Browsing by Author "Coşkun Ş."
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Item The use of intermittant dose azithromycin in children with sinusitis; [Çocukluk çaǧinda akut si̇nüzi̇t tedavi̇si̇nde i̇ntermi̇ttant doz azi̇tromi̇si̇n kullanimi](2001) Yüksel H.; Coşkun Ş.; Demir E.; Ikizoǧlu T.; Yilmaz D.; Onaǧ A.; Tanaç R.Aim: Antibiotic selection and the duration of its use are two of the most important factors that affect the prognosis of children with sinusitis. New effective antibiotherapy strategies with higher dose and short usage interval in children with sinusitis are needed because compliance to drug usage is difficult in childhood. In this study we aimed to compare 'single dose intermittent usage' of azithromycin (AZT) therapy and 'two doses per day for 15 days usage' of amoxisilin-clavunate (AMK) in the treatment of children with acute maxillary sinusitis. Material and Method: Sixty-one children diagnosed as having maxillary sinusitis (between 5 and 14 years old) were enrolled into study. Twenty-nine children were treated using single daily dose of AZT for five days. After a treatment- free period for 5 days, the drug was readministered for five days. Thirty-two children were treated using two doses of AMK for fifteen days. Clinical signs, symptom scores of sinusitis and compliance to the therapy were followed up for two weeks. Results: At the end of the first week, the mean symptom score of the AZT group was significantly lower than that of the AMK group (p<0.05). Although it was lower in AZT group, the symptom scores at the end of the second week were not significantly different between the two groups. Recovery rate from sinusitis was 93% in the AZT and 91% in the AMK group. Seven percent of the AZT group patients failed to use the total recommended dose and also 3% stopped the therapy earlier. In the AMK group, these were 24% and 15% respectively, and the difference between two groups was statistically significant (p<0.05). Satisfaction from using the drug was significantly higher in the AZT group than the AMK group. Conclusion: The therapy regimen with a single dose - intermittant usage of AZT for five days is as effective as two doses of AMK therapy for fifteen days. Furthermore, it was shown that intermittant dose AZT reduced symptom scores of sinusitis earlier. Thus, an intermittant dose of AZT recommendation may be a new, more compliant and effective therapy regiment in the treatment of children with sinusitis.Item The clinical significance of atrial and brain natriuretic peptides; [Atrial ve beyin natriüretik peptid'in klinik önemi](2002) Saribülbül O.; Coşkun Ş.Heart is not only a pump functionally, but also secrets two different significant peptides like an endocrine organ: ANP (Atrial Natruretic Peptide) and BNP (Brain Natriuretic Peptide). Many different effects of these peptides which have structural homology, on heart, kidneys, electrolytes and blood volume were proven. A different peptide, C-type natriuretic peptide, originates from vascular endothelial wall and since it doesn't originate from myocard, it is not mentioned together with others. ANP is secreted from atrium. Although BNP originates from cardiac ventricules, since it was first isolated from brain, it is called brain natriuretic peptide. The changing concentrations of ANP and BNP according to some physiological conditions like posture or effort were measured both in renal failure and after myocardial infarction and also particularly in heart failure. Besides, these findings revealed that the levels of ANP and BNP can be used to follow the clinical status of patients. According to recent studies, BNP can be used as an indicator to predict the prognosis of the patients with both asymptomatic and severe ischemic heart failure.Item Dientamoeba fragilis, a neglected cause of diarrhea, successfully treated with secnidazole(Blackwell Publishing Ltd., 2003) Girginkardeşler N.; Coşkun Ş.; Cüneyt Balcioǧlu I.; Ertan P.; Ok Ü.Z.Objective. To evaluate the pathogenicity of Dientamoeba fragilis by comparing it with Giardia lamblia and to investigate the effect of a single dose of secnidazole in dientamoebiasis. Methods. Stool samples of 400 patients, admitted to the Department of Parasitology, Celal Bayar University, were examined by direct wet mount, formalin-ethyl acetate concentration and trichrome staining methods on three consecutive days. All cases positive for D. fragilis were treated with a single dose of secnidazole, 30 mg/kg for children, and 2 g for adults. On the seventh and fourteenth days, at the end of the treatment, stool samples were examined by the same methods, and clinical symptoms were again evaluated. Results. D. fragilis and G. lamblia were detected in 35 (8.8%) and 34 (8.5%) cases, respectively. The most frequent symptoms were found to be abdominal pain and diarrhea in both infections. D. fragilis was eradicated in 34 (97.1%) patients with a single dose of secnidazole, but a second dose was necessary in one patient. Clinical symptoms disappeared in 27 (77.1%) and decreased in eight (22.9%) cases, after eradication. Conclusions. These data suggested that D. fragilis is as prevalent and pathogenic as G. lamblia, and secnidazole seems to be highly effective in achieving parasitologic and clinical cure. To our knowledge, this is the first report of secnidazole being used in the treatment of dientamoebiasis.Item Juvenile dermatomyositis resistant to steroids(2005) Polat M.; Akil I.; Ikizoǧlu T.; Serter S.; Özkol M.; Yilmaz Ikizoǧlu Ö.; Coşkun Ş.[No abstract available]Item Diabetic ketoacidosis presenting with pneumomediastinum(2007) Ersoy B.; Polat M.; Coşkun Ş.[No abstract available]Item The Factor v G1691A, Factor v H1299R, prothrombin G20210A polymorphisms in children with family history of premature coronary artery disease(2009) Çiftdoǧan D.Y.; Coşkun Ş.; Ulman C.; Tkz H.Atherosclerosis, the major cause of coronary artery disease (CAD), has a very long asymptomatic development phase, which begins in childhood. In this study, we describe the Factor V G1691A, Factor V H1299R and prothrombin G20210A gene polymorphisms in children with a family history of premature CAD. Evidence of these polymorphisms in these children may predict the probability of having atherosclerosis in the future. Our study included a total of 140 children, 72 males and 68 females between the ages of 4.9 and 15.7 years. Among these children, 73 had a parental history of premature CAD and the remaining 67 belonged to our control group. The participants were screened for the mutations Factor V G1691A, Factor V H1299R and prothrombin G20210A by polymerase chain reaction amplified DNA products with specific oligonucleotide probes. Our results suggested that frequencies of the mutated allele of Factor V G1691A and prothrombin G20210A are higher in children with a parental history of premature CAD. In conclusion, Factor V G1691A and prothrombin G20210A polymorphisms which were detected in higher frequencies in children with a parental history of premature CAD may indicate a risk for developing atherosclerosis and might be useful in screening for CAD in children; however, large population-based research is necessary to investigate further genetic risk assessment for CAD. © 2009 Wolters Kluwer Health | Lippincott Williams & Wilkins.Item The prevalence of microalbuminuria and relevant cardiovascular risk factors in Turkish hypertensive patients(2011) Kozan Ö.; Özcan E.E.; Sancaktar O.; Kabakci G.; Sözcüer A.H.; Kerpeten A.; Delice A.; Içli A.; Sökmen A.; Gürlek A.; Abaci A.; Bayram A.; Köşüş A.; Çamsari A.; Sakalli A.; Sert A.; Temizhan A.; Yilmaz A.; Daver A.; Aydinlar A.; Ergin A.; Kiliçoǧlu A.E.; Birdane A.; Aribaş A.; Lazoǧlu A.; Özdemir A.; Fiskeci A.; Çelik A.; Bitigen A.; Keskin A.; Yavuz A.; Akyüz A.; Karanfil A.; Ünsal A.; Sinci A.; Gülmez A.U.; Irmak A.; Vural A.; Güven A.; Ilerigelen B.; Erol B.; Polat B.; Tosun B.; Aǧçal C.; Genç C.; Kirdar C.; Rezzagil C.; Köz C.; Nazli C.; Ceyhan C.; Örem C.; Uyan C.; Türkoǧlu C.; Gaffari D.; Aytekin D.; Ural D.; Yeşilbursa D.; Aras D.; Semiz E.; Koçak E.; Atalar E.; Varol E.; Onrat E.; Şensoy E.; Acartürk E.; Akarca E.; Aygün E.; Ertaş F.S.; Koca F.; Özmen F.; Ulusoy F.V.; Özerkan F.; Inceer F.K.; Dönmez G.; Topkara G.; Daş G.; Bozkurt H.; Kültürsay H.; Tikiz H.; Akgöz H.; Kaymak H.; Öney H.; Yeǧin H.; Boǧa H.; Gök H.; Vural H.; Atasever H.; Arinç H.; Bozdemir H.; Gündüz H.; Tunar H.; Atmaca H.; Doǧru I.; Özdoǧru I.; Susal I.; Kurt I.T.; Dinçer I.; Biyik I.; Tandoǧan I.; Jordan J.; Kulan K.; Şahna K.; Öztaş K.; Dönmez K.; Övünç K.; Kaya K.; Aytemir K.; Özdemir K.; Tigen K.; Saraç L.; Sirkeci M.T.; Çakmak M.; Şahin M.; Kutlu M.; Bilge M.; Bostan M.; Melek M.; Sunay M.Ö.; Şeker M.; Güçel M.Ş.; Yazici M.; Kayikçioǧlu M.; Öç M.; Gürsürer M.; Daǧalp M.; Bilaloǧlu M.; Yalçin M.; Şerifi M.; Gökçe M.; Kiliçkap M.; Polat M.; Şan M.; Tahtasiz M.; Yilmaz M.; Etemoǧlu M.; Coşkun N.; Aran N.S.; Ata N.; Sönmez N.; Çam N.; Koylan N.; Özer N.; Keser N.; Döven O.; Tartanoǧlu O.; Ergene O.; Elönü O.H.; Onbaşili O.A.; Özbek Ö.; Pinar P.; Akdemir R.; Kargin R.; Topsakal R.; Yoldaş R.; Uçar R.; Ateşal S.; Toktaş S.; Cinsoy S.; Güleç S.; Aytekin S.; Çolak S.; Mecit S.; Sakalli S.; Sevimli S.; Topaloǧlu S.; Aydoǧdu S.; Turan S.C.; Kahraman S.; Yorganci S.; Coşkun Ş.; Ünal Ş.; Durmaz T.; Ulusoy T.; Keleş T.; Kirat T.; Gündoǧdu T.T.; Peker T.; Sümerkan U.; Aytekin V.; Koca V.; Çam V.; Gökçe V.; Gürlertop Y.; Balbay Y.; Çavuşoǧlu Y.; Erzurum Y.; Selçoki Y.; Yakar Y.; Işilak Z.; Tosun Z.; Kaplan Z.; Tartan Z.Objectives: A growing body of data illustrates the importance of microalbuminuria (MAU) as a strong predictor of cardiovascular risk in the hypertensive population. The present study was designed to define the prevalence of MAU and associated cardiovascular risk factors among Turkish hypertensive outpatients. Study design: Representing the Turkish arm of the multinational i-SEARCH study involving 1,750 sites in 26 countries around the world, a total of 1,926 hypertensive patients from different centers were included in this observational and cross-sectional survey study. Patients with reasons for a false-positive MAU test were excluded. The prevalence of MAU was assessed using a dipstick test, and patients were inquired about comorbidities, comedication, and known cardiovascular risk factors. Results: The overall prevalence of MAU was 64.7% and there was no difference between genders. Most of the patients (82.5%) had uncontrolled hypertension, 35.6% had dyslipidemia, and 35.5% had diabetes, predominantly type 2. Almost one-third of the patients (26.4%) had at least one cardiovascular-related comorbidity, with 20.3% having documented coronary artery disease (CAD). Almost all patients (96.8%) had one or more risk factors for cardiovascular disease in addition to hypertension, including family history of myocardial infarction or CAD, diabetes, dyslipidemia, lack of physical exercise, and smoking. A trend towards higher MAU values in the presence of CAD was determined. Conclusion: Microalbuminuria tests should be routinely used as a screening and monitoring tool for the assessment of subsequent cardiovascular morbidity and mortality among hypertensive patients. © 2011 Turkish Society of Cardiology.Item Coronary artery-pulmonary artery fistula detected by transthoracic echocardiography: Case report; [Transtorasik ekokardiyografi ile saptanan koroner arter ile pulmoner arter arasindaki fistül](2012) Çetin M.; Yildirimer M.; Evrengül H.; Özen S.; Genç B.; Coşkun Ş.Coronary artery fistulas are direct connections, devoid of a capillary system, between any coronary arteries and 4 chambers of the heart, superior vena cava, pulmonary artery, or pulmonary veins. Although definitive consensus has not been reached regarding treatment approaches, it has usually been reported that symptom-free small fistulas have a benign course and may be followed clinically and they should be closed in patients with symptomatic fistulas or related complications. Here, we presented a case of asymptomatic fistula between proxymal left descendant coronary artery and main pulmonary artery, that has been spotted by transthoracic echocardioghraphy. Copyright © 2012 by Türkiye Klinikleri.Item Diagnostic difficulties by the unusual presentations in children and adolescents with hashimoto thyroiditis(Korean society of pediatric endocrinology, 2016) Ersoy B.; Seniha K.Y.; Kızılay D.; Yılmaz M.; Coşkun Ş.Complex clinical presentation with diverse timing of particular symptoms may cause diagnostic difficulties, especially in children and adolescents. This paper presents diagnostic difficulties and pitfalls in 3 children with acquired primary hypothyroidism due to Hashimoto’s thyroiditis (HT) presenting with unusual manifestations. We described 3 children with acquired primary hypothyroidism due to HT. One of our patients had musculoskeletal pain and was diagnosed and treated as having connective tissue disease. Another patient presented with chest pain, dyspnea, and swelling in the abdomen. She had a massive pericardial effusion (PE). Two patients had severe growth failure. A third patient with Down syndrome had a small PE. Her complaint was dyspnea during sleep. All patients improved with thyroxin therapy. Patients with hypothyroidism due to HT who have complicated clinical manifestations were misdiagnosed and mismanaged at childhood and adolescence. Growth failure is an important sign in children and adolescents. In the presence of complicated manifestations in children and adolescents, thyroid dysfunction must be considered in differential diagnosis. © 2016 Annals of Pediatric Endocrinology & Metabolism.Item Idiopathic chest pain in children: Is it gastroesophageal reflux disease?(Ortadog u Reklam Tanitim Yayincilik Turizm Egitim Insaat Sanayi ve Ticaret A.S., 2016) Çetin M.; Yurttaş Ö.; Gözkeser E.; Coşkun Ş.; Kasirga E.Objective: Causes of chest pain in children, rarely due to cardiac disease and usually described as idiopathic, account for 20% to 45% of all cases. In this study, we investigated the frequency of gastroesophageal reflux in children with noncardiac chest pain and the characteristics of the pain. Material and Methods: Children with at least two episodes per month of chest pain for a maximum of six months were enrolled in the study. After diagnostic evaluation excluded a cardiac source of chest pain, all patients underwent 24-hour pH monitoring. Characteristics of chest pain and other symptoms were recorded daily by the patients or their parents using the symptom diary. Lansoprazole treatment was administered to patients diagnosed as having gastroesophageal reflux disease. Then, the results of the lansoprazole treatment were evaluated on the basis of the presence of chest pain and other symptoms at the second month after the completion of therapy. Results: Thirty-one children (17 boys and 14 girls) aged between eight and 18 years (11.6±2.4 years) with the primary complaint of chest pain were studied. Based on the 24-hour pH monitoring test results, eight patients (25.8%) for distal sensor and six patients (19.4%) for proximal sensor were defined as Gastroesophageal Reflux Disease (GERD)-positive. No significant difference was noted for characteristics of chest pain and other symptoms between the GERD-positive and GERD-negative groups. All GERD-positive children became symptom-free after the two-month lansoprazole therapy. Conclusion: The symptoms of GERD-induced chest pain are often non-specific, and can be determined with certainty only by 24-hour pH monitoring, so 24-hour pH monitoring may proposed to all children with idiopathic chest pain. Copyright © 2016 by Tür ki ye Kli nik le ri.Item Perimyocarditis mimicking acute coronary syndrome and intravenous immunoglobulin use: Case report; [Akut Koroner Sendromu Taklit Eden Perimiyokardit ve İntravenöz İmmünglobulin Kullanimi](Ortadog u Reklam Tanitim Yayincilik Turizm Egitim Insaat Sanayi ve Ticaret A.S., 2016) Alkan F.; Paytoncu Ş.; Çetin M.; Coşkun Ş.Perimyocarditis is an inflammatory syndrome characterized by myocardial and partly pericardial involvement. In developed countries, viral infections are the most common cause. The other reasons are idiopathic, bacterial or rheumatic diseases and immune drugs. The findings are subclinical, varies from chest pain, heart failure to death. Treatment is performed according to reasons. Anti-inflammatory drugs are used for signs and symptoms. Intravenous immunoglobulin is preferred in selected cases. In this article, we present a case with chest pain, electrocardiogram changes and elevated cardiac enzymes, exclusion of acute coronary syndrome with computed tomography coronary angiography, determination of diffuse myocardial involvement with cardiac magnetic resonance imaging and showing dramatic improvement with intravenous immunoglobulin for persistent clinical signs. Copyright © 2016 by Tür ki ye Kli nik le ri.Item A rare case of asymptomatic giant right atrial aneurysm: Case report(Ortadog u Reklam Tanitim Yayincilik Turizm Egitim Insaat Sanayi ve Ticaret A.S., 2017) Alkan F.; Bayturan Ö.; Çetin M.; Coşkun Ş.Right atrial aneurysm is a rare abnormality of the heart. This defect is seen in all age groups and is usually diagnosed incidentally. The aneurysm can be asymptomatic or present with symptoms related to supraventricular arrhythmias or thromboembolic phenomenon. We present the case report of a 74-year-old male with right atrial aneurysm which was incidentally detected during echocardiographic evaluation. Copyright © 2017 by Türkiye Klinikleri.Item Successful treatment of abdominal aorto-right atrial fistula by vascular plug: A previously unreported cardiac malformation(Turkish Society of Cardiology, 2017) Alkan F.; Pabuşcu Y.; Çetin M.; Coşkun Ş.[No abstract available]Item Asymmetric dimethylarginine levels and diabetes duration: Relationship with measures of subclinical atherosclerosis and cardiac function in children and adolescents with Type 1 diabetes(SAGE Publications Ltd, 2018) Ersoy B.; Eroğlu N.; Çetin M.; Onur E.; Özkol M.; Coşkun Ş.Aims: We aimed to evaluate asymmetric dimethylarginine levels in young patients with Type 1 diabetes mellitus according to diabetes duration and to examine the relationship between these levels and measures of atherosclerosis and myocardial function. Materials and methods: In total, 83 patients (8.5–22 years) with Type 1 diabetes mellitus were stratified by diabetes duration: 12–60 months (Group 1, n = 27), >60–120 months (Group 2, n = 29) and >120 months (Group 3, n = 27). Asymmetric dimethylarginine levels were assessed. Carotid intima–media thickness was measured. Myocardial function was assessed by M-mode, conventional Doppler and tissue Doppler echocardiography. Results: Asymmetric dimethylarginine level was significantly higher in Group 1, while carotid intima–media thickness was significantly greater in Group 3 (p < 0.05). Tissue Doppler echocardiography showed the ratio of peak early to peak late diastolic myocardial annular velocity decreased significantly in Groups 2 and 3 with a negative correlation with duration (r: −0.310, p = 0.004) and HBA1c levels (r = −0.391, p < 0.001). Myocardial performance index in all groups and isovolumic relaxation time in Group 3 increased significantly. Asymmetric dimethylarginine levels were negatively correlated with carotid intima–media thickness and isovolumic relaxation time (p < 0.05). Conclusion: In contrast to adult diabetics, asymmetric dimethylarginine concentration decreases as diabetes duration increases in young Type 1 diabetic patients and is associated with worsening measures of cardiovascular risk and poorer diastolic function. © 2018, © The Author(s) 2018.Item Life quality of children with congenital heart diseases(AVES, 2018) Sertçelik T.; Alkan F.; Yalın Sapmaz Ş.; Coşkun Ş.; Eser E.Aim: We aimed to evaluate the effects of the severity and symptoms of congenital heart disease and the emotional and behavioral problems of affected children on their quality of life. Material and Methods: The study was performed by interviewing 80 children aged between 6 and 16 years (40 with cyanotic heart disease and 40 with acyanotic disease) and their mothers. A sociodemographic data form, quality of life questionnaire, strength and difficulties questionnaire, and family life and parenting attitudes scale were used in the research. Life quality was the dependent variable of this research. Results: No significant relation was found between age, sex, and education level of the parents and all quality of life subscale scores (p>0.05). In terms of quality of life, total quality of life subscale, emotional well-being and self-esteem subscales were significantly lower in children with cyanotic congenital heart disease (p=0.02, p=0.007, p=0.006, respectively). The total quality of life subscale was significantly lower in children with a medical treatment and surgical history. In terms of clinical symptoms, self-esteem, friendship and school life quality subscales were affected in the presence of dyspnea. As scores from strength and difficulties questionnaire increased, which is used for the assessment of children’s psychological symptoms, all quality of life scores were significantly lowered except for school and family subscales. Conclusion: It was found that symptoms of congenital heart disease affected the psychosocial quality of life subscales rather than the physical subscales. In addition, it was observed that mental symptoms in both the mother and child negatively affected quality of life rather than disease-related parameters. © 2018 by Turkish Pediatric Association.Item Fetal pericardial effusion, cardiac mass and coincidental hypertrophic cardiomyopathy: A rare case report; [Fetal Perikardiyal Efüzyon, Kardiyak Kitle ve Koinsidensal Hipertrofik Kardiyomiyopati: Nadir Bir Olgu Sunumu](Ortadog u Reklam Tanitim Yayincilik Turizm Egitim Insaat Sanayi ve Ticaret A.S., 2018) Alkan F.; Ergani A.C.; Coşkun Ş.Prenatal cardiac masses are rare and mostly benign. However, they can cause life-threatening complications such as pericardial effusion, hydrops fetalis, arrhythmia, heart failure and sudden death. We present a case detected hypertrophic cardiomyopathy and pericardial effusion at 26 weeks of gestation and which was found cardiac mass in postnatal period. Copyright © 2018 by Türkiye Klinikleri.Item Percutaneous embolization of congenital portosystemic venous shunt in an infant with respiratory distress(Turkish Journal of Pediatrics, 2018) Alkan F.; Düzgün F.; Yüksel H.; Tarhan S.; Coşkun Ş.A 5-month-old boy with progressive respiratory distress was admitted to our hospital. Physical examination revealed mild tachypnea and retraction. The left main bronchus was found as severely collapsed between the right pulmonary artery and the descending aorta, on the bronchoscopic evaluation. Further evaluation revealed persistent ductus venosus (PDV). As in the fetal period the ductus venosus arises from the posterior aspect of the left portal vein, a PDV is considered another type of intrahepatic portosystemic shunt. Therefore, he was diagnosed with congenital portosystemic venous shunt, leading to persistent respiratory distress. The PDV was closed with Amplatzer vascular plug II, and then he had immediate clinical improvement. Congenital portosystemic venous shunts (CPSS) are rare vascular malformations associated with severe complications. Here we presented a case with progressive respiratory distress as a result of CPSS and rapid improvement after embolization. © 2018, Turkish Journal of Pediatrics. All rights reserved.Item Henoch–Schonlein purpura, post-streptococcal glomerulonephritis and acute rheumatic carditis after Group A β-haemolytic streptococcal infection(Taylor and Francis Ltd., 2018) Arslansoyu Çamlar S.; Soylu A.; Akil İ.; Ünlü M.; Coşkun Ş.; Ertan P.; Kavukçu S.Besides association with acute rheumatic fever (ARF) and acute glomerulonephritis (APSGN), in up to 40% of cases, Group A β-haemolytic streptococcal (GABHS) infections are also implicated as a trigger for Henoch–Schonlein purpura (HSP). A 7-year-old girl with GABHS throat infection who developed HSP, APSGN and rheumatic carditis is reported. She presented with palpable purpura and arthritis in both ankles and later developed carditis characterised by mitral/aortic regurgitation and glomerulonephritis characterised by mixed nephritic/nephrotic syndrome. She had a raised anti-streptolysin titre (ASOT), blood urea nitrogen and creatinine and hypocomplementaemia (C3), and renal biopsy demonstrated endocapillary and extracapillary proliferative glomerulonephritis with crescents. Immunofluorescence microscopy demonstrated a ‘full house’ of immunoglobulin and complement, viz. IgA + 2, IgG + 3, IgM + 2, C3c + 1, Clq + 2 with predominantly IgG deposition. One week earlier, her 4-year-old sister had presented to another hospital with HSP complicated by microscopic haematuria, nephrotic-range proteinuria and gastro-intestinal involvement, and with raised ASOT and low C3 levels. Although HSP has been associated with either ARF or APSGN, this is the first case of a child with HSP, ARF and APSGN in combination. © 2017 Informa UK Limited, trading as Taylor & Francis Group.Item Retrospective evaluation of myopericarditis/perimyocarditis patients: Retrospective research; [Miyoperikardit/perimiyokardit hastaların retrospektif değerlendirilmesi: Retrospektif araştırma](Ortadog u Reklam Tanitim Yayincilik Turizm Egitim Insaat Sanayi ve Ticaret A.S., 2021) Alkan F.; Coşkun Ş.Objective: Myocardium is predominantly affected in perimyocarditis and pericardium in myopericarditis; yet, both are inflammatory syndromes characterized by partial involvement of both myocardium and pericardium. This study aimed to evaluate the clinical presentation at the time of referral, laboratory differential diagnoses, imaging techniques, and our clinical experience in patients diagnosed with acute perimyocarditis/myopericarditis in our clinic, along with the effect of our treatment management on mortality. Material and Methods: The files of the patients diagnosed with perimyocarditis/myopericarditis referred to the pediatric cardiology unit between 01.01.2015-01.08.2017 were retrospectively analyzed. The patients’ demographic characteristics, physical examination findings and advanced imaging examination results were recorded. Results: The age range of the patients was 1-17 years (13±5.47). The referral complaints were chest pain in 16 (88.9%) patients, fever in one patient, and enteritis in one patient. Cardiac enzyme levels were high in all patients. The ejection fraction (EF) of five patients (27.7%) was below 55%. Mortality was observed in only one patient. There was no difference between patients who received intravenous immunoglobulin (IVIG) and those who did not, in terms of left ventricular diastolic and systolic diameters, EF, fractional shortening, and chest pain (p=0.566, 1.000, 0.095, 0.208, respectively). Conclusion: Perimyocarditis/myopericarditis should be considered in patients who present with complaints such as chest pain and palpitations and who have a history of upper respiratory tract infection. Although perimyocarditis/myopericarditis is often a self-limiting disease even without treatment, close follow-up of these patients with hospitalization should be taken into consideration, and IVIG administration together with non-steroidal anti-inflammatory drugs should be considered in selected patients. © 2021 by Türkiye Klinikleri.Item Normal Values of Echocardiographic Parameters Indicating Right Ventricular Systolic Functions in 607 Healthy Children(Brieflands, 2023) Yılmaz M.; Çetin M.; Dundar P.E.; Coşkun Ş.Background: This study aimed to define the normal ranges of echocardiographic parameters that are used to evaluate right ventricular systolic functions. Methods: A total of 607 children within the age range of 0-18 years without any cardiac pathology or chronic disorders were included in the study. The study population was categorized into different age groups and underwent transthoracic echocardiog-raphy. In this study, tricuspid annular plane systolic excursion (TAPSE), tricuspid annular peak systolic velocity (TAPSV), and right ventricular myocardial performance index (RVMPI) values were measured. Results: There was no statistically significant difference between the mean TAPSE and TAPSV values of male and female subjects. The mean RVMPI was higher in females than in males. The study population was categorized into nine groups according to their age. The TAPSE, TAPSV, and RVMPI values were calculated for each group. Additionally, the 5th, 10th, 25th, 50th, 75th, 90th, and 95th percentiles, and ± 2 standard deviation (SD) and ± 3 SD values of TAPSE measurements were calculated for each age group. The study population was divided into eight groups according to their body surface area (BSA). Moreover, the 5th, 10th, 25th, 50th, 75th, 90th, and 95th percentiles of TAPSE measurements were calculated. There was a strong positive correlation between TAPSE and BSA. The TAPSE was also positively correlated with TAPSV but not with RVMPI. Conclusions: This study determined the normal values for TAPSV and RVMPI. It is important to have knowledge of the normal ranges of these parameters to recognize right ventricular dysfunction early in various cardiac disorders. © 2023, Author(s).