Browsing by Author "Dogru, Y"

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    Effects of eccentric exercise-induced delayed onset muscle soreness on endoplasmic reticulum stress-related markers
    Dogru, Y; Varol, SR; Nalcakan, GR; Akyuz, M; Tas, M; Ulman, C
    Short Communications: Apelin, pentraxin3 (PTX3), and interleukin6 (IL6) parameters are known as inflammation markers and found to be related to endoplasmic reticulum (ER) stress. The aim of the study was to investigate the effect of eccentric exercise-induced delayed onset muscle soreness (DOMS) on ER stress-related markers in young athletes. Objectives and Methods: ER stress and DOMS-related blood markers, maximal strength level, and rate of perceived exertion using the visual analog scale (VAS) were assessed before, immediately after, 24, 48, and 72 h after the muscle damage protocol. Results: IL6 peaked 24 h after while creatine kinase and lactate dehydrogenase enzyme levels reached their peaks at 72 h after the protocol. The level of apelin continued to increase throughout the four measurements, and PTX3 peaked at 24 h, and then declined to the levels before the protocol but the differences were not significant. The significant decrease in the strength and the significant increase in VAS continued 48 h after the protocol. Conclusion: ER is activated and ER stress occurred, due to increases in IL6, PTX3 and apelin levels after the test protocol concluded that a single vigorous eccentric exercise should be avoided in harmful effect on health as parallel with Physical Activity Guidelines.
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    The effects of various strength training intensities on blood cardiovascular risk markers in healthy men
    Akyüz, M; Dogru, Y; Nalcakan, GR; Ulman, C; Tas, M; Varol, R
    Objectives Regular physical exercise, especially aerobic exercise, is known to have a protective effect on cardiovascular health. The aim of this research is to look at the impact of two separate resistance training programs on blood biomarkers that are associated with the early detection of cardiac risk. Methods Forty-five male participants (mean 41 years) were randomly divided into three groups: The low-intensity resistance exercise group (LIEG), the moderate-intensity resistance exercise group (MIEG), and the control group (CG). The programs were implemented three times a week and in two sets. MIEG consisted of 8-10 repeats at 70-80% density of one repetition maximum load (1RM), while LIEG consisted of 15-17 repeats at 50-60% density of 1RM. CG did not participate in any exercise program. Two-factor mixed-design ANOVA assessed the data. Results Before, fourth week, and after the exercise program in repeated measurements, there was a significant decrease in body mass (-1.7%), body mass index (-1.7%), apelin (-44%), and pentraxin 3 (-39%) levels in MIEG (p < 0.05). Additionally, our study noted a decrease in pentraxin 3 (-25%, p < 0.05) and interleukin 6 (-21%) levels, while there was an increase in creatine kinase (18%), and lactate dehydrogenase (7.4%) levels in LIEG. Strength levels improved significantly in exercise groups. Conclusions Eight weeks of moderate-resistance training can potentially reduce the cardiovascular risk in healthy men.
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    Effects of two different eight-week walking programs on insulin resistance and ER stress-related markers in pre-menopausal women
    Dogru, Y; Büyükyazi, G; Ulman, C; Taneli, F; Tikiz, H; Göral, M; Esen, H
    Objective: The relationship between exercise and endoplasmic reticulum (ER) stress, insulin resistance, and obesity is a new field of research. To our knowledge, there are no studies examining the effects of walking exercises on ER stress related markers and insulin resistance in pre-menopausal women. To examine the effect of two different eight-week walking programs on the tumor necrosis factor-alpha (TNF-alpha), Fetuin-A (alpha 2 - Heremans Schmid glycoprotein), c-Jun N-terminal kinase-1 (JNK-1) and retinol-binding protein-4 (RBP-4), the related markers of ER stress and insulin resistance in pre-menopausal women. Methods: Exercise groups (moderate tempo walking group; MTWG; n=11; brisk walking group BWG; n= 12) walked five days a week, starting from 30 minutes, gradually increasing up to 51 minutes. BWG walked at similar to 70-75% and MTWG at similar to 50-55 of HRRmax. Body mass index (BMI), body fat percentage (%), VO2max, serum TNF-alpha, Fetuin-A, JNK-1, RPB-4, blood lipids, and insulin resistance levels were determined before and after the intervention. Results: VO2max increased in both exercise groups favoring BWG; RBP-4 decreased in both exercise groups (p<0.05). Serum TNF-alpha and, TG (p<0.05), BMI and percent body fat (p<0.01), and insulin levels reduced significantly in BWG (p<0.05). The reductions observed in both exercise groups in insulin resistance, and the increases determined in the negative levels of JNK-1 in BWG may be clinically important. Conclusion: Both type of walking resulted in similar positive effects on RBP-4. The reduction observed in TNF-alpha, RBP-4, and the increases in the negative levels of JNK-1 in BWG show the positive effects of brisk walking on ER stress. The reduction in insulin resistance in relation to the possible reductions in ER stress and apoptosis in BWG may be more effective to prevent metabolic diseases.
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    Effects of aerobic plus explosive power exercises on bone remodeling and bone mineral density in young men
    Çay, V; Buyukyazi, G; Ulman, C; Taneli, F; Dogru, Y; Tikiz, H; Gümüser, G; Oran, A; Keskinoglu, P
    Objectives: This study aims to examine effects of aerobic jogging and explosive power exercises on body composition, maximal oxygen consumption (MaxVO(2)), bone mineral density (BMD) and bone turn-over markers: serum bone alkaline phosphatase (BAP), C terminal telopeptide (CTx), Procollagen type I N-terminal propeptide (PINP), in men aged between 20 and 40. Materials and methods: Thirty seven healthy males were divided into exercise group (EG, n = 19) and control group (CG, n = 18). EG completed 10 weeks of outdoor aerobic (jogging at 60-70% maximal heart rate reserve starting from 20 min steadily increasing up to 28 min) and explosive power exercises (in 2-3 sets, with maximum repetitions lasting 15 s), 3 times per week. All measurements were taken before and after the exercise program. BMD was measured via dual energy X-ray absorptiometry (DEXA). Results: Body mass index (p < 0.001) significantly decreased; MaxVO(2) (p < 0.001), femur neck (p = 0.036) and total score BMD significantly increased in EG (p = 0.034). BAP and vitamin D increased in both groups (p < 0.001). Conclusion: Performing our outdoor exercise program in spring months might have an important role in the significant increase (9 vs. 22 ng/mL) in mean vitamin D level, which reached above the fracture risk level of 20 ng/mL.
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    The effect of 8-week different-intensity walking exercises on serum hepcidin, IL-6, and iron metabolism in pre-menopausal women
    Buyukyazi, G; Ulman, C; Çelik, A; Çetinkaya, C; Sisman, AR; Çimrin, D; Dogru, Y; Kaya, D
    Objective: Hepcidin may be an important mediator in exercise-induced iron deficiency. Despite the studies investigating acute exercise effects on hepcidin and markers of iron metabolism, we found no studies examining the chronic effects of walking exercises (WE) on hepcidin and markers of iron metabolism in premenopausal women. The chronic effects of two 8-week different-intensity WE on hepcidin, interleukin 6 (IL-6), and markers of iron metabolism in pre-menopausal women were examined. Methods: Exercise groups (EG) [moderate tempo walking group (MTWG), n = 11; brisk walking group (BWG), n = 11] walked 3 days/week, starting from 30 to 51 min. Control group (CG; n = 8) did not perform any exercises. BWG walked at similar to 70%-75%; MTWG at similar to 50%-55% of HRRmax. VO2max, hepcidin, IL-6, and iron metabolism markers were determined before and after the intervention. Results: VO2max increased in both EGs, favoring the BWG. Hepcidin increased in the BWG (p < 0.01) and CG (p < 0.05). IL-6 decreased in the BWG and the MTWG (p < 0.05; p < 0.01). While iron, ferritin, transferrin, and transferrin saturation levels did not change in any group, total iron binding capacity (p < 0.05), red blood cells (p < 0.05), and hematocrit (p < 0.01) increased only in the BWG. Conclusion: Both WE types may be useful to prevent inflammation. However, brisk walking is advisable due to the positive changes in VO2max and some iron metabolism parameters, which may contribute to prevent iron deficiency. The increase in hepcidin levels remains unclear and necessitates further studies.