Browsing by Author "Civi M."

Now showing 1 - 3 of 3
  • No Thumbnail Available
    Item
    The effect of epidural and general anesthesia on newborn rectal temperature at elective cesarean section
    (Associacao Brasileira de Divulgacao Cientifica, 2009) Yentur E.A.; Topcu I.; Ekici Z.; Ozturk T.; Keles G.T.; Civi M.
    Both epidural and general anesthesia can impair thermoregulatory mechanisms during surgery. However, there is lack of information about the effects of different methods of anesthesia on newborn temperature. The purpose of this study was to determine whether there are differences in newborn rectal temperature related to type of anesthesia. Sixty-three pregnant women were randomly assigned to receive general or epidural anesthesia. Maternal core temperature was measured three times with a rectal probe just before anesthesia, at the beginning of surgery and at delivery. In addition, umbilical vein blood was sampled for pH. The rectal temperatures of the babies were recorded immediately after delivery, and Apgar scores were determined 1, 5, and 10 min after birth. The duration of anesthesia and the volume of intravenous fluid given during the procedure (833 ± 144 vs 420 ± 215 mL) were significantly higher in the epidural group than in the general anesthesia group (P < 0.0001). Maternal rectal temperatures were not different in both groups at all measurements. In contrast, newborn rectal temperatures were lower in the epidural anesthesia group than in the general anesthesia group (37.4 ± 0.3 vs 37.6 ± 0.3° C; P < 0.05) immediately after birth. Furthermore, the umbilical vein pH value (7.31 ± 0.05 vs 7.33 ± 0.01; P < 0.05) and Apgar scores at the 1st-min measurement (8.0 ± 0.9 vs 8.5 ± 0.7; P < 0.05) were lower in the epidural anesthesia group than in the general anesthesia group. Since epidural anesthesia requires more iv fluid infusion and a longer time for cesarean section, it involves a risk of a mild temperature reduction for the baby which, however, did not reach the limits of hypothermia.
  • No Thumbnail Available
    Item
    Balanced anesthesia with dexmedetomidine added desflurane or sevoflurane in spinal surgery
    (2012) Keles G.T.; Ozer M.; Dede G.; Temiz C.; Horasan G.D.; Civi M.
    Objectives: Sevoflurane and desflurane inhalational anesthetics are used for fast-track neuroanesthesia. Dexmedetomidine is used to provide analgesia, sedation and hemodynamic stability. Other anesthetic and analgesic requirements decrease when dexmedetomidine is administered, thus it is an interesting option for intraoperative agent for general anesthesia. We aim to compare desflurane and sevoflurane with dexmedetomidine in the operating room (OR) and Post-Anesthesia Care Unit (PACU) by using Fast-Tract -Criteria (FTC) and Aldrete Criteria (AC) for spinal surgery patients. Methods: A double-blind study was conducted. One hundred ASA I-II patients aged 18-65 were randomly divided into two groups. Following the standard anesthesia induction, Group (D+D) (n=50) received 2-4 % desflurane + 0.2 μg/kg/h dexmedetomidine and Group (S+D) (n=50) received 1-3 % sevoflurane + 0.2 μg/kg/h dexmedetomidine in 60 % N2O for anesthesia management. Extubation times, and FTC and AC were evaluated in the OR at the 5th and 10th minutes and in PACU at the 5th, 15th and 25th minutes. P< 0.05 was considered significant. Results: Demographic features of the patients in the two groups were similar. Extubation time in Group (D+D) was shorter than that in Group (S+D) (5.9 ± 2.4 and 8.3 ± 3.9 min respectively, p=0.001). In OR at the 10th min, and in PACU at the 5th min; Group (D+D) had a higher AC score than did Group (S+D) (p=0.001), and also at the 15th min., Group (D+D) had a higher FTC (P=0.01) and AC (p=0.007) scores than did Group (S+D). In all the patients, targeted discharge points were achieved at the 25th minute in PACU Conclusions: Balanced anesthesia with desflurane / dexmedetomidine combination is superior to sevoflurane / dexmedetomidine in extubation time and time to reach an AC ≥ 9 and FTC ≥ 13 in spinal surgery. © 2012 Keles GT, et al.
  • No Thumbnail Available
    Item
    The effects of lornoxicam on neuroprotection following diffuse traumatic brain injury in rats
    (Turkish Neurosurgical Society, 2013) Topcu I.; Vatansever S.; Bayram E.; Var A.; CetIn I.; Civi M.
    Aim: In this study, the effects of lornoxicam on the prevention of secondary brain injury via the apoptotic pathway were studied in a rat model of head injury. Ma terIal and Methods: Thirty adult male Wistar albino rats were anesthetized, and experimental closed head trauma was induced by allowing a 450 g weight to fall two meters onto a metallic disk fixed to the intact skull. After head injury, the rats were randomly divided into two groups: Group I (n=15) rats were administered 2 mL saline intraperitoneally (controls); Group II (n=15) rats were administered 2 mL 1.3 mg kg-1 lornoxicam intraperitoneally. Brain tissue samples were divided into two pieces by interhemispheric incision for biochemical and histological analysis. Results: TUNEL positivity was seen in neuroglia cells of the brain cortex in both groups. While the immunoreactivities of caspase 8, 9 and Fas/ Fas ligand were similar in both groups, the immunoreactivity of caspase 3 was greater in Group I than Group II. MDA was significantly lower in Group II than in Group I (p<0.05). The decrease in SOD level was higher in Group I than Group II. ConclusIon: Lornoxicam did not prevent apoptosis in this rat model of brain trauma but causes a decrease.