Browsing by Author "Coşkun M."

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    Second-line drug susceptibilities of multidrug-resistant Mycobacterium tuberculosis isolates in Aegean Region - Turkey
    (2008) Özkütük N.; Sürücüoǧlu S.; Gazi H.; Coşkun M.; Özkütük A.; Özbakkaloǧlu B.
    Aim: The emergence of multidrug-resistant tuberculosis (MDR-TB) is increasing, and the standard shortcourse regimen used for the treatment of TB is likely to be ineffective against MDR-TB, leading to the need for second-line drugs. In such situations, drug susceptibility testing is necessary to select an appropriate treatment regimen. Unfortunately, there are few studies showing the pattern of the second-line drug resistance in Turkey. We aimed to analyze the resistance to second-line anti-tuberculosis drugs of MDR strains of Mycobacterium tuberculosis isolated from the Aegean region of Turkey. Materials and Methods: In this study, drug susceptibility testing of 40 MDR-TB strains isolated from the Aegean region of Turkey was performed using the BACTEC 460 TB radiometric system. Capreomycin, ethionamide, kanamycin, amikacin, clofazimine and ofloxacin were tested in 1.25 μg/ml, 1.25 μg/ml, 5.0 μg/ml, 1.0 μg/ml, 0.5 μg/ml, and 2.0 μg/ml concentrations, respectively. Results: The results showed that 37.5% of the strains were resistant to ethionamide, 25% to capreomycin, 5% to kanamycin, amikacin and ofloxacin, and 2.5% to clofazimine. One (2.5%) of the 40 MDR-TB cases was defined as extensively drug-resistant tuberculosis (XDR-TB). Conclusions: The results of the study indicate that the high rates of resistance to ethionamide and capreomycin may be a problem in the treatment of patients with MDR-TB; XDR-TB is not yet a serious problem in our region. © TÜBİTAK.
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    The prevalence of childhood psychopathology in Turkey: a cross-sectional multicenter nationwide study (EPICPAT-T)
    (Taylor and Francis Ltd, 2019) Ercan E.S.; Polanczyk G.; Akyol Ardıc U.; Yuce D.; Karacetın G.; Tufan A.E.; Tural U.; Aksu H.; Aktepe E.; Rodopman Arman A.; Başgül S.; Bılac O.; Coşkun M.; Celık G.G.; Karakoc Demırkaya S.; Dursun B.O.; Durukan İ.; Fidan T.; Perdahlı Fiş N.; Gençoğlan S.; Gökçen C.; Görker I.; Görmez V.; Gündoğdu Ö.Y.; Gürkan C.K.; Hergüner S.; Tural Hesapçıoğlu S.; Kandemir H.; Kılıç B.G.; Kılınçaslan A.; Mutluer T.; Nasiroğlu S.; Özel Özcan Ö.; Öztürk M.; Öztop D.; Yalın Sapmaz S.; Süren S.; Şahin N.; Yolga Tahıroglu A.; Toros F.; Ünal F.; Vural P.; Perçinel Yazıcı İ.; Yazıcı K.U.; Yıldırım V.; Yulaf Y.; Yüce M.; Yüksel T.; Akdemir D.; Altun H.; Ayık B.; Bilgic A.; Hekim Bozkurt Ö.; Demirbaş Çakır E.; Çeri V.; Üçok Demir N.; Dinç G.; Irmak M.Y.; Karaman D.; Kınık M.F.; Mazlum B.; Memik N.Ç.; Foto Özdemir D.; Sınır H.; Ince Taşdelen B.; Taşkın B.; Uğur Ç.; Uran P.; Uysal T.; Üneri Ö.; Yilmaz S.; Seval Yılmaz S.; Açıkel B.; Aktaş H.; Alaca R.; Alıç B.G.; Almaidan M.; Arı F.P.; Aslan C.; Atabay E.; Ay M.G.; Aydemir H.; Ayrancı G.; Babadagı Z.; Bayar H.; Çon Bayhan P.; Bayram Ö.; Dikmeer Bektaş N.; Berberoğlu K.K.; Bostan R.; Arıcı Canlı M.; Cansız M.A.; Ceylan C.; Coşkun N.; Coşkun S.; Çakan Y.; Demir İ.; Demir N.; Yıldırım Demirdöğen E.; Doğan B.; Dönmez Y.E.; Dönder F.; Efe A.; Eray Ş.; Erbilgin S.; Erden S.; Ersoy E.G.; Eseroğlu T.; Kına Fırat S.; Eynallı Gök E.; Güler G.; Güles Z.; Güneş S.; Güneş A.; Günay G.; Gürbüz Özgür B.; Güven G.; Çelik Göksoy Ş.; Horozcu H.; Irmak A.; Işık Ü.; Kahraman Ö.; Kalaycı B.M.; Karaaslan U.; Karadağ M.; Kılıc H.T.; Kılıçaslan F.; Kınay D.; Kocael Ö.; Bulanık Koç E.; Kadir Mutlu R.; Lushi-Şan Z.; Nalbant K.; Okumus N.; Özbek F.; Akkuş Özdemir F.; Özdemir H.; Özkan S.; Yıldırım Özyurt E.; Polat B.; Polat H.; Sekmen E.; Sertçelik M.; Sevgen F.H.; Sevince O.; Süleyman F.; Shamkhalova Ü.; Eren Şimşek N.; Tanır Y.; Tekden M.; Temtek S.; Topal M.; Topal Z.; Türk T.; Uçar H.N.; Uçar F.; Uygun D.; Uzun N.; Vatansever Z.; Yazgılı N.G.; Miniksar Yıldız D.; Yıldız N.
    Aim: The aim of this study was to determine the prevalence of childhood psychopathologies in Turkey. Method: A nation-wide, randomly selected, representative population of 5830 children (6–13 years-old) enrolled as a 2nd,3rd or 4th grade student in 30 cities were evaluated for presence of a psychiatric or mental disorder by a Sociodemographic Form, Kiddie Schedule for Affective Disorders and Schizophrenia for School Age Children-Present and Lifetime Version (K-SADS-PL), and DSM-IV-Based Screening Scale for Disruptive Behavior Disorders in Children and Adolescents scales. Impairment criterion was assessed via a 3 point-Likert scale by the parent and the teacher independently. Results: Overall prevalence of any psychopathology was 37.6% without impairment criterion, and 17.1% with impairment criterion. Attention-deficit hyperactivity disorder was the most frequent diagnosis, followed by anxiety (19.5% and 16.7% without impairment, 12.4% and 5.3% with impairment, respectively). Lower education level and presence of a physical or psychiatric problem of the parents were independent predictors of any psychopathology of the offspring. Conclusion: This is the largest and most comprehensive epidemiological study to determine the prevalence of psychopathologies in children and adolescents in Turkey. Our results partly higher than, and partly comparable to previous national and international studies. It also contributes to the literature by determining the independent predictors of psychopathologies in this age group. © 2019, © 2019 The Nordic Psychiatric Association.
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    Effect of Impairment on the Prevalence and Comorbidities of Attention Deficit Hyperactivity Disorder in a National Survey: Nation-Wide Prevalence and Comorbidities of ADHD
    (SAGE Publications Inc., 2022) Ercan E.S.; Unsel-Bolat G.; Tufan A.E.; Karakoc Demirkaya S.; Bilac O.; Celik G.; Kılıç B.G.; Akyol Ardic U.; Yalin Sapmaz S.; Aksu H.; Yolga Tahiroglu A.; Karacetin G.; Tural U.; Aktepe E.; Rodopman Arman A.; Başgül S.; Coşkun M.; Dursun O.B.; Durukan İ.; Perdahli Fiş N.; Gençoğlan S.; Gökçen C.; Sarı Gokten E.; Görker I.; Görmez V.; Yıldız Gündoğdu Ö.; Hesapçioğlu S.T.; Kandemir H.; Mutluer T.; Nasiroğlu S.; Özcan Ö.; Şahin N.; Toros F.; Perçinel Yazici İ.; Yazici K.U.; Yulaf Y.; Yüksel T.; Bilgic A.; Altun H.; Akdemir D.; Mazlum B.; Çakın Memik N.; Foto Özdemir D.; Üneri Ö.; Ünal F.
    Objective: This study aimed to determine the prevalence and comorbidities of attention-deficit hyperactivity disorder (ADHD) by evaluating a large-scale nation-wide sample of children. Method: The inclusion criterion was being enrolled as a 2nd, 3rd, or 4th-grade student. A semi-structured diagnostic interview (K-SADS-PL), DSM-IV-Based Screening Scale for Disruptive Behavior Disorders, and assessment of impairment (by both parents and teachers) were applied to 5,842 participants. Results: The prevalence of ADHD was 19.5% without impairment and 12.4% with impairment. Both ADHD with and without impairment groups had similar psychiatric comorbidity rates except for oppositional defiant disorder (ODD) and conduct disorder (CD) diagnoses. Impairment in the ADHD group resulted in significantly higher ODD and CD diagnoses. Conclusion: Even when impairment is not described, other psychiatric disorders accompany the diagnosis of ADHD and may cause impairment in the future. Impairment in the diagnosis of ADHD significantly increases the likelihood of ODD and CD. © ©The Author(s) 2021.