but with acclimatization, heart rate and cardiac output tend to fall. Another important component that leads to decrease in cardiac output is the reduction in the stroke volume with acclimatization. During sleep at HA, the levels of CO2 in the blood can drop very low and this can switch off the drive to breathe. Only after the body senses a further drop in O2 levels breathing is started again. Periodic breathing is thought to result from instability in the control system through the hypoxic drive or the response to CO2. © 2013 Turhan San et al.
Jak-Stat signaling pathway may play a role in the pathogenesis of cholesteatoma
(2014) Eskiizmir G.; Seda Vatansever H.; Özgür E.; Aslan A.; Tanyeri G.; Gözüaçik D.; Kemal Özbilgin M.; Cingi C.
Purpose Jak-Stat signaling pathway is one of the major signal transduction cascades which regulates most of the cellular events such as cell proliferation, differentiation, cell migration and apoptosis. This study aims to determine the activity of Jak-Stat signaling pathway in the pathogenesis of cholesteatoma. Materials and Methods Cholesteatoma and skin samples were obtained from 10 patients who underwent tympanomastoidectomy for chronic otitis media with cholesteatoma. Immunohistochemical analysis of cholesteatoma and skin was performed using anti-Jak1, anti-Jak2, anti-Jak3, anti-Stat1, anti-Stat2, anti-Stat3, anti-Stat4 and anti-Stat5 antibodies. The immunoreactivities in cholesteatoma and skin were quantified using H-score measurement and statistical comparison was performed. Results Jak1, Jak2, Jak3, Stat1 and Stat3 immunoreactivities were not detected in cholesteatoma; in contrast to the skin (129.8; 226.7; 33.0; 66.4;115.9). In addition, when H-score measurements of Stat2, Stat4 and Stat5 immunoreactivities were compared between cholesteatoma (172.8; 166.7; 120.0) and skin (400.0; 284.9; 292.0), statistically significant differences were found (p < 0.0001, p < 0.0001, p < 0.0001). Conclusions A remarkable deficiency in the family members of Jak-Stat signaling pathway was demonstrated in cholesteatoma. Therefore, perturbations in Jak-Stat signaling pathway may play a role in the pathogenesis of cholesteatoma. © 2014 Elsevier Inc.
Inhibitory effect of N-acetyl cysteine and ascorbic acid on the development of myringosclerosis: AN experimental study
(Elsevier Ireland Ltd, 2014) Dündar R.; Inan S.; Muluk N.B.; Cingi C.; Ilknur A.E.; Katilmiş H.
Objectives: This study investigated the effects of ascorbic acid and N-acetyl cysteine (NAC) antioxidants on the development of myringosclerosis (MS) in an experimental model. Methods: Myringotomies were performed in the ears of 15 guinea pigs, and Spongostan® pieces were placed on the perforated regions of the tympanic membrane. The subjects were divided randomly into three groups and treated with three different solutions on the Spongostan-group 1: (control, 0.9% saline), group 2 (ascorbic acid), and group 3 (NAC). On day 15 after treatment, specimens from the tympanic membranes were obtained and examined via light microscopy. Sclerosis and inflammation scores and the tympanic membrane thicknesses were evaluated. Immunohistochemical methods were used to evaluate the expression of VEGF, TGF-β, iNOS, and IL1-β in all groups. Results: Lower sclerosis and inflammation scores and reduced tympanic membrane thicknesses were observed in groups treated with NAC or ascorbic acid compared with the control group. Immunohistochemical studies revealed significantly less expression of VEGF, TGF-β, and iNOS in groups 2 and 3 compared with group 1. Additionally, IL1-β expression was significantly less in group 3 than in group 1. Compared with group 1, group 2 animals exhibited reduced inflammation in the lamina propria, fewer active fibroblasts, less leukocyte infiltration, and decreased thickness of the vessels; group 3 animals exhibited decreased numbers of active fibroblasts and collagen fibers in the lamina propria. Conclusions: Inflammation scores, cellular infiltration, and expression of VEGF, TGF-β, and iNOS were reduced by ascorbic acid and/or NAC treatments, thereby decreasing MS development. Decreased expression of IL1-β was observed only in animals treated with NAC. © 2014 Elsevier Ireland Ltd.
The "physician on call patient engagement trial" (POPET): Measuring the impact of a mobile patient engagement application on health outcomes and quality of life in allergic rhinitis and asthma patients
(John Wiley and Sons Inc, 2015) Cingi C.; Yorgancioglu A.; Cingi C.C.; Oguzulgen K.; Muluk N.B.; Ulusoy S.; Orhon N.; Yumru C.; Gokdag D.; Karakaya G.; Çelebi S.; Çobanoglu H.B.; Unlu H.; Aksoy M.A.
Background: In this prospective, multicenter, randomized, controlled, double-blind study, we investigated the impact of a mobile patient engagement application on health outcomes and quality of life in allergic rhinitis (AR) and asthma patients. Methods: In total, 327 patients with diagnoses of persistent AR or mild-to-severe persistent asthma were randomized into 2 intervention groups and 2 control groups upon their admission at outpatient clinics. The intervention groups (POPET-AR and POPET-Asthma) received a mobile phone application ("physician on call patient engagement trial" [POPET]), enabling them to communicate with their physician, and record their health status and medication compliance. The AR groups completed the Rhinitis Quality of Life Questionnaire (RQLQ) at initiation and at the first month of the study. The asthma groups completed the Asthma Control Test (ACT) at initiation and at the third month of the study. Results: The POPET-AR group showed better clinical improvement than the control group in terms of the overall RQLQ score as well in measures of general problems, activity, symptoms other than nose/eye, and emotion domains (p < 0.05). In the POPET-Asthma group, more patients (49%) achieved a well-controlled asthma score (ACT > 19) compared with the control group (27%); this was statistically significant (p < 0.05). Conclusion: Use of a mobile engagement platform, such as POPET, can have a significant impact on health outcomes and quality of life in both AR and asthma, potentially decreasing the number of hospital admissions, repeat doctor visits, and losses in productivity. Improvements were seen in domains related to activity, productivity, perception of disease, and emotion. © 2015 ARS-AAOA, LLC.
In vivo tissue response and durability of five novel synthetic polymers in a rabbit model; [Biocompatibilità e durata in vivo di cinque nuovi polimeri sintetici testati su coniglio]
(Pacini Editore S.p.A., 2016) Sahin E.; Cingi C.; Eskiizmir G.; Altintoprak N.; Calli A.; Calli C.; Yilgör I.; Yilgör E.
Alloplastic materials are frequently used in facial plastic surgeries such as rhinoplasty and nasal reconstruction. Unfortunately, the ideal alloplastic material has not been found. This experimental study evaluates the tissue response and durability of five novel polymers developed as an alloplastic material. In this experimental study involving a tertiary university hospital, six subcuticular pockets were formed at the back of 10 rabbits for the implantation of each polymer and sham group. Each pocket was excised with its adjacent tissue after three months, and collected for histopathological examination. Semi-quantitative examination including neovascularisation, inflammation, fibrosis, abscess formation, multinucleated foreign body giant cells was performed, and integrity of polymer was evaluated. A statistical comparison was performed. No statically significant difference was detected in neovascularisation, inflammation, fibrosis, abscess formation and multinucleated foreign body giant cells when a paired comparison between sham and polymer II, III and IV groups was performed individually. Nevertheless, the degree of fibrosis was less than sham group in polymer I (p =. 027) and V (p =. 018), although the other variables were almost similar. The integrity of polymers III (9 intact, 1 fragmented) and IV (8 intact, 2 absent) was better than the other polymers. These novel synthetic polymers could be considered as good candidates for clinical applicability. All polymers provided satisfactory results in terms of tissue response; however, fibrovascular integration was higher in polymers II, III and IV. In addition, the durability of polymer III and IV was better than the others. © 2016, Pacini Editore S.p.A. All rights reserved.
Aria 2016 executive summary: Integrated care pathways for predictive medicine across the life cycle; [ARIA 2016 yönetici özeti: Yaşam döngüsü boyunca hastalıkları öngörmeye yönelik tıp uygulamaları için bütünleştirilmiş yaklaşım yolakları]
(Ankara University, 2017) Yorgancioğlu A.A.; Kalayci Ö.; Cingi C.; Gemicioğlu B.; Kalyoncu A.F.; Agache I.; Bachert C.; Bedbrook A.; Canonica G.W.; Casale T.; Cruz A.; Fokkens W.E.; Hellings P.; Samolinski B.; Bousquet J.
The Allergic Rhinitis and its Impact on Asthma (ARIA) initiative commenced during a World Health Organization (WHO) workshop in 1999. The initial goals were (i) to propose a new allergic rhinitis classification, (ii) to promote the concept of multi-morbidity in asthma and rhinitis and (iii) to develop guidelines with all stakeholders for global use in all countries and populations. ARIA-disseminated and implemented in over 70 countries globally- is now focusing on the implementation of emerging technologies for individualized and predictive medicine. MASK (MACVIA (Contre les MAladies Chroniques pour un VIeillissement Actif)-ARIA Sentinel NetworK) uses mobile technology to develop care pathways in order to enable the management of rhinitis and asthma by a multidisciplinary group or by patients themselves. An App (Android and iOS) is available in 20 countries and 15 languages. It uses a visual analogue scale to assess symptom control and work productivity as well as a clinical decision support system. It is associated with an inter-operable tablet for physicians and other health care professionals. The scaling up strategy uses the recommendations of the European Innovation Partnership on Active and Healthy Ageing. The aim of the novel ARIA approach is to provide an active and healthy life to rhinitis sufferers, whatever their age, sex or socio-economic status, in order to reduce health and social inequalities incurred by the disease. © 2017, Ankara University. All rights reserved.
CHRODIS criteria applied to the MASK (MACVIA-ARIA Sentinel NetworK) Good Practice in allergic rhinitis: A SUNFRAIL report
(BioMed Central Ltd., 2017) Bousquet J.; Onorato G.L.; Bachert C.; Barbolini M.; Bedbrook A.; Bjermer L.; De Sousa J.C.; Chavannes N.H.; Cruz A.A.; De Manuel Keenoy E.; Devillier P.; Fonseca J.; Hun S.; Kostka T.; Hellings P.W.; Illario M.; Ivancevich J.C.; Larenas-Linnemann D.; Millot-Keurinck J.; Ryan D.; Samolinski B.; Sheikh A.; Yorgancioglu A.; Agache I.; Arnavielhe S.; Bewick M.; Annesi-Maesano I.; Anto J.M.; Bergmann K.C.; Bindslev-Jensen C.; Bosnic-Anticevich S.; Bouchard J.; Caimmi D.P.; Camargos P.; Canonica G.W.; Cardona V.; Carriazo A.M.; Cingi C.; Colgan E.; Custovic A.; Dahl R.; Demoly P.; De Vries G.; Fokkens W.J.; Fontaine J.F.; Gemicioǧlu B.; Guldemond N.; Gutter Z.; Haahtela T.; Hellqvist-Dahl B.; Jares E.; Joos G.; Just J.; Khaltaev N.; Keil T.; Klimek L.; Kowalski M.L.; Kull I.; Kuna P.; Kvedariene V.; Laune D.; Louis R.; Magnan A.; Malva J.; Mathieu-Dupas E.; Melén E.; Menditto E.; Morais-Almeida M.; Mösges R.; Mullol J.; Murray R.; Neffen H.; O'Hehir R.; Palkonen S.; Papadopoulos N.G.; Passalacqua G.; Pépin J.L.; Portejoie F.; Price D.; Pugin B.; Raciborski F.; Simons F.E.R.; Sova M.; Spranger O.; Stellato C.; Todo Bom A.; Tomazic P.V.; Triggiani M.; Valero A.; Valovirta E.; Vandenplas O.; Valiulis A.; Van Eerd M.; Ventura M.T.; Wickman M.; Young I.; Zuberbier T.; Zurkuhlen A.; Senn A.
A Good Practice is a practice that works well, produces good results, and is recommended as a model. MACVIA-ARIA Sentinel Network (MASK), the new Allergic Rhinitis and its Impact on Asthma (ARIA) initiative, is an example of a Good Practice focusing on the implementation of multi-sectoral care pathways using emerging technologies with real life data in rhinitis and asthma multi-morbidity. The European Union Joint Action on Chronic Diseases and Promoting Healthy Ageing across the Life Cycle (JA-CHRODIS) has developed a checklist of 28 items for the evaluation of Good Practices. SUNFRAIL (Reference Sites Network for Prevention and Care of Frailty and Chronic Conditions in community dwelling persons of EU Countries), a European Union project, assessed whether MASK is in line with the 28 items of JA-CHRODIS. A short summary was proposed for each item and 18 experts, all members of ARIA and SUNFRAIL from 12 countries, assessed the 28 items using a Survey Monkey-based questionnaire. A visual analogue scale (VAS) from 0 (strongly disagree) to 100 (strongly agree) was used. Agreement equal or over 75% was observed for 14 items (50%). MASK is following the JA-CHRODIS recommendations for the evaluation of Good Practices. © 2017 The Author(s).
Transfer of innovation on allergic rhinitis and asthma multimorbidity in the elderly (MACVIA-ARIA) - EIP on AHA Twinning Reference Site (GARD research demonstration project)
(Blackwell Publishing Ltd, 2018) Bousquet J.; Agache I.; Aliberti M.R.; Angles R.; Annesi-Maesano I.; Anto J.M.; Arnavielhe S.; Asayag E.; Bacci E.; Bedbrook A.; Bachert C.; Baroni I.; Barreto B.A.; Bedolla-Barajas M.; Bergmann K.C.; Bertorello L.; Bewick M.; Bieber T.; Birov S.; Bindslev-Jensen C.; Blua A.; Bochenska Marciniak M.; Bogus-Buczynska I.; Bosnic-Anticevich S.; Bosse I.; Bourret R.; Bucca C.; Buonaiuto R.; Burguete Cabanas M.T.; Caillaud D.; Caimmi D.P.; Caiazza D.; Camargos P.; Canfora G.; Cardona V.; Carriazo A.M.; Cartier C.; Castellano G.; Chavannes N.H.; Cecci L.; Ciaravolo M.M.; Cingi C.; Ciceran A.; Colas L.; Colgan E.; Coll J.; Conforti D.; Correia de Sousa J.; Cortés-Grimaldo R.M.; Corti F.; Costa E.; Courbis A.L.; Cousein E.; Cruz A.A.; Custovic A.; Cvetkovski B.; Dario C.; da Silva J.; Dauvilliers Y.; De Blay F.; Dedeu T.; De Feo G.; De Martino B.; Demoly P.; De Vries G.; Di Capua Ercolano S.; Di Carluccio N.; Doulapsi M.; Dray G.; Dubakiene R.; Eller E.; Emuzyte R.; Espinoza-Contreras J.G.; Estrada-Cardona A.; Farrell J.; Farsi A.; Ferrero J.; Fokkens W.J.; Fonseca J.; Fontaine J.F.; Forti S.; Gálvez-Romero J.L.; García-Cobas C.I.; Garcia Cruz M.H.; Gemicioğlu B.; Gerth van Wijk R.; Guidacci M.; Gómez-Vera J.; Guldemond N.A.; Gutter Z.; Haahtela T.; Hajjam J.; Hellings P.W.; Hernández-Velázquez L.; Illario M.; Ivancevich J.C.; Jares E.; Joos G.; Just J.; Kalayci O.; Kalyoncu A.F.; Karjalainen J.; Keil T.; Khaltaev N.; Klimek L.; Kritikos V.; Kull I.; Kuna P.; Kvedariene V.; Kolek V.; Krzych-Fałta E.; Kupczyk M.; Lacwik P.; La Grutta S.; Larenas-Linnemann D.; Laune D.; Lauri D.; Lavrut J.; Lessa M.; Levato G.; Lewis L.; Lieten I.; Lipiec A.; Louis R.; Luna-Pech J.A.; Magnan A.; Malva J.; Maspero J.F.; Matta-Campos J.J.; Mayora O.; Medina-Ávalos M.A.; Melén E.; Menditto E.; Millot-Keurinck J.; Moda G.; Morais-Almeida M.; Mösges R.; Mota-Pinto A.; Mullol J.; Muraro A.; Murray R.; Noguès M.; Nalin M.; Napoli L.; Neffen H.; O'Hehir R.E.; Onorato G.L.; Palkonen S.; Papadopoulos N.G.; Passalacqua G.; Pépin J.L.; Pereira A.M.; Persico M.; Pfaar O.; Pozzi A.C.; Prokopakis E.; Pugin B.; Raciborski F.; Rimmer J.; Rizzo J.A.; Robalo-Cordeiro C.; Rodríguez-González M.; Rolla G.; Roller-Wirnsberger R.E.; Romano A.; Romano M.; Romano M.R.; Salimäki J.; Samolinski B.; Serpa F.S.; Shamai S.; Sierra M.; Sova M.; Sorlini M.; Stellato C.; Stelmach R.; Strandberg T.; Stroetmann V.; Stukas R.; Szylling A.; Tan R.; Tibaldi V.; Todo-Bom A.; Toppila-Salmi S.; Tomazic P.; Trama U.; Triggiani M.; Valero A.; Valovirta E.; Valiulis A.; van Eerd M.; Vasankari T.; Vatrella A.; Ventura M.T.; Verissimo M.T.; Viart F.; Williams S.; Wagenmann M.; Wanscher C.; Westman M.; Wickman M.; Young I.; Yorgancioglu A.; Zernotti E.; Zuberbier T.; Zurkuhlen A.; De Oliviera B.; Senn A.
The overarching goals of the European Innovation Partnership on Active and Healthy Ageing (EIP on AHA) are to enable European citizens to lead healthy, active and independent lives whilst ageing. The EIP on AHA includes 74 Reference Sites. The aim of this study was to transfer innovation from an app developed by the MACVIA-France EIP on AHA reference site (Allergy Diary) to other reference sites. The phenotypic characteristics of rhinitis and asthma multimorbidity in adults and the elderly will be compared using validated information and communication technology (ICT) tools (i.e. the Allergy Diary and CARAT: Control of Allergic Rhinitis and Asthma Test) in 22 Reference Sites or regions across Europe. This will improve the understanding, assessment of burden, diagnosis and management of rhinitis in the elderly by comparison with an adult population. Specific objectives will be: (i) to assess the percentage of adults and elderly who are able to use the Allergy Diary, (ii) to study the phenotypic characteristics and treatment over a 1-year period of rhinitis and asthma multimorbidity at baseline (cross-sectional study) and (iii) to follow-up using visual analogue scale (VAS). This part of the study may provide some insight into the differences between the elderly and adults in terms of response to treatment and practice. Finally (iv) work productivity will be examined in adults. © 2017 EAACI and John Wiley and Sons A/S. Published by John Wiley and Sons Ltd.

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