Browsing by Author "Dogan, Y"
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Item Ethanol Production from Vineplant Waste Hydrolysate Sugars by Native Yeast StrainsKaya, EÖ; Dogan, Y; Yalçin, HTBiomass from agricultural waste can be an excellent source of sustainable energy, the most notable of which is bioethanol. This study aimed to adapt and improve bioethanol production using a yeast strain that ferments the sugar content in undiluted and non-added nutrient vineplant bunch hydrolysates. Yeasts that were previously isolated and molecularly characterized were screened for their pentose fermenting capabilities, first in solid and then liquid mediums. Then, 10 native xylose fermenting yeast strains were tested for their ability to produce ethanol from acid hydrolysates from vineplant lignocellulosic waste. The five strains that exhibited the highest ethanol production underwent fermentation in the pure (non-detoxified) hydrolysate. The strain Pichia kudriavzevii D12 in the undiluted hydrolysate medium gave the highest ethanol concentrations and yields. Hence, P. kudriavzevii was selected for adaptation with sequential fermentations. As a result, a 59% increase in the ethanol production (g/L) was recorded for the D12 strain in the undiluted hydrolysate medium during the adaptation studies. A 2.9-fold increase in the yield (g/g) was obtained for this sample when compared with the reference medium. This study determined that a nondetoxified, organic waste medium prepared from vineplant bunches without added nutrients is a suitable substrate alternative for bioethanol production.Item A clinical and sociodemographic evaluation of youths with substance use disorders in a child and adolescent inpatient unit of mental health hospitalBilaç, Ö; Kavurma, C; Önder, A; Dogan, Y; Uzunoglu, G; Ozan, EObjective: The aim of this study was to evaluate the demographic and clinical data of substance users who were intreatment in Mental Health Hospital Child and Adolescent Psychiatry Inpatient Department. Method: Medical records of substance user patients treated between 2014 and 2017 in Inpatient Child Psychiatry Unit of Mental Health Hospital were examined retrospectively. SPSS 20.00 Statistical Package Program was used for statistical analysis. Results: Ninety-two substance user child and youth had been treated. The median age of cases was 15,4 (SD +/- 1,4), the onset age of substance use was 13,1 (SD +/- 1,4). 68,5% of these case is male gender and 31,5% is female. The most common substance used is marijuana and extacy (62%), the substance user youth have met with the substance around friends (90,2%). Living conditions were found to be lower socioeconomic level (50%). Discussion: According to our clinic results, substance use is an important problem affecting youths, especially at lower socioeconomic level and male adolescents. Our study represents only the clinical sample, so there is a need for more community-based epidemiological studies.Item Plants used as natural dye sources in TurkeyDogan, Y; Baslar, S; Mert, HH; Ay, GThis study was carried out in the regions where handcrafts such as carpet and rug weaving are common in Turkey. In the regions where natural dyes are used, 123 plant species belonging to 50 families were identified as sources of natural dyes. In natural dye production, different parts of the plant or the whole aboveground plant is used. Ten different colors are gained from the plants. Sometimes the same color can be obtained from different plants. By mixing different plants, it is possible to produce various colors. We also identified more than 12 natural and more than eight chemical assistant substances (mordant) that are used in the regions to bind dye to fibers, to maintain the strongness and brightness of the colors, and to obtain various colors.Item Evaluation of the parental attitudes, parental competency and attachment styles of the mothers of the children at pre-school period who were admitted to child psychiatryBilaç, Ö; Önder, A; Kavurma, C; Dogan, Y; Uzunoglu, G; Isildar, Y; Sapmaz, SYObjective: In this study we aimed to evaluate attitudes, attachment styles to their husbands and competence perceptions of the mothers towards their children's problems whose children were at pre-school period with no cognitive developmental delay. Method: Fourty children and their mothers were included into the study. The children were chosen among those who were aged between 0-72 months and had no developmental delay which was found out as a result of developmental test. As the control group, another 40 children and their mothers were included into the study. Child Adjustment and Parent Efficacy Scale (CAPES-TR) and Parent Attitude Research Instrument (PARI) were handed out to mothers in both groups. Finally, Experiences in Close Relationship Revised (ECC-R) was applied to mothers of both groups. SPSS20 was used for statistical analysis. Results: According to CAPES-TR results, emotional, behavioural and social problems in the group that were admitted to psychiatry clinic were higher than control group (p<0.05). According to same scale, mothers' self-confidence was found significantly lower (p<0.05). According to PARI results, the score of the group that applied to clinic for over-motherhood reasons was found higher (p<0.05). Likewise, authoritative attitude score was found higher in patient group (p<0.05). Discussion: The results of this study share similarities with other studies which found out that parental child-rearing attitude presents a risk factor for behavioural problems among children.Item TRACE ELEMENT CONTENTS IN PLANTS GROWING AT MT. AKDAG, DENIZLIKula, I; Yildiz, D; Dogan, Y; Ay, G; Baslar, SThe present study was conducted to determine the current level of atmospheric heavy metal pollution in the Akdag Mountain of Denizli Province. The increase in industrial activities and human population and the high urbanization in Denizli and its environs have made it one of the rapid developing cities in the Western Anatolian part of Turkey. For this reason, Akdag Mountain of Denizli was chosen as the study area. Twenty nine different plants were selected to study their potential as biomonitors of trace elements such as Pb, Cd, Ni, Zn, Fe and Mn (mu g g(-1), dry weight). The samples were collected from two different altitudes of Akdag, a mountain overlooking at Denizli province. The concentrations of trace elements were determined by atomic absorption spectrometry. The mean concentrations determined at 1000 m altitude ranged from 0.329 to 0.487, 0.011 to 0.882, 0.241 to 0.714, 0.532 to 9.396, and 0.155 to 3.439 (mu g g(-1), dry weight), for Pb, Ni, Zn, Fe and Mn, respectively. At 1600 m altitude, the values ranged from 0.263 to 0.889, 0.092 to 0.600, 0.272 to 0.834, 1.130 to 8.021 and 0.076 to 0.508 (mu g g(-1), dry weight) for Pb, Ni, Zn, Fe and Mn, respectively. No Cd was detected at both altitudes. Statistical significance was determined by the independent sample t-test. In the independent sample t-test, comparisons were made in order to determine whether there were any differences between the averages of the herbaceous plants and woody plants.Item DETERMINATION OF TRACE ELEMENTS IN THE PLANTS OF MT. BOZDAG, IZMIR, TURKEYYildiz, D; Kula, I; Ay, G; Baslar, S; Dogan, YThe aim of this study was to determine the current level of atmospheric heavy metal content on the Bozdag Mountain of the Aegean Region, Turkey. Twenty nine different plants were selected to study their potential as biomonitors of trace elements such as Ni, Zn, Fe, Pb, Mn and Cd (mu g g(-1), dry weight). The samples were collected from two different altitudes of Mt. Bozdag. The concentrations of trace elements were determined by atomic absorption spectrometry. The mean concentrations determined at 1000 m altitude ranged from 0.025 to 1.609, 0.232 to 0.731, 0.578 to 5.983, 0.287 to 0.565 and 0.176 to 2.659 (mu g g(-1), dry weight), for Ni, Zn, Fe, Pb and Mn, respectively. At the altitude of 1600 m, the values ranged from 0.023 to 0.939, 0.258 to 1.254, 0.839 to 5.176, 0.301 to 1.341 and 0405 to 3.351 (mu g g(-1), dry weight) for Ni, Zn, Fe, Pb and Mn, respectively. No Cd was detected at either altitude. Statistical significance was determined by the independent sample t-test and comparisons were made in order to determine if there were any differences between the averages of herbaceous and woody plants.Item Trace element biomonitoring by leaves of Populus nigra L. from Western Anatolia, TurkeyBaslar, S; Dogan, Y; Yenil, N; Karagoz, S; Bag, HThe West Anatolian Region is one of the most important areas for industrialization, population density and traffic in Turkey. Therefore, the leaves of Populus nigra L. (Salicaceae), which are used as biomonitor to investigate the levels of the trace elements Cd, Pb, Fe, Zn and Cu, were sampled at 30 locations having different pollution levels in the region. The concentrations of elements were determined by atomic absorption spectrometry. The samples were collected at both reference and contaminated locations where iron was found as the priority element. The strong association between a gradient of contamination and concentration in all samples tested indicates that they are reflecting well the environmental changes, and that they appear as appropriate biological indicators of heavy metal contamination.Item A Multicenter Analysis of Subjectivity of Indirect Immunofluorescence Test in Antinuclear Antibody ScreeningFarasat, VT; Ecemis, T; Dogan, Y; Sener, AG; Ece, GT; Dündar, PE; Sanlidag, TObjectives: This study aims to evaluate the interpretation of the antinuclear antibody (ANA)-indirect immunofluorescence (IIF) test results based on the interpreter-related subjectivity and to examine the inter-center agreement rates with the performance of each laboratory. Patients and methods: The ANA-IIF testing was carried out in a total of 600 sera and evaluated by four laboratories. The inter-center agreement rates were detected. The same results given by the four centers were accepted as gold standard and the predictive values of each center were calculated. Results: The inter-center agreement was reported for ANA-IIF test results from 392 of 600 (65.3%) sera, while 154 of 392 results were positive. Four study centers reported 213 (35.5%), 222 (37.0%), 266 (44.3%), and 361 (60.2%) positive test results, respectively. In terms of the patterns, the highest and lowest positive predictive values were 72.3% and 42.7%, respectively, while the highest and lowest negative predictive values were 99.6% and 61.5%, respectively. The agreement for semi-quantitative evaluation at three levels of fluorescence intensity stated by four centers was detected in 100 sera at 87% 3(+), while the other two levels were 6% and 7%. The highest predictive value for the highest fluorescence intensity of 3(+) was found to be 71.9%. Conclusion: Significant differences may be observed among laboratories in terms of qualitative results, patterns, and semi-quantitative determination of the fluorescence intensity in the ANA-IIF testing, particularly at low fluorescence intensity levels and in those with speckled patterns. In case of any discrepancy between ANA-IIF test and clinical prediagnosis, the test should be repeated in another laboratory, if necessary.Item A Study of Trace Element Contents in Plants Growing at Honaz Dagi-Denizli, TurkeyBaslar, S; Kula, I; Dogan, Y; Yildiz, D; Ay, GDenizli is one of the rapidly developing states in the West Anatolian Region of Turkey Keeping this in view, 30 different plants were selected to study their potential as biomonitors of trace elements like Pb, Cd, Ni, Zn, Fe and Mn (mu g g(-1), dry weight). The samples were collected from two different altitudes of Honaz Dagi, a mauntain overlooking at state of Denizli. The concentrations of trace elements were determined by flame atomic absorption spectrometry (FAAS). The mean concentrations determined at 1000 in altitude ranged between 0.273 to 0.488, 0.099 to 0.488, 0.306 to 0.682, 1.017 to 3.744, and 0.148 to 0.674 (mu g g(-1), dry weight), of Pb, Ni, Zn, Fe and Mn, respectively. At 1600 in altitude, the values ranged between 0.225 to 0.534, 0.150 to 0.842, 0.234 to 0.905, 1.082 to 3.864 and 0.023 to 0.982 (mu g g(-1), dry weight) of Pb, Ni, Zn, Fe, Pb and Mn, respectively. No Cd was detected at both altitudes.Item Changes in some Candida albicans virulence factors due to amphotericin-B post-antifungal effectOzkutuk, A; Dogan, Y; Kirdar, S; Ozkutuk, NItem The Frequency of Lysosomal Acid Lipase Deficiency in Children With Unexplained Liver DiseaseKuloglu, Z; Kansu, A; Selbuz, S; Kalayci, AG; Sahin, G; Kirsaclioglu, CT; Demirören, K; Dalgiç, B; Kasirga, E; Önal, Z; Islek, A; Eren, E; Hosnut, FÖ; Urganci, N; Yaman, A; Özkan, T; Bozbulut, E; Dogan, G; Eksi Bozbulut, N; Dogan, G; Durmaz Ugurcan, Ö; Usta, AM; Arslan, D; Akçam, M; Isik, IA; Ecevit, ÇÖ; Usta, Y; Özgür, T; Özçay, F; Balamtekin, N; Öztürk, Y; Balamtekin, N; Öztürk, Y; Cantez, S; Gülerman, F; Üstündag, GH; Emiroglu, HH; Karacabey, N; Comba, A; Erdemir, G; Aydogan, AU; Gökçe, S; Kuyum, P; Gülsan, M; Tosun, MS; Tokgöz, Y; Güven, B; Yüksekkaya, H; Tümgör, G; Eren, M; Baran, M; Gümüs, M; Canan, O; Kocamaz, H; Gerenli, N; Çakir, M; Agin, M; Hizli, S; Dogan, Y; Çeltik, Ç; Deveci, U; Balci Sezer, OObjectives: Evidence suggests that lysosomal acid lipase deficiency (LAL-D) is often underdiagnosed because symptoms may be nonspecific. We aimed to investigate the prevalence of LAL-D in children with unexplained liver disease and to identify demographic and clinical features with a prospective, multicenter, cross-sectional study. Methods: Patients (aged 3 months-18 years) who had unexplained transaminase elevation, unexplained hepatomegaly or hepatosplenomegaly, obesity-unrelated liver steatosis, biopsy-proven cryptogenic fibrosis and cirrhosis, or liver transplantation for cryptogenic cirrhosis were enrolled. A Web-based electronic data collection system was used. LAL activity (nmol/punch/h) was measured using the dried blood spot method and classified as LAL-D(<0.02), intermediate (0.02-0.37) or normal (>0.37). Asecond dried blood spot sample was obtained from patients with intermediate LAL activity for confirmation of the result. Results: A total of 810 children (median age 5.6 years) from 795 families were enrolled. The reasons for enrollment were unexplained transaminase elevation (62%), unexplained organomegaly (45%), obesity-unrelated liver steatosis (26%), cryptogenic fibrosis and cirrhosis (6%), and liver transplantation for cryptogenic cirrhosis (<1%). LAL activity was normal in 634 (78%) and intermediate in 174 (21%) patients. LAL-D was identified in 2 siblings aged 15 and 6 years born to unrelated parents. Dyslipidemia, liver steatosis, and mild increase in aminotransferases were common features in these patients. Moreover, the 15-year-old patient showed growth failure and microvesicular steatosis, portal inflammation, and bridging fibrosis in the liver biopsy. Based on 795 families, 2 siblings in the same family were identified as LAL-D cases, making the prevalence of LAL-D in this study population, 0.1% (0.125%-0.606%). In the repeated measurement (76/174), LAL activity remained at the intermediate level in 38 patients. Conclusions: Overall, the frequency of LAL-D patients in this study (0.1%) suggests that LAL-D seems to be rare even in the selected high-risk population.Item Familial Mediterranean Fever Mutation Analysis in Pediatric Patients With Inflammatory Bowel Disease: A Multicenter StudyUrganci, N; Ozgenc, F; Kuloglu, Z; Yüksekkaya, H; Sari, S; Erkan, T; Önal, Z; Çaltepe, G; Akçam, M; Arslan, D; Arslan, N; Artan, R; Aydogan, A; Balamtekin, N; Baran, M; Baysoy, G; Çakir, M; Dalgiç, B; Dogan, Y; Durmaz, Ö; Ecevit, Ç; Eren, M; Gökçe, S; Gülerman, F; Gürakan, F; Hizli, S; Isik, I; Kalayci, AG; Kansu, A; Kutlu, T; Karabiber, H; Kasirga, E; Kutluk, G; Hosnut, FÖ; Özen, H; Özkan, T; Öztürk, Y; Soylu, ÖB; Tutar, E; Tümgör, G; Ünal, F; Ugras, M; Ustundag, G; Yaman, ABackground: the aim of the study was to evaluate familial Mediterranean fever (FMF) mutation analysis in pediatric patients with inflammatory bowel disease (IBD). The relation between MEFV mutations and chronic inflammatory diseases hos been reported previously. Methods: Children with IBD (334 ulcerative colitis (UC), 224 Crohn's disease (CD), 39 indeterminate colitis (IC)) were tested for FMF mutations in this multicenter study. The distribution of mutations according to disease type, histopathological findings, and disease activity indexes was determined. Results: A total of 597 children (mean age: 10.8 +/- 4.6 years, M/F: 1.05) with IBD were included in the study. In this study, 41.9% of the patients had FMF mutations. E148Q was the most common mutation in UC and CD, and M694V in IC (30.5%, 34.5%, 47.1%, respectively). There was a significant difference in terms of endoscopic and histopathological findings according to mutation types (homozygous/heterozygous) in patients with UC (P <.05). There was a statistically significant difference between colonoscopy findings in patients with or without mutations (P=.031, P=.045, respectively). The patients with UC who had mutations had lower Pediatric Ulcerative Colitis Activity Index (PUCAI) scores than the patients without mutations (P=.007). Conclusion: Although FMF mutations are unrelated to CD patients, but observed in UC patients with low PUCAI scores, it was established that mutations do not hove a high impact on inflammatory response and clinical outcome of the disease.Item The use of wild edible plants in western and central Anatolia (turkey)Dogan, Y; Baslar, S; Ay, G; Mert, HHDogan, Yunus (Dokuz Eylul University, Faculty of Education, Department of Biology, 35150, Buca-Izmir, Turkey; e-mail yunus.dogan@deu.edu.tr), Suleyman Baslar (Dokuz Eylul University, Faculty of Education, Department of Biology, 35150, Buca-Izmir, Turkey), Gungor Ay (Celal Bayar University, Faculty of Science-Art, Department of Biology, Muradiye-Manisa, Turkey), and Hasan Huseyin Mert (Dokuz Eylul University, Faculty of Education, Department of Biology, 35150, Buca-Izmir, Turkey). THE USE OF WILD EDIBLE PLANTS IN WESTERN AND CENTRAL ANATOLIA (TURKEY). Economic Botany 58(4):684-690, 2004. In this study, 121 wild edible plants used as food in Anatolia were surveyed to determine the plant parts used and their detailed preparation methods. The results of this study show that the plants may be boiled, fried in fat, and eaten raw or as rolled vegetables. They may also be consumed as pickles, fruits, sweets and spices, and drunk as cold and hot drinks. Thirty species (8 genera) were identified as belonging to the Lamiaceae family, 15 species (15 genera) belong to the Asteraceae family, 13 species (5 genera) belong to the Rosaceae family, 8 species (7 genera) belong to the Brassicaceae family, 6 species (3 genera) belong to the Orchidaceae family and 5 species (5 genera) belong to the Apiaceae family. The genera represented by the highest number of species in the study are as follows: Sideritis L. is represented by 13 species, Origanum L. by 7 species, Rubus L. by 5 species, Thymus L. by 4 species and Rumex L. by 4 species.