Browsing by Author "Demir M."

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    The distribution and habitat of calomera littoralis mandli (mandl, 1967) (coleoptera: Cicindelidae) on the coastal margin of lake van in turkey
    (2006) Özgökçe M.S.; Atlihan R.; Kasap İ.; Özgökçe F.; Yıldız Ş.; Demir M.; Polat E.
    The tiger beetle Calomera littoralis mandli was found at Lake Van in eastern Anatolia at 20 out of 47 localities surveyed during 2004–2005. It occurs in open habitats with fine sand mixed with clay or in salt-marshes and with little plant cover. Three groups of larval burrows were determined, with average openings of 1.54 mm, 2.46 mm and 3.80 mm. These correspond to the 1st, 2nd and 3rd larval instars. © 2006 Taylor & Francis Group, LLC.
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    The evaluation of urine activity and external dose rate from patients receiving radioiodine therapy for thyroid cancer
    (2013) Demir M.; Parlak Y.; Çavdar I.; Yeyin N.; Tanyildizi H.; Gümüşer G.; Sayit E.; Erees S.; Sayman H.
    The aim of this study was to determine the external dose rate of iodine retention as a function of time in the bodies of thyroid cancer patients during their isolation period in the hospital. Urine samples were collected at 6th, 12th, 18th, 24th h and 2nd, 3rd, 4th, 5th d from 83 patients after oral administration of 131I and counted. The external dose rates were also simultaneously determined at the same time points. Then, it was expressed as retained radioiodine body activity versus dose rate. Effective half life calculated from urine sample measurements was found as 18.4±1.8 h within the first 24 h and 64±2.7 h between 48 and 120 h. According to this results, the external dose rate (<20 μSv h-1), which patients could be discharged, was achieved after 48 h for 3700 and 5550 MBq, and after 72 h for 7400 MBq of131I treatments. © The Author 2013. Published by Oxford University Press. All rights reserved.
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    A multicenter nationwide reference intervals study for common biochemical analytes in Turkey using Abbott analyzers
    (Walter de Gruyter GmbH, 2014) Ozarda Y.; Ichihara K.; Aslan D.; Aybek H.; Ari Z.; Taneli F.; Coker C.; Akan P.; Sisman A.R.; Bahceci O.; Sezgin N.; Demir M.; Yucel G.; Akbas H.; Ozdem S.; Polat G.; Erbagci A.B.; Orkmez M.; Mete N.; Evliyaoglu O.; Kiyici A.; Vatansev H.; Ozturk B.; Yucel D.; Kayaalp D.; Dogan K.; Pinar A.; Gurbilek M.; Cetinkaya C.D.; Akin O.; Serdar M.; Kurt I.; Erdinc S.; Kadicesme O.; Ilhan N.; Atali D.S.; Bakan E.; Polat H.; Noyan T.; Can M.; Bedir A.; Okuyucu A.; Deger O.; Agac S.; Ademoglu E.; Kaya A.; Nogay T.; Eren N.; Dirican M.; Tuncer G.; Aykus M.; Gunes Y.; Ozmen S.U.; Kawano R.; Tezcan S.; Demirpence O.; Degirmen E.
    Background: A nationwide multicenter study was organized to establish reference intervals (RIs) in the Turkish population for 25 commonly tested biochemical analytes and to explore sources of variation in reference values, including regionality. Methods: Blood samples were collected nationwide in 28 laboratories from the seven regions (≥400 samples/region, 3066 in all). The sera were collectively analyzed in Uludag University in Bursa using Abbott reagents and analyzer. Reference materials were used for standardization of test results. After secondary exclusion using the latent abnormal values exclusion method, RIs were derived by a parametric method employing the modified Box-Cox formula and compared with the RIs by the non-parametric method. Three-level nested ANOVA was used to evaluate variations among sexes, ages and regions. Associations between test results and age, body mass index (BMI) and region were determined by multiple regression analysis (MRA). Results: By ANOVA, differences of reference values among seven regions were significant in none of the 25 analytes. Significant sex-related and age-related differences were observed for 10 and seven analytes, respectively. MRA revealed BMI-related changes in results for uric acid, glucose, triglycerides, high-density lipoprotein (HDL)-cholesterol, alanine aminotransferase, and γ-glutamyltransferase. Their RIs were thus derived by applying stricter criteria excluding individuals with BMI >28 kg/m2. Ranges of RIs by non-parametric method were wider than those by parametric method especially for those analytes affected by BMI. Conclusions: With the lack of regional differences and the well-standardized status of test results, the RIs derived from this nationwide study can be used for the entire Turkish population. © by De Gruyter 2014.
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    Serum levels of trace elements in patients with testicular cancers
    (Brazilian Society of Urology, 2015) Kaba M.; Pirinççi N.; Yüksel M.B.; Geçit I.; Güneş M.; Demir M.; Akkoyun H.T.; Demir H.
    Introduction: Trace elements are primary components of biological structures; however, they can be toxic when their concentrations are higher than those needed for biological functions. Materials and Methods: In the present study serum levels of trace elements were measured in 30 patients (mean age was 26.9±11.2 years) newly diagnosed with germ cell testicular cancer and 32 healthy volunteers (mean age: 27.4±10.8) by using furnace atomic absorption spectrophotometer. Serum samples were stored at-20°C until assays. Results: In patients with germ cell testicular cancer, the diagnosis was seminoma in 15, mix germ cell tumor in 7, embryonal carcinoma in 4, yolk sac tumor in 2 and teratoma in 2 patients. There was stage I testicular tumor in 19 patients (63.3%) while stage II in 6 patients (20.0%), stage IIIA in 4 patients (13.3%) and stage IIIC in one patient (3.4%). It was found that serum Co, Cu, Mg and Pb levels were increased (p<0.05), whereas Fe, Mn, and Zn levels were decreased in patients with testicular cancer (p<0.05). Conclusions: These alterations may be important in the pathogenesis of testicular cancers; however, further prospective studies are needed to identify the relationship between testicular cancer and trace elements.
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    Bone marrow radiation dosimetry of high dose 131I treatment in differentiated thyroid carcinoma patients
    (Novin Medical Radiation Institute, 2016) Parlak Y.; Demir M.; Cavdar I.; Ereees S.; Gumuser G.; Uysal B.; Kaya G.C.; Koç M.; Sayit E.
    Background: Radiation absorbed dose to the red bone marrow, a critical organ in the therapy of thyroid carcinoma, is generally kept below 2 Gy for non-myeloablative therapies. The aim of this study was to calculate bone marrow radiation dose by using MIRDOSE3 package program and to optimize the safe limit of acivity to be administered to the thyroid cancer paients. Materials and Methods: In this study, 83 thyroid cancer patients were divided into 3 groups based on the amount of acivity administered into the body. In the groups, 3700 MBq, 5550 MBq and 7400 MBq activities were used respecively. The curves of ime-acivity were drawn from blood samples counts and effective half-life and residence time were calculated. Correlations of bone marrow radiation dose and radioiodine effective half-life were determined as a function of administered activity via ANOVA test. Tg levels and tumour diameters were compared using Spearman's correlation. Results: The effective half-lives of 131I for three groups of whole-body, receiving 3700 MBq, 5550 MBq and 7400 MBq were calculated as 20.57±5.4, 17.8±5.8 and 18.7±3.9 hours, respectively. The average bone marrow doses for 3 groups of patients were 0.32±0.08 Gy, 0.42±0.14 Gy and 0.60±0.24 Gy, respectively. Conclusion: It was concluded that, the bone marrow dose to the patients still remains within the recommended level even after administering an activity of 7400 MBq of 131I to the patients.
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    A nationwide multicentre study in Turkey for establishing reference intervals of haematological parameters with novel use of a panel of whole blood
    (Biochemia Medica, Editorial Office, 2017) Ozarda Y.; Ichihara K.; Bakan E.; Polat H.; Ozturk N.; Baygutalp N.K.; Taneli F.; Guvenc Y.; Ormen M.; Erbayraktar Z.; Aksoy N.; Sezen H.; Demir M.; Eskandari G.; Polat G.; Mete N.; Yuksel H.; Vatansev H.; Gun F.; Akin O.; Ceylan O.; Noyan T.; Gozlukaya O.; Aliyazicioglu Y.; Kahraman S.; Dirican M.; Tuncer G.O.; Kimura S.; Eker P.
    Introduction: A nationwide multicentre study was conducted to establish well-defined reference intervals (RIs) of haematological parameters for the Turkish population in consideration of sources of variation in reference values (RVs). Materials and methods: K2-EDTA whole blood samples (total of 3363) were collected from 12 laboratories. Sera were also collected for measurements of iron, UIBC, TIBC, and ferritin for use in the latent abnormal values exclusion (LAVE) method. The blood samples were analysed within 2 hours in each laboratory using Cell Dyn and Ruby (Abbott), LH780 (Beckman Coulter), or XT-2000i (Sysmex). A panel of freshly prepared blood from 40 healthy volunteers was measured in common to assess any analyser-dependent bias in the measurements. The SD ratio (SDR) based on ANOVA was used to judge the need for partitioning RVs. RIs were computed by the parametric method with/without applying the LAVE method. Results: Analyser-dependent bias was found for basophils (Bas), MCHC, RDW and MPV from the panel test results and thus those RIs were derived for each manufacturer. RIs were determined from all volunteers’ results for WBC, neutrophils, lymphocytes, monocytes, eosinophils, MCV, MCH and platelets. Gender-specific RIs were required for RBC, haemoglobin, haematocrit, iron, UIBC and ferritin. Region-specific RIs were required for RBC, haemoglobin, haematocrit, UIBC, and TIBC. Conclusions: With the novel use of a freshly prepared blood panel, manufacturer-specific RIs’ were derived for Bas, Bas%, MCHC, RDW and MPV. Regional differences in RIs were observed among the 7 regions of Turkey, which may be attributed to nutritional or environmental factors, including altitude. © by Croatian Society of Medical Biochemistry and Laboratory Medicine.
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    Acceptance Tests and Quality Control of the Positron Emission Tomography (PET) Systems; [Pozitron Emisyon Tomografi (PET) sistemlerinin kalite kontrolü ve kabul Testleri]
    (Galenos Publishing House, 2020) Hacıosmanoğlu T.; Demir M.; Toklu T.; Suna Kıraç F.; İnce M.; Parlak Y.; Kovan B.; Dönmez S.; Ayan A.; Özaslan İ.A.; Hiçürkmez M.; Yeyin N.; Poyraz L.
    Quality control (QC) applications are important for the reliability and accuracy of the results obtained from positron emission tomography (PET) imaging systems in clinical trials. With these applications, exposure of patients and employees to more radiation will be prevented, and it will be possible to detect the systems that lost their performance compared to their installation time. QC applications are grouped as acceptance and reference tests, routine periodic QC tests. PET performance tests standardized by National Electrical Manufacturers Association (NEMA) should be used as acceptance and reference tests. In addition, the performance of the device should be monitored by following these tests at six-month intervals. PET/computerized tomography (CT) manufacturers often recommend routine QC procedures for their equipment and require users to follow these recommendations to a minimum. If standards are not defined for routine QC procedures, it is recommended to comply with the general minimum standards for routine QC that all PET/CT centers must perform. Routine QC protocols, the image quality of the PET system; CT image quality and CT dose of the patient; the accuracy of CT-based attenuation corrections; the accuracy of the CT and PET co-registration should ensure that problems that can interact any of the performance characteristics are identified. Since performing PET/CT scans by equipment that does not comply with their specifications may compromise image quality, interpretation of images and reliability of results, daily QC parameters must be evaluated and necessary corrective procedures must be taken prior to scanning. The tests are carried out using the protocol provided by the manufacturer. © Telif Hakkı 2020 Türkiye Nükleer Tıp Derneği / Nükleer Tıp Seminerleri, Galenos Yayınevi tarafından yayınlanmıştır.
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    Radiation Safety Guide: General Definitions and Radiation Protection Rules in Nuclear Medicine Applications
    (Galenos Publishing House, 2020) Parlak Y.; Uysal B.; Kıraç F.S.; Kovan B.; Demir M.; Ayan A.; Poyraz L.; Özaslan İ.A.; Köseoğlu K.; Yeyin N.; Dönmez S.
    Ionizing radiation which is widely used in the field of medicine and industry, and in scientific studies leaves some or all of its energy to the tissue as it passes through living tissue. It causes known possible harmful effects on living organisms, from low exposure doses to high doses. These are stochastic effects (cancer, mutations) and deterministic effects which are recently named as tissue reactions (such as dermatitis, cataracts). It is important to keep the radiation exposure of the radiation workers and the public as low as possible and to keep within the acceptable dose limits in order to avoid unknown harmful effects. Radiation risks to health are assessed by radiation absorbed dose, dose equivalent and effective doses. In routine daily practices, as low as reasonably achievable dose and as low as reasonably practible dose principles, and also, occupational and public permissible dose limits defined by international and national atomic energy agencies should be complied. Radiation protection rules should be followed to reduce an exposure dose as much as possible while working in the radiation areas. Radiation accidents, transportation of radioactive materials and radioactive waste disposal are important special issues for the protection of environmental health, and compliance with radiation protection rules are necessary. With the development of new targeted radiopharmaceuticals, radionuclide treatments are frequently applied in nuclear medicine clinics, especially in the treatment of malignant diseases. Therefore, radiation protection is an important issue especially for the hospital workers performing procedures to the patients who die shortly after administration of high-dose radionuclide therapy. In this guide, the terms related to radiation will be presented at first, and then, the national and international radiation protection rules in radiation works will be given. © Telif Hakkı 2020 Türkiye Nükleer Tıp Derneği / Nükleer Tıp Seminerleri, Galenos Yayınevi tarafından yayınlanmıştır.
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    Acceptance and Quality Control Tests for the Single Photon Emission Computerized Tomography (SPECT) Gamma Cameras and SPECT/CT Systems; [Tek Foton Emisyon Kompüterize Tomografi (SPECT) Gama Kameralar ve SPECT/BT Sistemleri için Kabul ve Kalite Kontrol Testleri]
    (Galenos Publishing House, 2020) Dönmez S.; Ayan A.; Parlak Y.; Kovan B.; Hiçürkmez M.; Kıraç F.S.; Demir M.; Toklu T.; Hacıosmanoğlu T.; Özaslan İ.A.; Poyraz L.; ve Kalite Kontrol Çalışma Grubu Üyeleri T.R.G.
    Scintigraphic images play an important role in the diagnosis of diseases by providing accurate clinical information independent of the operator. However, the good quality image may not be obtained due to changes in the performance of the imaging system and/or external factors. A poor quality image will make difficult to interpretate clinical studies. Quality Control (QC) tests provide to reveal the conditions that will adversely affect the image quality before starting of scintigraphic imaging, and to make the necessary arrangements. Although QC tests show relative changes depending on the brand and model of gama camera, there are tests that must be done routinely. For gamma cameras [planar and single photon emission computerized tomography (SPECT)] to be newly installed in the Nuclear Medicine Clinic, “Acceptance Tests” should be carried out after the installation. “Checks before clinical studies” before. © Telif Hakkı 2020 Türkiye Nükleer Tıp Derneği / Nükleer Tıp Seminerleri, Galenos Yayınevi tarafından yayınlanmıştır.