Browsing by Author "Demir, M"

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    Serum Levels of Trace Elements in Patients with Testicular Cancers
    Kaba, M; Pirinççi, N; Yüksel, MB; Geçit, I; Günes, M; Demir, M; Akkoyun, H; Demir, H
    Introduction: Trace elements are primary components of biological structures; however, they can be toxic when their concentrations are higher than those needed for biological functions. Materials and Methods: In the present study serum levels of trace elements were measured in 30 patients (mean age was 26.9 +/- 11.2 years) newly diagnosed with germ cell testicular cancer and 32 healthy volunteers (mean age: 27.4 +/- 10.8) by using furnace atomic absorption spectrophotometer. Serum samples were stored at-20 degrees C until assays. Results: In patients with germ cell testicular cancer, the diagnosis was seminoma in 15, mix germ cell tumor in 7, embryonal carcinoma in 4, yolk sac tumor in 2 and teratoma in 2 patients. There was stage I testicular tumor in 19 patients (63.3%) while stage II in 6 patients (20.0%), stage IIIA in 4 patients (13.3%) and stage IIIC in one patient (3.4%). It was found that serum Co, Cu, Mg and Pb levels were increased (p<0.05), whereas Fe, Mn, and Zn levels were decreased in patients with testicular cancer (p<0.05). Conclusions: These alterations may be important in the pathogenesis of testicular cancers; however, further prospective studies are needed to identify the relationship between testicular cancer and trace elements.
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    The evaluation of urine activity and external dose rate from patients receiving radioiodine therapy for thyroid cancer
    Demir, M; Parlak, Y; Çavdar, I; Yeyin, N; Tanyildizi, H; Gümüser, G; Sayit, E; Erees, S; Sayman, H
    The aim of this study was to determine the external dose rate of iodine retention as a function of time in the bodies of thyroid cancer patients during their isolation period in the hospital. Urine samples were collected at 6th, 12th, 18th, 24th h and 2nd, 3rd, 4th, 5th d from 83 patients after oral administration of I-131 and counted. The external dose rates were also simultaneously determined at the same time points. Then, it was expressed as retained radioiodine body activity versus dose rate. Effective half life calculated from urine sample measurements was found as 18.41.8 h within the first 24 h and 642.7 h between 48 and 120 h. According to this results, the external dose rate (20 Sv h(1)), which patients could be discharged, was achieved after 48 h for 3700 and 5550 MBq, and after 72 h for 7400 MBq of I-131 treatments.
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    Determination of bone marrow radiation dose using MIRDOSE3 package program in thyroid cancer patients
    Parlak, Y; Demir, M; Erees, F; Gumuser, F; Uysal, B; Kaya, GC; Koc, M; Ergene, U; Bilgin, E
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    A nationwide multicentre study in Turkey for establishing reference intervals of haematological parameters with novel use of a panel of whole blood
    Ozarda, Y; Ichihara, K; Bakan, E; Polat, H; Ozturk, N; Baygutalp, NK; Taneli, F; Guvenc, Y; Ormen, M; Erbayraktar, Z; Aksoy, N; Sezen, H; Demir, M; Eskandari, G; Polat, G; Mete, N; Yuksel, H; Vatansev, H; Gun, F; Akin, O; Ceylan, O; Noyan, T; Gozlukaya, O; Aliyazicioglu, Y; Kahraman, S; Dirican, M; Tuncer, GO; Kimura, S; Eker, P
    Introduction: A nationwide multicentre study was conducted to establish well-defined reference intervals (Rls) of haematological parameters for the Turkish population in consideration of sources of variation in reference values (RVs). Materials and methods: K2-EDTA whole blood samples (total of 3363) were collected from 12 laboratories. Sera were also collected for measurements of iron, UIBC, TIBC, and ferritin for use in the latent abnormal values exclusion (LAVE) method. The blood samples were analysed within 2 hours in each laboratory using Cell Dyn and Ruby (Abbott), LH780 (Beckman Coulter), or XT-2000i (Sysmex). A panel of freshly prepared blood from 40 healthy volunteers was measured in common to assess any analyser-dependent bias in the measurements. The SD ratio (SDR) based on ANOVA was used to judge the need for partitioning RVs. Rls were computed by the parametric method with/without applying the LAVE method. Results: Analyser-dependent bias was found for basophils (Bas), MCHC, RDW and MPV from the panel test results and thus those Rls were derived for each manufacturer. Rls were determined from all volunteers' results for WBC, neutrophils, lymphocytes, monocytes, eosinophils, MCV, MCH and platelets. Gender-specific Rls were required for RBC, haemoglobin, haematocrit, iron, UIBC and ferritin. Region-specific Rls were required for RBC, haemoglobin, haematocrit, UIBC, and TIBC. Conclusions: With the novel use of a freshly prepared blood panel, manufacturer-specific Rls' were derived for Bas, Bas%, MCHC, RDW and MPV. Regional differences in Rls were observed among the 7 regions of Turkey, which may be attributed to nutritional or environmental factors, including altitude.
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    Bone marrow radiation dosimetry of high dose 131I treatment in differentiated thyroid carcinoma patients
    Parlak, Y; Demir, M; Cavdar, I; Ereees, S; Gumuser, G; Uysal, B; Kaya, GC; Koç, M; Sayit, E
    Background: Radiation absorbed dose to the red bone marrow, a critical organ in the therapy of thyroid carcinoma, is generally kept below 2 Gy for non-myeloablative therapies. The aim of this study was to calculate bone marrow radiation dose by using MIRDOSE3 package program and to optimize the safe limit of activity to be administered to the thyroid cancer patients. Materials and Methods: In this study, 83 thyroid cancer patients were divided into 3 groups based on the amount of activity administered into the body. In the groups, 3700 MBq, 5550 MBq and 7400 MBq activities were used respectively. The curves of time-activity were drawn from blood samples counts and effective half-life and residencetime were calculated. Correlations of bone marrow radiation dose and radioiodine effective half-life were determined as a function of administered activity via ANOVA test. Tg levels and tumour diameters were compared using Spearman's correlation. Results: The effective half-lives of I-131 for three groups of whole-body, receiving 3700 MBq, 5550 MBq and 7400 MBq were calculated as 20.57 +/- 5.4, 17.8 +/- 5.8 and 18.7 +/- 3.9 hours, respectively. The average bone marrow doses for 3 groups of patients were 0.32 +/- 0.08 Gy, 0.42 +/- 0.14 Gy and 0.60 +/- 0.24 Gy, respectively. Conclusion: It was concluded that, the bone marrow dose to the patients still remains within the recommended level even a 9 er administering an activity of 7400 MBq of I-131 to the patients.
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    A multicenter nationwide reference intervals study for common biochemical analytes in Turkey using Abbott analyzers
    Ozarda, Y; Ichihara, K; Aslan, D; Aybek, H; Ari, Z; Taneli, F; Coker, C; Akan, P; Sisman, AR; Bahceci, O; Sezgin, N; Demir, M; Yucel, G; Akbas, H; Ozdem, S; Polat, G; Erbagci, AB; Orkmez, M; Mete, N; Evliyaoglu, O; Kiyici, A; Vatansev, H; Ozturk, B; Yucel, D; Kayaalp, D; Dogan, K; Pinar, A; Gurbilek, M; Cetinkaya, CD; Akin, O; Serdar, M; Kurt, I; Erdinc, S; Kadicesme, O; Ilhan, N; Atali, DS; Bakan, E; Polat, H; Noyan, T; Can, M; Bedir, A; Okuyucu, A; Deger, O; Agac, S; Ademoglu, E; Kaya, A; Nogay, T; Eren, N; Dirican, M; Tuncer, G; Aykus, M; Gunes, Y; Ozmen, SU; Kawano, R; Tezcan, S; Demirpence, O; Degirmen, E
    Background: A nationwide multicenter study was organized to establish reference intervals (RIs) in the Turkish population for 25 commonly tested biochemical analytes and to explore sources of variation in reference values, including regionality. Methods: Blood samples were collected nationwide in 28 laboratories from the seven regions (>= 400 samples/region, 3066 in all). The sera were collectively analyzed in Uludag University in Bursa using Abbott reagents and analyzer. Reference materials were used for standardization of test results. After secondary exclusion using the latent abnormal values exclusion method, RIs were derived by a parametric method employing the modified Box-Cox formula and compared with the RIs by the non-parametric method. Three-level nested ANOVA was used to evaluate variations among sexes, ages and regions. Associations between test results and age, body mass index (BMI) and region were determined by multiple regression analysis (MRA). Results: By ANOVA, differences of reference values among seven regions were significant in none of the 25 analytes. Significant sex-related and age-related differences were observed for 10 and seven analytes, respectively. MRA revealed BMI-related changes in results for uric acid, glucose, triglycerides, high-density lipoprotein (HDL)-cholesterol, alanine aminotransferase, and.-glutamyltransferase. Their RIs were thus derived by applying stricter criteria excluding individuals with BMI >28 kg/m(2). Ranges of RIs by non-parametric method were wider than those by parametric method especially for those analytes affected by BMI. Conclusions: With the lack of regional differences and the well-standardized status of test results, the RIs derived from this nationwide study can be used for the entire Turkish population.
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    Bone Marrow Radiation Dose in Thyroid Carcinoma Patients Treated with Iodine-131
    Parlak, Y; Demir, M; Erees, S; Gumuser, G; Uysal, B; Kaya, GC; Koc, M; Ergene, U; Sayit, E