Browsing by Author "Dittmann S."

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    The International Society for Bipolar Disorders-Battery for Assessment of Neurocognition (ISBD-BANC)
    (2010) Yatham L.N.; Torres I.J.; Malhi G.S.; Frangou S.; Glahn D.C.; Bearden C.E.; Burdick K.E.; Martínez-Arán A.; Dittmann S.; Goldberg J.F.; Ozerdem A.; Aydemir O.; Chengappa K.N.R.
    Objectives: Although cognitive impairment is recognized as an important clinical feature of bipolar disorder, there is no standard cognitive battery that has been developed for use in bipolar disorder research. The aims of this paper were to identify the cognitive measures from the literature that show the greatest magnitude of impairment in bipolar disorder, to use this information to determine whether the Measurement and Treatment Research to Improve Cognition in Schizophrenia (MATRICS) Consensus Cognitive Battery (MCCB), developed for use in schizophrenia, might be suitable for bipolar disorder research, and to propose a preliminary battery of cognitive tests for use in bipolar disorder research. Methods: The project was conducted under the auspices of the International Society for Bipolar Disorders and involved a committee that comprised researchers with international expertise in the cognitive aspects of bipolar disorder. In order to identify cognitive tasks that show the largest magnitude of impairment in bipolar disorder, we reviewed the literature on studies assessing cognitive functioning (including social cognition) in bipolar disorder. We further provided a brief review of the cognitive overlap between schizophrenia and bipolar disorder and evaluated the degree to which tasks included in the MCCB (or other identified tasks) might be suitable for use in bipolar disorder. Results: Based on evidence that cognitive deficits in bipolar disorder are similar in pattern but less severe than in schizophrenia, it was judged that most subtests comprising the MCCB appear appropriate for use in bipolar disorder. In addition to MCCB tests, other specific measures of more complex verbal learning (e.g., the California Verbal Learning Test) or executive function (Stroop Test, Trail Making Test-part B, Wisconsin Card Sorting Test) also show substantial impairment in bipolar disorder. Conclusions: Our analysis reveals that the MCCB represents a good starting point for assessing cognitive deficits in research studies of bipolar disorder, but that other tasks including more complex verbal learning measures and tests of executive function should also be considered in assessing cognitive compromise in bipolar disorder. Several promising cognitive tasks that require further study in bipolar disorder are also presented. © 2010 The Authors. Journal compilation © 2010 John Wiley & Sons A/S.
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    Neuropsychological testing of cognitive impairment in euthymic bipolar disorder: An individual patient data meta-analysis
    (2013) Bourne C.; Aydemir O.; Balanzá-Martínez V.; Bora E.; Brissos S.; Cavanagh J.T.O.; Clark L.; Cubukcuoglu Z.; Dias V.V.; Dittmann S.; Ferrier I.N.; Fleck D.E.; Frangou S.; Gallagher P.; Jones L.; Kieseppä T.; Martínez-Aran A.; Melle I.; Moore P.B.; Mur M.; Pfennig A.; Raust A.; Senturk V.; Simonsen C.; Smith D.J.; Bio D.S.; Soeiro-de-Souza M.G.; Stoddart S.D.R.; Sundet K.; Szöke A.; Thompson J.M.; Torrent C.; Zalla T.; Craddock N.; Andreassen O.A.; Leboyer M.; Vieta E.; Bauer M.; Worhunsky P.D.; Tzagarakis C.; Rogers R.D.; Geddes J.R.; Goodwin G.M.
    Objective: An association between bipolar disorder and cognitive impairment has repeatedly been described, even for euthymic patients. Findings are inconsistent both across primary studies and previous meta-analyses. This study reanalysed 31 primary data sets as a single large sample (N = 2876) to provide a more definitive view. Method: Individual patient and control data were obtained from original authors for 11 measures from four common neuropsychological tests: California or Rey Verbal Learning Task (VLT), Trail Making Test (TMT), Digit Span and/or Wisconsin Card Sorting Task. Results: Impairments were found for all 11 test-measures in the bipolar group after controlling for age, IQ and gender (Ps ≤ 0.001, E.S. = 0.26-0.63). Residual mood symptoms confound this result but cannot account for the effect sizes found. Impairments also seem unrelated to drug treatment. Some test-measures were weakly correlated with illness severity measures suggesting that some impairments may track illness progression. Conclusion: This reanalysis supports VLT, Digit Span and TMT as robust measures of cognitive impairments in bipolar disorder patients. The heterogeneity of some test results explains previous differences in meta-analyses. Better controlling for confounds suggests deficits may be smaller than previously reported but should be tracked longitudinally across illness progression and treatment. © 2013 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.