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Browsing by Author "Dinçalp, H"

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New thiophene-based azo ligands containing azo methine group in the main chain for the determination of copper(II) ions
Dinçalp, H; Toker, F; Dutucasu, I; Avcibasi, N; Icli, S
New kind of azo chromophores containing thiophene moiety and salicyaldimine-based ligand as side chains have been synthesized by a sequential process for optical sensing of Cu2+ metal ions in organic solution. Compounds have been characterized by IR and UV-vis spectrophotometer, H-1 NMR, C-13 NMR, MS, TGA and CV instruments. Spectral characteristics of the synthesized compounds have been investigated in five organic solvents of different polarity. Polarizibility effects of the solvents on the spectral characteristics and the dipole moments in the excited state are estimated. The fluorescence quantum yields of the synthesized compounds have been calculated to be in the range of 0.0035-0.0095 in solvents of different polarity. The fluorescence emission quenching experiments between the synthesized compounds and electron donor (pyrene, anthracene), electron acceptor (Co2+) compounds give the bimolecular quenching rate constants of 10(11) and 10(14) M-1 s(-1), respectively. The free energies of photo-electron transfer process (Delta G(ET)) between the azo dyes and the quenchers have been found to be about -19 kcal/mol. Cyclic voltammetry studies indicate that synthesized azo ligands undergo two- or three-reversible reduction potentials (versus ferrocene) and give LUMO energy value of -3.07 eV which is lower than that of TiO2 conduction band and has a band gap value of similar to 2.5 eV. These results may point that synthesized azo, dyes could be used as hole conducting materials in solid DSSC (Dye Sensitized Solar Cell) devices. Thermal decomposition behavior of the azo dyes gives more information about the structure of the studied materials. The photoisomerization behavior of the synthesized compounds has been investigated in ethyl acetate under Xe lamp irradiation in the fluorescence spectrophotometer for 1 h. Photoisomerization rate constants of cis-trans orientation (k(c-t)) have been found to be about 10(-5) s(-1). The complexation process of synthesized thienylidene azo dyes gives subtle changes in their absorption spectra. (C) 2006 Elsevier Ltd. All rights reserved.
Bromo-substituted cibalackrot backbone, a versatile donor or acceptor main core for organic optoelectronic devices
Dinçalp, H; Saltan, GM; Zafer, C; Kiymaz, DA
Cibalackrot (Ci-I), one of the latest highly conjugated compound possessing bis-lactam structure, was investigated with respect to their brominated derivatives in order to determine their suitable substitution points for the syntheses of new class of small molecules for optoelectronic devices. 7,14-Bis(4-bromophenyl) (Ci-II) and 3,10-dibromo (Ci-III) derivatives of cibalackrot possess moderately narrow band gaps of 2.15 and 2.09 eV, respectively. Notably, Ci-III dye exhibits more red-shifted ultraviolet -visible (UV vis) absorption and fluorescence emission spectra as compared to that of Ci-II dye because Ci-Ill shows more prominent intramolecular charge transfer (ICT) complex than that of Ci-II dye. Electron mobilities of the order of 7.0 x 10(-4) cm(2)/V and 3.1 x 10(-4) cm(2)/V were measured using Ci-II and Ci-III as active layer, respectively. Charge transfer properties of the molecules were investigated in bulk heterojunction device configuration wherein Ci-III showed p-type behavior against n-type PCBM in photovoltaic device. Photovoltaic performance of Ci-III dye which was used as donor component is 20 times higher than that of the device in which this dye was used as acceptor. (C) 2018 Elsevier B.V. All rights reserved.
Targeted Singlet Oxygen Generation Using Different DNA-Interacting Perylene Diimide Type Photosensitizers
Dinçalp, H; Kizilok, S; Içli, S
Singlet oxygen quantum yields (I broken vertical bar (Delta)) of different perylene diimides (PDIs) containing phenyl (PDI-Ph), pyrene (PDI-Pyr), and indole (PDI-In) units in bay positions of the ring were determined using 1,3-diphenylisobenzofuran (DPBF) method in toluene/methanol (99:1) system. Pyrene-substituted PDI were the most efficient singlet oxygen generator among the investigated photosensitizers with a quantum yield of I broken vertical bar (Delta) = 0.93 in toluene/methanol. Additionally, their binding affinities to G-quadruplex DNA structure were investigated by steady-state measurements. There were marked red shifts of absorbance bands for PDI-Pyr/DNA strand complexes with respect to the absorption maxima of DNA-free solution of PDI-Pyr in phosphate buffer at pH 6.
Effect of side chain substituents on the electron injection abilities of unsymmetrical perylene diimide dyes
Dinçalp, H; Askar, Z; Zafer, C; Içli, S
Three near-infrared (NIR) absorbing unsymmetrical perylene diimide D A D type dyes containing 6-undecanoxy as donor group were utilized in dye-sensitized nanocrystalline TiO(2) solar cells. Structure of the acceptor side of the molecules were improved by adding 4-[2-methyl-5-(cyanoacrylic acid)-3-thienyl]-phenyl (V), 3-carboxy-2-pyridil (VI) and 3-carboxy-2-pyrazyl (VII) moieties attached to one of the N-side of the dye. The relationship between the molecular structure of the acceptor sites of the dyes and the photovoltaic performances were discussed. Electrochemical measurements indicated that band gaps of the dyes were energetically favorable for electron injection from the excited state of the dyes to the conduction band of TiO(2) nanoparticles. However, three dyes gave lower conversion efficiency on DSSC applications. Strong electron-withdrawing nature of perylene core might not permit to transfer the photo-generated electrons to the carboxyl groups anchoring to TiO(2) surface, and then solar-to-electricity conversion efficiencies of the dyes were reduced. (C) 2011 Elsevier Ltd. All rights reserved.
Coordination entities of a pyrene-based iminopyridine ligand: Structural and photophysical properties
Ayadi, A; Branzea, DG; Allain, M; Canevet, D; Dinçalp, H; EI-Ghayoury, A
A pyrene-based iminopyridine ligand L has been prepared and displays the absorption and emission properties expected for pyrene-based derivatives in solution. Ligand L, as well as two neutral and, one monocationic coordination entities, respectively formulated as [ZnLCl2] 1, [ReLCl(CO)(3)] 3 and [CuL2] (BF4) 2, have been crystallized and analyzed by single crystal X-ray diffraction analysis. The corresponding crystal structures indicate the formation of supramolecular architectures generated by offset pi...pi stacking between pyrene fragments and strong C-H center dot center dot center dot pi is interactions in coordination entity 1. For the cationic coordination entity 2, the crystal packing reveals the presence of C-H center dot center dot center dot F and C-H center dot center dot center dot pi interactions and numerous C-H center dot center dot center dot pi contacts interconnecting the molecules into a 3D network. As for coordination entity 3, hydrogen bonding and pi center dot center dot center dot pi stacking link the molecules in a three dimensional manner. Zinc(II) and copper(I) coordination entities have also been studied through isothermal titration calorimetry, which indicate a strong binding and a different stoichiometry for both coordination entities. Photophysical studies of the ligand and corresponding coordination entities show a monomer type pyrene emission and a higher fluorescence quantum yield for the zinc coordination entity 1 as compared with copper 2 and rhenium 3 coordination entities. (C) 2017 Elsevier Ltd. All rights reserved.
Synthesis and G-quadruplex binding study of a novel full visible absorbing perylene diimide dye
Dinçalp, H; Kizilok, S; Birel, OH; Içli, S
A novel perylene diimide dye containing glucopyranosyl groups in 1- and 7-positions of the perylene ring has been synthesized and characterized to obtain highly efficient and stable photosensitized material in photodynamic therapy. Solvatochromic studies on this dye in solvents of different polarities have indicated that absorption bands of the dye cover the whole visible spectrum in more polar organic solvents. It shows absorption bands localized at 350-500 nm and 600-850 urn in benzonitrile giving a green color. Also, the dye has a wide absorption region which covers the wavelength between 400 and 800 nm in more polar solvents by changing the dye concentration in the solvents. Singlet oxygen generation efficiency and G-quadruplex binding affinity of the dye have been tested. Theoretical calculations through semi-empirical methods have been performed and a detailed spectroscopic assignment of the molecule has been also presented. (C) 2012 Elsevier B.V. All rights reserved.
Synthesis, characterization and optoelectronic properties of a new perylene diimide-benzimidazole type solar light harvesting dye
Dinçalp, H; Çimen, O; Ameri, T; Brabec, CJ; Içli, S
A perylene diimide type small molecule (BI-PDI) has been synthesized through Suzuki coupling reaction between N,N'-bis(2,6-diisopropylphenyl)-1,7-dibromoperylene-3,4,9,10-tetracarboxylic diimide and 2-(2-hydroxyphenyl)-7-phenyl-1H-benzimidazole-4-boronic acid. BI-PDI small molecule has showed an absorption band between 350 and 750 nm on thin films. HOMO and LUMO energy levels of BI-PDI dye have been calculated to be about -5.92 eV and -3.82 eV, respectively. Solution-processed bulk heterojunction (BHJ) solar cells have been constructed using BI-PDI as donor and [6,6]-phenyl-C-61-butyric acid methyl ester (PC61BM) as acceptor or poly(3-hexylthiophene) (P3HT) as donor and BI-PDI as acceptor. The external quantum efficiencies (EQE) of the devices cover the most of the visible region between 400 and 700 nm for both configurations. Photovoltaic performances of BI-PDI-based organic solar cells are limited by the aggregation tendency of PDI structure and poor hole/electron mobilities of the active layer. (C) 2014 Elsevier B.V. All rights reserved.
Optical and photovoltaic properties of salicylaldimine-based azo ligands
Dinçalp, H; Yavuz, S; Hakli, Ö; Zafer, C; Özsoy, C; Durucasu, I; Içli, S
A series of azo dyes containing salicylaldimine-based ligands as side chains were prepared and characterized. Absorption and emission data in five solvents of different polarities were studied. Photoirradiation studies under an oxygen atmosphere in water showed that the Schiff base side chains enhanced the photo-oxidative stability of the azo chromophore. The electrochemical properties of the dyes were investigated by a cyclic voltammetry. The synthesized salicylaldimine-based azo dyes gave two irreversible oxidation potentials. Complexation behavior of synthesized compounds with titanium (IV) ions was illustrated by the change in their absorption spectra. These ligands are appropriate sensitizers for anchoring to the TiO2 surface chemically in dye-sensitized solar cell (DSSC) productions. Electron injection capacities to TiO2 and photovoltaic performance of the synthesized salicylaidimine-based azo dyes were tested with DSSC. (C) 2009 Elsevier B.V. All rights reserved.
Small biomolecule dopant retinals: Electron blocking layer in P3HT:PCBM type organic solar cells
Kirmaci, E; Dinçalp, H; Saltan, GM; Kiran, M; Zafer, C
We present a comparative study of the photophysics and electron/hole properties of all-trans retinal-benzimidazole type molecules decorated with different electronic moieties (such as -OCH3, -N(CH3)(2), -F, -CF3) in organic photovoltaic (OPV) devices in solution end on solid thin films. Steady-state spectra of synthesized dyes give large Stokes shifts (6887-13152 cm(-1)) in studied solvents. Decay times of these dyes were found to be substituent dependent giving a bi-exponential decay for fluorine containing retinals. Trans to cis photo-isomerization rate constants of synthesized dyes were found to be about 3.3-16.4 x 10(-6) s(-1). Using a cyclic voltammetry measurements, HOMO and LUMO energy levels of fluorine-substituted dyes shift to lower values as compared to that of unfluorinated derivatives. We compared unusual electron blocking behavior of methoxy- and N,N-dimethylamino-substituted derivatives (Ret-I and Ret-II, respectively) in bulk heterojunction solar cells (BHJ-SCs) incorporating an active layer of P3HT:PCBM doped with Ret derivatives at various weight ratios. Hole mobility values for fluorine containing retinals were found to be about 1.0 x 10(-4) and 7.1 x 10(-4) cm(2)/V s for Retail and Ret-IV dyes, respectively.
Indigo-Based Acceptor Type Small Molecules: Synthesis, Electrochemical and Optoelectronic Characterizations
Saltan, GM; Kiymaz, DA; Zafer, C; Dinçalp, H
In this paper, we report design and synthesis of novel low bandgap small molecules, indigo-benzimidazole (Tyr-3) and indigo-schiff base (Tyr-4) type acceptors. In these structures, tert-butoxycarbonyl (t-BOC) group has been attached to indigo nitrogen atom in order to increase the solubility. UV-vis absorption spectra of Tyr-3 and Tyr-4 dyes exhibit wide absorption bands ranging from 350 to 600 nm, indicating the relatively low bandgap giving around 2.07 eV for each. Excitation of both Tyr-3 and Tyr-4 dyes at 485 nm displays characteristic emission features of indigo moiety and also intramolecular charge transfer complex (ICT) related with their subunits. Besides increasing fluorescence quantum yields as compared to model compound, biexponential decay times for fluorescence life times were also obtained for Tyr-3 and Tyr-4 dyes. Their appropriate energy levels along with low HOMO levels are desired for light harvesting acceptors for organic solar cells when blended with poly[N-9'-heptadecanyl-2,7-carbazole-alt-5,5-(4,7-di-2-thienyl-2',1',3'-benzothiadiazole] (PCDTBT) as donor polymer. Photovoltaic behavior of the synthesized dyes were examined in bulk heterojunction concept and achieved photovoltaic conversion efficiencies were discussed.
Optoelectronic performance comparison of new thiophene linked benzimidazole conjugates with diverse substitution patterns
Saltan, GM; Dinçalp, H; Kirmaci, E; Kiran, M; Zafer, C
In an approach to develop efficient organic optoelectronic devices to be used in light-driven systems, a series of three thiophene linked benzimidazole conjugates were synthesized and characterized. The combination of two thiophene rings to a benzimidazole core decorated with different functional groups (such as -OCH3, N(CH3)(2), CF3) resulted in donor-acceptor type molecular scaffold. The effect of the electronic behavior of the substituents on the optical, electrochemical, morphological and electron/hole transporting properties of the dyes were systematically investigated. DTBI2 dye exhibited distinct absorption properties among the other studied dyes because N,N-dimethylamino group initiated intramolecular charge transfer (ICT) process in the studied solvents. In solid state, the dyes exhibit peaks extending up to 600 nm. Depending on the solvent polarities, dyes show significant wavelength changes on their fluorescence emission spectra in the excited states. Morphological parameters of the thin films spin-coated from CHCl3 solution were investigated by using AFM instrument; furthermore photovoltaic responses are reported, even though photovoltaic performances of the fabricated solar cells with different configurations are quite low. (C) 2017 Elsevier B.V. All rights reserved.
Photoinduced electron transfer-catalyzed processes of sulfoamino perylene diimide under concentrated sun light
Dinçalp, H; Içli, S
A new water-soluble perylene diimide derivative, N,N'-bis(12-sulfoaminododecyl)-3,4,9,10-perylenetetracarboxdiimide (SULFAPER), has been synthesized and characterized by visible, fluorescence, IR, H-1 and C-13 NMR, mass, CV and time resolved measurements. Its photophysical properties in aqueous and organic solutions have been described. The singlet energy levels of the synthesized compound have been found to be 57.8 kcal/mol and 59.2 kcal/mol in aqueous and methanol solution, respectively. The LUMO energy level of SULFAPER has been determined by solid state cyclic voltammetry, and found to be -3.60 eV. SULFAPER undergoes two electron reduction process (-0.64 V and -0.42 V) versus ferrocene. SULFAPER has an energy band gap of 2.56 eV. The absorption maximum of the synthesized compound gives bathochromic shift of 12 nut in water with respect to its visible spectrum in methanol solution. The fluorescence quantum yields of the compound are low both in water and methanol solution because of the aggregation effect. Time-resolved fluorescence measurements have showed that the fluorescence decay times of the SULFAPER are tau(1) = 4.1 ns and tau(2) = 0.8 ns in water, and tau(1) = 4.0 ns and tau(2) = 2.5 ns in methanol solutions. The aqueous solution of SULFAPER is stable under UV-VIS irradiation, but a slight loss of fluorescence emission (25%) has been detected at a rate of k(p) = 6.3 x 10(-5) s(-1) in methanol solution, which might be the result of either the quenching of fluorescence emission by reactive oxygen species, or by enhanced aggregation effect. SULFAPER-sensitized photooxidations of (E)-cinnamic acid and methyl acrylate have been found to give selective photoproduct formations under concentrated sun light in organic phase. (E)-cinnamic acid has been seen to favor photochemical E-Z isomerization and methyl acrylate has been seen to favor the formation of methyl 2-oxopropanoate. The quantum yield of (E)-cinnamic acid (Phi(CA)) under concentrated solar irradiation process has been calculated to be about 0.015, by the employment of an actinometry method developed by Erten and Icli. (c) 2005 Elsevier Ltd. All rights reserved.
Comparison of the Optoelectronic Performance of Neutral and Cationic Forms of Riboflavin
Saltan, GM; Kiymaz, DA; Zafer, C; Dinçalp, H
The riboflavin dye 2,3,4,5-tetra-O-acetyl-1-[3-(6-bromohexyl)-7,8-dimethyl-2,4-dioxo-3,4-dihydrobenzo[g]pteridin-10(2H)-yl]-1-deoxypentitol and its pyridinium salt were synthesized, and studied by absorption and fluorescence spectroscopy in solutions and on thin film states. The first absorption band of riboflavin-pyridinium salt derivative is red-shifted by 10 nm compared to neutral one on film. Cationic riboflavin derivative shows significant wavelength changes on its fluorescence emission spectrum in the excited state depending on the solvent polarity and the electronic environment. The fluorescence quantum yields of cationic riboflavin gave much higher values as compared to that of its neutral form. The fluorescence lifetimes were found to be in the range of 5.5-6.6 ns with mono - exponential behavior. These dyes possess low-lying HOMO energy levels which are suitable to be able to inject holes to donor polymers so that they can be used as acceptor component in the active layer of bulk heterojunction solar cells (BHJ-SCs). Photovoltaic responses are reported for P3HT:riboflavin active layer wherein the synthesized dyes are used as acceptor component. Also, neutral riboflavin shows greater electron mobility value of 1.3 x 10(-3) cm(2)/Va (TM) s compared to its cationic derivative.
Studies on UV-vis and fluorescence changements in Co2+ and Cu2+ recognition by a new benzimidazole-benzothiadiazole derivative
Çimen, OZ; Dinçalp, H; Varlikli, C
A novel fluorescent sensor (BI-T) was synthesized by the coupling reaction of 2-(2-hydroxyphenyl)-7-phenyl-1H-benzimidazole-4-boronic acid with 4,7-dibromo-2,1,3-benzothiadiazole via Pd-catalysed Suzuki reaction. Its photophysical properties were investigated systematically in different solvents to analyze its potential usage in the fluorescence detection for transition metal ions such as Co2+ and Cu2+ in solutions. In benzonitrile solution, new absorption bands for complex structure of BI-T at 470 nm and 580 nm were appeared in the presence of Co2+ ions with respect to the uncomplexed form of the sensor absorption. BI-T sensor is usable for both Co2+ and Cu2+ sensation through on-off fluorescence change in benzonitrile. In ethanol solution, BI-T shows similar optical performances to detect Co2+ and Cu2+ ions. BI-T detects trace amount of transition metals in ethanol with estimated limit of detection around 4.1 x 10(-7) M and 5.5 x 10(-7) M for Co2+ and Cu2+ ions, respectively. Possible formation of metal-to-ligand charge transfer (MLCT) state during the titration with Co2+ ion is supported by the detection of long-lived species in the excited state. (C) 2014 Elsevier B.V. All rights reserved.
Synthesis and photophysical characterization of isoindigo building blocks as molecular acceptors for organic photovoltaics
Dinçalp, H; Saltan, GM; Zafer, C; Mutlu, A
Five isoindigo-based donor-acceptor-donor (D-A-D) type small molecules have been synthesized in order to investigate their intramolecular charge transfer characteristics. UV-vis absorption of these dyes exhibits a wide absorption band ranging from 300 to 650 nm with two distinct bands, giving the narrow bandgaps between 1.72 and 1.85 eV. Taking into account their HOMO-LUMO energy levels and bandgaps, isoindigo dyes have been used in the active layer of organic solar cell (OSC) devices. When these small molecule semiconductors were used as acceptors with the donor poly(3-hexylthiophene-2,5-diyl (P3HT) polymer in the inverted OSC devices, the highest power conversion efficiency (PCE) was obtained as 0.10% for pyrene-substituted isoindigo derivative. (C) 2018 Elsevier B.V. All rights reserved.
Synthesis and determination of fluorescence properties of new soluble diketopyrrolopyrrole type photosensitizers
Türkçen, S; Dinçalp, H; Saltan, GM
Four organic small molecules bearing phenyl diketopyrrolopyrrole (DPP) unit as the main acceptor group and indole as the main thermal group with soluble units, coded as DPP3(a-b) and DPP4(a-b), were synthesized and their optical/electrochemical properties were investigated. Intense visible absorption bands around 480 nm were assigned to the DPP main core, as well as bands around 600 nm were attributed to the formation of charge-transfer complex between the electron-rich indole units and electron-withdrawing DPP core in chloroform solution. All of the compounds were found to be fluorescent in solution and on thin films with emission wavelengths between 500 and 700 nm. The fluorescence decay kinetic measurements of these dyes were also studied. The synthesized compounds have electrochemical energy band gaps from 2.15 to 2.28 eV. Then, the potential usage of the final products in bulk heterojunction solar cells (BFIJ-OSCs) were evaluated. (C) 2019 Elsevier B.V. All rights reserved.
Fluorene Based Ferric Complex as Colorimetric and Fluorometric Probe for Highly Selective Detection of CN- and S2- Anions
Saltan, GM; Dinçalp, H
A series of new chemosensor molecules bearing benzothiazole-, quinoline- and phthalazine-functionalized fluorene derivatives were synthesized and their complexation behaviors with Fe3+ and Sn2+ ions were investigated. The sensing abilities of their complexes towards both cyanide and sulfide anions were investigated by colorimetric and fluorometric techniques in detail. The sensing mechanism was investigated by Job's and Scatchard plots evaluations, and also absorption/fluorescence titration experiments. Among the studied dye/metal binary systems, F-BT sensor to Fe3+ giving the detection limits of 3.1 mu g has also displayed high selectivity and sensitivity towards CN- and S2- anions, lead to a significant color change of the solution observable by the naked eye.
Pyrene bisiminopyridine ligand and its zinc complex
Ayadi, A; Branzea, D; Dinçalp, H; Zouari, N; El-Ghayoury, A
The synthesis of a pyrene bisiminopyridine ligand L was successfully accomplished by condensation between 1-aminopyrene and 2,6-pyridinecarboxaldehyde. The complexation of L with zinc triflate afforded a neutral metal complex formulated as [Zn(H2O)LCF3SO3)(2)]center dot 2Et(2)O. In the complex, the ligand is coordinated to zinc(II) through its three nitrogen atoms which form a distorted octahedral environment together with three oxygen atoms, two from the triflate anions and one from aqua ligand. Both compounds have been characterized using NMR, elemental analysis, mass spectrometry, electronic absorption (UV-Vis) and infrared. Luminescence properties of these compounds show an emission maxima at 412 nm, indicating a pyrene monomer emission.
Synthesis and Spectroscopic Properties of a Novel Perylenediimide Derivative
Hakli-Birel, Ö; Dinçalp, H; Zafer, C; Demiç, S; Colladet, K; Vanderzande, D; Yürüm, Y; Içli, S
A novel symmetric 3,4,9,10-perylenetetracarboxylic acid derivative (PDI1) dye based on thiophene donor group was synthesized and characterized by FT-IR and H-1 NMR. Cyclic Voltammetry analysis is performed to determine the energy levels of the perylene derivative. Optical characteristics were determined by visible absorption and fluorescence emission spectra. Spectral behavior and fluorescence quantum yield of PDI1 have been measured in different solvents. The dye exhibits high fluorescence quantum yield (Phi(f): 0.94-0.99). But the quantum yield PDI1 is very low in the n-butanol solution (Phi(f): 0.12). The photophysical properties have important implications for use in a variety of electroactive and photovoltaic applications. A photovoltaic device was fabricated with PDI1 as transporting material. The conversion efficiency for DSSC sensitized by PDI1 is 0.0065%. PDI1 exhibits electrochromic behavior by switching between neutral (red) and oxidized (blue) states. Electron transfer capacity of PDI to the TiO2 was investigated by incorporation of dye as sensitizer in dye sensitized solar cell (DSSC). Soluble dye molecules are very important to prepare dye sensitized solar cell. Solubility was increased with thiophene group.
Preliminary tests of the radiopharmaceutical potential of N-(2,6-diisopropylphenyl)-N'-(4-pyridyl)-perylene-3,4,9,10-tetracarboxylic diimide radiolabeled with 131I
Avcibasi, U; Dinçalp, H; Ünak, T; Yildirim, Y; Avcibasi, N; Duman, Y; Içli, S
Perylene diimide derivatives are one of the G-quadruplex DNA interactive agents which are thought to be useful in application of cancer treatment Starting from this consideration, N-(2,6-diisopropylphenyl)-N'-(4-pyridyl)-perylene-3,4,9,10-tetracarboxylic diimide (PYPER) was synthesized, radioiodinated with I-131, and its radiopharmaceutical potentials were tested on a male Albino rabbit and male Albino Wistar rats. This compound was successfully radioiodinated with I-131 with a radioiodination yield of about 100%. Scintigraphic imaging with the radiiodinated compound (I-131-PYPER) was performed on a rabbit. Static images were obtained from posterior projection using a Diacan gamma camera at several time intervals. The scintigrams clearly showed that the radioiodinated compound was not quickly cleared from the metabolism, accumulating in the stomach over about 30 minutes. The clearance time of this compound was considerably longer than 5 hours. The results obtained in this study agreed with that of the biodistribution studies and indicated that I-131-PYPER might be used as a scintigraphic agent for examining stomach diseases.

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