Browsing by Author "Deniz I."
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Item Aeration-enhanced bioethanol production(Elsevier, 2014) Deniz I.; Imamoglu E.; Vardar-Sukan F.coli KO11 was studied under microaerated conditions.44% higher ethanol production was achieved using aeration. In recent years, growing attention has been devoted to maximize the product yield for the conversion of biomass into ethanol. In this study, microaerated conditions were established to enhance the ethanol yield by Eschericia coli KO11. According to the results, limited aeration was found to be an important factor to increase the ethanol yield by improving the consumption of sugars and the production of biomass. The best result was obtained using oxygen transfer rate (OTR) of 5. mmol/L/h, reaching 19.66. g/L of ethanol at 48. h using quince pomace as substrate. The assays showed that less than 5% of the initial sugar remained at the end of the fermentation, achieving a biomass concentration of 7.3. g/L. In conclusion, we successfully carried out lab-scale production of bioethanol from quince pomace using the ethanologenic E. coli KO11. In particular, microaerobic ethanol fermentation at OTR = 5. mmol/L/h is suggested for the efficient utilization of sugars in quince pomace. Considering the abundance of raw material and the ease of large-scale production, this improvement will have a considerable impact on the total cost of bioethanol. © 2014 Elsevier B.V.Item Evaluation of scale-up parameters of bioethanol production from Escherichia coli KO11; [Escherichia coli KO11 suşundan biyoetanol üretimi için ölçek büyütme parametrelerinin değerlendirilmesi](Turkish Biochemistry Society, 2015) Deniz I.; Imamoglu E.; Sukan F.V.into fuel ethanol, as one of the cleanest liquid fuel alternatives to fossil fuels. However, industrial production of bioethanol is related with successful scaling-up studies. Methods: In this study, the experimental designs of scale-up procedures based on constant mixing time, impeller tip speed and oxygen mass transfer coefficient were performed in 8 L stirred tank reactor and were compared in terms of product yield and productivity with those obtained from 2 L stirred tank reactor using quince pomace as a substrate for bioethanol production by Escherichia coli KO11. Results: Scale-up based on constant mixing time yielded a maximum ethanol concentration of 23.42 g/L which corresponded to 0.4 g ethanol/ g reduced sugar in 8 L stirred tank reactor. Moreover, shear stress increased only 1.1 fold which resulted in low cell damage and high cell viability. Conclusion: Constant mixing time was identified as the most important key parameter especially for scaling-up of viscous fermentation broths of bioethanol production due to the significance of the homogeneity. © 2015, Turkish Biochemistry Society. All rights reserved.Item Innovations in photobioreactors to investigate microalgal production(Nova Science Publishers, Inc., 2017) Deniz I.; Imamoglu E.Development of innovative, cost-effective and highly efficient photobioreactors (PBRs) is becoming highly important because of the increasing demand for microalgal products. This chapter introduces the potential properties of microalgal PBR production. Recent studies on hydrodynamic parameters and geometrical configurations of photobioreactors are reviewed. Moreover, the large-scale production and industrial applications of PBRs, such as new trends for hydrogen production, advanced waste-water treatments and high-value products, are elucidated. Finally, economic assessments are explained. Recent examples are discussed in detail to raise the awareness PBR usage in various industrial areas. © 2017 by Nova Science Publishers, Inc. All rights reserved.Item Trends in red biotechnology: Microalgae for pharmaceutical applications(Elsevier Inc., 2017) Deniz I.; García-Vaquero M.; Imamoglu E.This chapter introduces the pharmaceutical applications of microalgae with respect to their potential properties. It overviews the previous and recent studies on antioxidant, antiinflammatory, antitumor, anticancer, antimicrobial, antiviral and antiallergic activities of microalgal bioactive molecules. It explains the potential mechanism underlying the effects of these molecules with the related pathways. By the end of the chapter the future prospects on the red biotechnology, including the developments in research and industry are explained. A full discussion of recent examples is included to raise the possibility of microalgal resources to become a promising compound in various types of industrial areas with the key concept of potential usage. © 2017 Elsevier Ltd All rights reserved.Item Enhanced microalgal lipid production in internally illuminated airlift photobioreactor(Marine Technology Society Inc., 2019) Deniz I.; Demirel Z.; Imamoglu E.; Dalay M.C.Internal illumination systems are being considered for use as an alternative light supply technique in microalgal products. The main goal of the study was to analyze the roles of different light wavelengths in internally illuminated airlift photobioreactors (PBRs) providing the light energy in an efficient way for the biomass production, lipid yield, and fatty acid composition of Amphora capitellata. The maximum chlorophyll-a concentration per unit biomass (2.62 ± 0.16 mg L-1) was obtained under red light, which was only 14% higher than under blue light in internally illuminated airlift PBR, whereas low chlorophyll-a content was found under white light. Maximum specific growth rate of 0.317 day-1, which corresponded to a doubling time of 2.185 days, was obtained under red light for A. capitellata. It was found that lipid content increased with decreasing growth rate for A. capitellata. Palmitic acid (C16:0) and palmitoleic acid (C16:1) were the principal fatty acids accounting for between 31%-33% and 31%-32% of total fatty acids, respectively. It is important to underline that red and blue light spectrum ranges contribute to improved biomass growth, whereas white light has the potential to support lipid content of diatoms. © 2019, Marine Technology Society Inc.. All rights reserved.Item Production of Microbial Proteases for Food Industry(Springer Nature, 2019) Deniz I.Microbial proteases have become more and more attractive in the food industry regarding to its specific properties, such as high production yield, specificity for a certain substrate, and high activity as well as being environmentally friendly. Proteases have also activity in a wide range of temperature (20–80 °C) and pH values (3–13), which increases the fields of application. Chymosin and papain are the well-known proteases and recently novel enzymes and production techniques are studied due to the increase in application areas. Proteases are available in a broad diversity of microorganisms, plants, and animals. However microbial protease productions offer numerous benefits in terms of technical and economic properties such as higher yields in less time and less cost with a higher overall productivity. In this chapter, the studies on microbial protease productions for industrial applications are briefly overviewed. Trend microorganisms and bioreactor configurations are presented together with their potential uses in food industry. © 2019, Springer Nature Singapore Pte Ltd.Item Comparison of different photobioreactor configurations and empirical computational fluid dynamics simulation for fucoxanthin production(Elsevier B.V., 2019) Aslanbay Guler B.; Deniz I.; Demirel Z.; Oncel S.S.; Imamoglu E.Microalgae production in culture systems has been a topic of intense study for a long time. Optimization of cultivation conditions and design parameters of photobioreactors are essential for the development of economically and technically feasible algae technologies. The present study aimed to evaluate the effect of different photobioreactor (PBR) configurations on biomass and fucoxanthin production from Phaeodactylum tricornutum and to examine culture conditions by using Computational Fluid Dynamics (CFD) simulation for the photobioreactor having the maximum yield. The cells were first cultivated in three different PBRs (flat plate, airlift and stirred tank) and the maximum cell concentration of 5.94 ± 0.12 × 107 cells/ml was obtained in flat plate PBR. Also, highest fucoxanthin amount was found in the same PBR with the value of 2.43 ± 0.23 mg g−1. Flat plate PBR was simulated using CFD and the obtained results were used to evaluate mixing efficiency, flow dynamics and velocity fields. The extent of mixing was found sufficient to achieve homogenous culture medium and mean turbulent kinetic energy field suggested a homogeneous dissipation, also higher intensities of turbulence were observed around the nozzles and at the liquid-gas interphase. However, dead zones and vortex formations were observed in a small proportion of PBR. For further researches, assembling mixers or baffles into the PBR may be a feasible and effective method to improve the mixing efficiency and to prevent hydrodynamic problems. It was shown that the result of cultivation experiment had good agreement with that of CFD prediction. © 2018 Elsevier B.V.Item State of Art Strategies for Biodiesel Production: Bioengineering Approaches(wiley, 2019) Deniz I.; Aslanbay B.; Imamoglu E.Sustainable and renewable energy demand is a universal challenge since the depletion of petroleum fuels, the increase in population globally, the accumulation of greenhouse gases and the concerns of climate change. These challenges along with the nutritional problems have given rise to the exploitation of third-generation biodiesel production from microalgae. In this chapter, the novel trends in biodiesel production in bioengineering perspective are overviewed. Microalgal strains that have been conventionally used and new approaches towards metabolic engineering of algae are presented together with their advantages and bottlenecks. Moreover, new photobioreactor (PBR) types and configurations will be discussed in terms of design approaches, hydrodynamic parameters and kinetics. The chapter ends with the concept of the future possibilities of microalgal biodiesel production to meet the recent progress made in the field. © 2019 Scrivener Publishing LLC. All rights reserved.Item Production, purification and characterization of a proteolytic enzyme from Streptomyces sp. 2M21(Taylor and Francis Ltd, 2019) Deniz I.; Zihnioglu F.; Öncel S.S.; Hames E.E.; Vardar-Sukan F.The recent application studies on keratinase lead to new application areas for the enzyme to be used in novel industries such as pharmaceuticals and biodegradable composites. Thus, designing an economical and environmentally friendly keratinase production and purification with new features turned into an intriguing objective for its commercialization. In this study, keratinase enzyme was produced using a bioreactor of 5 L by a native Streptomyces sp. 2M21 and purified by ion exchange chromatography using step-wise gradient with 24.1-fold purification. Purified keratinase showed optimum activity at pH 9 and 30 °C. The enzyme was shown to be able to decompose different complex substrates such as chicken feather, wool and nail. Moreover, the addition of DTT enhanced the hydrolysis of wool and chicken feather to 3.4- and 3.2-fold, respectively. The potential of Streptomyces sp. to produce significant levels of keratinase using feathers as a substrate might establish cleaner applications for the production of high value-added products and degrading of keratin-containing wastes. © 2019, © 2019 Informa UK Limited, trading as Taylor & Francis Group.Item Transition from start-up to scale-up for fucoxanthin production in flat plate photobioreactor(Springer Netherlands, 2019) Aslanbay Guler B.; Deniz I.; Demirel Z.; Oncel S.S.; Imamoglu E.Fucoxanthin is one of the most important carotenoids and is found in diatoms such as Phaeodactylum tricornutum. The aim of this study was to evaluate the use of both the constant volumetric power consumption rate as scale-up strategy and the constant light energy per unit volume for transition from 1000-mL bottle to 2-L and 7-L flat plate photobioreactors for fucoxanthin production in P. tricornutum, considering whether an increase in the fucoxanthin yield could be achieved. The cell concentration and fucoxanthin content were enhanced with increasing the cultivation volume. It was found that the fucoxanthin yield increased 2.3 times in 2-L photobioreactor and 2.6 times in 7-L photobioreactor in comparison to the value of 1.05 mg g−1 dry weight in the cultivation bottle. Consequently, fucoxanthin production was successfully step-wise scaled-up from 1000-mL bottle to 7-L photobioreactor using both constant volumetric power consumption rate and the constant light energy per unit volume under laboratory conditions. © 2019, Springer Nature B.V.Item Computational fluid dynamics simulation in scaling-up of airlift photobioreactor for astaxanthin production(Elsevier B.V., 2020) Aslanbay Guler B.; Deniz I.; Demirel Z.; Imamoglu E.The unicellular green microalga Haematococcus pluvialis accumulates large amounts of the red ketocarotenoid astaxanthin. Aiming to cultivate these microalgae with high astaxanthin efficiency, cultivations were scaled-up from 1000 mL bottle to 2 L and 8 L airlift photobioreactor using volumetric power consumption rate (W/m3) as scale up strategy. After cultivations, computational fluid dynamics (CFD) simulation was used to investigate the flow patterns, mixing efficiency and gas holdup profile within the 2 L photobioreactor. At the end, astaxanthin content was enhanced with increasing the cultivation volume and highest astaxanthin amount of 49.39 ± 1.64 mg/g cell was obtained in 8 L photobioreactor. Hydrodynamic characteristics of photobioreactor was simulated and gas holdup showed difference between the riser and the downcomer regions. Velocity profiles of air and medium had higher values inside the draft tube than obtained in downcomer region. However liquid circulation was achieved from draft tube to the downcomer, mixing was not provided effectively considering the turbulence kinetic energy. For the further research, some developments about column configuration, sparger diameter may be necessary to enhance the mixing characteristics. © 2019 The Society for Biotechnology, JapanItem Bio-designing of Culture Conditions for Chlorella vulgaris Using Response Surface Methodology(İstanbul University Faculty of Aquatic Sciences, 2020) Karaveli Ö.; Deniz I.Microalgae are microscopic organisms and show a geographical distribution depending on the physical, dynamic, and chemical factors of the environment. These factors are mostly important for attachment and development of microalgae. Substrate, temperature, light, agitation, and turbidity can be given as examples of physical factors, whereas salinity, pH value, and vitamins can be categorized as chemical factors. In this study, the optimization of Chlorella vulgaris production was carried out by response surface methodology (RSM) using two factors of agitation rate (100-250 rpm) and nitrogen source concentration (1-4 g/L) in the cultivation of BG11 medium. Moreover, the usage of urea instead of NaNO3 was investigated and discussed. © 2021 Psychopharmakotherapie. All rights reserved.Item Evaluation of scale-up methodologies and computational fluid dynamics simulation for fucoxanthin production in airlift photobioareactor(John Wiley and Sons Ltd, 2020) Aslanbay Guler B.; Deniz I.; Demirel Z.; Imamoglu E.Researches about commercial-scale production of fucoxanthin are increasing day by day due to the much interest of its broad beneficial health effects. The aim of this study was to investigate the scale-up methodologies in airlift photobioreactor and to simulate fluid flow using computational fluid dynamics (CFD) for fucoxanthin production from Phaeodactylum tricornutum microalgae. During the transition process from 1-L cultivation bottle to the 2-L airlift photobioreactor, the constant mixing time, the constant volumetric oxygen transfer coefficient, and the constant volumetric power consumption rate were evaluated as scale-up methodologies under laboratory conditions. Maximum fucoxanthin yield was found as 1.01 ± 0.07 mg g−1 using scale-up strategy based on constant volumetric power consumption rate. After that, CFD simulation was performed in order to examine flow characteristics, mixing efficiency, hydrodynamics, and gas holdup for selected operation conditions. It was observed that mixing efficiency was low because the draft tube configuration prevented the circulation of fluid and caused a heterogenic culture medium inside the reactor. It is possible to overcome this bottleneck by developing the effective draft tube. © 2020 Curtin University and John Wiley & Sons, Ltd.Item Marine anticancer agents: An overview with a particular focus on their chemical classes(MDPI, 2020) Barreca M.; Spanò V.; Montalbano A.; Cueto M.; Díaz Marrero A.R.; Deniz I.; Erdoğan A.; Bilela L.L.; Moulin C.; Taffin-De-Givenchy E.; Spriano F.; Perale G.; Mehiri M.; Rotter A.; Thomas O.P.; Barraja P.; Gaudêncio S.P.; Bertoni F.The marine environment is a rich source of biologically active molecules for the treatment of human diseases, especially cancer. The adaptation to unique environmental conditions led marine organisms to evolve different pathways than their terrestrial counterparts, thus producing unique chemicals with a broad diversity and complexity. So far, more than 36,000 compounds have been isolated from marine micro- and macro-organisms including but not limited to fungi, bacteria, microalgae, macroalgae, sponges, corals, mollusks and tunicates, with hundreds of new marine natural products (MNPs) being discovered every year. Marine-based pharmaceuticals have started to impact modern pharmacology and different anti-cancer drugs derived from marine compounds have been approved for clinical use, such as: cytarabine, vidarabine, nelarabine (prodrug of ara-G), fludarabine phosphate (pro-drug of ara-A), trabectedin, eribulin mesylate, brentuximab vedotin, polatuzumab vedotin, enfortumab vedotin, belantamab mafodotin, plitidepsin, and lurbinectedin. This review focuses on the bioactive molecules derived from the marine environment with anticancer activity, discussing their families, origin, structural features and therapeutic use. © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).Item A New Network for the Advancement of Marine Biotechnology in Europe and Beyond(Frontiers Media S.A., 2020) Rotter A.; Bacu A.; Barbier M.; Bertoni F.; Bones A.M.; Cancela M.L.; Carlsson J.; Carvalho M.F.; Cegłowska M.; Dalay M.C.; Dailianis T.; Deniz I.; Drakulovic D.; Dubnika A.; Einarsson H.; Erdoğan A.; Eroldoğan O.T.; Ezra D.; Fazi S.; FitzGerald R.J.; Gargan L.M.; Gaudêncio S.P.; Ivošević DeNardis N.; Joksimovic D.; Kataržytė M.; Kotta J.; Mandalakis M.; Matijošytė I.; Mazur-Marzec H.; Massa-Gallucci A.; Mehiri M.; Nielsen S.L.; Novoveská L.; Overlingė D.; Portman M.E.; Pyrc K.; Rebours C.; Reinsch T.; Reyes F.; Rinkevich B.; Robbens J.; Rudovica V.; Sabotič J.; Safarik I.; Talve S.; Tasdemir D.; Schneider X.T.; Thomas O.P.; Toruńska-Sitarz A.; Varese G.C.; Vasquez M.I.Marine organisms produce a vast diversity of metabolites with biological activities useful for humans, e.g., cytotoxic, antioxidant, anti-microbial, insecticidal, herbicidal, anticancer, pro-osteogenic and pro-regenerative, analgesic, anti-inflammatory, anti-coagulant, cholesterol-lowering, nutritional, photoprotective, horticultural or other beneficial properties. These metabolites could help satisfy the increasing demand for alternative sources of nutraceuticals, pharmaceuticals, cosmeceuticals, food, feed, and novel bio-based products. In addition, marine biomass itself can serve as the source material for the production of various bulk commodities (e.g., biofuels, bioplastics, biomaterials). The sustainable exploitation of marine bio-resources and the development of biomolecules and polymers are also known as the growing field of marine biotechnology. Up to now, over 35,000 natural products have been characterized from marine organisms, but many more are yet to be uncovered, as the vast diversity of biota in the marine systems remains largely unexplored. Since marine biotechnology is still in its infancy, there is a need to create effective, operational, inclusive, sustainable, transnational and transdisciplinary networks with a serious and ambitious commitment for knowledge transfer, training provision, dissemination of best practices and identification of the emerging technological trends through science communication activities. A collaborative (net)work is today compelling to provide innovative solutions and products that can be commercialized to contribute to the circular bioeconomy. This perspective article highlights the importance of establishing such collaborative frameworks using the example of Ocean4Biotech, an Action within the European Cooperation in Science and Technology (COST) that connects all and any stakeholders with an interest in marine biotechnology in Europe and beyond. © Copyright © 2020 Rotter, Bacu, Barbier, Bertoni, Bones, Cancela, Carlsson, Carvalho, Cegłowska, Dalay, Dailianis, Deniz, Drakulovic, Dubnika, Einarsson, Erdoğan, Eroldoğan, Ezra, Fazi, FitzGerald, Gargan, Gaudêncio, Ivošević DeNardis, Joksimovic, Kataržytė, Kotta, Mandalakis, Matijošytė, Mazur-Marzec, Massa-Gallucci, Mehiri, Nielsen, Novoveská, Overlingė, Portman, Pyrc, Rebours, Reinsch, Reyes, Rinkevich, Robbens, Rudovica, Sabotič, Safarik, Talve, Tasdemir, Schneider, Thomas, Toruńska-Sitarz, Varese and Vasquez.Item Computational fluid dynamics modelling of stirred tank photobioreactor for Haematococcus pluvialis production: Hydrodynamics and mixing conditions(Elsevier B.V., 2020) Aslanbay Guler B.; Deniz I.; Demirel Z.; Oncel S.S.; Imamoglu E.Agitated photobioreactors (PBR) have been widespread for the cultivation of microalgae because of their advantages in mixing and mass transfer conditions. However, it is difficult to investigate the behaviors of cultivation broth flow with experimental procedures in these PBRs. Computational Fluid Dynamics (CFD) is a common method that has been used to simulate the performance of fluid containing systems in order to investigate the fluid flow, reduce the design cost and improve the efficiency. The objective of this study was to evaluate hydrodynamics and mixing conditions of stirred tank PBR for Haematococcus pluvialis production experimentally and numerically. The cells were first cultivated in a stirred tank PBR containing Rushton turbine impeller and the cell growth was examined during 10 days. At the end of cultivation, the cell concentration was reached the value of 3.1 ± 0.1 × 105 cells mL−1 with the total carotenoid content of 2.47 ± 0.01 mg L−1. Then, the hydrodynamic analyses were conducted to evaluate the average velocity magnitude, turbulence properties and dead zone inside the PBR. The simulation results obtained from realizable k-ε turbulence model showed that the uniformity index of average velocity was found as 0.86. This result showed that the fluid flow showed similar behavior in the most parts of PBR except around the impellers. The velocity contours supported that the mixing conditions were supplied efficiently, however the vortex formation was observed around the impellers in spite of the baffles. In addition, the turbulence kinetic energy having a vital influence on mixing characteristics was found between the values of 1.0 × 10−2 and 3.0 × 10−2 m2 s−2 and the lowest values were observed between two impellers due to extent of mixing. Obtained results could be used to re-design PBR configurations considering the impeller type, the distance between impellers and cultivation conditions. © 2020 Elsevier B.V.Item Scaling-up of Haematococcus pluvialis production in stirred tank photobioreactor(Elsevier Ltd, 2020) Deniz I.The objective of this study was to evaluate three most common scale-up criteria for Haematococcus pluvialis production from cultivation bottles to 2 and 10 L of stirred tank PBRs. Constant volumetric power input (P/V) was found to be the most suitable criterion for H. pluvialis production. Total carotenoid amount per biomass concentration in 2 L and 10 L stirred tank PBRs were determined to be 4.57 mg/g and 4.77 mg/g, respectively. Antioxidant activity of total carotenoids extracted from H. pluvialis was also higher at constant P/V criterion where 46.91% inhibition rate with a total phenolic content of 11.76 mg gallic acid/L was achieved. Obtained results could be used to expand the bioproduction of H. pluvialis and its extracts in commercial scale. © 2020 Elsevier LtdItem Enzyme Technology in Food Processing: Recent Developments and Future Prospects(Elsevier, 2020) Sindhu R.; Shiburaj S.; Sabu A.; Fernandes P.; Singhal R.; Mathew G.M.; Nair I.C.; Jayachandran K.; Vidya J.; de Souza Vandenberghe L.P.; Deniz I.; Madhavan A.; Binod P.; Sukumaran R.K.; Kumar S.S.; Anusree M.; Nagavekar N.; Soumya M.; Jayakumar A.; Radhakrishnan E.K.; Karp S.G.; Giovana M.; Pagnoncelli M.G.B.; de Melo Pereira G.V.; Soccol C.R.; Dogan S.; Pandeyl A.The use of enzymes in food processing is an age-old process. With the advancement of research and development (R&D) and new technologies, several novel enzymes with a wide range of applications have been developed. This chapter gives an insight into different microbial enzymes which find applications in food processing. Various types of food processing and the use of enzymes in various stages of operation are detailed in the chapter. Enzymes such as amylases, proteases, alpha galactosidase, beta galactosidase, lipase, phospholipase, asparaginase, glutaminase, phytase, naringinase, laccase, and invertase are described in detail with their characteristics pertinent to their use in food processing highlighted. The application of these enzymes in food processing and challenges to make these applications economically viable are also discussed. © 2021 Elsevier Inc. All rights reserved.Item A novel subcritical fucoxanthin extraction with a biorefinery approach(Elsevier B.V., 2020) Aslanbay Guler B.; Deniz I.; Demirel Z.; Yesil-Celiktas O.; Imamoglu E.Eco-friendly, cost efficient and effective extraction methods have become significant for the industries applying zero waste principles. The two main objectives of this study were; to examine fucoxanthin extraction from wet Phaeodactylum tricornutum using subcritical fluid extraction and to characterize the residual biomass in order to determine the potential application areas. The highest fucoxanthin yield of 0.69 ± 0.05 mg/g wet cell weight was achieved using methanol with solvent-to-solid ratio of 200:1 at 120 rpm, 20 MPa pressure and at 35 °C for 60 min by subcritical extraction. Microscopy images showed that most of the cells were disrupted and intracellular components were effectively released. Based on the results of energy dispersive spectroscopy, biomass contained a mixture of organic molecules including mainly carbon (57–72%), oxygen (26–41%), magnesium (0.6–1.4%) and silica (0.4–1%) (wt%). These results make the residual biomass a potential candidate for various areas such as bioenergy, material sciences and sensor technologies. © 2019 Elsevier B.V.Item Energy Efficient Buildings with Algae(IOP Publishing Ltd, 2021) Yaman Y.; Tokuç A.; Sener I.; Altunacar N.; Köktürk G.; Deniz I.; Ezan M.A.The biggest part of the energy consumption of buildings is for thermal comfort. Awareness on climate change and concerns about the depletion of natural resources made the necessity to use renewable energy sources in buildings evident. In this context, microalgae have high surface efficiency and consume inorganic carbon, thus enabling carbon-neutral operation. They can be integrated into building façades with photobioreactors to reduce energy demands. This paper aims to clarify and discuss the role of microalgal technologies in energy-efficient architecture. The thermal performance and energy generation properties of microalgae façades are comprehensively reviewed. The results show that microalgae provide dynamic shading and thermal insulation, thus have the potential to significantly reduce the thermal load and energy demands of buildings and increase the building performance. Consequently, besides the thermal performance of microalgae façades, evaluation of daylight, lighting, environmental and cost performance, technical applicability and aesthetics are necessary. © Published under licence by IOP Publishing Ltd.