Browsing by Author "Demir, D"

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    Synthesis and characterization of a novel 3-amino-1,2,4-triazole lead(II) coordination polymer
    Sözerli, SE; Özen, A; Kani, I; Demir, D
    A novel [Pb-2(mu-atrz)(2)(mu-CH3COO)(CH3COO)](n) (atrz = 3 amino-1,2,4-triazole) complex was synthesized and characterized by IR spectroscopy, thermogravimetric analysis, and single crystal X-ray diffraction. The molecular structure shows that the complex is a coordination polymer in which there are 2 different lead(II) ions with coordination number of 5, Pb(2), and, with a coordination number of 4, Pb(1). Each atrz acts as a bridging ligand between 2 Pb(II) ions through the 2 adjacent nitrogen atoms of the triazole ring. The acetate anions show different types of coordination mode: one acts as a bridge by coordination of the same oxygen atom with Pb(II) ions and the other as a monodentate coordination by one of the oxygen atoms with Pb(2).
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    The Association of the Epidermal Growth Factor Receptor (EGFR) Immunoexpression With Prognostic Parameters in Adenocarcinoma Patients Receiving Neoadjuvant Treatment
    Demir, D; Parvizi, M; Pehlivanoglu, B; Ergin, E; Ayhan, S; Doganavsargil, B
    The epidermal growth factor receptor (EGFR) expression is considered to play an essential role in the pathogenesis of colorectal adenocarcinoma. This study assessed the expression and predictive/prognostic value of EGFR expression in pre -op biopsy and post -op resection specimens in patients receiving neoadjuvant radiotherapy/neoadjuvant chemoradiotherapy (NRT/NCRT). Thirty-four consecutive patients were included in this study. The association between the prognostic features and EGFR immunohistochemical expression was analyzed in pre- (n=34) and post -treatment (n=22) tissue samples in cases with available tissue blocks. Of 34, 23 (67.6%) were men. The median age was 60.50 +/- 10.69 (range, 31-84) years. EGFR expression was detected in 88.2% of biopsy specimens and in 91.2% of surgical specimens. There was only slight agreement between pre -op and post -op EGFR expression scores (kappa value 0.11). There was no significant correlation between pre -op and post -op EGFR expression scores (p>0.05). Although pre -op EGFR positivity and higher pre -op EGFR scores seemed to indicate a worse prognosis, this association between pre -op EGFR expression and overall survival (OS) or disease -specific survival (DSS) did not reach statistical significance (p>0.05). The only case with a post -op EGFR score of three who died of the disease experienced local recurrence and had distant metastasis. In conclusion, EGFR positivity in pre -op biopsy samples seems to be associated with shorter survival, and increased EGFR expression in post -treatment resection specimens predicts aggressive behavior in patients with rectal adenocarcinoma who received NRT/NCRT. However, due to the molecular heterogeneity, EGFR expression status should be evaluated in resection specimens rather than in pre -op biopsy samples for optimal prognosis prediction.
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    Reduction of [Cp*2Mo2O5] in aqueous medium: Structure and properties of a triangular mixed oxo-hydroxo-bridged product, [Cp*3Mo3(μ-O)2(μ-OH)4](X)2 (X =CF3CO2 or CF3SO3)
    Demirhan, F; Çagatay, B; Demir, D; Baya, M; Daran, JC; Poli, R
    The reduction of [CP*2MO2O5] with Zn in a MeOH/H2O solotion acidified with either CF3COOH or CF3SO3H leads to the formation of the [CP*3MO3(mu-O)(2)(mu-OH)(4)](2+) ion as its trifluoroacetate or trifluoromethanesulfonate salt. The structure of the compound was confirmed by X-ray analyses. The anions establish hydrogen-bonding interactions with all four bridging OH groups. Density functional calculations afford bonding parameters in close agreement with the observed structure and indicate that the cluster is best described as a valence-delocalized Mo-3(13+) species. The five metal electrons are distributed among an a-type (z(2)) orbital, which accounts for most of the metal-metal attraction, and two essentially metal-metal nonbonding e-type (xy) orbitals with a slight Mo(mu-O) pi*-type contribution. Because of the C-2 symmetry, the latter orbitals are not degenerate. The calculations show that the unpaired electron is located in a molecular orbital with equal contribution from two Mo atoms, in agreement with the experimental observation of coupling of the unpaired electron to two Mo atoms in the isotropic EPR spectrum. (c) Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Gerniany, 2006.
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    Epidermal growth factor receptor expression and adjuvant chemoradiotherapy in rectal cancer Epidermal growth factor recepto in operated rectal cancer
    Parvizi, M; Demir, D; Kut, E; Ergin, E; Ayhan, S; Doganavsargil, B
    Aim: Epidermal Growth Factor Receptor (EGFR) is a trans-membrane protein with tyrosine kinase activity and is expressed in 25-80% of colon cancer cases. EFGR expression is prognostic in patients with metastatic colorectal cancer, and anti-EGR- based therapies are routinely used in the treatment of patients with metastatic colorectal cancer. To the best of our knowledge, the relationship between EGFR expression and prognosis in directly operated patients who did not receive neoadjuvant treatment and subsequently received chemo-radiotherapy is unknown. Therefore, we retrospectively evaluated patients with stage 3 rectal cancer who underwent surgery without any preoperative treatment in our center and aimed to investigate the relationship between EGFR expression and prognosis in patients who received adjuvant chemoradiotherapy. Material and Methods: The data of patients who underwent surgery for rectal cancer and received chemoradiotherapy between 2010 and 2016 at Manisa State Hospital were retrospectively analyzed. Results: According to EGFR expression, it was 127.01 (95% CI, 85.43-168.59) months in the group with 10% less staining and 47.44 (95% CI, 26.77-68.12) months in the group with 10% or more staining. Lymphovascular invasion (p=0.032), perineural invasion (p=0.023), histologic grade (p=0.004) and EGFR expression percentage (p=0.005) were significantly associated with survival in multivariate analyses Discussion: The presence of 10% or more EGFR expression, LVI, PNI, and histological grade are significantly associated with survival in stage 3 rectal cancer patients who have undergone surgery and received postoperative chemotherapy. These markers can be used as prognostic biomarkers in the follow-up and treatment of these patients.
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    Outcomes of coronary artery bypass surgery in syrian refugees
    Demir, D; Abanoz, M; Tulay, CM; Aydin, MS; Kasapoglu, BO; Merdanoglu, M; Altiparmak, IH; Gücü, A
    Background: In recent years, an increasing number of individuals have become refugees as a result of wars and domestic disturbance in their countries. The struggle for life of refugees under difficult conditions, increasing health problems, and insufficient Access to health services result in the loss of human lives. The aim of the present study was to present the outcomes of coronary artery bypass surgery in Syrian refugees. Methods: We performed emergency or elective bypass surgery to 53 Syrian refugees who ran away from civil war in Syria, between 2012 and 2014. The preoperative, intraoperative, and postoperative data of the patients were evaluated. Results: Of the patients, 18.9% sustained myocardial infarction, 34% had diabetes, 28.3% had COPD, and 52.8% were smokers. Two patients had emergency surgery and 51 patients had elective surgery. In the postoperative period, five patients (9.4%) were found to have atrial fibrillation. Cerebrovascular disease was observed at three patients (5.7%) in the postoperative period, and one patient had wound infection. A total of three patients (5.7%) died. Conclusion: The authors believe that under appropriate conditions, refugee patients should also receive therapy for chronic disorders in addition to emergency interventions.