Browsing by Author "Doğan M."
Now showing 1 - 12 of 12
Results Per Page
Sort Options
Item Turner syndrome and associated problems in turkish children: A multicenter study(Galenos Yayincilik,, 2015) Yeşilkaya E.; Bereket A.; Darendeliler F.; Baş F.; Poyrazoğlu Ş.; Aydın B.K.; Darcan Ş.; Dündar B.; Büyükinan M.; Kara C.; Sarı E.; Adal E.; Akıncı A.; Atabek M.E.; Demirel F.; Çelik N.; Özkan B.; Özhan B.; Orbak Z.; Ersoy B.; Doğan M.; Ataş A.; Turan S.; Gökşen D.; Tarım Ö.; Yüksel B.; Ercan O.; Hatun Ş.; Şimşek E.; Ökten A.; Abacı A.; Döneray H.; Özbek M.N.; Keskin M.; Önal H.; Akyürek N.; Bulan K.; Tepe D.; Emeksiz H.C.; Demir K.; Kızılay D.; Topaloğlu A.K.; Eren E.; Özen S.; Abalı S.; Akın L.; Eklioğlu B.S.; Kaba S.; Anık A.; Baş S.; Ünüvar T.; Sağlam H.; Bolu S.; Özgen T.; Doğan D.; Çakır E.D.; Şen Y.; Andıran N.; Çizmecioğlu F.; Evliyaoğlu O.; Karagüzel G.; Pirgon Ö.; Çatlı G.; Can H.D.; Gürbüz F.; Binay Ç.; Baş V.N.; Fidancı K.; Polat A.; Gül D.; Açıkel C.; Demirbilek H.; Cinaz P.; Bondy C.Objective: Turner syndrome (TS) is a chromosomal disorder caused by complete or partial X chromosome monosomy that manifests various clinical features depending on the karyotype and on the genetic background of affected girls. This study aimed to systematically investigate the key clinical features of TS in relationship to karyotype in a large pediatric Turkish patient population. Methods: Our retrospective study included 842 karyotype-proven TS patients aged 0-18 years who were evaluated in 35 different centers in Turkey in the years 2013-2014. Results: The most common karyotype was 45,X (50.7%), followed by 45,X/46,XX (10.8%), 46,X,i(Xq) (10.1%) and 45,X/46,X,i(Xq) (9.5%). Mean age at diagnosis was 10.2±4.4 years. The most common presenting complaints were short stature and delayed puberty. Among patients diagnosed before age one year, the ratio of karyotype 45,X was significantly higher than that of other karyotype groups. Cardiac defects (bicuspid aortic valve, coarctation of the aorta and aortic stenosi) were the most common congenital anomalies, occurring in 25% of the TS cases. This was followed by urinary system anomalies (horseshoe kidney, double collector duct system and renal rotation) detected in 16.3%. Hashimoto’s thyroiditis was found in 11.1% of patients, gastrointestinal abnormalities in 8.9%, ear nose and throat problems in 22.6%, dermatologic problems in 21.8% and osteoporosis in 15.3%. Learning difficulties and/or psychosocial problems were encountered in 39.1%. Insulin resistance and impaired fasting glucose were detected in 3.4% and 2.2%, respectively. Dyslipidemia prevalence was 11.4%. Conclusion: This comprehensive study systematically evaluated the largest group of karyotype-proven TS girls to date. The karyotype distribution, congenital anomaly and comorbidity profile closely parallel that from other countries and support the need for close medical surveillance of these complex patients throughout their lifespan. © Journal of Clinical Research in Pediatric Endocrinology.Item Growth curves for Turkish girls with turner syndrome: Results of the Turkish turner syndrome study group(Galenos Yayincilik,, 2015) Darendeliler F.; Yeşilkaya E.; Bereket A.; Baş F.; Bundak R.; Sarı E.; Aydın B.K.; Darcan Ş.; Dündar B.; Büyükinan M.; Kara C.; Mazıcıoğlu M.M.; Adal E.; Akıncı A.; Atabek M.E.; Demirel F.; Çelik N.; Özkan B.; Özhan B.; Orbak Z.; Ersoy B.; Doğan M.; Ataş A.; Turan S.; Gökşen D.; Tarım Ö.; Yüksel B.; Ercan O.; Hatun Ş.; Şimşek E.; Ökten A.; Abacı A.; Döneray H.; Özbek M.N.; Keskin M.; Önal H.; Akyürek N.; Bulan K.; Tepe D.; Emeksiz H.C.; Demir K.; Kızılay D.; Topaloğlu A.K.; Eren E.; Özen S.; Demirbilek H.; Abalı S.; Akın L.; Eklioğlu B.S.; Kaba S.; Anık A.; Baş S.; Ünüvar T.; Sağlam H.; Bolu S.; Özgen T.; Doğan D.; Çakır E.D.; Şen Y.; Andıran N.; Çizmecioğlu F.; Evliyaoğlu O.; Karagüzel G.; Pirgon Ö.; Çatlı G.; Can H.D.; Gürbüz F.; Binay Ç.; Baş V.N.; Sağlam C.; Gül D.; Polat A.; Açıke C.; Cinaz P.Objective: Children with Turner syndrome (TS) have a specific growth pattern that is quite different from that of healthy children. Many countries have population-specific growth charts for TS. Considering national and ethnic differences, we undertook this multicenter collaborative study to construct growth charts and reference values for height, weight and body mass index (BMI) from 3 years of age to adulthood for spontaneous growth of Turkish girls with TS. Methods: Cross-sectional height and weight data of 842 patients with TS, younger than 18 years of age and before starting any therapy, were evaluated. Results: The data were processed to calculate the 3rd, 10th, 25th, 50th, 75th, 90th and 97th percentile values for defined ages and to construct growth curves for height-for-age, weight-for-age and BMI-for-age of girls with TS. The growth pattern of TS girls in this series resembled the growth pattern of TS girls in other reports, but there were differences in height between our series and the others. Conclusion: This study provides disease-specific growth charts for Turkish girls with TS. These disease-specific national growth charts will serve to improve the evaluation of growth and its management with growth-promoting therapeutic agents in TS patients. © Journal of Clinical Research in Pediatric Endocrinology, Published by Galenos Publishing.Item Anthropometric findings from birth to adulthood and their relation with karyotpye distribution in Turkish girls with Turner syndrome(Wiley-Liss Inc., 2016) Sari E.; Bereket A.; Yeşilkaya E.; Baş F.; Bundak R.; Aydin B.K.; Darcan S.; Dündar B.; Büyukinan M.; Kara C.; Adal E.; Akinci A.; Atabek M.E.; Demirel F.; Çelik N.; Özkan B.; Özhan B.; Orbak Z.; Ersoy B.; Doğan M.; Ataş A.; Turan S.; Gökşen D.; Tarim O.; Yüksel B.; Ercan O.; Hatun S.; Şimşek E.; Ökten A.; Abaci A.; Döneray H.; Özbek M.N.; Keskin M.; Önal H.; Akyürek N.; Bulan K.; Tepe D.; Emeksiz H.C.; Demir K.; Kizilay D.; Topaloğlu A.K.; Eren E.; Özen S.; Demirbilek H.; Abali S.; Akin L.; Eklioğlu B.S.; Kaba S.; Anik A.; Baş S.; Unuvar T.; Sağlam H.; Bolu S.; Özgen T.; Doğan D.; Çakir E.D.; Şen Y.; Andiran N.; Çizmecioğlu F.; Evliyaoğlu O.; Karagüzel G.; Pirgon O.; Çatli G.; Can H.D.; Gürbüz F.; Binay C.; Baş V.N.; Fidanci K.; Gül D.; Polat A.; Acikel C.; Cinaz P.; Darendeliler F.To evaluate the anthropometric features of girls with Turner syndrome (TS) at birth and presentation and the effect of karyotype on these parameters. Data were collected from 842 patients with TS from 35 different centers, who were followed-up between 1984 and 2014 and whose diagnosis age ranged from birth to 18 years. Of the 842 patients, 122 girls who received growth hormone, estrogen or oxandrolone were excluded, and 720 girls were included in the study. In this cohort, the frequency of small for gestational age (SGA) birth was 33%. The frequency of SGA birth was 4.2% (2/48) in preterm and 36% (174/483) in term neonates (P<0.001). The mean birth length was 1.3cm shorter and mean birth weight was 0.36kg lower than that of the normal population. The mean age at diagnosis was 10.1±4.4 years. Mean height, weight and body mass index standard deviation scores at presentation were -3.1±1.7, -1.4±1.5, and 0.4±1.7, respectively. Patients with isochromosome Xq were significantly heavier than those with other karyotype groups (P=0.007). Age at presentation was negatively correlated and mid-parental height was positively correlated with height at presentation. Mid-parental height and age at presentation were the only parameters that were associated with height of children with TS. The frequency of SGA birth was found higher in preterm than term neonates but the mechanism could not be clarified. We found no effect of karyotype on height of girls with TS, whereas weight was greater in 46,X,i(Xq) and 45,X/46,X,i(Xq) karyotype groups. © 2016 Wiley Periodicals, Inc.Item CAUSAL RELATIONSHIP AMONG THE SOURCES OF ANXIETY, SELF-EFFICACY, AND PROFICIENCY IN L2 LISTENING(Routledge, 2020) Canaran Ö.; Bayram İ.; Doğan M.; Baturay M.H.Recent research focusing on the sources of listening anxiety identified individual and external factors (IEF), listeners’ control over input (LC), and perceived level of task difficulty (PTD) as the main causes of anxiety among L2 listeners. This correlational study aims to explore whether the sources of anxiety in L2 listening have a causal relationship to listeners’ self-efficacy and listening proficiency. Data were gathered from 347 students studying in the preparatory program of English in Turkey through Foreign Language Anxiety Scale (FLAC), Listening Self-efficacy Scale (LSS), and listening test scores of the students. Structural equation modeling (SEM) technique was conducted for data analysis. Results showed that there were strong negative associations between individual and external factors causing anxiety and self-efficacy while there were moderate level, negative associations between the perceived level of task difficulty and self-efficacy in L2 listening. Our work further proved that the listeners’ control over input was positively and moderately related to the levels of listeners’ self-efficacy, which was positively and strongly correlated with proficiency in L2 listening. © 2020, © 2020 International Listening Association.Item Smartphone addiction among adults: The role of smartphone use, fear of missing out (FoMO), and self-efficacy among Turkish adults(AVES, 2023) Gökçearslan Ş.; Eşiyok E.; Griffiths M.D.; Doğan M.; Turancı E.Due to its computer-like features and applications, smartphone use has become a globally popular activity. Moreover, smartphones have become an important part of individuals’ daily lives. However, using smartphones excessively may result in smartphone addiction for a small minority of individuals. Consequently, the present study investigated the role of smartphone and social network site use, fear of missing out, and perceived self-efficacy in smartphone addiction among adults. In total, 488 adults (aged 20–65 years) participated in the study. The participants were recruited utilizing convenience sampling. Data were collected using an online questionnaire, and the relationship between the variables was tested using structural equation modeling. The results of the structural equation modeling showed that both smartphone use and fear of missing out positively affected smartphone addiction. The effect of social networking site use on smartphone use was significant. The findings of the present study found that fear of missing out and the time spent on smartphones explained 31% of the variance of smartphone addiction among adults, and smartphone usage predicted smartphone addiction. Based on the findings, excessive smartphone use and a higher level of fear of missing out appear to play a role in smartphone addiction. Social networking site use is also associated with an increase in the time spent on smartphones. Smartphone addiction prevention activities should focus on young adults. For future studies, psychological issues other than fear of missing out could be taken into consideration when examining the contribu-tory factors of smartphone addiction. © Author(s).Item Efficacy of subsequent treatments in patients with hormone-positive advanced breast cancer who had disease progression under CDK 4/6 inhibitor therapy(BioMed Central Ltd, 2023) Karacin C.; Oksuzoglu B.; Demirci A.; Keskinkılıç M.; Baytemür N.K.; Yılmaz F.; Selvi O.; Erdem D.; Avşar E.; Paksoy N.; Demir N.; Göksu S.S.; Türker S.; Bayram E.; Çelebi A.; Yılmaz H.; Kuzu Ö.F.; Kahraman S.; Gökmen İ.; Sakin A.; Alkan A.; Nayır E.; Uğraklı M.; Acar Ö.; Ertürk İ.; Demir H.; Aslan F.; Sönmez Ö.; Korkmaz T.; Celayir Ö.M.; Karadağ İ.; Kayıkçıoğlu E.; Şakalar T.; Öktem İ.N.; Eren T.; Urul E.; Mocan E.E.; Kalkan Z.; Yıldırım N.; Ergün Y.; Akagündüz B.; Karakaya S.; Kut E.; Teker F.; Demirel B.Ç.; Karaboyun K.; Almuradova E.; Ünal O.Ü.; Oyman A.; Işık D.; Okutur K.; Öztosun B.; Gülbağcı B.B.; Kalender M.E.; Şahin E.; Seyyar M.; Özdemir Ö.; Selçukbiricik F.; Kanıtez M.; Dede İ.; Gümüş M.; Gökmen E.; Yaren A.; Menekşe S.; Ebinç S.; Aksoy S.; İmamoğlu G.İ.; Altınbaş M.; Çetin B.; Uluç B.O.; Er Ö.; Karadurmuş N.; Erdoğan A.P.; Artaç M.; Tanrıverdi Ö.; Çiçin İ.; Şendur M.A.N.; Oktay E.; Bayoğlu İ.V.; Paydaş S.; Aydıner A.; Salim D.K.; Geredeli Ç.; Yavuzşen T.; Doğan M.; Hacıbekiroğlu İ.Background: There is no standard treatment recommended at category 1 level in international guidelines for subsequent therapy after cyclin-dependent kinase 4/6 inhibitor (CDK4/6) based therapy. We aimed to evaluate which subsequent treatment oncologists prefer in patients with disease progression under CDKi. In addition, we aimed to show the effectiveness of systemic treatments after CDKi and whether there is a survival difference between hormonal treatments (monotherapy vs. mTOR-based). Methods: A total of 609 patients from 53 centers were included in the study. Progression-free-survivals (PFS) of subsequent treatments (chemotherapy (CT, n:434) or endocrine therapy (ET, n:175)) after CDKi were calculated. Patients were evaluated in three groups as those who received CDKi in first-line (group A, n:202), second-line (group B, n: 153) and ≥ 3rd-line (group C, n: 254). PFS was compared according to the use of ET and CT. In addition, ET was compared as monotherapy versus everolimus-based combination therapy. Results: The median duration of CDKi in the ET arms of Group A, B, and C was 17.0, 11.0, and 8.5 months in respectively; it was 9.0, 7.0, and 5.0 months in the CT arm. Median PFS after CDKi was 9.5 (5.0–14.0) months in the ET arm of group A, and 5.3 (3.9–6.8) months in the CT arm (p = 0.073). It was 6.7 (5.8–7.7) months in the ET arm of group B, and 5.7 (4.6–6.7) months in the CT arm (p = 0.311). It was 5.3 (2.5–8.0) months in the ET arm of group C and 4.0 (3.5–4.6) months in the CT arm (p = 0.434). Patients who received ET after CDKi were compared as those who received everolimus-based combination therapy versus those who received monotherapy ET: the median PFS in group A, B, and C was 11.0 vs. 5.9 (p = 0.047), 6.7 vs. 5.0 (p = 0.164), 6.7 vs. 3.9 (p = 0.763) months. Conclusion: Physicians preferred CT rather than ET in patients with early progression under CDKi. It has been shown that subsequent ET after CDKi can be as effective as CT. It was also observed that better PFS could be achieved with the subsequent everolimus-based treatments after first-line CDKi compared to monotherapy ET. © 2023, The Author(s).Item Correction: Efficacy of subsequent treatments in patients with hormone-positive advanced breast cancer who had disease progression under CDK 4/6 inhibitor therapy (BMC Cancer, (2023), 23, 1, (136), 10.1186/s12885-023-10609-8)(BioMed Central Ltd, 2023) Karacin C.; Oksuzoglu B.; Demirci A.; Keskinkılıç M.; Baytemür N.K.; Yılmaz F.; Selvi O.; Erdem D.; Avşar E.; Paksoy N.; Demir N.; Göksu S.S.; Türker S.; Bayram E.; Çelebi A.; Yılmaz H.; Kuzu Ö.F.; Kahraman S.; Gökmen İ.; Sakin A.; Alkan A.; Nayır E.; Uğraklı M.; Acar Ö.; Ertürk İ.; Demir H.; Aslan F.; Sönmez Ö.; Korkmaz T.; Celayir Ö.M.; Karadağ İ.; Kayıkçıoğlu E.; Şakalar T.; Öktem İ.N.; Eren T.; Erul E.; Mocan E.E.; Kalkan Z.; Yıldırım N.; Ergün Y.; Akagündüz B.; Karakaya S.; Kut E.; Teker F.; Demirel B.Ç.; Karaboyun K.; Almuradova E.; Ünal O.Ü.; Oyman A.; Işık D.; Okutur K.; Öztosun B.; Gülbağcı B.B.; Kalender M.E.; Şahin E.; Seyyar M.; Özdemir Ö.; Selçukbiricik F.; Kanıtez M.; Dede İ.; Gümüş M.; Gökmen E.; Yaren A.; Menekşe S.; Ebinç S.; Aksoy S.; İmamoğlu G.İ.; Altınbaş M.; Çetin B.; Uluç B.O.; Er Ö.; Karadurmuş N.; Erdoğan A.P.; Artaç M.; Tanrıverdi Ö.; Çiçin İ.; Şendur M.A.N.; Oktay E.; Bayoğlu İ.V.; Paydaş S.; Aydıner A.; Salim D.K.; Geredeli Ç.; Yavuzşen T.; Doğan M.; Hacıbekiroğlu İ.Following publication of the original article [1], the authors reported an error in the author name of Enes Erul. Incorrect: Enes Urul Correct: Enes Erul, The original article [1] has been corrected. © 2023, The Author(s).Item Impact of corporate governance and related controversies on the market value of banks(Elsevier Ltd, 2023) Komath M.A.C.; Doğan M.; Sayılır Ö.Effective corporate governance of financial institutions, particularly in the banking sector, is vital for the stability of the financial system and the prevention of financial crises. Thus, this study examines the impact of corporate governance and related controversies on the market value of banks. For this purpose, we utilized Refinitiv's corporate governance scores, including management, shareholder value, and corporate social responsibility (CSR), as well as its corporate governance controversies scores to analyze their impact on the market value of 242 banks in 43 countries. Using Refinitiv's ESG database from 2017 to 2021, we conducted a path analysis and found a positive and statistically significant relationship between the CSR strategy scores and the market value of banks as well as between the management scores and the market value of banks. Moreover, there is a statistically significant relationship between the corporate governance controversies scores and the market value of banks. © 2023 Elsevier B.V.Item The prognostic impact of Her2 status in early triple negative breast cancer: a Turkish Oncology Group (TOG) study(Nature Research, 2024) Özyurt N.; Alkan A.; Gülbağcı B.; Seyyar M.; Aydın E.; Şahbazlar M.; Türker M.; Kınıkoğlu O.; Yerlikaya T.; Dinç G.; Aytaç A.; Kalkan Z.; Ebinç S.; Gültürk İ.; Keskinkılıç M.; İşleyen Z.S.; Çağlayan D.; Türkel A.; Şakalar T.; Sekmek S.; Yıldırım N.; Koçak S.; Okutur K.; Özveren A.; Dursun B.; Kitaplı S.; Eren O.Ö.; Beypınar İ.; Hacıbekiroğlu İ.; Çabuk D.; Karaman E.; Acar Ö.; Paydaş S.; Eryılmaz M.K.; Demir B.; Oruç Z.; Yılmaz M.; Biricik F.S.; Salim D.K.; Tanrıverdi Ö.; Doğan M.The studies evaluating the impact of Her2 levels in neoadjuvant setting have conflicting data. The aim of the study was to evaluate the prognostic impact of Her2 status in early triple negative breast cancer(TNBC). In the study TNBC patients who were treated with neoadjuvant chemotherapy (NAC) and surgery were analyzed retrospectively. The primary aim of the study was to analyze the impact of Her2 status(Her2-0 and Her2-low) on pathological complete response (pCR). The secondary objectives were disease free survival (DFS) and overall survival (OS). 620 female triple negative breast cancer patients were evaluated. 427 patients (68.9%) had Her2-0 and 193(31.1%) had her2-low pathology. The pCR rates were similar between Her2-0 and Her2-low patients (33.0% vs. 27.5%, p = 0.098). Although Her2-0 group has better DFS (106 vs. 50 months, p = 0.002), in multivariate analysis it had a HR of 0.74 (p = 0.06). In addition, OS was similar (131 vs. 105 months, p = 0.13) with a HR of 0.88 (p = 0.61). In multivariate analysis; presence of LVI (HR:2.2 (95% CI 1.1–3.5) p = 0.001), Clinical stage T1/T2 (HR:0.39 (95% CI 0.2–0.6) p < 0.001) and lymph node negativity (HR:0.35 (95% CI 0.1–0.9) p = 0.03) were independent factors for OS. Although there were pathological and clinical differences, the pCR, DFS and OS were similar between Her2-0 and Her2-low TNBC patients. The importance of Her2 status of TNBC in neoadjuvant setting should be further studied. © The Author(s) 2024.Item Correction to: The prognostic impact of Her2 status in early triple negative breast cancer: a Turkish Oncology Group (TOG) study (Scientific Reports, (2024), 14, 1, (23556), 10.1038/s41598-024-75293-5)(Nature Research, 2025) Özyurt N.; Alkan A.; Gülbağcı B.; Seyyar M.; Aşık E.; Şahbazlar M.; Türker M.; Kınıkoğlu O.; Yerlikaya T.; Dinç G.; Aytaç A.; Kalkan Z.; Ebinç S.; Gültürk İ.; Keskinkılıç M.; İşleyen Z.S.; Çağlayan D.; Türkel A.; Aydın E.; Şakalar T.; Sekmek S.; Yıldırım N.; Koçak S.; Okutur K.; Özveren A.; Dursun B.; Kitaplı S.; Eren O.Ö.; Beypınar İ.; Hacıbekiroğlu İ.; Çabuk D.; Karaman E.; Acar Ö.; Paydaş S.; Eryılmaz M.K.; Demir B.; Oruç Z.; Yılmaz M.; Biricik F.S.; Salim D.K.; Tanrıverdi Ö.; Doğan M.Correction to: Scientific Reportshttps://doi.org/10.1038/s41598-024-75293-5, published online 09 October 2024 The original version of this Article contained an error in the spelling of the author Esra Aşık which was incorrectly given as Esra Aydın. The original Article has been corrected. © The Author(s) 2024.Item Prediction of market value of firms with corporate sustainability performance data using machine learning models(Elsevier Ltd, 2025) Doğan M.; Sayılır Ö.; Komath M.A.C.; Çimen E.This study attempts to build models for prediction of market value of firms with Corporate Sustainability Performance data using machine learning models. We analyze a comprehensive global dataset of 5,450 firms operating in 10 sectors. Machine learning models of Random Forest, XGBoost, SVM, and Nearest Neighbor models were constructed with E,S,G,C scores (Environmental, Social, Governance, and ESG Controversies) and financial ratios obtained from the Refinitiv (LSEG) Database. The most suitable model (Random Forest Model) built for Market Capitalization prediction shows that Environmental (E) and ESG Controversies (C) scores stand out as important predictors of market value. The findings of the study emphasize the importance of integrating ESGC factors into market value prediction models. Moreover, our findings suggest that the importance of corporate sustainability performance factors (E, S, G, C) is more pronounced in Europe and America compared to other regions. This study may provide insights for companies, investors, and analysts to achieve a more sophisticated assessment of market value. © 2025 Elsevier Inc.Item The relationships between corporate sustainability and market value: mediating role of revenue and moderating role of profitability(Palgrave Macmillan, 2025) Komath M.A.C.; Sayilir Ö.; Doğan M.This study attempts to analyze the relationships between corporate sustainability performance and market value. We employ 2018–2022 annual data obtained from Refinitiv ESG Database comprising 5450 companies. We utilize Hayes Process Modeling to investigate this relationship and also the mediating role of revenue and the moderating role of profitability in this relationship. Our findings show that all corporate sustainability performance measures (overall ESG, environmental pillar, social pillar, and governance pillar scores) have a significant relationship with the market value of firms. Total revenues seem to mediate the relationship between corporate sustainability performance and market value. The direct effect of corporate sustainability performance measures on the market value as well the indirect effect of corporate sustainability performance on market value through revenues is moderated by profitability (Return on Assets). Our findings may provide valuable insights for companies seeking to leverage corporate sustainability performance to improve market value. © The Author(s), under exclusive licence to Springer Nature Limited 2025.