Browsing by Author "Deveci, A"

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    Postnatal depression in Turkey: epidemiological and cultural aspects
    Danaci, AE; Dinç, G; Deveci, A; Sen, FS; Içelli, I
    Background in some periods of a womans life the risk of depression increases and the postnatal period is one of these. The prevalence and the risk factors of postnatal depression are not systematically studied in Turkey. The aim of this study is to investigate the epidemiological aspects and the cultural factors that may affect postnatal depression in our country. Method According to the records of ten primary health care centres in Manisa, a city in western Turkey, there were 1,337 women who had given birth in the previous 6 months. A sample group of 317 mothers were randomised among these women and 257 (81.7%) of the sample group could be reached. Data were collected by use of the Edinburgh Postnatal Depression Scale and a questionnaire on sociodemographic variables designed for this study. Results The mean depression score was found to be 7.54 +/- 4.66. When the cut-off point was taken into consideration, 14% of mothers had a syndromal depression. The factors which affected the prevalence of depression were the number of living children, living in a shanty, being an immigrant, serious health problems in the baby, previous psychiatric history, psychiatric disorder in the spouse, and having bad relations with the spouse and his parents. Conclusion These findings revealed that the prevalence of postnatal depression in the Manisa province and the factors affecting it were very similar to other studies; but the negative impact of bad relations of the mother with her family-in-law on postnatal depression seems to be a distinguishing aspect of Turkish culture.
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    Mode of delivery and pelvic floor muscle strength and sexual function after childbirth
    Baytur, YB; Deveci, A; Uyar, Y; Ozcakir, HT; Kizilkaya, S; Caglar, H
    Objective: To investigate the respective roles of the mode of delivery and strength of pelvic floor muscles in the sexual function of women. Method: Thirty-two women who were delivered vaginally and 21 women who underwent cesarean delivery at the Celal Bayar University School of Medicine Obstetrics Department were enrolled in the study, and 15 nulliparas were recruited as controls. Sexual function was assessed in all women by a validated questionnaire (the Female Sexual Function Index). Desire, arousal, lubrication, orgasm, satisfaction, and pain were measured separately, and pelvic floor muscle strength was assessed by a perineometer. Sexual function was compared among the 3 groups. The correlation between pelvic floor muscle strength and sexual function was also investigated. Results: Pelvic floor muscle strength was significantly lower in the group vaginally delivered compared with the group delivered by cesarean section and the nulliparous group (P < 0.05). There was no difference between the groups regarding sexual function (P > 0.05), and there was also no correlation between sexual function and pelvic muscle strength. Conclusion: Pelvic floor muscle strength and mode of delivery did not affect sexual function in our study participants. The muscular component of female sexual function should be further investigated. (c) 2005 International Federation of Gynecology and Obstetrics. Published by Elsevier Ireland Ltd. All rights reserved.
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    Sexual Dysfunction in Female Patients With Neurodermatitis
    Ermertcan, AT; Gencoglan, G; Temeltas, G; Horasan, GD; Deveci, A; Ozturk, F
    Neurodermatitis is a chronic disease affecting the patient's psychosocial status and quality of life. It is associated with a variety of psychologic problems, including demoralization, depression, anxiety, obsessive-compulsive disorder, and sleep disturbances. Coexistence of sexual dysfunction, especially in women, with several systemic diseases has gained interest in recent years. In this study, we evaluated sexual function in female patients with neurodermatitis. We enrolled 89 women (43 patients, 46 controls) in the study. Quality of life was assessed with the Dermatology Life Quality Index (DLQI), and the Female Sexual Function Index (FSFI) was used to determine sexual function. Individuals with psychiatric disorders and/or those using antidepressants were excluded. The total DLQI score was 11.95 +/- 5.65 in patients with neurodermatitis. The total FSFI score was significantly lower in patients compared with healthy controls (22.76 +/- 5.31 and 28.83 +/- 3.50, respectively; P=.001). Domain scores of FSFI (desire, arousal, lubrication, orgasm, and satisfaction) except pain were significantly lower in patients with neurodermatitis (P=.001). The pain score was also lower in patients than controls, but the difference was not statistically significant (P=.073). Neurodermatitis may be associated with sexual dysfunction, and patients with neurodermatitis should be evaluated with regard to sexual function to provide a better quality of life.
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    Risk factors for delaying treatment seeking in obsessive-compulsive disorder
    Demet, MM; Deveci, A; Taskin, EO; Dündar, PE; Ermertcan, AT; Demet, SM; Bayraktar, D; Öztürkcan, S
    Background: Despite the multiple alternatives of treatment, it is well known that patients with obsessive-compulsive disorder (OCD) delay seeking treatment. In this study, the aim was to determine the risk factors for delaying treatment seeking in OCD patients. Methods: The sample consisted of 132 OCD who completed the Yale-Brown Obsessive-Compulsive Scale, Yale-Brown Obsessive-Compulsive Scale Symptom Checklist, and Beck Depression Inventory. Results: In univariate analyses with risk evaluation, income level, being single or divorced, having a history of psychiatric treatment, poor insight for the symptoms, and obsessions of hoarding were the variables that were found to be significant. In the regression model, history of psychiatric treatment and duration of OCD were the 2 variables that remained statistically significant. Conclusion: This was the first study wherein the sample included patients who were recruited from a nonpsychiatric department: the dermatology clinic. Application to dermatology has not been determined as a risk factor for delaying treatment seeking in OCD patients. (c) 2010 Elsevier Inc. All rights reserved.
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    Improvement in sleep quality with allergen-spesific immunotherapy in patients with allergic rhinitis
    Bayrak Degirmenci, P; Kirmaz, C; Deveci, A; Yüksel, H; Yilmaz, Ö
    Objective: In the medical literature, it has been shown that quality of life and sleep quality are impaired due to allergic rhinitis and are improved with treatment. In this study, we aimed to determine the change in sleep quality of patients with allergic rhinitis using allergen-specific immunotherapy. Materials and Methods: Seventy-four patients diagnosed with allergic rhinitis according to the clinical evaluation and skin prick test findings in Celal Bayar University Allergy-Immunology Outpatient Department were enrolled in our study. Sleep quality was evaluated with Pittsburgh Sleep Quality Index (PSQI) just before specific immunotherapy was initiated and at the end of the first year of treatment with specific immunotherapy. Results: Frequency of having healthy sleep increased significantly after specific immunotherapy in the patients (p<0.001). A significant correlation was detected between the changes in symptom score and PSQI when evaluated with Spearman correlation analysis (p= 0.01). Improvement was demonstrated in subjective sleep quality, sleep latency, sleep duration, sleep efficacy, factors influencing sleep, use of hypnotics, and daytime somnolence parameters of the PSQI with a decrease in symptom score. Conclusion: In our study, chronic sleep disorder disappeared and improvement in sleep quality was detected in most patients during the second evaluation one year after initiation of specific immunotherapy. Sleep quality increased as the symptom score decreased. These findings demonstrated improvement in the patients' sleep quality with improvement in symptoms following specific immunotherapy treatment. These data should be supported with longer specific immunotherapy therapy in patients with allergic rhinitis.
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    Does cancer diagnosis cause suicide? How can risk perception and reduction be done?
    Aydin, O; Deveci, A; Esen-Danaci, A
    Cancer is a disease that requires a long-term treatment, therefore, its psychological impact on patients is important for clinical oncology. Despite improvements in medicine over the years, cancer continues to be an illness that inspires panic and anxiety among people, involves ambiguity, and evokes a death fraught with pain and suffering. Various studies show increased risk of suicide in people diagnosed with cancer. The prevalence of psychiatric disorders among inpatient and outpatient cancer patients is approximately 50%. Many studies have shown that unrelieved pain, major depression, loss of control, emotional distress, and loss of physical functioning are the leading factors that may cause suicidal thoughts in cancer patients. The physician should be alert to such patient characteristics, make a good risk assessment, and be able to take appropriate action especially on patients at a high risk for suicide. The patient who attempted suicide must be seen by a psychiatrist as soon as the medical intervention is completed. Because, this period is often referred to as the period when people are in need for help like they have never been before. Psychotherapeutic modalities should not be time consuming; they should take into account the general condition of the patients, and involve their family members and the treatment team as necessary. It is both the psychiatrists' and the patient's primary physician's responsibility to find out and resolve the psychiatric conditions associated with the suicide. Solution-focused interventions that comply with this approach will contribute greatly to improving the quality of life of patients.
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    Sexual dysfunction in patients with psoriasis
    Ermertcan, AT; Temeltas, G; Deveci, A; Dinç, G; Güler, HB; Öztürkcan, S
    Psoriasis can have a significant impact upon sexual function. The aim of this study was to investigate sexual function in females and males with psoriasis and to evaluate whether coexistent depression has an additional negative effect on sexual function in these patients. A total of 66 female subjects (39 with psoriasis and 27 healthy volunteers as a control group) and 70 male subjects (39 with psoriasis and 31 healthy volunteers as a control group) were enrolled in the study. A Psoriasis Area and Severity Index (PASI) was used to determine the severity of psoriasis for the patient groups. The Female Sexual Function Index (FSFI) was used to assess female sexual function and the International Index of Erectile Function (IIEF) was used to evaluate male sexual function. Quality of life was assessed with the Dermatology Life Quality Index (DLQI). The diagnosis of depression was made according to the Structured Clinical Interview for DSM-IV (SCID-I) interview and Hamilton Depression Rate Scale (HDRS) was used for grading depression. FSFI total score was found to be significantly decreased in female psoriatic patients without depression and psoriatic patients plus depression compared with healthy controls (24.09 +/- 5.33 vs. 24.25 +/- 4.52 vs. 28.12 +/- 3.48, respectively, p = 0.004). However, FSFI score was not significantly different between patients with psoriasis without depression and those with psoriasis plus depression (p > 0.05). IIEF total score was also found to be significantly decreased in male psoriasis without depression and psoriasis plus depression patients compared with healthy controls (54.21 +/- 13.07 vs. 52.0 +/- 14.73 vs. 61.69 +/- 9.49, respectively, p = 0.023). The difference in IIEF scores between patients with psoriasis without depression and in those with psoriasis plus depression were not statistically significant (p > 0.05). The results of the study demonstrated that patients with psoriasis, especially females have distinct sexual dysfunction compared with healthy controls, and coexistent depression has no additional negative effect on sexual dysfunction in our patients. Patients with psoriasis should be evaluated in terms of sexual function in order to provide a better quality of life.
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    Parental Acceptance/Rejection Perceptions and Attachment Styles of Men With Online Gambling Disorder
    Kaya, E; Deveci, A
    Online gambling disorder has recently emerged as a significant public health issue. Family dynamics play an important role in the development of online gambling disorder. In this research, the aimed to compare the parental acceptance/rejection and attachment styles of individuals with online gambling disorder with a healthy control group. Also, the relationship between parental acceptance/rejection and attachment styles was examined in individuals with online gambling disorder. The study group consisted of 53 male patients with online gambling disorder and 57 healthy controls. The individuals with online gambling disorder perceived more rejection from mothers but especially from fathers than the individuals in the control group. Paternal hostility/aggression and indifference/neglect are determinants of online gambling behavior. The individuals with online gambling disorder had lower levels of secure attachment and higher levels of dismissive and fearful attachment than the individuals in the control group. Both secure attachment style and dismissive attachment style are thought to be determinants of gambling behavior. Mother-father rejection and insecure attachment are important in terms of creating risk for online gambling. Assessment of the effects of maternal and especially paternal rejection in online gambling disorder will be beneficial within the scope of preventive mental health.
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    Relationship Between Socio-Demographic Features, Work-Related Conditions, and Level of Anxiety Among Turkish Primary Health Care Workers
    Picakciefe, M; Turgut, A; Igneci, E; Cayli, F; Deveci, A
    The purpose of this study was to investigate the relationship among Turkish primary health care workers' socio-demographic characteristics, working conditions, and anxiety. A cross-sectional study was conducted with 88 of 103 (85.4%) eligible health care workers from the city of Mugla participating. The participants' average age was 31 years, 85.2% were university graduates, 30.7% were nurses, and 64.8% had been working between 11 and 20 years at the time of the study; 93.6% worked 8 hours each day or less. State anxiety scores for males (p = .016), health care workers age 31 or older (p = .035), nurse participants (p = .043), and individuals who had worked 11 or more years (p = .044) were significantly higher than the rest of the sample; however, trait anxiety scores for participants who did not work overtime and were not scheduled for shift work were significantly higher (p = .033 and p = .004, respectively) than the rest of the sample. According to the logistic regression analysis, risk factors for anxiety included being male and older than 31 years.
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    The effect of chronic antidepressant treatment on serum brain-derived neurotrophic factor levels in depressed patients: a preliminary study
    Aydemir, O; Deveci, A; Taneli, F
    Recent studies suggested a role of brain-derived neurotrophic factor (BDNF) in depression. While BDNF levels are lower in depressed patients, antidepressant treatment increases serum BDNF levels of depressed patients. Our study aims to test the effect of chronic venlafaxine treatment on serum BDNF levels in patients with a major depressive disorder. Ten patients diagnosed as major depressive disorder according to DSM-IV are included in the study. Two of the patients had their first episode and were drug-naive, the other eight patients were drug-free for at least 4 weeks. The severity of depression was assessed with Hamilton Depression Rating Scale (HDRS). The control group consisted of ten age- and sex-matched subjects without any psychiatric disorder. Blood samples were collected at the baseline and after 12 weeks of antidepressant treatment (during remission). At the baseline the mean serum BDNF level was 17.9 +/- 9.1 ng/ml and the mean HDRS score was 23.2 +/- 4.6. Serum BDNF levels of the study group were significantly lower than in the control group (31.6 +/- 8.6 ng/ml). At the end of the study, the mean serum BDNF level was 34.6 +/- 7.1 ng/ml whereas the mean HDRS score was 8.2 +/- 3.9. From the baseline to the remission after 12 weeks of treatment, the increase in serum BDNF level and the decrease in HDRS score were statistically significant, respectively. When we compared the serum BDNF level of depressed patients at remission to that of the controls, there was no statistically significant difference. This study shows that venlafaxine treatment of depression improves serum BDNF level which may be considered as a nonspecific peripheral marker of depression. (C) 2004 Elsevier Inc. All rights reserved.
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    Depression and anxiety in hypothyroidism
    Demet, MM; Ozmen, B; Deveci, A; Boyvada, S; Adiguzel, H; Aydemir, O
    The aim of the study was to determine the prevalence and severity of depression and anxiety inpatients with hypothyroidism and to compare this with euthyroid patients. Thirty patients with hypothyroidism and 30 euthyroid controls attending the Endocrinology outpatient department of Celal Bayar University, Medical Faculty were included in the study. The hormonal screening was done by immunoassay and haemagglutination methods. Then, for psychiatric assessment, Hospital Anxiety and Depression Scale (HAD), Hamilton Depression Rating Scale (HAM-D), and Hamilton Anxiety Rating Scale (HAM-A) were used There was no difference between the two groups in terms of demographic features. Total scores obtained from the scales used in the study did not differ significantly (p > 0.05). The frequency of items of both HAM-D and HAM-A did not show any differences in the two groups. By Wilks' Lambda discriminant analysis, depressive mood (HAM-D#1) was found to be the discriminating feature between the hypothyroid group and the euthyroid group. Therefore, depression and anxiety were not outstanding features in hypothyroidism. However depression was more significant in the hypothyroid than euthyroid group.
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    Serum brain-derived neurotrophic factor levels in conversion disorder: Comparative study with depression
    Deveci, A; Aydemir, O; Taskin, O; Taneli, F; Esen-Danaci, A
    The aim of the present study was to compare serum brain-derived neurotrophic factor (BDNF) levels of patients with major depressive disorder (MDD) and conversion disorder (CD). Serum BDNF levels were measured in the following three groups: 15 CD patients without any comorbid diagnosis of psychiatric disorder, 24 patients with MDD, and 26 healthy subjects without any psychiatric diagnosis or psychiatric treatment. The serum BDNF level of the healthy control group (31.4 +/- 8.8 ng/mL) was statistically higher than the level of the MDD group (21.2 +/- 11.3 ng/mL) and the CD group (24.3 +/- 9.0 ng/mL; P = 0.008). This suggests that BDNF level may play a similar role in the pathophysiology of MDD and CD.
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    Mirtazapine Combination in Treatment-Resistant Major Depressive Disorder: A Retrospective Evaluation of Six Weeks
    Aydemir, O; Deveci, A; Taskin, EO
    Objective: Despite the adequate time and dose of antidepressant treatment, approximately one-third of the patients with major depression do not respond. In previous trials, mirtazapine combination was found lobe efficacious in treatment-resistant depression which is non-response to two previous adequate antidepressant drug treatments from different classes. In this present study, it is aimed to assess the efficacy and the tolerability of mirtazapine combination treatment in patients with treatment-resistant major depression by retrospective chart review. Method: During the period between August 2004 and July 2005, all the charts of the patients with treatment resistant major depressive disorder were selected. For the assessment, Hamilton Depression Rating Scale (HAM-D) and Clinical Global Impression (CGI) were used. For the assessment of adverse effects, the report of the patients was considered. Forty-three in- or outpatients with major depression who previously received two antidepressants of different groups and did not respond (<50% of symptom reduction in HAM-D) to either treatment were assessed. Of the 43 patients who fulfilled the inclusion criteria, 39 patients had complete data for the assessment. The study was based on the chart records of 39 patients. At the time of assessment, 18 (41.9%) patients were receiving venlafaxine, and 25 (58.1%) patients were receiving an SSRI (15 on citalopram, 6 on sertraline, and 4 on paroxetine). Result: The mean age of the study group was 42.2 +/- 12.9, and 74.4% (n=32) female. Of the whole sample, 14 (32.6%) patients were having their first episode, whereas 29(67.4%) patients had a recurrent major depression. Ten (23.3%) patients were inpatients and 33 (76.7%) patients were outpatients. The mean HDRS score was decreased from 23.1 +/- 5.1 to 7.3 +/- 5.6 at the end of the assessment of six weeks, and 21 (53.8%) patients achieved remission (HDRS<7). When the primary antidepressant was taken into consideration, patients on venlafaxine had significantly more remission rate compared to patients on selective serotonin reuptake inhibitors (SSRI). In 27.9% (n=12) of the patients, adverse events were emerged, and weight gain was predominant with 8 patients. In two patients who were dropped out due to adverse events, one patient experienced weight gain (8 kg/4 weeks) and the other had anxiety and agitation. Discussion: Mirtazapine combination treatment is an efficacious and well-tolerated alternative in treatment-resistant major depression. When the primary antidepressant is venlafaxine, this combination therapy seems to be more effective.
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    Obsessive-compulsive disorder in a dermatology outpatient clinic
    Demet, MM; Deveci, A; Taskin, EO; Ermertcan, AT; Yurtsever, F; Deniz, F; Bayraktar, D; Ozturkcan, S
    Objective: The aims of present study were to (a) to determine the prevalence of obsessive-compulsive disorder (OCD) in dermatological patients, (b) to determine the possible relationship between dermatological lesions and OCD and (c) to determine the clinical and phenomenological features of the OCD subgroup. Method: The sample consisted of 166 out of 250 consecutively presenting dermatological patients who agreed to participate in the study. The subjects were assessed with the Structured Clinical Interview for DSM-IV Turkish Version (SCID-I) and also completed the Yale-Brown Obsessive Compulsive Scale (Y-BOCS). Results: Of the whole sample, 41 (24.7%) met DSM-IV criteria for OCD. Only 14.6% of them had previously been diagnosed as OCD. The mean score of Y-BOCS in the OCD group was 17.05 +/- 9.75. The most common obsessions were contamination (61 %) and pathologic doubt (53.7%), while washing (61%) and checking (51.2%) were the most frequent compulsions. Those suffering from diseases of sebaceous glands were the only group that showed a significant difference between the OCD and non-OCD group. onclusion: There is a high prevalence of OCD in dermatological patients, although the nature of the relationship between OCD and dermatology has not previously been ascertained. Genetic-based studies and future researches focused on individual anxiety, and sensitivity may provide information that better explains this relationship. (c) 2005 Elsevier Inc. All rights reserved.
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    Prevalence of pseudoneurologic conversion disorder in an urban community in Manisa, Turkey
    Deveci, A; Taskin, O; Dinc, G; Yilmaz, H; Demet, MM; Erbay-Dundar, P; Kaya, E; Ozmen, E
    There is not a wide agreement upon rate of conversion disorder within Turkish population. The aim of this study was to determine the prevalence of conversion disorder with pseudoneurological symptoms or deficits and related risk factors in a city. In total, 1,086 people, aged 15-65 years old, were selected from the city of Manisa, Turkey to take part in the study. We applied sociodemographic and health information questionnaires and the Composite International Diagnostic Interview (CIDI) Somatization Subscales to the samples. The likelihood that an individual might have conversion disorder with pseudoneurological symptoms or deficits was found to be 5.6% (n = 61). The prevalence of conversion disorder with pseudoneurological symptoms or deficits was significantly higher among women (p < 0.0001), 15-24 year old women (p = 0.011) and 25-34 year old women (p = 0.003), people who live as squatters (p = 0.03), those with a history of psychiatric disorder (p < 0.0001) and those having a mother with a psychiatric disorder (p = 0.04). This study has shown the conversion disorder with pseudoneurological symptoms or deficits is inadequately frequent in the population.
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    Serum Brain-Derived Neurotrophic Factor (BDNF) Levels in Schizophrenic Patients with Depressive Sypmptoms: A Preliminary Study
    Esen-Danaci, A; Aydemir, Ö; Deveci, A; Taneli, F; Taskin, O
    Objectives: Evidence from clinical, pharmacological and animal studies, have led to neurodevelopment, neurodegeneration, and dopamine hypotheses, and to the investigation of BDNF as a potential candidate molecule in the pathophysiology of schizophrenia, The aim of this study is to investigate the BNDF levels of schizophrenic patients with depression and compare them with major depression patients and controls in order to understand the nature of depressive symptoms seen in schizophrenia. Methods: The BDNF levels of eight schizophrenic patients with depressive symptomatology (SD) were compared with two control groups. The first group consisted of major depressed patients (MDD) (n=24) and the second was the healthy control group (n=26). Results: SD group had BDNF levels similar to control group and MDD group had significantly lower levels than the other two groups. Conclusion: This difference of BDNF levels between schizophrenia with depression group and major depression group supports the hypothesis of distinct etiologies.
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    Depression and anxiety in hyperthyroidism
    Demet, MM; Özmen, B; Deveci, A; Boyvada, S; Adigüzel, H; Aydemir, Ö
    Background. Our objective was to determine symptomatology of depression and anxiety in patients with untreated hyperthyroidism and compare with euthyroid patients. Methods. Thirty-two patients with hyperthyroidism (high free T3 and free T4, and suppressed TSH) and 30 euthyroid (normal free T3, free T4, and TSH) controls attending the Endocrinology Out-Patient Department at Celal Bayar University Hospital in Manisa, Turkey were included in the study. Hormonal screening was performed by immunoassay and hernagglutination method. For psychiatric assessment, Hospital Anxiety and Depression Scale [HAD], Hamilton Depression Rating Scale [HAM-D], and Hamilton Anxiety Rating Scale [HAM-A] were used. There was no difference between the two groups in terms of demographic features. Results. Total scores obtained both from HAM-D and HAM-A were significantly greater in the hyperthyroidism group than that of the euthyroid group (P < 0.05); there was no difference in terms of HAD. When compared in terms of symptomatology, early insomnia (HAM-D#6), work and activities (HAM-D#7), psychic anxiety (HAM-D#10), weight loss (HAM-D#16), insomnia (HAM-A#4), and cardiovascular symptoms (HAM-A#8) were significantly more frequent in the hyperthyroidism group. By Wilks lambda discriminant analysis, psychomotor agitation (HAM-D#9), weight loss (HAM-D#16), and insomnia (HAM-A#4) were found as the discriminating symptoms for the hyperthyroidism group, whereas somatic anxiety (HAM-A#11) and loss of interest (HAD#14) were distinguishing symptoms of the euthyroidism group. Conclusions. Hyperthyroidism and syndromal depression-anxiety have overlapping features that can cause misdiagnosis during acute phase. For differential diagnosis, one should follow-up patients with hyperthyroidism with specific hormonal treatment and evaluate persisting symptoms thereafter. In addition to specific symptoms of hyperthyroidism, psychomotor retardation, guilt, muscle pain, energy loss, and fatigue seem to appear more frequently in patients with comorbid depression and hyperthyroidism; thus, presence of these symptoms should be a warning sign to nonpsychiatric professionals for the need for psychiatric consultation. (C) 2002 IMSS. Published by Elsevier Science Inc.
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    Serum BDNF levels in suicide attempters related to psychosocial stressors: A comparative study with depression
    Deveci, A; Aydemir, O; Taskin, O; Taneli, F; Esen-Danaci, A
    Although many studies have examined the neurobiological aspects of suicide, the molecular mechanisms and pathophysiologic mechanisms associated with suicide remain unclear. In this study, it is aimed to investigate whether there is a difference in serum brain-derived neurotrophic factor ( BDNF) levels among suicide attempters without a major psychiatric disorder, compared to major depressive disorder patients and healthy subjects. It was undertaken with the hypothesis that suicide per se lowers serum BDNF levels, since it is a source of stress. The study was carried out in Celal Bayar University Hospital, Manisa, Turkey. Ten suicide attempters, 24 patients with major depressive disorder and 26 subjects without any psychiatric diagnosis and any psychiatric treatment were included in the study. All subjects were asked to give their written consent. Blood samples were collected at the baseline. Serum BDNF was kept at - 70 degrees C before testing, and assayed with an ELISA kit ( Promega; Madison, Wisc., USA) after dilution with the block and sample solution provided with the kit. The data were subjected to the Kruskal-Wallis test for nonparametric analysis of variance. Mean serum BDNF levels were significantly lower in the suicide group (21.2 +/- 12.4 ng/ml) and the major depressive disorder group (21.2 +/- 11.3 ng/ml) than the control group (31.4 +/- 8.8 ng/ml; p = 0.004). These results suggest that BDNF may play an important role in the neurobiology of suicidal behavior. BDNF levels may be a biological marker for suicidal behavior. To investigate the role of BDNF in suicide, further studies with a wider sample size and a variety of psychiatric diagnoses accompanying suicide attempt are needed. Copyright (c) 2007 S. Karger AG, Basel.
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    Evaluation of microRNA expression levels during the craving period of patients diagnosed with severe alcohol use disorder
    Asçibasi, K; Deveci, A; Özyilmaz, B; Erdogan, KM; Çakiroglu, E
    BackgroundThe aim of this study is to compare the serum MicroRNA (miRNA) expression levels on the first day of hospitalization and at the end of the first month of treatment in patients with alcohol use disorder and severe craving symptoms. Through the obtained data, biological agents targeting microRNA for alcohol craving may be developed.MethodsThe volunteer group consists of four patients diagnosed with severe alcohol use disorder. Sociodemographic and Clinical Information Form, DSM-5 Structured Clinical Interview-Clinical Version (SCID-5-CV), Penn Alcohol Craving Scale (PACS) were used as clinical assessment tools. Peripheral blood samples were obtained at the time of application and on the 30th day. miRNA isolation was performed. The expression levels of 2578 different mature human miRNAs were measured.ResultsThe miRNAs showing statistically significant differences in peripheral blood samples taken on the 1st and 30th days from alcohol users are as follows: miR-19a-3p, miR-6849-5p, miR-6726-5p, miR-6848-5p, miR-186-5p, miR-6889-5p, miR-933, miR-370-3p, miR-5739, miR-103a-2-5p, miR-6860, miR-1254, miR-1260a, miR-3921, miR-127-3p, miR-8064, miR-6870-5p, miR-4688ConclusionsA significant difference was found between the 1st and 30th days in 18 of 2578 miRNAs scanned. It is aimed to investigate these 18 miRNAs in larger sample groups during the alcohol craving period.