Browsing by Author "Coşkun S."

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    Diagnosis of asymptomatic atrial septal aneurysms using two-dimensional color Doppler and contrast transthoracic echocardiography
    (2003) Coşkun S.; Sekuri C.; Bayturan Ö.; Yüksel H.; Saribülbül O.; Bilge A.
    Objective. To evaluate the dimensions of atrial septal aneurysm (ASA), the presence and characteristics of interatrial shunt, the movement of the wall of the aneurysm, and correlation between these findings and sign and/or symptoms suggesting embolism in Manisa, a district of a western Anatolian city of Turkey. Methods. Two thousand five hundred cases were examined by routine transthoracic echocardiography (TTE) in both pediatric and adult cardiology outpatient clinics. ASA was detected in 20 cases and evaluated by two-dimensional color Doppler echocardiography (CDE). The length of the base, the maximum radius and the maximum displacement of ASA were measured. The shunt between the atria was examined by CDE. In cases where a shunt could not be found, galactose and palmitic acid was injected. Standard 12-lead electrocardiogram (ECG) and exercise stress test were also performed. Results. No clinical signs or symptoms were found, suggesting a systemic or cerebral embolism. The maximum displacement of ASA was between 2 and 5 mm. All of the aneurysms were localized in the right atrium, and the walls of the aneurysm did not move beyond the base of the left atrium during the maximum displacement. Interatrial shunt was detected in 14 of 20 patients (70%) by CDE and in the remaining six cases by contrast TTE. Frequent ventricular ectopic beats were observed in one patient. Conclusion. During routine TTE we observed 0.8% asymptomatic ASA in our population. The use of a contrast agent was found to be a valuable additional method in patients with ASA when the shunt could not be detected by CDE. The risk for embolism is not high when the maximum displacement of the wall of ASA was 5 mm or less and no bulge into the left atrium was observed. Based on our experience with this method, TTE is easy to perform, well-tolerated and acceptable.
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    A province-based study using sampling method to investigate the prevalence of cystic echinococcosis among primary school children in Manisa, Turkey
    (2007) Ok U.Z.; Özkol M.; Kilimcioǧlu A.A.; Dinç G.; Bayindir P.; Östan I.; Pabuşçu Y.; Özcan C.; Korkmaz M.; Coşkun S.; Yüksel H.; Girginkardeşler N.
    A province-based field study using a portable ultrasound scanner (US) was performed for the first time using sampling method to investigate the prevalence of cystic echinococcosis (CE) in primary school children in Manisa, Turkey. A total of 6093 children from 37 primary schools was selected as the representative sample of the total number of 166,766 primary school children, and examined by the US. Prevalence was found to be 0.15%, as nine children were diagnosed with CE, seven new and two previously operated. A questionnaire applied to the children revealed no significant relationship between the risk factors and the infection (P > 0.05). In conclusion, it would be advisable to repeat the study at the same schools in eight years' time, in order to evaluate the efficacy of the control programs, since nearly all students involved in this study will have graduated by then. Besides, it is recommended to choose a sampling group to find the prevalence of an infection in a defined region. © 2007 Elsevier B.V. All rights reserved.
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    Exercise test results of children with family history of hypertension; [Ailede Hipertansiyon Öyküsü Olan Çocuklarin Egzersiz Testi Yanitlari]
    (2013) Yilmaz M.; Pirim U.; Çetin M.; Kiremitçi S.; Coşkun S.
    Objective: Early detection of high blood pressure in children with family history of hypertension that can not be determined during rest, is important for early treatment and prevention of complications. Exercise test is a noninvasive and inexpensive method that can detect the increases in blood pressure due to exercise. Therefore, the aim of this study is to determine the differences in blood pressure response to exercise test between children with family history of hypertension and children without a risk factor and to evaluate the exercise recommendation in the light of these findings. Material and Methods: This study enrolled 60 normotensive aged 8-16 years. Thirty children with family history of hypertension formed the disease group while thirty without family history formed the control group. Echocardiography, resting blood pressure measurement and exercise test were performed. Results: Mean ages of the children in disease and control groups were 12.0±2.8 years and 11.7±1.8 years, respectively (p=0.58; CI:-0.88-1.55). Resting systolic blood pressure was significantly higher in the disease group compared to the control group (99.5±6.7 mmHg and 95.3 ± 8.0, mmHg respectively; p=0.03; CI=0.38-8.02). Mean diastolic blood pressures were not different among the groups (p=0.53; CI=-1.51-2.91). Maximal heart rate during exercise test was significantly higher in the disease group compared to the control group (181.5±20.3/min and 170.4±22.7/min, respectively; p=0.05; CI=0.01-22.3). Mean maximal systolic and diastolic blood pressures during exercise test children in disease and control groups were 147.8 ± 18.5 mmHg, 80.7±12.2 mmHg and 151.5±20.4 mmHg, 79.4±16.1 mmHg respectively. Blood pressures during exercise test were not significantly different between the groups (p= 0.47; p=0.72). Conclusion: The results of this study demonsrate that systolic and diastolic blood pressure responses of the normotensive children with and without family history of hypertension to exercise are not different. Also no complications were observed children during exercise test. Therefore, it was thought that exercise restriction is not required in children with family history of hypertension. Copyright © 2013 by Türkiye Klinikleri.
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    The prevalence of childhood psychopathology in Turkey: a cross-sectional multicenter nationwide study (EPICPAT-T)
    (Taylor and Francis Ltd, 2019) Ercan E.S.; Polanczyk G.; Akyol Ardıc U.; Yuce D.; Karacetın G.; Tufan A.E.; Tural U.; Aksu H.; Aktepe E.; Rodopman Arman A.; Başgül S.; Bılac O.; Coşkun M.; Celık G.G.; Karakoc Demırkaya S.; Dursun B.O.; Durukan İ.; Fidan T.; Perdahlı Fiş N.; Gençoğlan S.; Gökçen C.; Görker I.; Görmez V.; Gündoğdu Ö.Y.; Gürkan C.K.; Hergüner S.; Tural Hesapçıoğlu S.; Kandemir H.; Kılıç B.G.; Kılınçaslan A.; Mutluer T.; Nasiroğlu S.; Özel Özcan Ö.; Öztürk M.; Öztop D.; Yalın Sapmaz S.; Süren S.; Şahin N.; Yolga Tahıroglu A.; Toros F.; Ünal F.; Vural P.; Perçinel Yazıcı İ.; Yazıcı K.U.; Yıldırım V.; Yulaf Y.; Yüce M.; Yüksel T.; Akdemir D.; Altun H.; Ayık B.; Bilgic A.; Hekim Bozkurt Ö.; Demirbaş Çakır E.; Çeri V.; Üçok Demir N.; Dinç G.; Irmak M.Y.; Karaman D.; Kınık M.F.; Mazlum B.; Memik N.Ç.; Foto Özdemir D.; Sınır H.; Ince Taşdelen B.; Taşkın B.; Uğur Ç.; Uran P.; Uysal T.; Üneri Ö.; Yilmaz S.; Seval Yılmaz S.; Açıkel B.; Aktaş H.; Alaca R.; Alıç B.G.; Almaidan M.; Arı F.P.; Aslan C.; Atabay E.; Ay M.G.; Aydemir H.; Ayrancı G.; Babadagı Z.; Bayar H.; Çon Bayhan P.; Bayram Ö.; Dikmeer Bektaş N.; Berberoğlu K.K.; Bostan R.; Arıcı Canlı M.; Cansız M.A.; Ceylan C.; Coşkun N.; Coşkun S.; Çakan Y.; Demir İ.; Demir N.; Yıldırım Demirdöğen E.; Doğan B.; Dönmez Y.E.; Dönder F.; Efe A.; Eray Ş.; Erbilgin S.; Erden S.; Ersoy E.G.; Eseroğlu T.; Kına Fırat S.; Eynallı Gök E.; Güler G.; Güles Z.; Güneş S.; Güneş A.; Günay G.; Gürbüz Özgür B.; Güven G.; Çelik Göksoy Ş.; Horozcu H.; Irmak A.; Işık Ü.; Kahraman Ö.; Kalaycı B.M.; Karaaslan U.; Karadağ M.; Kılıc H.T.; Kılıçaslan F.; Kınay D.; Kocael Ö.; Bulanık Koç E.; Kadir Mutlu R.; Lushi-Şan Z.; Nalbant K.; Okumus N.; Özbek F.; Akkuş Özdemir F.; Özdemir H.; Özkan S.; Yıldırım Özyurt E.; Polat B.; Polat H.; Sekmen E.; Sertçelik M.; Sevgen F.H.; Sevince O.; Süleyman F.; Shamkhalova Ü.; Eren Şimşek N.; Tanır Y.; Tekden M.; Temtek S.; Topal M.; Topal Z.; Türk T.; Uçar H.N.; Uçar F.; Uygun D.; Uzun N.; Vatansever Z.; Yazgılı N.G.; Miniksar Yıldız D.; Yıldız N.
    Aim: The aim of this study was to determine the prevalence of childhood psychopathologies in Turkey. Method: A nation-wide, randomly selected, representative population of 5830 children (6–13 years-old) enrolled as a 2nd,3rd or 4th grade student in 30 cities were evaluated for presence of a psychiatric or mental disorder by a Sociodemographic Form, Kiddie Schedule for Affective Disorders and Schizophrenia for School Age Children-Present and Lifetime Version (K-SADS-PL), and DSM-IV-Based Screening Scale for Disruptive Behavior Disorders in Children and Adolescents scales. Impairment criterion was assessed via a 3 point-Likert scale by the parent and the teacher independently. Results: Overall prevalence of any psychopathology was 37.6% without impairment criterion, and 17.1% with impairment criterion. Attention-deficit hyperactivity disorder was the most frequent diagnosis, followed by anxiety (19.5% and 16.7% without impairment, 12.4% and 5.3% with impairment, respectively). Lower education level and presence of a physical or psychiatric problem of the parents were independent predictors of any psychopathology of the offspring. Conclusion: This is the largest and most comprehensive epidemiological study to determine the prevalence of psychopathologies in children and adolescents in Turkey. Our results partly higher than, and partly comparable to previous national and international studies. It also contributes to the literature by determining the independent predictors of psychopathologies in this age group. © 2019, © 2019 The Nordic Psychiatric Association.
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    MicroRNA dysregulation in manic and euthymic patients with bipolar disorder
    (Elsevier B.V., 2020) Camkurt M.A.; Karababa İ.F.; Erdal M.E.; Kandemir S.B.; Fries G.R.; Bayazıt H.; Ay M.E.; Kandemir H.; Ay Ö.I.; Coşkun S.; Çiçek E.; Selek S.
    Background: Bipolar disorder (BPD) is a major psychiatric disorder with an unclear pathophysiology. Peripheral blood samples are easily drawn, making them are good candidates for diagnosing diseases. MicroRNAs are small non-coding RNA transcripts that regulate gene expression by binding to the 3′- UTR of mRNAs and directing their degradation. The aim of this study was to use blood plasma to investigate microRNA dysregulations in bipolar manic and euthymic patients. Subjects and Methods: Blood samples were collected from 58 patients with bipolar I disorder (19 manic, 39 euthymic) and 51 healthy controls. Results: Four microRNAs (miR-29a-3p, p = 0.035; miR-106b-5p, p = 0.014; miR-107, p = 0.011; and miR-125a-3p, p = 0.014) were upregulated in the entire bipolar group, compared to the healthy controls. Seven microRNAs (miR-9-5p, p = 0.032; miR-29a-3p, p = 0.001; miR-106a-5p, p = 0.034; miR-106b-5p, p = 0.003; miR-107, p < 0.001; miR-125a-3p, p = 0.016; and miR-125b-5p, p = 0.004) were more upregulated in bipolar manic patients compared to the healthy controls, and two microRNAs (miR-106a-5p, p = 0.013, and miR-107, p = 0.021) showed statistically significant upregulation in the manic patients compared to the euthymic patients. Conclusions: Our results showed greater miRNA dysregulation in the manic patients than in the euthymic patients. Two microRNAs could be more selective for bipolar manic episodes. Future studies should include depressive patients along with euthymic and manic patients. © 2019
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    Analyses of damaged effects on jacket type offshore platform; [Analize učinaka oštećenja na rešetkasto postolje izvanobalne platforme]
    (Croatian Association of Civil Engineers, 2023) Gücüyen E.; Coşkun S.; Tuğrul Erdem R.
    In this paper, an offshore platform subjected to dynamic loading for different damage cases was modelled via fluid-structure interaction (FSI) analysis. Different damage models were considered in the case where one leg was broken, and the Young’s modulus of the damaged member was reduced with four different severity ratios. In addition to the five damaged structures, the undamaged structure was modelled according to two different leg spacing conditions. Thus, the damaged models were compared among themselves as well as with undamaged models. In this study, models were investigated using a numerical FSI technique. The numerical technique was verified using semi-analytical modelling. At this stage, the equation of motion of one of the structural models was solved using a semi-analytical method based on a multi-degree-of-freedom system. In addition, the numerical environment model was verified using a semi-analytical solution of the free-surface motion equation and the wave velocity-wave force curve. An Abaqus finite-element analysis program was used to model the structures and their surroundings. While the structures were modelled using the Lagrangian technique, the fluid surroundings were modelled using the Eulerian technique. Both the conditions of leg spacing and different severity ratios were modelled, and the most negative damage type was revealed. © 2023, Croatian Association of Civil Engineers. All rights reserved.