Browsing by Author "Doğan Y."

Now showing 1 - 6 of 6
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    A clinical and sociodemographic evaluation of youths with substance use disorders in a child and adolescent inpatient unit of mental health hospital; [Bir bölge ruh sağlığı hastanesi çocuk ve ergen yataklı servisinde madde kullanımı nedeniyle yatarak tedavi gören gençlerin klinik ve sosyodemografik özellikleri]
    (ANP Publishing, 2019) Bilaç Ö.; Kavurma C.; Önder A.; Doğan Y.; Uzunoğlu G.; Ozan E.
    Objective: The aim of this study was to evaluate the demographic and clinical data of substance users who were intreatment in Mental Health Hospital Child and Adolescent Psychiatry Inpatient Department. Method: Medical records of substance user patients treated between 2014 and 2017 in Inpatient Child Psychiatry Unit of Mental Health Hospital were examined retrospectively. SPSS 20.00 Statistical Package Program was used for statistical analysis. Results: Ninety-two substance user child and youth had been treated. The median age of cases was 15,4 (SD±1,4), the onset age of substance use was 13,1 (SD±1,4). 68,5% of these case is male gender and 31,5% is female. The most common substance used is marijuana and extacy (62%), the substance user youth have met with the substance around friends (90,2%). Living conditions were found to be lower socioeconomic level (50%). Discussion: According to our clinic results, substance use is an important problem affecting youths, especially at lower socioeconomic level and male adolescents. Our study represents only the clinical sample, so there is a need for more community-based epidemiological studies. © 2019 ANP Publishing. All rights reserved.
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    Ethanol production from vineplant waste hydrolysate sugars by native yeast strains
    (North Carolina State University, 2019) Kaya E.Ö.; Doğan Y.; Yalçin H.T.
    Biomass from agricultural waste can be an excellent source of sustainable energy, the most notable of which is bioethanol. This study aimed to adapt and improve bioethanol production using a yeast strain that ferments the sugar content in undiluted and non-added nutrient vineplant bunch hydrolysates. Yeasts that were previously isolated and molecularly characterized were screened for their pentose fermenting capabilities, first in solid and then liquid mediums. Then, 10 native xylose fermenting yeast strains were tested for their ability to produce ethanol from acid hydrolysates from vineplant lignocellulosic waste. The five strains that exhibited the highest ethanol production underwent fermentation in the pure (non-detoxified) hydrolysate. The strain Pichia kudriavzevii D12 in the undiluted hydrolysate medium gave the highest ethanol concentrations and yields. Hence, P. kudriavzevii was selected for adaptation with sequential fermentations. As a result, a 59% increase in the ethanol production (g/L) was recorded for the D12 strain in the undiluted hydrolysate medium during the adaptation studies. A 2.9-fold increase in the yield (g/g) was obtained for this sample when compared with the reference medium. This study determined that a nondetoxified, organic waste medium prepared from vineplant bunches without added nutrients is a suitable substrate alternative for bioethanol production. © 2018, BioResources.
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    Investigation of the dual cascade algorithm in the diagnosis of antinuclear antibodies
    (Walter de Gruyter GmbH, 2019) Ecemiş T.; Faraşat V.T.; Doğan Y.; Şener A.G.; Ece G.T.; Dündar P.E.; Şanlıdağ T.
    Background: The dual cascade algorithm which involves screening and confirmation of antinuclear antibodies (ANAs) by further reflex testing is widely used in the detection of ANAs. We aimed to investigate this algorithm which is commonly used in many laboratories. Methods: A total of 475 sera obtained from patients with a clinical suspicion of systemic autoimmune rheumatic diseases (SARDs) upon which three expert assessors agreed for interpretation in the indirect immunofluorescence (IIF) test were determined and tested by the line immunoassay (LIA) containing 16 antigens. The results of the tests were statistically compared and evaluated. Results: In 141 of the sera (29.7%), there was an agreement between ANA-IIF(+) and LIA(+) results. The overall agreement rate between the two tests for positivity and negativity only was 85.5% with a Cohen’s κ coefficient of 0.69. In 118 of these 141 sera (83.7%), pattern and associated ANA agreement was detected with an overall agreement rate of 80.6% and a Cohen’s κ coefficient of 0.57. The highest agreement between the pattern and associated ANAs was seen in centromere, dense fine speckled (DFS) and cytoplasmic reticular patterns. In these patterns, the rate of anti-centromere-associated protein B (CENP-B), anti-DFS and anti-antimitochondrial antibody M2 (anti-AMA-M2) antibodies were 93.4%, 92.3% and 66.7%, respectively. Conclusions: We found an overall moderate agreement between IIF screening and LIA confirmation tests. However, the level of agreement varies according to the pattern type. The discrepancy in agreement rates may cause false reflex test requests. Our results highlight the need for collaboration between clinical and laboratory professionals in selected cases instead of the reflex testing approach. © 2019 Walter de Gruyter GmbH. All rights reserved.
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    A multicenter analysis of subjectivity of indirect immunofluorescence test in antinuclear antibody screening
    (Turkish League Against Rheumatism (TLAR), 2019) Turan Faraşat V.; Ecemış T.; Doğan Y.; Şener A.G.; Terek Ece G.; Erbay Dündar P.; Şanlidağ T.
    Objectives: This study aims to evaluate the interpretation of the antinuclear antibody (ANA)-indirect immunofluorescence (IIF) test results based on the interpreter-related subjectivity and to examine the inter-center agreement rates with the performance of each laboratory. Patients and methods: The ANA-IIF testing was carried out in a total of 600 sera and evaluated by four laboratories. The inter-center agreement rates were detected. The same results given by the four centers were accepted as gold standard and the predictive values of each center were calculated. Results: The inter-center agreement was reported for ANA-IIF test results from 392 of 600 (65.3%) sera, while 154 of 392 results were positive. Four study centers reported 213 (35.5%), 222 (37.0%), 266 (44.3%), and 361 (60.2%) positive test results, respectively. In terms of the patterns, the highest and lowest positive predictive values were 72.3% and 42.7%, respectively, while the highest and lowest negative predictive values were 99.6% and 61.5%, respectively. The agreement for semi-quantitative evaluation at three levels of fluorescence intensity stated by four centers was detected in 100 sera at 87% 3(+), while the other two levels were 6% and 7%. The highest predictive value for the highest fluorescence intensity of 3(+) was found to be 71.9%. Conclusion: Significant differences may be observed among laboratories in terms of qualitative results, patterns, and semi-quantitative determination of the fluorescence intensity in the ANA-IIF testing, particularly at low fluorescence intensity levels and in those with speckled patterns. In case of any discrepancy between ANA-IIF test and clinical prediagnosis, the test should be repeated in another laboratory, if necessary. © 2019 Turkish League Against Rheumatism.
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    Evaluation of the parental attitudes, parental competency and attachment styles of the mothers of the children at pre-school period who were admitted to child psychiatry; [Okul öncesi dönemde çocuk psikiyatrisi polikliniği'ne başvuran çocukların annelerinin tutumlarının, yeterliliklerinin ve bağlanma biçimlerinin değerlendirilmesi]
    (ANP Publishing, 2020) Bilaç Ö.; Önder A.; Kavurma C.; Doğan Y.; Uzunoğlu G.; Isildar Y.; Sapmaz Ş.Y.
    Objective: In this study we aimed to evaluate attitudes, attachment styles to their husbands and competence perceptions of the mothers towards their children's problems whose children were at pre-school period with no cognitive developmental delay. Method: Fourty children and their mothers were included into the study. The children were chosen among those who were aged between 0-72 months and had no developmental delay which was found out as a result of developmental test. As the control group, another 40 children and their mothers were included into the study. Child Adjustment and Parent Efficacy Scale (CAPES-TR) and Parent Attitude Research Instrument (PARI) were handed out to mothers in both groups. Finally, Experiences in Close Relationship Revised (ECC-R) was applied to mothers of both groups. SPSS20 was used for statistical analysis. Results: According to CAPES-TR results, emotional, behavioural and social problems in the group that were admitted to psychiatry clinic were higher than control group (p<0.05). According to same scale, mothers' self-confidence was found significantly lower (p<0.05). According to PARI results, the score of the group that applied to clinic for over-motherhood reasons was found higher (p<0.05). Likewise, authoritative attitude score was found higher in patient group (p<0.05). Discussion: The results of this study share similarities with other studies which found out that parental child-rearing attitude presents a risk factor for behavioural problems among children. © 2020 ANP Publishing. All rights reserved.
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    SARcopenia Assessment in Hypertension
    (Lippincott Williams and Wilkins, 2023) Kara M.; Kara Ö.; Ceran Y.; Kaymak B.; Kaya T.C.; Çıtır B.N.; Durmuş M.E.; Durmuşoğlu E.; Razaq S.; Doğan Y.; Shehab D.; Alkandari S.A.; Abdulsalam A.J.; Ata A.M.; Koyuncu E.G.; Coşkun E.; Turan G.; Dilek B.; Culha M.A.; Yıldırım P.; Mezian K.; Doğu B.; Kılıç G.; Ünlü Z.; Barbosa J.; Pinho S.; Analay P.; Palamar D.; Güvener O.; Ocak H.; Malas F.Ü.; Baday M.; Çakır B.; Özçakar L.
    Objectives: The aims of the study were to investigate the relationship between sarcopenia and renin-angiotensin system-related disorders and to explore the effects of angiotensin-converting enzyme inhibitors and angiotensin II receptor blockers on muscle mass/function and physical performance. Design: This multicenter, cross-sectional study was performed using ISarcoPRM algorithm for the diagnosis of sarcopenia. Results: Of the 2613 participants (mean age = 61.0 ± 9.5 yrs), 1775 (67.9%) were hypertensive. All sarcopenia-related parameters (except chair stand test in males) were worse in hypertensive group than in normotensive group (all P < 0.05). When clinical/potential confounders were adjusted, hypertension was found to be an independent predictor of sarcopenia in males (odds ratio = 2.403 [95% confidence interval = 1.514-3.813]) and females (odds ratio = 1.906 [95% confidence interval = 1.328-2.734], both P < 0.001). After adjusting for confounding factors, we found that all sarcopenia-related parameters (except grip strength and chair stand test in males) were independently/negatively related to hypertension (all P < 0.05). In females, angiotensin-converting enzyme inhibitors users had higher grip strength and chair stand test performance values but had lower anterior thigh muscle thickness and gait speed values, as compared with those using angiotensin II receptor blockers (all P < 0.05). Conclusions: Hypertension was associated with increased risk of sarcopenia at least 2 times. Among antihypertensives, while angiotensin-converting enzyme inhibitors had higher muscle function values, angiotensin II receptor blockers had higher muscle mass and physical performance values only in females. © 2022 Wolters Kluwer Health, Inc.