Browsing by Author "Daǧlar Z."

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    Congenital midline cervical cleft: A rare embryo pathogenic disorder
    (2002) Genç A.; Taneli C.; Arslan O.A.; Daǧlar Z.; Mir E.
    Congenital midline cervical cleft (CMCC) is a rare disorder of the ventral neck. The cleft consists of an epithelium-covered, longitudinal central depression with a protuberance at the cervical end. The adjacent skin is tethered by scar tissue forming a depression, which ends in a blind sinus at the caudal end. Although a variety of embryological mechanisms are proposed, its etiology is obscure. Up to the present time, fewer than 50 cases have been reported in the English literature. CMCC can be seen in association with several midline anomalies related to the branchial arches, including median cleft of the lower lip and mandible, and hypoplasia or absence of other midline neck structures. We present a 36-day-old boy with CMCC to illustrate its clinical presentation and the result at 24 months postoperatively. © Springer-Verlag 2002.
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    MURCS association and rectovestibular fistula: Case report of a patient treated with one-stage posterior sagittal anorectoplasty and sigmoid loop vaginoplasty
    (W.B. Saunders, 2003) Günşar C.; Genç A.; Şencan A.; Daǧlar Z.; Alparslan O.; Mir E.
    MURCS association is rare, first described by Duncan in 1979, including nonrandom association of Mullerian duct aplasia or hypoplasia (MU), renal agenesis or ectopy (R), and cervicothoracic somite dysplasia. A 5-year-old girl was admitted to the clinic with a complaint of anteriorly located anus. Physical and radiologic examination of the patient found MURCS association with anorectal malformation (ARM) of rectovestibular-type fistula. She had multiple vertebral anomalies, left renal agenesis, vaginal and uterine agenesia, with a normal female 46,XX karyotype. Posterior sagittal anorectoplasty (PSARP) and sigmoid loop vaginal reconstruction was performed as a one-stage operation for the treatment of vaginal agenesis and ARM, There were no complications in the postoperative period. This combined one-stage operation can be used easily in the treatment of some components of the MURCS association such as vaginal agenesis and ARM as an associated anomaly. Copyright 2003, Elsevier Science (USA). All rights reserved.
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    The effect of circumcision status on periurethral and glanular bacterial flora
    (2004) Günşar C.; Kurutepe S.; Alparslan O.; Yilmaz Ö.; Daǧlar Z.; Şencan A.; Genç A.; Taneli C.; Mir E.
    Introduction: Circumcision is a historical operation which is still performed for different purposes. The aim of this study is to investigate the changes in periurethral and glanular sulcus flora due to circumcision to determine the role of circumcision on urinary tract infections (UTIs). Patients and Methods: Fifty patients who were circumcised for social-religious reasons between January 2000 and January 2001 were evaluated in this prospective study. Two swabs were taken from the periurethral and glanular sulcus regions both just before circumcision and 4 weeks after, and the bacteria cultured were recorded. Results: We isolated pathogenic bacteria in the periurethral region of 32 (64%) patients (enterococci in 14 cases; Escherichia coli in 12 cases) before circumcision, and this number decreased to 5 (10%) after circumcision. Similarly, pathogenic bacteria were cultured from the glanular sulcus swabs of 33 (68%) patients (enterococci in 14 cases; E. coli in 10 cases), as well as coagulase-negative staphylococci in another 15 patients before circumcision. Following circumcision, we detected pathogenic bacteria in the glanular cultures of only 4 cases, whereas 40 children had non-pathogenic skin flora. Only 1 of 5 children with history of UTIs (n = 1) and retractable phimosis (n = 4) had periurethral pathogenic bacteria (Proteus spp.) in the post-circumcision period. The differences between pre- and post-circumcision values of the pathogenic bacterial colonizations were statistically significant in both groups sampled (p < 0.05). Conclusion: Non-circumcised patients have similar pathogenic bacterial colonizations in the periurethral and the inner preputial regions, although they have no phimosis. The origin of periurethral flora should be the deeper preputial regions. The flora greatly changed with skin commensals after circumcision. Circumcision might be beneficial from this point of view. Copyright © 2004 S. Karger AG, Basel.
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    Testis-fixation in prepubertal rats: Fibrin glue versus transparenchymal sutures reduces testicular damage
    (2004) Şencan A.; Genç A.; Günşar C.; Daǧlar Z.; Yilmaz Ö.; Ulukuş Ç.; Özer E.; Taneli C.; Mir E.
    Experimental studies have shown that different suture materials used in testis fixation cause some degree of inflammation in the testis. This study was planned to compare the histological changes that were caused by fibrin glue which is a tissue sealant and by silk and polypropylene for transparenchymal testis fixation. 28 prepubertal rats were divided into 4 groups. Testis was fixed to the tunica vaginalis by fibrin glue in group 1, by silk in group 2 and by polypropylene in group 3. Group 4 was planned as a control. Testicular inflammation and seminiferous tubular diameter were evaluated for histological changes. The least inflammation was observed in the fibrin glue group, while the most inflammation occurred in the silk group. Seminiferous tubular diameter was 241.55 ± 45.90 in the fibrin glue group, 151.90 ± 8.34 in the silk group and 161.36 ± 9.96 in the polypropylene group. In conclusion, fibrin glue, when used for testis fixation, causes less inflammation and less destruction of seminiferous tubular diameter compared with silk and polypropylene.
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    The effects of diclofenac on experimental testis torsion; [Diklofenak'in deneysel testis torsiyonundaki etkileri]
    (2009) Daǧlar Z.; Günşar C.; Neşe N.; Şencan A.; Yilmaz Ö.; Genç A.; Taneli C.; Mir E.
    Aim: To investigate the late testicular effects of spermatic cord torsion and role of diclofenac on testicular injury. Material and Methods: In the first group (G1) of rats detorsion followed 4 hours of left testis torsion. For the second group (G2), detorsion followed 4 hours of torsion and diclofenac (2,5 mg/kg IM) administration. For the last group (G3), detorsion was performed after 4 hours of torsion and combined Diclofenac and Verapamil (10 mg/kg/IM) administration. Bilateral orchiectomy was done after 4 weeks. Spermatogenic activity and diameter of seminiferious tubules were evaluated. Results: When testicular weights were evaluated, the most significant increase was detected in the Diclofenac Group, whereas Verapamile group showed significant decrease both in the ipsilateral and contralateral testes. There were significant differences between 'G1 and G2' (p:0,002), 'G1 and G3' (p:0,04) and 'G2 and G3' (p:0,02) by means of seminiferious tubule diameters of torsioned testes. The most prominent increases in diameters were in the Diclofenac Group. We found significant differences for the seminiferious tubule diameters of the contralateral testes in between 'G1 and G3' (p:0,03) and 'G2 and G3' (p:0,003). Significant differences were found by means of spermatogenic activity of the torsioned testes between 'G1 and G2' (p:0.005), 'G1 and G3' (p:0.004), and 'G2 and G3'(p:0.02) groups. For the contralateral testes; the differences between 'G1 and G2'(p:0.003) and 'G1 and G3' (p:0.007)were significant. Conclusion: Unilateral testicular torsion-detorsion causes permanent damage in ipsilateral testes. Diclofenac partially prevented this injury. After sufficient investigations, its use in patients with testicular torsion can be beneficial.