Browsing by Author "Dogan, A"
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Item ADENOMA MALIGNUM WITH OVARIAN MUCINOUS ADENOCARCINOMACingillioglu, B; Gokcu, M; Seyhan, S; Goklu, R; Dogan, AItem A rare cause of reversible dilated cardiomyopathy: HypocalcemiaAvsar, A; Dogan, A; Tavli, THypocalcemia is a rare cause of reversible heart failure. We reported a 40-year-old woman who had severe heart failure resistant to the usual antifailure therapy. She had severe hypocalcemia due to hypoparathyroidism after strumectomy. Echocardiography showed a large left ventricle with very low ejection fraction of 25% and moderate mitral regurgitation. After supplementation of calcium and vitamin D, her clinical situation and hemodynamics improved rapidly. At 15 months, myocardial impairment resolved fully. In conclusion, hypocalcemia should be considered in the differential diagnosis of resistant severe heart failure.Item Geodetic evidence for aseismic fault movement on the eastern segment of the Gediz Graben system (western Anatolia extensional province, Turkey) and its significance for settlementsDogan, A; Kaygusuz, Ç; Tiryakioglu, I; Yigit, CO; Sözbilir, H; Özkaymak, Ç; Turgut, BAseismic dip-slip normal fault displacement related to numerous fast-slipping active faults was recently observed in several localities in the western Anatolia extensional province. Still, the characteristics of displacements along with the behavior of individual fault segments are poorly known. Here we analyze an aseismically active normal fault affecting the settlement area of the Sarigol district, Turkey, at the surface rupture area of the 1969 magnitude 6.5 Alasehir earthquake. A precise leveling method was implemented in this area between July 2017 and 2020, to determine the vertical movements of the hanging wall relative to the footwall of the Sarigol fault. The yearly vertical movement on the surface along Profile 1 was - 7.0, - 7.3, and - 7.0 cm, respectively, for the three years starting in July 2017, and on Profile 2 it was - 7.7, - 8.7, and - 7.8 cm for the same time period. This persistent deformation, especially in the summer and fall seasons, suggests that may be related to groundwater level changes. Intensive agriculture is conducted in the region and a high level of irrigation activity in the summer period causes a decrease in groundwater levels. In addition, the continued deformation together with intensive precipitation in winter and spring despite high groundwater levels leads to the idea that tectonic creep movement could be a second reason for the deformation in the area. In the current study, the most important result is that the aseismic deformation starting after the 1969 Mw6.5 Alasehir earthquake still continues rapidly today with a velocity of 70-80 mm/year down-dip. This indicates that the damage zone of the Sarigol fault is not appropriate for settlements in the Sarigol district due to continuous high amounts of vertical displacement, and that appropriate building policy and awareness campaigns are needed.Item Determination of periodic deformation from InSAR results using the FFT time series analysis method in Gediz GrabenHastaoglu, KO; Poyraz, F; Erdogan, H; Tiryakioglu, I; Ozkaymak, C; Duman, H; Gül, Y; Guler, S; Dogan, A; Gul, YPermanent Scatterers (PS) point velocities obtained by the interferometric synthetic aperture radar (InSAR) method are generally determined using the linear regression model, which ignores periodic and seasonal effects. In this study, software was developed that can detect periodic effects by applying fast Fourier transformation (FFT) time series analysis to InSAR results. Using the FFT time series analysis, the periodic components of the surface movements at the PS points were determined, and then the annual velocity values free from periodic effects were obtained. The study area was chosen as the Gediz Graben, a tectonically active region where aseismic surface deformations have been observed in recent years. As a result, using the developed method, seasonal effects were successfully determined with the InSAR method at the PS points in the study area with a period of 384 days and an average amplitude of 19 mm. In addition, groundwater level changes of a water well in the region were modeled, and 0.93 correlation coefficient values were calculated between seasonal InSAR displacement values and water level changes. Thus, using the developed methodology, the relationship between the tectonic movement in the Gediz Graben in Turkey and the seasonal movements and the change in the groundwater level was determined.Item Analysis of clinical and pathological characteristics, treatment methods, survival, and prognosis of uterine papillary serous carcinomaSolmaz, U; Ekin, A; Mat, E; Gezer, C; Dogan, A; Biler, A; Peker, N; Hasdemir, PS; Sanci, MPurpose: Uterine papillary serous carcinoma (UPSC) is an atypical variant of endometrial carcinoma with a poor prognosis. It is commonly associated with an increased risk of extrauterine disease. The aim of this study was to investigate clinical and pathological characteristics, therapeutic methods, and prognostic factors in women with UPSC. Methods: All patients who underwent surgery for UPSC at a single high-volume cancer center between January 1995 and December 2010 were retrospectively reviewed. Patients who did not undergo surgical staging and those with mixed tumor histology were excluded. Univariate and multivariate regression models were used to identify the risk factors for overall survival (OS) and progression-free survival (PFS). Results: A total of 46 patients were included, the majority of whom having stage I disease (IA, 13 [28.2%] and IB, 12 [26.7%]). Stages II, III, and IV were identified in 5 (10.9%), 8 (17.4%), and 8 (17.4%) women, respectively. Optimal cytoreduction was obtained in 67.3% of patients. Recurrences developed in 8 (17.4%) patients. Multivariate analysis confirmed that lymphovascular space invasion (LVSI) (odds ratio [OR] 26.83, p = 0.003) was the only independent prognostic factor for OS, whereas LVSI and optimal cytoreduction were found to be independent prognostic factors for PFS (OR 6.91, p = 0.013 and OR 2.69, p = 0.037, respectively). The 5-year overall survival rate was 63%. Conclusions: Our study demonstrated that LVSI is the only independent prognostic factor for OS, whereas LVSI and optimal cytoreduction are independent prognostic factors for PFS in patients with UPSCItem Lymphovascular space invasion and cervical stromal invasion are independent risk factors for nodal metastasis in endometrioid endometrial cancerSolmaz, U; Mat, E; Dereli, M; Turan, V; Gungorduk, K; Hasdemir, P; Tosun, G; Dogan, A; Ozdemir, A; Adiyeke, M; Sanci, MAimsThe purpose of this study was to investigate the potential roles of pathological variables in the prediction of nodal metastasis in women with endometrioid endometrial cancer (EC). Materials and MethodsWomen who underwent surgery for endometrioid EC between 1995 and 2012 were retrospectively reviewed. Those who underwent prior neoadjuvant chemotherapy or radiotherapy and inadequate lymphadenectomy as well as those with nonendometrioid histology, synchronous cancers, International Federation of Gynecology and Obstetrics stage IV disease, gross uterine serosal and/or gross adnexal involvement were excluded. Lymph node dissemination was defined as occurring in the following circumstances: (i) when nodal metastasis with pelvic and/or para-aortic (P/PA) lymph node dissection (LND) was performed or (ii) when there was recurrence in the P/PA lymph nodes after a negative LND or when LND was not performed. Univariate and multivariate logistic regression models were used to identify the pathological predictors of lymphatic dissemination. ResultsA total of 827 women with endometrioid EC were assessed; 516 (62.4%) of whom underwent P/PA LND and 205 (24.8%) underwent P LND. Sixty-seven (13%) women in the P/PA LND group and 5 (2.4%) in the P LND group had positive lymph nodes. Multivariate analysis confirmed cervical stromal invasion (OR 4.04, 95% CI 2.02-8.07 (P<0.001)) and lymphovascular space invasion (LVSI) (OR 110.18, 95% CI 38.43-315.87 (P<0.001)) as independent predictors of lymphatic dissemination. ConclusionCervical stromal invasion and LVSI are highly associated with LN metastasis. These markers may serve as a surrogate for nodal metastasis.Item Effects of axial impacts at different temperatures on failure response of adhesively bonded woven fabric glass fiber/epoxy composite jointsSayman, O; Soykok, IF; Dogan, T; Dogan, A; Arikan, VEvaluating post-impact failure responses of single-lap adhesively bonded composite-to-composite joints in uniaxial static tensile loading was the main objective of the current experimental study. At first, axial tensile impacts having various energy levels (10, 15, 20, and 25J) were applied to the joints at different temperatures (-20, 0, room temperature, 50, and 80?). Afterward, the samples were secondarily subjected to static tensile loading at ambient temperature, so that reductions in joint strengths arising from the impacts performed under different loading conditions could be assessed. Consequently, it was definitely proved that each of the axial impacts performed in any loading case has a noticeable effect on ultimate joint strengths, proportionally to the acting condition. Besides, the combination of high energy and temperature sometimes appeared to be the reason of impact failure, which occurs instantly without being able to perform axial static tests. When applied energy and/or absolute difference from room temperature is increased, lower joint resistances could be measured during secondary tensile tests.Item POLYMORPHISMS OF THE HUMAN PLATELET ANTIGENS HPA-1 IN SLOW CORONARY FLOWYücel, H; Dogan, A; Içli, A; Akçay, S; Ersoy, IItem Evaluation of Endothelial Nitric Oxide Synthase Gene Polymorphism (T-786 C) in Patients with Slow Coronary FlowYücel, H; Dogan, A; Türker, Y; Içli, A; Akcay, S; Ersoy, I; Uysal, BA; Sütçü, RItem Lack of Association between the Glu298Asp Polymorphism of Endothelial Nitric Oxide Synthase and Slow Coronary FlowYücel, H; Dogan, A; Türker, Y; Içli, A; Akçay, S; Ersoy, I; Aksoy, F; Sütçü, RItem Current status (as of end of 2020) of marine alien species in TurkeyÇinar, ME; Bilecenoglu, M; Yokes, MB; Öztürk, B; Taskin, E; Bakir, K; Dogan, A; Açik, SThe 2020's update of marine alien species list from Turkey yielded a total of 539 species belonging to 18 taxonomic groups, 404 of which have become established in the region and 135 species are casual. A total of 185 new alien species have been added to the list since the previous update of 2011. The present compilation includes reports of an ascidian species (Rhodosoma turcicum) new to the marine fauna of Turkey and range extensions of six species. Among the established species, 105 species have invasive characters at least in one zoogeographic region, comprising 19% of all alien species. Mollusca ranked first in terms of the number of species (123 species), followed by Foraminifera (91 species), Pisces (80 species) and Arthropoda (79 species). The number of alien species found in seas surrounding Turkey ranged from 28 (Black Sea) to 413 (Levantine Sea). The vectoral importance of the Suez Canal diminishes when moving from south to north, accounting for 72% of species introductions in the Levantine Sea vs. only 11% of species introductions in the Black Sea. Most alien species on the coasts of Turkey were originated from the Red Sea (58%), due to the proximity of the country to the Suez Canal. Shipping activities transported 39% of alien species, mainly from the Indo-Pacific area (20%) and the Atlantic Ocean (10%). Misidentified species (such as Pterois volitans, Trachurus declivis, etc.) and species those classified as questionable or cryptogenic were omitted from the list based on new data gathered in the last decade and expert judgements. The documented impacts of invasive species on socio-economy, biodiversity and human health in the last decade as well as the legislation and management backgrounds against alien species in Turkey are presented.Item Increased Mean Platelet Volume in Hypertrophic CardiomyopathyIcli, A; Aksoy, F; Dogan, A; Arslan, A; Akcay, S; Yücel, H; Ersoy, I; Gorgulu, OThromboembolic events may be seen in patients with hypertrophic cardiomyopathy (HCM). We investigated the mean platelet volume (MPV), an indicator of platelet activation in patients with HCM. This study included 112 patients with HCM, in which 40 were patients with hypertrophic obstructive cardiomyopathy (HOCM), and 106 were control participants. The MPV was significantly higher in patients with HCM than in controls (9.1 +/- 0.3 vs 7.9 +/- 0.3 fL, P = .01). In the subgroup analyses, MPV was also higher in patients with HOCM compared to those with hypertrophic nonobstructive cardiomyopathy (HNCM; 9.3 +/- 0.3 vs 9.0 +/- 0.2 fL, P = .01). Similarly, patients with HNCM had higher MPV values than controls (9.0 +/- 0.2 vs 7.9 +/- 0.3 fL, P = .01). The MPV was significantly and positively correlated with left ventricular outflow tract (LVOT) obstruction (r = .42, P = .001) and septal thickness (r =.62, P = .001). In linear regression analysis, MPV was independently associated only with septal thickness (beta = .07, 95% confidence interval: 0.04-0.09, P = .001). The MPV can be elevated in patients with HCM regardless of the obstruction of LVOT and may be associated with the severity of septal thickness.Item APOLIPOPROTEIN E GENE POLYMORPHISM IN SLOW CORONARY FLOWYücel, H; Dogan, A; Içli, A; Türker, Y; Akçay, S; Uysal, BAItem Plasma lipoprotein(a) levels in patients with slow coronary flowYucel, H; Dogan, A; Altinbas, A; Akcay, S; Icli, A; Ceyhan, BMIntroduction: Slow coronary flow (SCF) is a microvascular disorder characterized by delayed opacification of coronary vessels with normal coronary angiogram. It may be due to endothelial dysfunction and diffuse atherosclerosis. Lipoprotein(a) [Lp(a)] is related to cardiovascular events. Plasma Lp(a) levels have not been studied previously in SCF patients. Aim: We investigated plasma Lp(a) and fibrinogen levels, and their relation to coronary flow rate in patients with SCE Material and methods: This cross-sectional study included 50 patients with SCF and 30 age- and sex-matched controls who had normal coronary arteries and normal flow. Coronary flow rates of patients and controls were counted with the thrombolysis in myocardial infarction (TIMI) frame count. Plasma Lp(a) and fibrinogen levels were measured in SCF patients and controls, with routine biochemical tests. Results: There were no significant differences between the two groups with respect to plasma Lp(a) (21 mg/dl vs. 14 mg/dl, p = 0.11) and fibrinogen (278 mg/dl vs. 291 mg/dl, p = 0.48) levels. The TIMI frame count was not correlated with plasma Lp(a) (r = 0.13, p = 0.25) or fibrinogen (r = -0.14, p = 0.28) levels. Conclusions: Our results show that there is no significant association between SCF and Lp(a) and fibrinogen levels.Item INSERTION/DELETION POLYMORPHISM OF THE ANGIOTENSIN-CONVERTING ENZYME GENE IN SLOW CORONARY FLOWYücel, H; Dogan, A; Içli, A; Akçay, SItem Plasma Lipoprotein (a) Levels in Patients with Slow Coronary FlowYücel, H; Dogan, A; Altinbas, A; Akçay, S; Içli, A; Bas, HA; Ceyhan, BM; Arslan, AItem Unpublished Mediterranean and Black Sea records of marine alien, cryptogenic, and neonative speciesRagkousis, M; Zenetos, A; Ben Souissi, J; Hoffman, R; Ghanem, R; Taskin, E; Muresan, M; Karpova, E; Slynko, E; Dagli, E; Fortic, A; Surugiu, V; Macic, V; Trkov, D; Bahri, WR; Tsiamis, K; Ramos-Espla, AA; Petovic, S; Ferrario, J; Marchini, A; Sconfietti, R; Ammar, I; Alo, A; Edelist, D; Begun, T; Teaca, A; Tari, G; Huseyinoglu, MF; Karachle, PK; Dogrammatzi, A; Apostolopoulos, GA; Crocetta, F; Kytinou, E; Digenis, M; Skouradakis, G; Tomas, F; Bariche, M; Kaminas, A; Konida, K; Deidun, A; Marrone, A; Fraschetti, S; Mihneva, V; Bianchi, CN; Morri, C; Gerovasileiou, V; Lipej, L; Sini, M; Mangialajo, L; Zotou, M; Skolka, M; Azzurro, E; Vella, A; Dailianis, T; Grigoriou, P; Jimenez, C; Tsirintanis, K; Oikonomidis, G; Mancini, E; Papadakis, O; Di Martino, V; Chatzigeorgiou, G; Ben Amor, MM; Vernadou, E; Arda, Y; Minasidis, V; Azzola, A; Hadjioannou, L; Montefalcone, M; Baldacchino, Y; Stancanelli, B; Bonifazi, A; Occhipinti-Ambrogi, A; Smeraldo, S; Evans, J; Kondylatos, G; Falautano, M; Castriota, L; Lamprou, A; Rizgalla, J; Mavric, B; Papadimitriou, E; Kersting, DK; Schembri, PJ; Khamassi, F; Nikolaou, A; Ballesteros, E; Dimitriadis, C; García, M; Anastasiadis, A; Kalogirou, S; Nalmpanti, M; Altamirano, M; Grech, D; Mavrouleas, D; Vella, N; Darmanin, SA; Dragicevic, B; Poursanidis, D; Tsatiris, A; Corsini-Foka, M; Orlando-Bonaca, M; Insacco, G; Tsalapatis, A; Scannella, D; Tiralongo, F; Verdura, J; Vitale, S; Valsamidis, MA; Bazairi, H; Mannino, AM; Virgili, R; Coccia, FC; El Zrelli, R; Nikolidakis, S; Rabaoui, LJ; Yapici, S; Zaouali, J; Zava, B; Agrotis, N; Bilecenoglu, M; Çinar, ME; Moraitis, ML; Albano, PG; Kaddouri, N; Kosma, I; Falsone, F; Fossati, V; Geraci, ML; Zamuda, LL; Mancuso, FP; Petrou, A; Resaikos, V; Aydin, I; Batjakas, IE; Bos, AR; El Ouamari, N; Giallongo, G; Kampouris, TE; Ounifi-Ben Amor, K; Dogan, A; Dulcic, J; Okudan, ES; Rilov, G; Rosso, A; Royo, L; Selfati, M; Gaglioti, M; Giakoumi, S; Kousteni, V; Micu, D; Nicoara, M; Orfanidis, S; Papatheodoulou, M; Tempesti, J; Triantaphyllou, M; Tsourou, T; Yalgin, F; Baltag, E; Cerim, H; Filiz, H; Georgiadis, CG; Papadamakis, P; Rammou, DL; Samargiu, MD; Sciuto, F; Sinopoli, M; Türker, A; Chiarore, A; Tamburello, L; Karray, S; Hassen, B; Katsanevakis, STo enrich spatio-temporal information on the distribution of alien, cryptogenic, and neonative species in the Mediterranean and the Black Sea, a collective effort by 173 marine scientists was made to provide unpublished records and make them open access to the scientific community. Through this effort, we collected and harmonized a dataset of 12,649 records. It includes 247 taxa, of which 217 are Animalia, 25 Plantae and 5 Chromista, from 23 countries surrounding the Mediterranean and the Black Sea. Chordata was the most abundant taxonomic group, followed by Arthropoda, Mollusca, and Annelida. In terms of species records, Siganus luridus, Siganus rivulatus, Saurida lessepsianus, Pterois miles, Upeneus moluccensis, Charybdis (Archias) longicollis, and Caulerpa cylindracea were the most numerous. The temporal distribution of the records ranges from 1973 to 2022, with 44% of the records in 2020-2021. Lethrinus borbonicus is reported for the first time in the Mediterranean Sea, while Pomatoschistus quagga, Caulerpa cylindracea, Grateloupia turuturu, and Misophria pallida are first records for the Black Sea; Kapraunia schneideri is recorded for the second time in the Mediterranean and for the first time in Israel; Prionospio depauperata and Pseudonereis anomala are reported for the first time from the Sea of Marmara. Many first country records are also included, namely: Amathia verticillata (Montenegro), Ampithoe valida (Italy), Antithamnion amphigeneum (Greece), Clavelina oblonga (Tunisia and Slovenia), Dendostrea cf. folium (Syria), Epinephelus fasciatus (Tunisia), Ganonema farinosum (Montenegro), Macrorhynchia philippina (Tunisia), Marenzelleria neglecta (Romania), Paratapes textilis (Tunisia), and Botrylloides diegensis (Tunisia).Item Clinical outcomes of cyclin-dependent kinase 4-6 (CDK 4-6) inhibitors in patients with male breast cancer: A multicenter studyYildirim, HC; Mutlu, E; Chalabiyev, E; Özen, M; Keskinkiliç, M; Ön, S; Çelebi, A; Dursun, B; Acar, O; Kahraman, S; Aykan, MB; Kaman, O; Dogan, A; Erdogan, AP; Celayir, OM; Günenç, D; Güven, DC; Bayoglu, IV; Yavuzsen, T; Hacibekiroglu, I; Inanç, M; Kiliçkap, S; Yalçin, S; Aksoy, SBackground: Since breast cancer is less common in men than in women, data on the use of new therapeutic agents, including cyclin-dependent kinase 4-6 (CDK 4-6) inhibitors, are limited in patients with metastatic hormone receptor positive (HR+), human epidermal growth factor receptor 2-negative (HER2-) male breast cancer. Therefore; we aimed to investigate the treatment responses of metastatic HR+, HER2-male breast cancer patients treated with CDK 4-6 inhibitors in a multicenter real-life cohort. Methods: Male patients with a diagnosis of HR+ and HER2-metastatic breast cancer, treated with any CDK 4-6 inhibitor, were included in the study. Demographic and clinical characteristics of the patients were recorded. We aimed to determine progression-free survival (PFS) time, response rates and drug related side effects. Results: A total 25 patients from 14 institutions were recruited. The mean age at diagnosis was 57 years. Median follow-up was 19.53 (95% CI: 14.04-25.02) months. The overall response rate was 60%. While the median PFS was 20.6 months in the whole cohort, it wasn't reached in those using CDK 4-6 inhibitors in first line and 10 months in the subsequent lines (p:0.009). No new adverse events were encountered. Conclusion: In our study, we found that CDK 4-6 inhibitors are effective and safe options in men with HR+ and HER2-metastatic breast cancer as in women. Our results support the use of CDK 4-6 inhibitor-based combinations in the first-line treatment of HR+ and HER2-metastatic male breast cancer.Item The clinicopathological features and survival of Castleman disease: a multicenter Turkish studyYildiz, J; Bagci, M; Sayin, S; Kaya, A; Yilmaz, F; Ekinci, O; Dal, MS; Basturk, A; Aydogdu, I; Albayrak, M; Dogan, A; Erkurt, MA; Korkmaz, S; Ulas, T; Eser, B; Altuntas, FOBJECTIVE: In this study, we aimed to investigate the clinicopathological features and survival of CD, which is quite rare and has many unknowns. PATIENTS AND METHODS: This study was conducted by retrospectively evaluating patients diagnosed with CD in six different centers in Turkey. RESULTS: The median age of 33 patients included in the study was 49 and 51.5% (n = 17) of these patients were women. 18 (54.5%) patients were in the hyaline vascular subtype and most of the patients were UCD (n = 20, 60.6%). The most common involvement region was head and neck (n = 19, 57.5%). The UCD group was younger than the MCD group (p=0.027). Visceral lymph node involvement was higher in MCD than in UCD (p=0.001). Similarly, it was observed that there was more hepatomegaly (p=0.035) and splenomegaly (p=0.013) in the MCD group. During the median 19.5 months follow-up period, there were no patients who died. CONCLUSIONS: It was observed that UCD and MCD are different clinical entities. Promising survival times can be achieved with surgical and systemic treatments in both subtypes of this extremely rare disease. However, this re- suit should be supported by well-designed prospective comprehensive studies.Item Coralligenous assemblages along their geographical distribution: Testing of concepts and implications for managementÇinar, ME; Féral, JP; Arvanitidis, C; David, R; Taskin, E; Sini, M; Dailianis, T; Dogan, A; Gerovasileiou, V; Evcen, A; Chenuil, A; Dagli, E; Aysel, V; Issaris, Y; Bakir, K; Nalmpanti, M; Sartoretto, S; Salomidi, M; Sapouna, A; Açik, S; Dimitriadis, C; Koutsoubas, D; Katagan, T; Öztürk, B; Koçak, F; Erdogan-Dereli, D; Önen, S; Özgen, Ö; Türkçü, N; Kirkim, F; Önen, MThe coralligenous habitat was studied at the large Mediterranean scale, by applying a standardized, non-destructive photo-sampling protocol, developed in the framework of the CIGESMED project. The results provided evidence to support the following statements: (a) the assemblage pattern is not homogeneously distributed across the four Mediterranean ecoregions studied (biotic gradients hypothesis); and (b) the assemblage pattern does not change significantly when the information is aggregated to higher taxonomic levels (taxonomic sufficiency hypothesis). Surrogate taxonomic categories higher than species, such as genus and family, can be used to reveal the multivariate pattern of the coralligenous assemblages. Although preliminary at the pan-Mediterranean scale, these outcomes set the scene for future comparisons as more data sets become available but also for comparisons between taxonomic and functional patterns. 1.2.3.4.