Browsing by Author "Colak H."

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    Correlation of the Volume Control Parameters with Health Related Quality of Life in Renal Transplant Patients
    (Elsevier USA, 2015) Colak H.; Sert I.; Ekmekci C.; Tugmen C.; Kurtulmus Y.; Kursat S.; Töz H.
    Introduction Transplantation is the most effective treatment strategy for end-stage renal failure. We aimed to investigate the correlation of volume control parameters with health-related quality of life (HRQoL) in renal transplantation patients during the pre- and post-transplantation periods. Material and Methods Seventy-seven patients who underwent renal transplantation from deceased donors between January 2011 and January 2013 were included in the study. The biochemical markers, complete blood count, and creatinine levels were measured during pretransplantation and at post-transplantation month 6. The Turkish version of the Short Form 36 (SF-36) health survey questionnaire was used for the assessment of HRQoL. Blood pressure (BP) and echocardiographic measurements were used to evaluate the volume status. Results Significant improvements were achieved in all echocardiographic measurements, biochemical parameters except Ca++, and SF-36 questionnaire domain scores (DSs) except vitality in the post-transplantation period. Systolic BP (SBP), the left atrium index, vena cava inferior collapsibility index (VCCI), and diastolic BP were associated with vitality (P =.02,.03,.05, and.04, respectively); SBP was associated with social functioning (P <.01) and role emotional (P <.01); and left ventricular mass index was associated with mental health (P =.05) DSs during the pretransplantation period. In the post-transplantation period, VCCI, left ventricular mass index, and SBP were associated with general health (P =.02,.05, and.05, respectively); VCCI and SBP were also associated with mental health (P =.05 and.01, respectively); and left atrium index was associated with role emotional (P =.05) DSs. Conclusion Concomitant improvement in the volemic status may contribute to improvements in HRQoL after renal transplantation. © 2015 Elsevier Inc. All rights reserved.
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    Allergic rhinitis and its relationship with autoimmune thyroid diseases
    (OceanSide Publications Inc., 2015) Degirmenci P.B.; Kirmaz C.; Oz D.; Bilgir F.; Ozmen B.; Degirmenci M.; Colak H.; Yilmaz H.; Ozyurt B.
    Background: Autoimmune thyroid diseases are the most common of all autoimmune diseases. In the literature, Hashimoto thyroiditis (HT) is considered to be a T-helper (Th) type 1 dominant condition, and Graves disease is considered a Th2-dominant condition. Objective: The aim of this study was to highlight a new aspect of the relationships among Th cell subgroups by determining the incidence of autoimmune thyroid disease in patients with allergic rhinitis (AR). Methods: Patients were diagnosed with AR based on their medical histories, physical examinations, and skin-prick test results in an outpatient clinic. The levels of free triiodothyronine, free thyroxine, thyroid-stimulating hormone, thyroid peroxidase antibodies, and thyroglobulin antibodies were measured in peripheral blood samples from all study subjects. Results: A total of 1239 patients with AR and 700 consecutive, age- and sex-matched healthy subjects were included in the study. Thyroid function tests showed that 1037 patients with AR (83.7%) had normal thyroid function, 171 (13.8%) had euthyroid HT, and 31 (2.5%) had hypothyroid HT. Among the control subjects, thyroid function test results showed that 688 subjects (98.2%) had normal thyroid function, 10 subjects (1.4%) had euthyroid HT, and 2 subjects(0.4%) had hypothyroid HT. Conclusion: The incidence of HT in the general population is 1.5%; in contrast, it was observed in 16.3% of our patients with AR, which represented a much higher rate than that in the overall population. Graves disease was not detected in our study subjects. A high incidence of HT in patients with AR, in which Th2 responses are dominant, indicates that further studies of the relationships among atopy, autoimmune diseases, and Th cell subgroups are needed. Copyright © 2015, OceanSide Publications, Inc., U.S.A.
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    Allergic rhinitis and its relationship with IL-10, IL-17, TGF-β, IFN-γ, IL 22, and IL-35
    (Hindawi Limited, 2018) Degirmenci P.B.; Aksun S.; Altin Z.; Bilgir F.; Arslan I.B.; Colak H.; Ural B.; Kahraman D.S.; Diniz G.; Ozdemir B.; Kırmaz C.
    Background. We aimed in our study to research the role of new cytokines such as IL-35, IL-22, and IL-17 that may form a target for novel treatment approaches. Methods. IL-10, IL-17, TGF-β, IFN-γ, IL-22, and IL-35 serum levels of allergic rhinitis (AR) patients were measured using ELISA method. Allergic sensitization was demonstrated by the skin prick test. Patients only with olive tree sensitivity were evaluated for seasonal AR (SAR). Patients only with mite sensitivity were included in the study for perennial AR (PAR). AR clinic severity was demonstrated by the nasal symptom scores (NSS). Results. In total, 65 AR patients (patient group), having 31 PAR and 34 SAR patients, and 31 healthy individuals (control group) participated in the study. Cytokine levels between the patient group and the control group were compared; IL-17 (p = 0 038), IL-22 (p = 0 001), and TGF-β (p = 0 031) were detected as high in the patient group, and IFN-γ (p < 0 001) was detected as low in the patient group. When correlation analysis was made between age, gender, prick test result, NSS, AR duration, and cytokine levels in the patient group, a negative correlation was detected only between IFN-γ (p = 0 032/r = −0 266) level and NSS. Conclusions. Accompanied by the literature information, these results made us think that T cell subgroups and cytokines have an important role in AR immunopathogenesis. It is thought that future studies to be conducted relating to this subject will form new targets in treatment. Copyright © 2018 P. Bayrak Degirmenci et al.