Browsing by Author "Doğru Y."

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    Effects of two different eight-week walking programs on insulin resistance and ER stressrelated markers in pre-menopausal women; [Premenopozal kadınlarda 8 haftalık farklı şiddetteki yürüyüş antrenmanlarının insülin direnci ve ER stresiyle ilişkili markerler üzerine etkileri]
    (Turkish Biochemistry Society, 2016) Doğru Y.; Büyükyazı G.; Ulman C.; Taneli F.; Tıkız H.; Göral M.; Esen H.
    Objective: The relationship between exercise and endoplasmic reticulum (ER) stress, insulin resistance, and obesity is a new field of research. To our knowledge, there are no studies examining the effects of walking exercises on ER stress related markers and insulin resistance in pre-menopausal women. To examine the effect of two different eight-week walking programs on the tumor necrosis factor-alpha (TNF-α), Fetuin-A (α2 - Heremans Schmid glycoprotein), c-Jun N-terminal kinase-1 (JNK-1) and retinol- binding protein-4 (RBP-4), the related markers of ER stress and insulin resistance in pre-menopausal women. Methods: Exercise groups (moderate tempo walking group; MTWG; n=11; brisk walking group BWG; n=12) walked five days a week, starting from 30 minutes, gradually increasing up to 51 minutes. BWG walked at ~70–75% and MTWG at ~50–55 of HRRmax. Body mass index (BMI), body fat percentage (%), VO2max, serum TNF-α, Fetuin-A, JNK-1, RPB-4, blood lipids, and insulin resistance levels were determined before and after the intervention. Results: VO2max increased in both exercise groups favoring BWG; RBP-4 decreased in both exercise groups (p<0.05). Serum TNF-α and, TG (p<0.05), BMI and percent body fat (p<0.01), and insulin levels reduced significantly in BWG (p<0.05). The reductions observed in both exercise groups in insulin resistance, and the increases determined in the negative levels of JNK-1 in BWG may be clinically important. Conclusion: Both type of walking resulted in similar positive effects on RBP-4. The reduction observed in TNF-α, RBP-4, and the increases in the negative levels of JNK-1 in BWG show the positive effects of brisk walking on ER stress. The reduction in insulin resistance in relation to the possible reductions in ER stress and apoptosis in BWG may be more effective to prevent metabolic diseases. © 2016, Turkish Biochemistry Society. All rights reserved.
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    Comparison of some plasma inflammation markers in elite master athletes, recreational athletes and sedentary males; [Elit Master Atletler, Rekreasyonal Atletler ve Sedanter Erkeklerde Bazı Plazma İnflamasyon Markerlerinin Karşilaştinlmasi]
    (Turkiye Klinikleri, 2019) Gİrgİner F.; Büyükyazi G.; Ulman C.; Doğru Y.; Taneli F.; Yildiz R.; Taş M.; Keskİnoğlu P.
    Objective: It is known that high-intensity exercises lead to muscle damage and fibrosis. This study aims to compare some plasma inflammation markers in elite master athletes, recreational athletes and sedentary males to determine muscle injury. Material and Methods: 60 healthy male participants (min-max 45-65 years) were divided into 3 groups: Elite master athletes performing high intensity training (EMAG; n=22), recreational athletes performing moderate intensity training (RG; n=21) and sedentary controls (CG; n=17). Resting serum levels of the monocyte chemoattractant protein-1 (MCP-1), High-Sensitivity C-Reactive Protein (hsCRP), Tumor Necrosis Factor Alfa (TNF-α), Transforming Growth Factor Beta-1 (TGF-β-1), and Klotho hormone were compared among the groups. Results: Body weight, fat percentages, body mass index were lower and MaxVO2 was higher in EMAG than those of both RG and CG. TGF-β-1 and Klotho Hormone levels of EMAG and RG were higher than CG. Vitamin D levels of EMAG were found higher than those of CG. Conclusion: Regular long-term endurance training has a long-term positive impact on the regeneration of muscle damage and inflammation. The high levels of Klotho hormone determined in EMAG provides a longer and healthier life by extending the initiation process of many illnesses including metabolic diseases. © 2019 by Türkiye Klinikleri.
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    The effects of various strength training intensities on blood cardiovascular risk markers in healthy men; [Sağlıklı erkeklerde farklı kuvvet egzersizi yoğunluklarının kan kardiyovasküler risk belirteçleri üzerindeki etkileri]
    (De Gruyter Open Ltd, 2021) Akyüz M.; Doğru Y.; Nalcakan G.R.; Ulman C.; Taş M.; Varol R.
    Objectives: Regular physical exercise, especially aerobic exercise, is known to have a protective effect on cardiovascular health. The aim of this research is to look at the impact of two separate resistance training programs on blood biomarkers that are associated with the early detection of cardiac risk. Methods: Forty-five male participants (mean 41 years) were randomly divided into three groups: The low-intensity resistance exercise group (LIEG), the moderate-intensity resistance exercise group (MIEG), and the control group (CG). The programs were implemented three times a week and in two sets. MIEG consisted of 8–10 repeats at 70–80% density of one repetition maximum load (1RM), while LIEG consisted of 15–17 repeats at 50–60% density of 1RM. CG did not participate in any exercise program. Two-factor mixed-design ANOVA assessed the data. Results: Before, fourth week, and after the exercise program in repeated measurements, there was a significant decrease in body mass (−1.7%), body mass index (−1.7%), apelin (−44%), and pentraxin 3 (−39%) levels in MIEG (p < 0.05). Additionally, our study noted a decrease in pentraxin 3 (−25%, p < 0.05) and interleukin 6 (−21%) levels, while there was an increase in creatine kinase (18%), and lactate dehydrogenase (7.4%) levels in LIEG. Strength levels improved significantly in exercise groups. Conclusions: Eight weeks of moderate-resistance training can potentially reduce the cardiovascular risk in healthy men. © 2021 Murat Akyüz et al., published by De Gruyter.