Browsing by Author "Deniz F."

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    Prevalence of prescription of psychotropic drugs and drug-drug interactions: The cytochrome P450 system; [Psikotrop i̇laç yazilma sikliǧi ve i̇laç etkileşimleri: Sitokrom P450 sistemi]
    (2003) Demet M.M.; Deniz F.; Şimşek E.; Taşkin E.O.; Deveci A.
    Objective: In this study, it is aimed to determine the prevalence of prescribing of psychotropic drugs and the combination of these drugs with the others, and to evaluate these combinations in terms of cytochrome p450 system interactions. Method: Out of 105 pharmacies in Manisa downtown area, fifty were visited. The sample consisted of 2164 prescriptions which had more than one drug. The combinations involved were recorded to a database and were evaluated according to cytochrome p450 system in terms of drug-drug interactions. Results: Of the whole prescriptions, 16.6% (360) had one or more psychotropic drug and the antidepressants were in first rank (9.3%) among psychotropic drugs. The number of prescriptions having any combination with possible drug-drug interactions was 19 (0.87% of the whole sample and 5.27% of the prescriptions which had psychotropic drug). Conclusion: It is a pleasing result that the amount of prescriptions that had possible drug-drug interactions in terms of cytochrome p450 system was small. Moreover, it is important that this study calls attention to possible drug interactions in terms of cytochrome system in addition to determine the present condition.
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    Obsessive-compulsive disorder in a dermatology outpatient clinic
    (2005) Demet M.M.; Deveci A.; Taskin E.O.; Ermertcan A.T.; Yurtsever F.; Deniz F.; Bayraktar D.; Ozturkcan S.
    Objective: The aims of present study were to (a) to determine the prevalence of obsessive-compulsive disorder (OCD) in dermatological patients, (b) to determine the possible relationship between dermatological lesions and OCD and (c) to determine the clinical and phenomenological features of the OCD subgroup. Method: The sample consisted of 166 out of 250 consecutively presenting dermatological patients who agreed to participate in the study. The subjects were assessed with the Structured Clinical Interview for DSM-IV Turkish Version (SCID-I) and also completed the Yale-Brown Obsessive Compulsive Scale (Y-BOCS). Results: Of the whole sample, 41 (24.7%) met DSM-IV criteria for OCD. Only 14.6% of them had previously been diagnosed as OCD. The mean score of Y-BOCS in the OCD group was 17.05±9.75. The most common obsessions were contamination (61%) and pathologic doubt (53.7%), while washing (61%) and checking (51.2%) were the most frequent compulsions. Those suffering from diseases of sebaceous glands were the only group that showed a significant difference between the OCD and non-OCD group. Conclusion: There is a high prevalence of OCD in dermatological patients, although the nature of the relationship between OCD and dermatology has not previously been ascertained. Genetic-based studies and future researches focused on individual anxiety, and sensitivity may provide information that better explains this relationship. © 2005 Elsevier Inc. All rights reserved.
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    Prevalence of Vitamin D Deficiency and Hypervitaminosis D Among Adult Patients Admitted to the Tertiary Care Hospitals in Turkey
    (Turkiye Klinikleri, 2022) Yavuz D.G.; Ersoy R.; Altuntaş Y.; Bilen H.; Pamuk B.; Apaydın T.; Temizkan Ş.; Altuntaş H.; Mert M.; Akalın A.; Sert M.; Şimşir I.Y.; Hekimsoy Z.; Cantürk Z.; Üç Z.A.; İplikçi S.; Yaşar M.; Unubol M.; Sezer K.; Toplaoğlu Ö.; İyidir Ö.T.; Pekkolay Z.; Atmaca A.; Dikbaş O.; Özdemir N.; Gül K.; Deniz F.; Ertörer E.; Karaca Z.; Elbüken G.; Arpacı D.; Ağbaht K.; Turan E.; Anaforoğlu İ.; Bayraktaroğlu T.; Haklar G.; Dağlıoğlu G.; Tuzcu A.; Şahin İ.; Çetinkalp Ş.
    Objective: Vitamin D deficiency is a common health problem around the world. This study aimed to evaluate the nationwide prevalence of vitamin D status in tertiary care hospitals in Turkey. Methods: Retrospectively, the data on vitamin D levels from 33 tertiary care hospitals’ clinical biochemistry laboratories around Turkey between January and December were collected. Results: In total, 706 434 serum samples from adult subjects (female/male: 469 028/237 406; 66.4%/33.6%) were included. While vitamin D levels were sufficient in 20.3% (n = 14 222), they were insufficient in 21.9% (n = 154 360) and deficient in 57.8% (n = 408 882). We observed the highest rates of deficiency in those aged between 18 and 29 years (62.9%, n = 70 235) and lowest rates between 60 and 69 years (52.3%, n = 61 121) and between 70 and 79 years (52.3%, n = 32 397). Hypervitaminosis D was detected in 5.5% of adult subjects; highest rates of hypervitaminosis D were observed in those who were over 80 years (6.6%) and 70-79 years (6.5%) and the lowest in 18-29 years (2.8%). Discussion: In this cohort, over half of the subjects admitted to the tertiary care hospitals in Turkey had vitamin D deficiency and required vitamin D supplementation. The elderly population had the lowest prevalence of vitamin D insufficiency and the highest prevalence of hypervitaminosis D. © Author(s).