Browsing by Author "Demirel, C"

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    The preventive effect of N-acetylcysteine on radiation-induced dermatitis in a rat model
    Demirel, C; Kilciksiz, S; Evirgen-Ayhan, S; Gurgul, S; Erdal, N
    Purpose: We investigated the potential radioprotective effects of N-acetylcysteine (NAG) comparing its effects with that of amifostine (WR-2721), as a representative of clinically used radioprotecor, in ameliorating skin injury from irradiation in rats (single dose, 18 Gy to the left hind legs of the rats). Methods: The rats (n=28) were divided randomly and equally into 4 groups: Control (C), Radiation (R), R+WR-2721 (received irradiation and 200 mg/kg of WR-2721) and R+NAC (received irradiation and 1000 mg/kg of NAG). Acute skin reactions were assessed every 3 days by a radiation oncologist and a biophysicist. Light microscopic findings were assessed by an expert pathologist. Results: Clinically and histopathologically, irradiation increased dermatitis when compared with the control group (p<0.05). The severity of radiodermatitis of the rats in the R+NAC and R+WR-2721 groups was significantly lower than in the R group (p<0.05). The protective effects of NAC and WR-2721 on irradiation increased dermatitis were clinically and histopathologically similar (p>0.05). Conclusion: The study gives clues about the beneficial effects of NAC against radiation-induced dermatitis.
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    N-acetylcysteine ameliorates nitrosative stress on radiation-inducible damage in rat liver
    Kilciksiz, S; Demirel, C; Ayhan, SE; Erdal, N; Gurgul, S; Tamer, L; Ayaz, L
    Purpose: The present study was designed to investigate the potential radioprotective effects of N-acetylcysteine (NAC) on radiation-induced nitrosative stress caused by gamma irradiation (single dose, 6 Gy) in rat liver Methods: The rats (n=40) were divided randomly and equally into 4 groups: Control (C), Radiation (R), R+NAC (received irradiation and 1,000 mg/kg of NAC) and R+WR-2721 (received irradiation and 200 mg/kg of WR-2721). Liver tissue of each animal was harvested and utilized for 3-nitrotyrosine (3-NT) detection using high-performance liquid chromatography-ultraviolet (HPLC-UV) system. Results: In the R rats, 3-NT levels significantly increased when compared to those of the C rats (p<0.05). There were no significant differences in the 3-NT levels among R+NAC and R+WR-2721 rats. Histologically examined liver tissue samples showed no obvious differences. Conclusion: The present study suggests that irradiation has a negative effect on the cellular proteins by enhancing 3-NT formation. The prophylactic use of NAC seems to reduce the nitrosative damage during radiotherapy.
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    Push and Pull Factors of Why Medical Students Want to Leave Turkiye: A Countrywide Multicenter Study
    Eser, E; Cil, E; Sen Gundogan, NE; Col, M; Ozturk, ENY; Thomas, DT; Sunter, AT; Arslan, HN; Citil, R; Onder, Y; Picakciefe, M; Dede, B; Demirel, C; Aydin, N; Caglayan, C; Aker, AA; Borlu, A; Durmus, H; Can, G; Siddikoglu, E; Sumer, EH; Uygun, T; Alkoy, S; Aycan, KA; Koruk, I; Kuzan, R; Demir, LS; Hacilar, E; Sari, H; Kilinc, Z; Onal, O; Dogan, E; Emek, M; Terzioglu, R; Yapici, G; Erdal, D; Eser, S; Akman, EA; Kosan, Z; Yilmaz, S; Ayoglu, FN; Acikgoz, B; Musal, B; Suner, AF; Erdogan, A; Cilburunoglu, I; Saygun, M; Daymaz, D; Arslantas, D; Onsuz, MF; Beyhun, NE; Ustundag, MG; Ekuklu, G; Tas, FO; Abacigil, F; Oncu, S; Hidiroglu, S; Ozaydin, AN; Pirincci, E; Bulut, I; Tozun, M; Eskiocak, M; Gunel, P; Torun, SD; Yavuz, M; Hasde, M; Camur, D; Gunes, G; Kurt, B; Baysoy, NG; Bakirci, N; Demir, F; Catak, B; Ozyurda, F; Turan, M
    Phenomenon: Physician immigration from other countries is increasing as developed countries continue to be desirable destinations for physicians; however, the determinants of Turkish physicians' migration decisions are still unclear. Despite its wide coverage in the media and among physicians in Turkiye, and being the subject of much debate, there is insufficient data to justify this attention. With this study, we aimed to investigate the tendency of senior medical students in Turkiye to pursue their professional careers abroad and its related factors. Approach: This cross-sectional study involved 9881 senior medical students from 39 different medical schools in Turkiye in 2022. Besides participants' migration decision, we evaluated the push and pull factors related to working, social environment and lifestyle in Turkiye and abroad, medical school education inadequacy, and personal insufficiencies, as well as the socioeconomic variables that may affect the decision to migrate abroad. The analyses were carried out with a participation rate of at least 50%. Findings: Of the medical students, 70.7% had emigration intentions. Approximately 60% of those want to stay abroad permanently, and 61.5% of them took initiatives such as learning a foreign language abroad (54.5%) and taking relevant exams (18.9%). Those who wanted to work in the field of Research & Development were 1.37 (95% CI: 1.22-1.54) times more likely to emigrate. The push factor that was related to emigration intention was the working conditions in the country (OR: 1.89, 95% CI: 1.56-2.28) whereas the social environment/lifestyle abroad was the mere pull factor for the tendency of emigration (OR: 1.73, 95% CI: 1.45-2.06). In addition, the quality problem in medical schools also had a significant impact on students' decisions (OR: 2.20, 95% CI: 1.83-2.65). Insights: Although the percentage of those who want to emigrate definitely was at the same level as in the other developing countries, the tendency to migrate permanently was higher in Turkiye. Improving working conditions in the country and increasing the quality of medical faculties seem vital in preventing the migration of physicians.
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    Push and Pull Factors of Why Medical Students Want to Leave Türkiye: A Countrywide Multicenter Study
    Eser, E; Cil, E; Sen Gundogan, NE; Col, M; Ozturk, ENY; Thomas, DT; Sunter, AT; Arslan, HN; Citil, R; Onder, Y; Picakciefe, M; Dede, B; Demirel, C; Aydin, N; Caglayan, C; Aker, AA; Borlu, A; Durmus, H; Can, G; Siddikoglu, E; Sumer, EH; Uygun, T; Alkoy, S; Aycan, KA; Koruk, I; Kuzan, R; Demir, LS; Hacilar, E; Sari, H; Kilinc, Z; Onal, O; Dogan, E; Emek, M; Terzioglu, R; Yapici, G; Erdal, D; Eser, S; Akman, EA; Kosan, Z; Yilmaz, S; Ayoglu, FN; Acikgoz, B; Musal, B; Suner, AF; Erdogan, A; Cilburunoglu, I; Saygun, M; Daymaz, D; Arslantas, D; Onsuz, MF; Beyhun, NE; Ustundag, MG; Ekuklu, G; Tas, FO; Abacigil, F; Oncu, S; Hidiroglu, S; Ozaydin, AN; Pirincci, E; Bulut, I; Tozun, M; Eskiocak, M; Gunel, P; Torun, SD; Yavuz, M; Hasde, M; Camur, D; Gunes, G; Kurt, B; Baysoy, NG; Bakirci, N; Demir, F; Catak, B; Ozyurda, F; Turan, M
    Phenomenon: Physician immigration from other countries is increasing as developed countries continue to be desirable destinations for physicians; however, the determinants of Turkish physicians' migration decisions are still unclear. Despite its wide coverage in the media and among physicians in T & uuml;rkiye, and being the subject of much debate, there is insufficient data to justify this attention. With this study, we aimed to investigate the tendency of senior medical students in T & uuml;rkiye to pursue their professional careers abroad and its related factors. Approach: This cross-sectional study involved 9881 senior medical students from 39 different medical schools in T & uuml;rkiye in 2022. Besides participants' migration decision, we evaluated the push and pull factors related to working, social environment and lifestyle in T & uuml;rkiye and abroad, medical school education inadequacy, and personal insufficiencies, as well as the socioeconomic variables that may affect the decision to migrate abroad. The analyses were carried out with a participation rate of at least 50%. Findings: Of the medical students, 70.7% had emigration intentions. Approximately 60% of those want to stay abroad permanently, and 61.5% of them took initiatives such as learning a foreign language abroad (54.5%) and taking relevant exams (18.9%). Those who wanted to work in the field of Research & Development were 1.37 (95% CI: 1.22-1.54) times more likely to emigrate. The push factor that was related to emigration intention was the working conditions in the country (OR: 1.89, 95% CI: 1.56-2.28) whereas the social environment/lifestyle abroad was the mere pull factor for the tendency of emigration (OR: 1.73, 95% CI: 1.45-2.06). In addition, the quality problem in medical schools also had a significant impact on students' decisions (OR: 2.20, 95% CI: 1.83-2.65). Insights: Although the percentage of those who want to emigrate definitely was at the same level as in the other developing countries, the tendency to migrate permanently was higher in T & uuml;rkiye. Improving working conditions in the country and increasing the quality of medical faculties seem vital in preventing the migration of physicians.