Browsing by Author "Coşkun A.Ş."

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    The effect of nicotine among active, passive smoker health personnel; [Saǧlik çalişanlarinda, aktif ve pasif sigara i̇çicilerde nikotin etkilenim düzeyleri]
    (2009) Temel O.; Coşkun A.Ş.; Gök Ş.; Çelik P.; Yorgancioǧlu A.
    Objective: It is aimed to evaluate the effect of environmental tobacco smoke among active and passive smoker and non-smoker health staff. Material and Method: 209 volunteers were included; age, gender, occupation and smoking habits were recorded. Exhaled air carbon monoxide (CO), urinary cotinine levels and Fagerström Nicotine Tolerance Questionnaire were performed. Results: 106 (55%) of 117 active, 66 (32%) passive smokers and 26 (13%) non-smokers were male and the mean age was 30.3 ± 6.6 (18-55). 56 (27%), 33 (16%), 80 (38%), and 40 (19%) were doctors, nurses, assistant staff and officers respectively. Mean CO level was higher in active smokers (18 ppm) than passive smokers (1.9 ppm) and non-smokers (1.5 ppm) (p=0.001). Mean urinary cotinine level was higher in active smokers (949.5 ng/ml), than passive smokers (11.3 ng/ml) and non-smokers (0.00 ng/ml) (p=0.000). Nicotine consumption in active smokers was positively and significantly related with CO, urine cotinine levels and nicotine dependency (<0.05). Conclusion: It is concluded that environmental tobacco smoke has been found to be very high in hospitals and smoke-free hospital programs should ibe started immediately.
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    Relationship of systemic antiinflammatory markers and functional parameters in chronic obstructive pulmonary disease; [Kronik obstrüktif akciǧer hastalıǧında fonksiyonel paramatrelerle sistemik antiinflamatuar belirteçlerin ilişkisi]
    (AVES, 2011) Satar S.; Alpaydin A.Ö.; Var A.; Coşkun A.Ş.; Çelik P.; Yorgancioǧlu A.
    Objective: Airway inflammation and oxidative stress biomarkers increase in chronic obstructive pulmonary disease (COPD) and this is thought to be related to faster decrease in lung functions. Systemic markers of oxidative stress include nitric oxide (NO) and malonyl dialdehyde (MDA), while antioxidant markers are erythrocyte superoxide dismutase (SOD) and gluthathionperoxidase (GSH-Px). We investigated the relationship between levels of systemic oxidative/antioxidant markers and functional parameters. Material and Method: Fifty-one COPD patients without any systemic inflammation were included in the study. Pulmonary function test parameters were evaluated. 6-minute walk test (6MWT) and dyspnea severity were recorded. Twelve healthy persons in a control group were also included in the study. Venous blood specimens of the patients and the control group were collected and serum NO, MDA and erythrocyte SOD, GSHPx levels were measured. Results: Mean age of the patients were 62.94±10.56 years. When the control group and COPD patients were compared; MDA (p<0.001), NO (p=0.012) and GSH-Px (p=0.012) were significantly higher in the control group than COPD patients. However, when the age factor was controlled, only MDA(p=0.017) was found higher in the control group. As forced expiratory volume in 1st second (FEV1) decreased; NO, SOD, MDA and GSH-Px increased, although there was no statistical significance. Like FEV1, 6MWT and dyspnea severity by VAS did not show any statistical significance with the parameters investigated. Conclusion: From the results, we could not observe the reflections of oxidant/antioxidant imbalance on functional parameters in COPD. This may be due to incomplete systemic response to local disorders as well as the attempts of antioxidant systems to maintain an equilibrium resembling that in healthy individuals.
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    Toll-like receptor 2 expression and peripheral blood CD4+/CD8+ T cell ratio in COPD
    (AVES Ibrahim Kara, 2014) Ulutaş G.Ş.; Alpaydin A.Ö.; Taneli F.; Çetinkaya C.; Ulman C.; Güvenç Y.; Horasan G.D.; Coşkun A.Ş.
    OBJECTIVES: We aimed to evaluate toll-like receptor 2 (TLR-2) expression on monocytes and peripheral blood CD4+/CD8+ T cell ratio, as well as the relationship of these cells with pulmonary functions in chronic obstructive pulmonary disease (COPD) patients. MATERIAL AND METHODS: Forty COPD patients and 40 healthy volunteers were included. Participants were analysed in four groups according to their smoking status. Peripheral blood CD4+ and CD8+ T cells and monocyte TLR-2 expression were measured by flow cytometry in the whole study population. RESULTS: No significant difference was observed in TLR-2 expression, number of CD4+ and CD8+ T cells, and CD4+/CD8+ T cell ratio between the study groups. CD4+/CD8+ T cell ratio and FEV1/FVC were found to have a mild positive correlation (r=0.295, p=0.022). A mild negative correlation was observed between smoking intensity and CD4+/CD8+ T cell ratio (r=-0.274, p=0.034). CONCLUSION: We demonstrated a mild correlation between pulmonary functions and peripheral blood CD4+/CD8+ T cell ratio. However, we did not find a significant difference in TLR-2 expression of CD14+ monocytes in patients with airway obstruction. © 2014 by Turkish Thoracic Society.
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    Smoking prevalence of elementary school students in Manisa; [Manisa ili ilköğretim öğrencilerinde sigara içme prevalansı]
    (Ankara University, 2018) Alkaç Ç.; Çelik P.; Özyurt B.C.; Coşkun A.Ş.; Alpaydın A.Ö.; Göktalay T.; Demet M.; Yorgancıoğlu A.A.
    Introduction: In this study it is aimed to evaluate the prevalence of smoking, factors affecting smoking status, and the attitudes of the elementary school students towards the smoking prohibition law which was approved in July 2009, in city. Materials and Methods: The universe of this descriptive study was 6 th -7 th -8 th class, 8236 urban and 4937 semi-urban, total 13.173 elementary schools students in city center. Study population was determined on the basis of a previous study in which the smoking trial prevalence was found 17.5%, 831 students in 6 urban 3 semi-urban, total 9 schools were chosen randomly. A questionnaire was prepared investigating smoking status, the effects of smoking and family history. Among the 9 chosen schools, the questionnaire was applied to 615 students. SPSS 14.0 statistical package was used. Results: Forty-seven percentages of the students were female. Prevalence of smoking trial was found 23.5% (16% in urban, 35% in semi-urban schools) while the prevalence of smoking was 7.1% (1.7% in urban, 15.7% in semi-urban schools). Mean age of first smoking trial was 10.04 ± 2.3. The smoking prohibition law was supported by 86.6% of the students, the warnings on the cigarette package was thought to be effective by 43.3% students and 35.2% of the students were exposed to passive smoke. Male gender, social status, education level of the family, smoker family member or close friends were found to be important risk factors for smoking prevalence of the students. Conclusion: The early onset of smoking should guide the smoking struggle be concentrated in elementary school especially in semi-urban areas where the smoking prevalence is high. © 2018, Ankara University. All rights reserved.
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    Use of tobacco products in turkish children and young people: Is there an alarm for hookah use?
    (AVES, 2020) Göktalay T.; Coşkun A.Ş.; Havlucu Y.; Horasan G.D.
    OBJECTIVES: In the recent years, it has been observed that the use of hookah, a tobacco product, has increased in children and young people in Turkey. This study was conducted to determine the prevalence of cigarette and hookah use in children and young people specific to age and gender and to define the factors relevant to the use of hookah. MATERIALS AND METHODS: The study was conducted with secondary/high school students between 11 and 17 years of age (Survey 1, n=4718) and with university students between 18 and 23 years of age (Survey 2, n=1588) as two groups, which made a total of 6306 students. The students were asked to fill in a questionnaire which consisted of questions about socio-demographic data and the use of tobacco and tobacco products. RESULTS: It was determined that the use of cigarette and hookah was high in males, and it increased as the age increased in both genders (p<0.05). It was also determined that parents and friends using cigarette and hookah affected the use of cigarette and hookah in the study groups in both surveys (p<0.05). Additionally, it was determined that the educational level of the parents and being of a high social class were the social determiners of hookah use (p<0.05). CONCLUSION: It is important that we fight against the use of all tobacco products, especially in young people. Education about the damages of tobacco and applying tobacco products should start at an early age, and accurate tobacco control models may provide support in this field. © 2020 by Turkish Thoracic Society.
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    Clinical Course of Coronavirus disease 2019 C-19 in Patients with Bronchiectasis
    (AVES, 2024) Edis E.Ç.; Çilli A.; Kızılırmak D.; Coşkun A.Ş.; Sayıner A.; Çiçek S.; Gülmez İ.; Ağca M.Ç.; Çağlayan B.; Özçelik N.; Köktürk N.; Ocaklı B.; Uçan E.S.; Günlüoğlu G.; Niksarlıoğlu Y.; Zamani A.; Berk S.; Barış S.A.; Başyiğit İ.; Gülhan P.Y.; Kabak M.; Çolak M.; Toprak O.B.; Berk H.; Oğuzülgen K.; Demirdöğen E.; Eyüboğlu F.Ö.; Havlucu Y.; Babayiğit C.
    OBJECTIVE: Coronavirus disease 2019 (COVID-19) has affected the whole world and caused the death of more than 6 million people. The disease has been observed to have a more severe course in patients with chronic lung diseases. There are limited data regarding COVID-19 in patients with bronchiectasis. The aim of this article is to investigate the course of COVID-19 and factors affecting the clinical outcome in patients with bronchiectasis. MATERIAL AND METHODS: This study was conducted using the Turkish Adult Bronchiectasis Database (TEBVEB) to which 25 centers in Türkiye contributed between March 2019 and January 2022. The database consisted of 1035 patients, and COVID-19-related data were recorded for 606 patients. RESULTS: One hundred nineteen (19.6%) of the bronchiectasis patients (64 female, mean age 57.3 ± 13.9) had COVID-19. Patients with bronchiectasis who developed COVID-19 more frequently had other comorbidities (P = .034). They also more frequently had cystic bron-chiectasis (P = .009) and their Bronchiectasis Severity Index was significantly higher (P = .019). Eighty-two (68.9%) of the patients who had COVID-19 were followed up in the outpatient clinic, 27 (22.7%) in the inpatient ward and 10 (8.4%) patients in the intensive care unit. There tended to be a higher percentage of males among patients admitted to the hospital (P = .073); similarly, the mean age of the patients admitted to the hospital was also higher (60.8 vs 55.8 years for the outpatients), but these differences did not reach statistical significance (P = .071). CONCLUSION: In conclusion, this study showed that severe bronchiectasis, presence of cystic bronchiectasis and worse Bronchiectasis Severity Index are associated with the development of COVID-19, but not with the severity of infection. © 2024, AVES. All rights reserved.
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    Bronchiectasis in Türkiye: Data from a Multicenter Registry (Turkish Adult Bronchiectasis Database)
    (Galenos Publishing House, 2024) Edis E.Ç.; Çilli A.; Kızılırmak D.; Coşkun A.Ş.; Güler N.; Çiçek S.; Sevinç C.; Ağca M.Ç.; Gülmez İ.; Çağlayan B.; Kabak M.; Niksarlıoğlu E.Y.Ö.; Köktürk N.; Sayıner A.
    Background: Bronchiectasis is a chronic lung disease characterized by permanent bronchial wall dilatation. Although it has been known as an orphan disease, it has recently gained attention because of registry-based studies and drug research. Aims: We aimed to use a multicenter database to analyze and compare data regarding the etiology, associated comorbidities, microbiological characteristics, and preventive strategies of bronchiectasis in Türkiye to those of other countries. Study Design: A multicenter prospective cohort study. Methods: The multicenter, prospective cohort study was conducted between March 2019 and January 2022 using the Turkish Adult Bronchiectasis Database, in which 25 centers in Türkiye participated. Patients aged > 18 years who presented with respiratory symptoms such as cough, sputum, and dyspnea and were diagnosed with non-cystic fibrosis bronchiectasis using computed tomography were included in the study. Demographic information, etiologies, comorbidities, pulmonary functions, and microbiological, radiological, and clinical data were collected from the patients. Results: Of the 1,035 study participants, 518 (50%) were females. The mean age of the patients was 56.1 ± 16.1 years. The underlying etiology was detected in 565 (54.6%) patients. While postinfectious origin was the most common cause of bronchiectasis (39.5%), tuberculosis was identified in 11.3% of the patients. An additional comorbidity was detected in 688 (66.5%) patients. The most common comorbidity was cardiovascular disease, and chronic obstructive pulmonary disease (COPD) and bronchiectasis was identified in 19.5% of the patients. The most commonly detected microbiological agent was Pseudomonas aeruginosa (29.4%). Inhaled corticosteroids (ICS) were used in 70.1% of the patients, and the frequency of exacerbations in the last year was significantly higher in patients using ICS than in nonusers (p < 0.0001). Age [odds ratio (OR): 1.028; 95% confidence interval (CI): 1.005-1.051], cachexia (OR: 4.774; 95% CI: 2,054-11,097), high modified medical research council dyspnea scale score (OR: 1,952; 95% CI: 1,459-2,611), presence of chronic renal failure (OR: 4,172; 95% CI: 1,249-13,938) and use of inhaled steroids (OR: 2,587; 95% CI: 1,098-6,098) were significant risk factors for mortality. Mortality rates were higher in patients with COPD than in those with no COPD (21.7-9.1%, p = 0.016). Patients with bronchiectasis and COPD exhibited more frequent exacerbations, exacerbation-related hospitalizations, and hospitalization in the intensive care unit in the previous year than patients without COPD. Conclusion: This is the first multicenter study of bronchiectasis in Türkiye. The study results will provide important data that can guide the development of health policies in Türkiye on issues such as infection control, vaccination, and the unnecessary use of antibiotics and steroids. © Author(s).